HU225774B1 - Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives, method for their preparation, pharmaceutical compositions comprising thereof and their use - Google Patents
Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives, method for their preparation, pharmaceutical compositions comprising thereof and their use Download PDFInfo
- Publication number
- HU225774B1 HU225774B1 HU0002514A HUP0002514A HU225774B1 HU 225774 B1 HU225774 B1 HU 225774B1 HU 0002514 A HU0002514 A HU 0002514A HU P0002514 A HUP0002514 A HU P0002514A HU 225774 B1 HU225774 B1 HU 225774B1
- Authority
- HU
- Hungary
- Prior art keywords
- phenyl
- methyl
- ethyl
- fluoro
- acetic acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 34
- 239000002253 acid Substances 0.000 title claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 10
- 238000002360 preparation method Methods 0.000 title claims description 9
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- 150000001875 compounds Chemical class 0.000 claims description 132
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- -1 chloro, methyl Chemical group 0.000 claims description 44
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
- 239000000651 prodrug Substances 0.000 claims description 22
- 229940002612 prodrug Drugs 0.000 claims description 22
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- 230000002401 inhibitory effect Effects 0.000 claims description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 8
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- 206010061218 Inflammation Diseases 0.000 claims description 6
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- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 claims description 5
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- DIBRALKMONMLNT-UHFFFAOYSA-N 2-[2-(2-chloro-4,6-difluoroanilino)-5-methylphenyl]acetic acid Chemical compound OC(=O)CC1=CC(C)=CC=C1NC1=C(F)C=C(F)C=C1Cl DIBRALKMONMLNT-UHFFFAOYSA-N 0.000 claims 1
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6983797P | 1997-08-28 | 1997-08-28 | |
| US5780397P | 1997-08-28 | 1997-08-28 | |
| PCT/EP1998/005414 WO1999011605A1 (en) | 1997-08-28 | 1998-08-26 | Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0002514A2 HUP0002514A2 (hu) | 2000-12-28 |
| HUP0002514A3 HUP0002514A3 (en) | 2002-11-28 |
| HU225774B1 true HU225774B1 (en) | 2007-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| HU0002514A HU225774B1 (en) | 1997-08-28 | 1998-08-26 | Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives, method for their preparation, pharmaceutical compositions comprising thereof and their use |
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| CO4960662A1 (es) * | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| WO2000025779A1 (en) * | 1998-11-02 | 2000-05-11 | Merck & Co., Inc. | Method of treating migraines and pharmaceutical compositions |
| US20040053900A1 (en) * | 1998-12-23 | 2004-03-18 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an aromatase inhibitor as a combination therapy |
| US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
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- 1998-08-26 SI SI9830448T patent/SI1007505T1/xx unknown
- 1998-08-26 AU AU95340/98A patent/AU743371B2/en not_active Expired
- 1998-08-26 KR KR1020007001982A patent/KR100637296B1/ko not_active Expired - Lifetime
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- 1998-08-26 HU HU0002514A patent/HU225774B1/hu active Protection Beyond IP Right Term
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2000
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2001
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2002
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2003
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2007
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2009
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