DE69426880T2 - Verfahren zur herstellung von aminosäureester von nukleosid analogen - Google Patents

Verfahren zur herstellung von aminosäureester von nukleosid analogen

Info

Publication number
DE69426880T2
DE69426880T2 DE69426880T DE69426880T DE69426880T2 DE 69426880 T2 DE69426880 T2 DE 69426880T2 DE 69426880 T DE69426880 T DE 69426880T DE 69426880 T DE69426880 T DE 69426880T DE 69426880 T2 DE69426880 T2 DE 69426880T2
Authority
DE
Germany
Prior art keywords
amino acid
pct
acid esters
nucleoside analogs
producing amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69426880T
Other languages
English (en)
Other versions
DE69426880D1 (de
Inventor
Paul Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rolabo SL
Original Assignee
Rolabo SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939311952A external-priority patent/GB9311952D0/en
Priority claimed from GB939320645A external-priority patent/GB9320645D0/en
Application filed by Rolabo SL filed Critical Rolabo SL
Publication of DE69426880D1 publication Critical patent/DE69426880D1/de
Application granted granted Critical
Publication of DE69426880T2 publication Critical patent/DE69426880T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69426880T 1993-06-10 1994-06-09 Verfahren zur herstellung von aminosäureester von nukleosid analogen Expired - Fee Related DE69426880T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939311952A GB9311952D0 (en) 1993-06-10 1993-06-10 Process
GB939320645A GB9320645D0 (en) 1993-10-07 1993-10-07 Process
PCT/GB1994/001245 WO1994029311A1 (en) 1993-06-10 1994-06-09 Amino acid ester of nucleoside analogues

Publications (2)

Publication Number Publication Date
DE69426880D1 DE69426880D1 (de) 2001-04-19
DE69426880T2 true DE69426880T2 (de) 2001-10-31

Family

ID=26303037

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69426880T Expired - Fee Related DE69426880T2 (de) 1993-06-10 1994-06-09 Verfahren zur herstellung von aminosäureester von nukleosid analogen

Country Status (7)

Country Link
US (1) US5831075A (de)
EP (1) EP0702682B1 (de)
AT (1) ATE199719T1 (de)
AU (1) AU6854694A (de)
DE (1) DE69426880T2 (de)
ES (1) ES2157259T3 (de)
WO (1) WO1994029311A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
AU1592897A (en) * 1996-01-26 1997-08-20 F. Hoffmann-La Roche Ag Process for preparing purine derivatives
IT1283447B1 (it) * 1996-07-18 1998-04-21 Ind Chimica Srl Processo di preparazione del valaciclovir e relativi intermedi
EP1436295A4 (de) * 2001-09-07 2007-07-11 Teva Pharma Kristalline formen von valacyclovir-hydrochlorid
CA2465928C (en) * 2001-11-14 2010-01-19 Teva Pharmaceutical Industries Ltd. Synthesis and purification of valacyclovir
EP1575953A1 (de) * 2002-12-09 2005-09-21 Texcontor Etablissement Wasserfreie kristalline form von valacyclovirhydrochlorid
EP1633753A1 (de) * 2003-05-30 2006-03-15 EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. Neue kristallmodifikationen von valacyclovir-hydrochlorid
KR100871621B1 (ko) * 2003-06-02 2008-12-02 테바 파마슈티컬 인더스트리즈 리미티드 발라시클로비르 히드로클로라이드의 신규한 결정질 형태
WO2005023827A1 (en) * 2003-09-11 2005-03-17 F. Hoffmann-La Roche Ag Process for preparing antiviral nucleoside derivatives
US20070167353A1 (en) * 2003-10-24 2007-07-19 John Hilfinger Prodrug composition
US20050137141A1 (en) * 2003-10-24 2005-06-23 John Hilfinger Prodrug composition
US20060178512A1 (en) * 2005-02-04 2006-08-10 Cheruthur Govindan Method for preparing amino acid esters of nucleoside analogues
EP1746098A1 (de) * 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir Polymorphe und Verfahren zu deren Herstellung
US20080281099A1 (en) * 2007-05-07 2008-11-13 Mayur Devjibhai Khunt Process for purifying valacyclovir hydrochloride and intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds

Also Published As

Publication number Publication date
WO1994029311A1 (en) 1994-12-22
DE69426880D1 (de) 2001-04-19
EP0702682B1 (de) 2001-03-14
AU6854694A (en) 1995-01-03
ES2157259T3 (es) 2001-08-16
EP0702682A1 (de) 1996-03-27
ATE199719T1 (de) 2001-03-15
US5831075A (en) 1998-11-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee