LU88746I2 - Valaciclovir facultativement sous la forme d'un sel pharmaceutiquement acceptable y compris le sel d'addition de l'acide chlorhydrique - Google Patents

Valaciclovir facultativement sous la forme d'un sel pharmaceutiquement acceptable y compris le sel d'addition de l'acide chlorhydrique

Info

Publication number
LU88746I2
LU88746I2 LU88746C LU88746C LU88746I2 LU 88746 I2 LU88746 I2 LU 88746I2 LU 88746 C LU88746 C LU 88746C LU 88746 C LU88746 C LU 88746C LU 88746 I2 LU88746 I2 LU 88746I2
Authority
LU
Luxembourg
Prior art keywords
valaciclovir
optionally
pharmaceutically acceptable
hydrochloric acid
acceptable salt
Prior art date
Application number
LU88746C
Other languages
English (en)
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26292613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU88746(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB878719367A external-priority patent/GB8719367D0/en
Priority claimed from GB878725939A external-priority patent/GB8725939D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of LU88746I2 publication Critical patent/LU88746I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
LU88746C 1987-08-15 1988-08-12 Valaciclovir facultativement sous la forme d'un sel pharmaceutiquement acceptable y compris le sel d'addition de l'acide chlorhydrique LU88746I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878719367A GB8719367D0 (en) 1987-08-15 1987-08-15 Therapeutic compounds
GB878725939A GB8725939D0 (en) 1987-11-05 1987-11-05 Therapeutic compounds

Publications (1)

Publication Number Publication Date
LU88746I2 true LU88746I2 (fr) 1996-10-04

Family

ID=26292613

Family Applications (1)

Application Number Title Priority Date Filing Date
LU88746C LU88746I2 (fr) 1987-08-15 1988-08-12 Valaciclovir facultativement sous la forme d'un sel pharmaceutiquement acceptable y compris le sel d'addition de l'acide chlorhydrique

Country Status (30)

Country Link
EP (2) EP0308065B1 (fr)
JP (2) JPH0662623B2 (fr)
KR (2) KR960002849B1 (fr)
CN (1) CN1033701C (fr)
AP (2) AP160A (fr)
AT (1) ATE138660T1 (fr)
AU (1) AU612393C (fr)
CS (1) CS276903B6 (fr)
CY (1) CY1833A (fr)
DE (1) DE3855333T2 (fr)
DK (2) DK170045B1 (fr)
ES (1) ES2087639T3 (fr)
FI (1) FI89713C (fr)
GR (1) GR3020372T3 (fr)
HU (1) HU201071B (fr)
IE (1) IE65551B1 (fr)
IL (1) IL87434A (fr)
LU (1) LU88746I2 (fr)
LV (1) LV5264A3 (fr)
MC (1) MC1968A1 (fr)
MX (1) MX9203418A (fr)
MY (1) MY103760A (fr)
NL (1) NL960001I2 (fr)
NO (2) NO167805C (fr)
NZ (1) NZ225809A (fr)
PL (1) PL158285B1 (fr)
PT (1) PT88261B (fr)
SA (1) SA95160244B1 (fr)
SG (1) SG26346G (fr)
SU (1) SU1634138A3 (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
GB8816760D0 (en) * 1988-07-14 1988-08-17 Wellcome Found Therapeutic compounds
ATE123285T1 (de) * 1988-12-19 1995-06-15 Wellcome Found Antivirale pyrimidin- und purinverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate.
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
DE4008858A1 (de) * 1990-03-20 1991-09-26 Hoechst Ag Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
NZ266527A (en) * 1993-06-08 1999-10-28 Cancer Res Campaign Tech Alkylguanine derivatives and pharmaceutical compositions
DE69426880T2 (de) * 1993-06-10 2001-10-31 Rolabo S.L., Zaragoza Verfahren zur herstellung von aminosäureester von nukleosid analogen
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9320316D0 (en) * 1993-10-01 1993-11-17 Smithkline Beecham Plc Pharmaceuticals
TW282470B (fr) * 1993-11-18 1996-08-01 Ajinomoto Kk
DE69513313T2 (de) * 1994-02-01 2000-07-13 Ajinomoto Co., Inc. Verfahren zur Herstellung von Nukleinsäurebasenderivaten
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5856481A (en) * 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
GB9501142D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Compounds for use in medicine
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
GB9501127D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Tablet
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
PT874631E (pt) * 1996-01-19 2004-04-30 Glaxo Group Ltd Utilizacao de valaciclovir para a manufactura de um medicamento para o tratamento de herpes genital por aplicacao diaria unica
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
KR100491941B1 (ko) * 1996-01-26 2005-08-05 에프. 호프만-라 로슈 아게 푸린유도체의제조방법
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
IT1283447B1 (it) * 1996-07-18 1998-04-21 Ind Chimica Srl Processo di preparazione del valaciclovir e relativi intermedi
WO1998031683A1 (fr) * 1997-01-17 1998-07-23 Ajinomoto Co., Inc. Nouveaux cristaux de z-valacyclovir
CA2332961A1 (fr) * 1998-05-21 1999-11-25 Michael Zasloff Procede de stimulation de la production de defensine par exposition a de l'isoleucine
SK1592004A3 (sk) * 2001-09-07 2005-03-04 Teva Pharmaceutical Industries Ltd. Kryštalické formy valaciklovírus hydrochlóridu
WO2004000265A2 (fr) 2002-06-24 2003-12-31 Ranbaxy Laboratories Limited Procede de preparation de formulations solides de comprimes de chlorhydrate de valacyclovir
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
CN1309732C (zh) * 2002-10-28 2007-04-11 南京长澳医药科技有限公司 6－烷氧基－2’，3’－双脱氧鸟嘌呤核苷的制备方法
WO2005000850A2 (fr) * 2003-06-02 2005-01-06 Teva Pharmaceutical Industries, Ltd. Nouvelles formes cristallines de chlorhydrate de valacyclovir
CN1331471C (zh) * 2003-09-22 2007-08-15 陈云芳 盐酸万乃洛韦软胶囊组合物
WO2005073233A1 (fr) * 2004-01-21 2005-08-11 Teva Pharmaceutical Industries Ltd. Procede de preparation d'hydrochlorure de valacyclovir
GB2413017A (en) * 2004-04-06 2005-10-12 Ford Global Tech Llc An electrical connector for a vehicle
WO2006035452A1 (fr) * 2004-09-27 2006-04-06 Matrix Laboratories Ltd Nouveau pseudomorphe d'hydrochlorure de valaciclovir
ES2379804T3 (es) 2005-05-25 2012-05-03 Eli Lilly And Company Ésteres de ciclopropanocarboxilato de aciclovir
EP1746098A1 (fr) 2005-07-21 2007-01-24 SOLMAG S.p.A. Des polymorphes de valacyclovir et procédé pour leur fabrication
CN101456859B (zh) * 2009-01-06 2011-07-20 华南理工大学 抗病毒药物缬昔洛韦的制备方法
WO2011158252A1 (fr) 2010-06-15 2011-12-22 Matrix Laboratories Ltd Méthode de préparation de la forme polymorphe ii du chlorhydrate de valacyclovir
CN102850354B (zh) * 2012-10-10 2014-07-23 山东金城医药化工股份有限公司 高纯度cbz-万乃洛韦的制备方法
CN106632335A (zh) * 2016-12-27 2017-05-10 河南康达制药有限公司 一种盐酸伐昔洛韦的制备方法
RU2750867C1 (ru) * 2020-05-18 2021-07-05 Александр Сергеевич Самойлов Производные гуанина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
DE3534774A1 (de) * 1985-09-30 1987-04-02 Robugen Gmbh Nucleosid-analoge verbindungen mit antiviraler aktivitaet, verfahren zu deren herstellung sowie arzneimittel mit antiviraler wirkung
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.

Also Published As

Publication number Publication date
NO883612L (no) 1989-02-16
PL274215A1 (en) 1990-02-19
NL960001I2 (nl) 1996-11-01
JPS6468373A (en) 1989-03-14
FI89713B (fi) 1993-07-30
HUT47935A (en) 1989-04-28
MY103760A (en) 1993-09-30
DK82694A (da) 1994-07-08
AP8800099A0 (en) 1988-08-01
FI89713C (fi) 1993-11-10
EP0308065A2 (fr) 1989-03-22
CS276903B6 (en) 1992-09-16
GR3020372T3 (en) 1996-09-30
CN1032538A (zh) 1989-04-26
NL960001I1 (nl) 1996-03-01
NZ225809A (en) 1991-07-26
HU201071B (en) 1990-09-28
PT88261B (pt) 1995-03-01
KR960004940B1 (ko) 1996-04-18
LV5264A3 (lv) 1993-10-10
FI883757A0 (fi) 1988-08-12
JPH07113025B2 (ja) 1995-12-06
AU612393C (en) 2006-08-17
AU612393B2 (en) 1991-07-11
CY1833A (en) 1995-12-01
FI883757L (fi) 1989-02-16
AU2097888A (en) 1989-02-16
SU1634138A3 (ru) 1991-03-07
AP55A (en) 1989-09-26
NO883612D0 (no) 1988-08-12
NO167805C (no) 1991-12-11
DK451388A (da) 1989-02-16
EP0308065A3 (en) 1989-09-27
PT88261A (pt) 1989-06-30
MX9203418A (es) 1992-07-01
CN1033701C (zh) 1997-01-01
JPH03115284A (ja) 1991-05-16
NO1996015I1 (no) 1996-12-17
NO167805B (no) 1991-09-02
SG26346G (en) 1995-09-01
PL158285B1 (en) 1992-08-31
ES2087639T3 (es) 1996-07-16
IE882463L (en) 1989-02-15
IL87434A (en) 1993-06-10
DE3855333T2 (de) 1996-12-05
DK170045B1 (da) 1995-05-08
JPH0662623B2 (ja) 1994-08-17
IE65551B1 (en) 1995-11-01
KR890003761A (ko) 1989-04-17
DK170803B1 (da) 1996-01-22
IL87434A0 (en) 1989-01-31
EP0596542A1 (fr) 1994-05-11
MC1968A1 (fr) 1989-09-29
SA95160244B1 (ar) 2006-10-02
EP0596542B1 (fr) 1996-05-29
ATE138660T1 (de) 1996-06-15
KR960002849B1 (ko) 1996-02-27
DK451388D0 (da) 1988-08-12
EP0308065B1 (fr) 1995-01-04
DE3855333D1 (de) 1996-07-04
AP160A (en) 1991-11-18
CS8805594A2 (en) 1990-06-13

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