HU201071B - Process for producing new 9-(2-hydroxy-ethoxy-methyl)-guanin-esters and pharmaceutical compositions containing them - Google Patents
Process for producing new 9-(2-hydroxy-ethoxy-methyl)-guanin-esters and pharmaceutical compositions containing them Download PDFInfo
- Publication number
- HU201071B HU201071B HU884332A HU433288A HU201071B HU 201071 B HU201071 B HU 201071B HU 884332 A HU884332 A HU 884332A HU 433288 A HU433288 A HU 433288A HU 201071 B HU201071 B HU 201071B
- Authority
- HU
- Hungary
- Prior art keywords
- esters
- pharmaceutical compositions
- guanin
- ethoxy
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Description
Szabadalmas:
: THE WELLCOME FOUNDATION
LIMITED, London, (GB) ¢54) ELJÁRÁS 9— (2-HIDROXI-ETOXI-METIL ) —
-GUÁNXN-ÉSZTEREKfeS ILYEN VEGYÜLETEKET TARTALMAZÓ GYÓGYÁSZATI KÉSZÍTMÉNYEK ELŐÁLLÍTÁSÁRA (57) KIVONAT
A találmány tárgya eljárás (I) általános képletű 9- (2- hidroxi-etoxi- metil)- g uanin-észterek vagy gyógyászatilag alkalmas sóik előállításé- 5 ra, amelynél egy (II) általános képletű vegyületet adott esetben védett valinnal vagy izoleucinnal vagy ezek funkcionálisan egyenértékű származékával reagáltatnak, vagy egy (IV) általános képletű vegyületet és egy (V) 10 általános képletű vegyületet reagáltatnak, majd adott esetben - tetszés szerinti sorrendben i) eltávolítanak valamely védócsoportót, 15 ii) ha a kapott vegyület (I) általános képletű vegyület, azt gyógyászatilag alkalmas sójává alakítják és iii) ha a kapott vegyület az (I) általános képletű vegyület gyógyászatilag alkalmas sója, azt (I) általános képiétű vegyületté alakítják.
A képletekben
Rí jelentésé -CH(CHs)2 vagy -CH(CH3)CH2CHa csoport,
X jelentése adott esetben védett hidroxilcsoport,
Y jelentése adott esetben védett aminocsoport,
Q jelentése kilépő atom vagy csoport,
A jelentése kilépő atom vagy csoport és R2 jelentése adott esetben védett aminocsoport.
Claims (2)
- A vegyületekböl vírusellenes hatású gyógyszerkészítmények állíthatók elő.A leírás terjedelme: 14 oldalt 1 rajt, 4 ábra-1OHCH2OCH2CH2OHN lúr.w ( II ) .Y^Nf ^N' ó (, iv i ach2 och2ch2oqochiír,jr2 tv cí
- 2·
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878719367A GB8719367D0 (en) | 1987-08-15 | 1987-08-15 | Therapeutic compounds |
GB878725939A GB8725939D0 (en) | 1987-11-05 | 1987-11-05 | Therapeutic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
HUT47935A HUT47935A (en) | 1989-04-28 |
HU201071B true HU201071B (en) | 1990-09-28 |
Family
ID=26292613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU884332A HU201071B (en) | 1987-08-15 | 1988-08-12 | Process for producing new 9-(2-hydroxy-ethoxy-methyl)-guanin-esters and pharmaceutical compositions containing them |
Country Status (30)
Country | Link |
---|---|
EP (2) | EP0596542B1 (hu) |
JP (2) | JPH0662623B2 (hu) |
KR (2) | KR960002849B1 (hu) |
CN (1) | CN1033701C (hu) |
AP (2) | AP160A (hu) |
AT (1) | ATE138660T1 (hu) |
AU (1) | AU612393C (hu) |
CS (1) | CS276903B6 (hu) |
CY (1) | CY1833A (hu) |
DE (1) | DE3855333T2 (hu) |
DK (2) | DK170045B1 (hu) |
ES (1) | ES2087639T3 (hu) |
FI (1) | FI89713C (hu) |
GR (1) | GR3020372T3 (hu) |
HU (1) | HU201071B (hu) |
IE (1) | IE65551B1 (hu) |
IL (1) | IL87434A (hu) |
LU (1) | LU88746I2 (hu) |
LV (1) | LV5264A3 (hu) |
MC (1) | MC1968A1 (hu) |
MX (1) | MX9203418A (hu) |
MY (1) | MY103760A (hu) |
NL (1) | NL960001I2 (hu) |
NO (2) | NO167805C (hu) |
NZ (1) | NZ225809A (hu) |
PL (1) | PL158285B1 (hu) |
PT (1) | PT88261B (hu) |
SA (1) | SA95160244B1 (hu) |
SG (1) | SG26346G (hu) |
SU (1) | SU1634138A3 (hu) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP160A (en) * | 1987-08-15 | 1991-11-18 | The Wellcome Foundation Ltd | Therapeutic acyclic nucleosides. |
GB8816760D0 (en) * | 1988-07-14 | 1988-08-17 | Wellcome Found | Therapeutic compounds |
GB8829571D0 (en) * | 1988-12-19 | 1989-02-08 | Wellcome Found | Antiviral compounds |
AU618436B2 (en) * | 1988-12-19 | 1991-12-19 | Wellcome Foundation Limited, The | Antiviral cytosine and guanine derivatives |
DE4008858A1 (de) * | 1990-03-20 | 1991-09-26 | Hoechst Ag | Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel |
ES2157259T3 (es) * | 1993-06-10 | 2001-08-16 | Rolabo Sl | Procedimiento para preparar esteres de aminoacidos y analogos de nucleosidos. |
GB9317146D0 (en) * | 1993-08-18 | 1993-10-06 | Wellcome Found | Therapeutic combinations |
GB9320316D0 (en) * | 1993-10-01 | 1993-11-17 | Smithkline Beecham Plc | Pharmaceuticals |
TW282470B (hu) * | 1993-11-18 | 1996-08-01 | Ajinomoto Kk | |
DE69513313T2 (de) * | 1994-02-01 | 2000-07-13 | Ajinomoto Kk | Verfahren zur Herstellung von Nukleinsäurebasenderivaten |
US5840891A (en) * | 1994-07-28 | 1998-11-24 | Syntex (U.S.A.) Inc. | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative |
US5543414A (en) * | 1994-07-28 | 1996-08-06 | Syntex (Usa) Inc. | Achiral amino acid acyl esters of ganciclovir and its derivatives |
PE32296A1 (es) * | 1994-07-28 | 1996-08-07 | Hoffmann La Roche | Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables |
GB9501178D0 (en) * | 1995-01-20 | 1995-03-08 | Wellcome Found | Guanine derivative |
GB9501142D0 (en) * | 1995-01-20 | 1995-03-08 | Wellcome Found | Compounds for use in medicine |
GB9501127D0 (en) * | 1995-01-20 | 1995-03-08 | Wellcome Found | Tablet |
DE19536164A1 (de) * | 1995-09-28 | 1997-04-03 | Boehringer Ingelheim Kg | Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir) |
DK0874631T3 (da) * | 1996-01-19 | 2004-03-22 | Glaxo Group Ltd | Anvendelse af valaciclovir til fremstilling af et medikament til behandling af genital herpes ved en enkelt daglig anvendelse |
US5756736A (en) * | 1996-01-26 | 1998-05-26 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
US6040446A (en) | 1996-01-26 | 2000-03-21 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative |
US5700936A (en) * | 1996-01-26 | 1997-12-23 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate |
ES2180923T5 (es) * | 1996-01-26 | 2005-10-16 | F. Hoffmann-La Roche Ag | Proceso para la preparacion de derivados de purina. |
US5840890A (en) * | 1996-01-26 | 1998-11-24 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
US6703394B2 (en) | 1996-02-16 | 2004-03-09 | Medivir Ab | Acyclic nucleoside derivatives |
US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
IT1283447B1 (it) * | 1996-07-18 | 1998-04-21 | Ind Chimica Srl | Processo di preparazione del valaciclovir e relativi intermedi |
AU5495898A (en) * | 1997-01-17 | 1998-08-07 | Ajinomoto Co., Inc. | Novel z-valacyclovir crystals |
AU4007699A (en) * | 1998-05-21 | 1999-12-06 | Mark Anderson | A method for stimulation of defensin production by exposure to isoleucin |
SK1592004A3 (sk) * | 2001-09-07 | 2005-03-04 | Teva Pharmaceutical Industries Ltd. | Kryštalické formy valaciklovírus hydrochlóridu |
WO2004000265A2 (en) | 2002-06-24 | 2003-12-31 | Ranbaxy Laboratories Limited | Process for the preparation of robust formulations of valacyclovir hydrochloride tablets |
US20050043329A1 (en) * | 2002-09-06 | 2005-02-24 | Shlomit Wizel | Crystalline forms of valacyclovir hydrochloride |
CN1309732C (zh) * | 2002-10-28 | 2007-04-11 | 南京长澳医药科技有限公司 | 6-烷氧基-2’,3’-双脱氧鸟嘌呤核苷的制备方法 |
KR100871621B1 (ko) * | 2003-06-02 | 2008-12-02 | 테바 파마슈티컬 인더스트리즈 리미티드 | 발라시클로비르 히드로클로라이드의 신규한 결정질 형태 |
CN1331471C (zh) * | 2003-09-22 | 2007-08-15 | 陈云芳 | 盐酸万乃洛韦软胶囊组合物 |
CA2552560A1 (en) * | 2004-01-21 | 2005-08-11 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of valacyclovir hydrochloride |
GB2413017A (en) * | 2004-04-06 | 2005-10-12 | Ford Global Tech Llc | An electrical connector for a vehicle |
WO2006035452A1 (en) * | 2004-09-27 | 2006-04-06 | Matrix Laboratories Ltd | Novel pseudomorph of valaciclovir hydrochloride |
WO2006127217A2 (en) | 2005-05-25 | 2006-11-30 | Eli Lilly And Company | Cyclopropanecarboxylate esters of acyclovir |
EP1746098A1 (en) | 2005-07-21 | 2007-01-24 | SOLMAG S.p.A. | Valacyclovir polymorphs and a process for the preparation thereof |
CN101456859B (zh) * | 2009-01-06 | 2011-07-20 | 华南理工大学 | 抗病毒药物缬昔洛韦的制备方法 |
WO2011158252A1 (en) | 2010-06-15 | 2011-12-22 | Matrix Laboratories Ltd | Process for the preparation of valacyclovir hydrochloride polymorphic form ii |
CN102850354B (zh) * | 2012-10-10 | 2014-07-23 | 山东金城医药化工股份有限公司 | 高纯度cbz-万乃洛韦的制备方法 |
CN106632335A (zh) * | 2016-12-27 | 2017-05-10 | 河南康达制药有限公司 | 一种盐酸伐昔洛韦的制备方法 |
RU2750867C1 (ru) * | 2020-05-18 | 2021-07-05 | Александр Сергеевич Самойлов | Производные гуанина |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8202626A (nl) * | 1982-06-29 | 1984-01-16 | Stichting Rega V Z W | Derivaten van 9-(2-hydroxyethoxymethyl)guanine. |
DE3627024A1 (de) * | 1985-09-24 | 1987-04-02 | Hoechst Ag | In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine |
DE3534774A1 (de) * | 1985-09-30 | 1987-04-02 | Robugen Gmbh | Nucleosid-analoge verbindungen mit antiviraler aktivitaet, verfahren zu deren herstellung sowie arzneimittel mit antiviraler wirkung |
AP160A (en) * | 1987-08-15 | 1991-11-18 | The Wellcome Foundation Ltd | Therapeutic acyclic nucleosides. |
-
1988
- 1988-08-10 AP APAP/P/1991/000238A patent/AP160A/en active
- 1988-08-10 AP APAP/P/1988/000099A patent/AP55A/en active
- 1988-08-11 MC MC881999A patent/MC1968A1/xx unknown
- 1988-08-12 DE DE3855333T patent/DE3855333T2/de not_active Expired - Lifetime
- 1988-08-12 FI FI883757A patent/FI89713C/fi not_active IP Right Cessation
- 1988-08-12 LU LU88746C patent/LU88746I2/fr unknown
- 1988-08-12 NZ NZ225809A patent/NZ225809A/en unknown
- 1988-08-12 HU HU884332A patent/HU201071B/hu unknown
- 1988-08-12 IL IL87434A patent/IL87434A/xx not_active IP Right Cessation
- 1988-08-12 AU AU20978/88A patent/AU612393C/en not_active Expired
- 1988-08-12 AT AT93120604T patent/ATE138660T1/de not_active IP Right Cessation
- 1988-08-12 IE IE246388A patent/IE65551B1/en not_active IP Right Cessation
- 1988-08-12 KR KR1019880010298A patent/KR960002849B1/ko not_active IP Right Cessation
- 1988-08-12 PL PL1988274215A patent/PL158285B1/pl unknown
- 1988-08-12 EP EP93120604A patent/EP0596542B1/en not_active Expired - Lifetime
- 1988-08-12 DK DK451388A patent/DK170045B1/da not_active IP Right Cessation
- 1988-08-12 PT PT88261A patent/PT88261B/pt not_active IP Right Cessation
- 1988-08-12 EP EP88307512A patent/EP0308065B1/en not_active Expired - Lifetime
- 1988-08-12 CN CN88106535A patent/CN1033701C/zh not_active Expired - Lifetime
- 1988-08-12 ES ES93120604T patent/ES2087639T3/es not_active Expired - Lifetime
- 1988-08-12 JP JP63200320A patent/JPH0662623B2/ja not_active Expired - Lifetime
- 1988-08-12 CS CS885594A patent/CS276903B6/cs not_active IP Right Cessation
- 1988-08-12 MY MYPI88000934A patent/MY103760A/en unknown
- 1988-08-12 NO NO883612A patent/NO167805C/no not_active IP Right Cessation
- 1988-08-12 SU SU884356404A patent/SU1634138A3/ru active
-
1990
- 1990-08-28 JP JP2226434A patent/JPH07113025B2/ja not_active Expired - Lifetime
-
1992
- 1992-06-25 MX MX9203418A patent/MX9203418A/es unknown
- 1992-12-18 LV LV920335A patent/LV5264A3/xx unknown
-
1994
- 1994-07-08 DK DK082694A patent/DK170803B1/da not_active IP Right Cessation
-
1995
- 1995-02-24 SG SG1995903373A patent/SG26346G/en unknown
- 1995-09-20 SA SA95160244A patent/SA95160244B1/ar unknown
- 1995-12-01 CY CY183395A patent/CY1833A/xx unknown
-
1996
- 1996-01-17 KR KR1019960000775A patent/KR960004940B1/ko not_active IP Right Cessation
- 1996-01-18 NL NL960001C patent/NL960001I2/nl unknown
- 1996-06-27 GR GR960401743T patent/GR3020372T3/el unknown
- 1996-12-17 NO NO1996015C patent/NO1996015I1/no unknown
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