HUE025528T2 - 1'-szubsztituált carba-nukleozid analógok antivirális kezeléshez - Google Patents
1'-szubsztituált carba-nukleozid analógok antivirális kezeléshez Download PDFInfo
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- HUE025528T2 HUE025528T2 HUE09734175A HUE09734175A HUE025528T2 HU E025528 T2 HUE025528 T2 HU E025528T2 HU E09734175 A HUE09734175 A HU E09734175A HU E09734175 A HUE09734175 A HU E09734175A HU E025528 T2 HUE025528 T2 HU E025528T2
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- C—CHEMISTRY; METALLURGY
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (2)
- :S?aikaáatoí1. Köptet ? ««mtivegyőlel:kápíaR; s vagy Mtiaik gyógymi^siseiukg $$1¾ $ *1: Π, OR* NíR'L N;, CN; NO;, S(0)aRs. r,*M*.. j , V^K ** > '»>K kJ 4M vx vWl"."v* 'S *'N * ' ^ 0 '* a' \ν«Λ ^tóXUáJV «.!&*>"«.·· K'5- Cs)&ííí.íííJÚ iCrCi;}-SA«bsít!i«ísk OkOO vssív K:iRCO:s)OkR; v&gy prfsselylk: két R\ 0, b\ 0 vm:0 ^<^éé&s *zm mm>kmi, h& smt - 10 OíCQp· hí: t'gyüu va®É véve * gy§*§ ajady^áte-i^soi&áasíf, te»#* sfetssak; Rí: OR'; m%*’>·:- N* CK >í% SíO^Rk -C{«0}&u. «C(-DX>R|*, - |íO)Eí!t -$φ}&η> 'Síö}(Orí;). .,..::^0^.. <CrC$.)»iM:> t«ír c0Kb®mmii íc&mtewmii *ί*ι <&$&&*#& «μ, ^c^m, |.§ :(^v<ía)sáiii'Si:;5i3.sU aUciaiL vagy snU'C*· QsOlal '·&¥? & ***? R v*®' R ' rs3 íisyiití v&saa*· vöv* OfCOm ásísáögyik a %gsfcül S, Ε -ν&ρ ?; ; W^y\k. SÓ Rigg«tit>a|jl ir^C^OsJsIk!^. (CrC^lNftli ~:Cs>síi£«í OaJks^ísMskMk HPH>jRUv "C{-0}0ltu( b^9^,>ri^9Mj SiMé:\ m í>mor% ~%oum% vagy ok>>hr;'E!í; 0 i, 4j*oy&l\ -Cí'-"OK)R;\ .a*0)NR*}RiS, ~C{“0}$R!\ -S(0)R''. SujsjR' .-^kííO^' j. v$(0>s(ORl'!}v v&gy«Ufttyfc v vagy V'' . O, S< NR. Τ*)*». >*<»'. 'NíOROR;. vagy ^R·.; 2$ Ψ és W\ fe cgyön v^k vív* ^ v*& W" β®** R * "d *** r -«t -Ψ- ésWS-«gyW' i&ástka U?\# **'. vagy W* & W* rogyik*. 9b«L«»>'· «gy k^í«t te botsán;képi st .shcíl: : mindegyik \ö: " m&mm l ' ' SX ^ x χλγν \ N RR s ^ N !S(Ö>,vágySÍ:Ö)j; : ϊ^"·ί^γϊ|ζ v ^ &§g«Ueftti! 0, S, v&gy NA; M2 lg J vagy 2: aaksáegyík R* űsggitksiR Ry v&gy a fesplsr.ahes: ^ mskifcgyjk Mis,: UH, hMU ö *&gy; 1; M*fc 0. ι.ί,Μ,^δ.τΛΜΜ* v«n( ;: ffsjíiásgyjks' SiíggsPíífsuí íijCs>^ k. v·',. .^; \ yy \k ' " 'Γ', íX'^k- NiK- 4®, -$;o;x -¾¾¾ Moumi ^{«y^-oc^fpíí, ~ SC5(' Y!}R; ~S€K“V'}0&< 'SGp Y'Jv^PXí .-^^Rjec^y·^ ♦ íg «KjfcNRt, -CN, -N> XG*> -ÖR, vsgy W3; vagy fc* ^8.v»sk m^M0? *#«^2<50'«», S-? aafeaiaxeos kiMx:;vá.kiS:0.'í gyvsví sikoi: jKíKífagysk'11 ííiggeUssüi H. íCj^-s? *iSt,K (i.VCy> s;}sib«s;R^U a&& (03·4··ί},**&κι*1> s^í-C*.? «mh%ttÍKá)t aikftőii, &VCs.> aM (CrC*) saa'&tóstó 8&ma. c, Qs vút Crt* fcZ»*«&«éH arii, tv C>c. hítffi-isákb; Γ,Ό.κ sSuUihm&k HiíaryVli, anííPki; vagy &*ubszsteis!s. arüslkit; 20 \vs vxgy Wp X R^€(Y1;Rk-C(YiP^\..so^Rk^y^O;Wk.é5W> egy kaibeePhss vagy hvt'íi''"«slsb.ss, aVasW' JSggí*ie««l éasib'Kíuvy»»: 0*5 Ψ* cxopoxysk «xiadígyikX^a&vX* XgeVVk O-R >v-N. .^adegyjk Rs bsJo*«>. K'ki:.R’\ N(k'!)OR!if N<, NÖ> NO*. CHO. CN, - CF^NRX -CH-'-';NHH'R:\ -CH«-Ni'ORi:}. 'CH{OR;i}5< <'(»0}:NRí!R!\ 4:XS)NE:\Rs\ CÍ"O}0E!\ 2S (CrCsteíkü, (CyC^^rr-l fCrQmimil (C^Q}kaírhoí-M^tM, Dpei&UUm **uh*zümii ml opcks'^ksía-s síAlteto&t haercatü. <tf"0){Cs*Q»Ikjl» "SíO)*{€i-C*}*lk& sPRQX>s^> OK" v*$?. SR}Í; χχοά«ΑΥ& ír vs.gy Η”' B, Ns ' N(R K?K xv ^ x ^ T40?, c*>. CH. -€tíH^!X .C!!*NHNR5\*CH«N(ORiKa «0*0»“* 'C{<í}NR;iH.l5; .-C{-S)NRiS.S:;, ssísáiftfvÉ R'1 m$y Éi:i S?( (0*Gf&&ií> i€^}xbsmíi> f^C^feiásGi**· β €t)k3íb^ikli!sikíS. «jfétóiSfcá sril spsiásá&ss. s^ssz^lt .fec&s&saíü, « -^««Οχϋ,- v&gy sn!PeG}s« SSÍ5&X5& ksgsxsIMR $&y bi S3í&$* §s$ f ksiy&sMasss gyílsii fcs«íyss; « Umk^fsl·· -ex - S- vm í;hol :^j«4sgyife:CCrC,Jsia Cfc€s)§!fce«?i íCy ^gy «3£rof aMwik R* is M> r?s r4, i?; e* r« #:, $φ«Μ, t&etoei»w férném m *m **»* *· feküí: Msgésg Sktefc CHS N>. N(R''}>. vsgy 01*; #.« a CC,-G}aíkú asm tenants μΛομο$» -Ov·*· vagy-KIO. a. Asr ?,· ig^^öíS sze&ntiysgyüUs, sstóys?. * s#ks il MpNMritf ..... " , : :: ií : képiét 15 ásf Xs 0>p!JGs mkáégyisG G Y: Ό.:;: E i, vagy 2, igóiypost ssfastatt v®g5^2«í, gköí :: se I^R -., P[E )GK , mnmnx% QRihm$ywnf. 4. A* 1-5. M^etypontok '$ánnd>-<ke ugrimi vigyük? ah»· R* H vagy ΝΕ’Έ". 5. λ* !A^^yp^íokb«xs)é^^^naí{v«|?>iifeu&hol E' Kvagy•NA ά-v? Íi.. ΛΧ {«$. igíaypjííök bé«8«$yR* *«>*»«* vegylUsg ultit A4 <2k\ N* Mog&x Í-G *»*$> kxisSJímAE ^a;isbx£íj?tislí SS«G> eas?R> sa&'satifcsáR «ten*·, vagy ««teiíG;?. snml ?. Aa I -E ^s^MfeR*>áná«lps« «.orsaí; vigyük &hoi X" Őrt «» RJ é$ iV mtsKkgysk H $. M1". ^&^8Rá.:Í«#e smk& V«gy0)«k R* vagy E* koxö? lc.g»m *gy GR4. 9, -te í*$Pigé)Sy^tak báneéS??^ A£«».5» Nr»\«tei. 4Í*N λ N ''λΟ R" ^hoi R' H, GlsgéK- CK f4gyt>ps*ssÁü%'x á2«E*xi>n*M mm®?*......... •0. As ).* igényporM- oSraftlyü* «.««i'Hi νΦ»^,at»i R‘c«^' ssstakgyifeORx II. AK 1Ί0. Ig^yposíok bá«as^iR« mno® Vfigyaast, ah*>i R'«*K -'5^' 51 As M L 5|;ís^s*^í!í.M.ymeSy5ls« v§gy5ÍS«$, dsjl A' !i J3. Ak |-||. ígáöypjíiiok: béríádyöíe sassssU AsgySSíA skAi .A' C-H.
- 54, As 143. sg«s:v>«ostöl·' MrraAÍyöcé assrisá wgsAi shöl W K, m«H5s. CHjOii CHjF, M&Siú^ vsgy essil. 3 i$. Az Ι-Ή. igesypaiiSvik Mixiidyiks sKexisA vegy&At 4x4 W! és Ψ2 ötía^gyjfcs,. iSggeíissűi, s képiéi .bísopíst 1« As 144, igásytsojsok bán&§l>'&4 sssAxxti vsgyűfci, s&»5ki VSS viisssivs & 5®v'«tke,Aik kASíü:ahol 'A s ^ggíAsosSL ágy ksAés, 0, vagy CBA, •3 57, Aa 544, ;gásy|xsSökbáx!Sdyskux«xiA5ss^gyiii&i, sM B.; &. i A As ·. igsxsxypöSAxk bscsselyiks ss«ns5i vsgyiíkA sm4yvagy $6$%·;·- ..*$. l ' ->" "> '!VV mV \N\ - n \ 4, i , ,, <?< S{.»t < i '{sv ».s Ν' 50 íiiUtO'vTi-'X poUsfttsrí. pssíüáfipiiiiswf*lsk.h&& vagy srsrtrf siskhaí; '-«fi iík^ SO, : 4 4 kuxpspskk S:SS^|>'i^jSí§feaxg8 «ζ :í|«S|pipt# b&SKsMy&®íSa«ppíX Vagyaid "; vevápiásat; hatása* RurnttyKégtí & gjtógy^testjfeg dfcíg&áfe&tö h^3x<Mr,ya%o& it. Á M. j#s##í s^feá g^gv^^s^ií koötjkBfkdé, 'mely sombM'^0bb s0 íövékki t«á$íj*s 5 21 A. Ζ%,χφ%ρ>& u^^^^^s^iéi^Mposski^ ahe< s további terápiás §«srki vaa váktsivs. pv«t^*’í;ékMI Má t^tporgM uttftfctWK'lf a&ayjjp «n*i4$& NS3 prukMa fcsbitaasfok, NSSs í?5h;bi>orok; &S$t> ftdiméMa tnhfc&ttsfe, iJallMíörbk, JkbSiin lahibitöíok, hepswvédök, Ht'V asm- wklá)*® Mmtixm P isis HCV fcdéséts. sí, ik-i-B. wntMű jppfcá|teám 10 Vágy vinxsos tnibkdó k«f?ksífí, 3r««iycs f/>ív?sgró&a i«úsd vinsgs «k>;;utt. 24. A. 23, ®%0M sksl: a. wms& élteiét β k&vítkíSík:»; íilló vsGpöitíxd van kivéiiásxn<s ássps virus, sPpIP virus. kyiupi sM&si vfefS»· $ψ&8 ^^«A.’SÍfea: «ω&Ββ* vln;S, Kmjin vírus. M'unsy Vslky euüph«Í5d< virus, St U»l «sspkgőíis: vlasra, Omsk Jsprprifisgikas Ma vims, fcökss vsasS Maiskp víma 1¾ vMs és 15 J-lspakisC vPis. 2&, -M 34 igtmsjtORt sáenhá Vegyid &ί:"* viÉ^,'::i8ÉI&Í!^ HepííSfe üO virus okozza. 24,: μ 24,2$. spSypusp. kámgsyiP saödíks v*#Öfct íMhssKpásrsg «tv ísts&lm^a legalább *gy árvItéMaMpés sssrsdagMssM, 20 22,: * M. |po;#í$í mstMí vep&lsfc· ától δ w -WÉs k^é.'w « MvsteőkM SaMimd m^mMí *m Mtélmsmc hmks«««k ál»#rt» kfiííiSpK, » psiste »ífeé, Ν» iksl&tek, Η» polios kkbdcrőM síiMglukéMMa * Mlíibei5.: dkteSsx trJ:dbijorok,.hsg5«íovéíii>k; HCV ftm-tsdcko»á inhibits! & más gpgysasrp: HCV kezelésére.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4726308P | 2008-04-23 | 2008-04-23 | |
US13944908P | 2008-12-19 | 2008-12-19 |
Publications (1)
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HUE025528T2 true HUE025528T2 (hu) | 2016-05-30 |
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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HUE15155479A HUE038946T2 (hu) | 2008-04-23 | 2009-04-22 | 1'-szubsztituált carba-nukleozid analógok antivirális kezelésre |
HUE09734175A HUE025528T2 (hu) | 2008-04-23 | 2009-04-22 | 1'-szubsztituált carba-nukleozid analógok antivirális kezeléshez |
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