ATE199719T1 - Verfahren zur herstellung von aminosäureester von nukleosid analogen - Google Patents
Verfahren zur herstellung von aminosäureester von nukleosid analogenInfo
- Publication number
- ATE199719T1 ATE199719T1 AT94917117T AT94917117T ATE199719T1 AT E199719 T1 ATE199719 T1 AT E199719T1 AT 94917117 T AT94917117 T AT 94917117T AT 94917117 T AT94917117 T AT 94917117T AT E199719 T1 ATE199719 T1 AT E199719T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- pct
- nucleoside analogue
- acid esters
- producing amino
- Prior art date
Links
- 229940127073 nucleoside analogue Drugs 0.000 title abstract 4
- 150000001413 amino acids Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 amino acid ester Chemical class 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939311952A GB9311952D0 (en) | 1993-06-10 | 1993-06-10 | Process |
| GB939320645A GB9320645D0 (en) | 1993-10-07 | 1993-10-07 | Process |
| PCT/GB1994/001245 WO1994029311A1 (en) | 1993-06-10 | 1994-06-09 | Amino acid ester of nucleoside analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199719T1 true ATE199719T1 (de) | 2001-03-15 |
Family
ID=26303037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94917117T ATE199719T1 (de) | 1993-06-10 | 1994-06-09 | Verfahren zur herstellung von aminosäureester von nukleosid analogen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5831075A (de) |
| EP (1) | EP0702682B1 (de) |
| AT (1) | ATE199719T1 (de) |
| AU (1) | AU6854694A (de) |
| DE (1) | DE69426880T2 (de) |
| ES (1) | ES2157259T3 (de) |
| WO (1) | WO1994029311A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5543414A (en) * | 1994-07-28 | 1996-08-06 | Syntex (Usa) Inc. | Achiral amino acid acyl esters of ganciclovir and its derivatives |
| US6083953A (en) * | 1994-07-28 | 2000-07-04 | Syntex (U.S.A.) Inc. | 2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative |
| GB9501178D0 (en) * | 1995-01-20 | 1995-03-08 | Wellcome Found | Guanine derivative |
| US6040446A (en) | 1996-01-26 | 2000-03-21 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative |
| US5756736A (en) * | 1996-01-26 | 1998-05-26 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
| US5700936A (en) * | 1996-01-26 | 1997-12-23 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate |
| WO1997027194A1 (en) * | 1996-01-26 | 1997-07-31 | F. Hoffmann-La Roche Ag | Process for preparing purine derivatives |
| US5840890A (en) * | 1996-01-26 | 1998-11-24 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
| IT1283447B1 (it) * | 1996-07-18 | 1998-04-21 | Ind Chimica Srl | Processo di preparazione del valaciclovir e relativi intermedi |
| KR100774271B1 (ko) * | 2001-09-07 | 2007-11-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 발라사이클로비르 염산염의 결정질 형태 |
| JP2005508993A (ja) * | 2001-11-14 | 2005-04-07 | テバ ファーマシューティカル インダストリーズ リミティド | バラシクロビルの合成及び精製 |
| WO2004052892A1 (en) * | 2002-12-09 | 2004-06-24 | Texcontor Etablissement | Anhydrous crystalline form of valacyclovir hydrochloride |
| AU2003232719A1 (en) * | 2003-05-30 | 2005-01-21 | Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. | Novel crystalline forms of valacyclovir hydrochloride |
| KR100871621B1 (ko) * | 2003-06-02 | 2008-12-02 | 테바 파마슈티컬 인더스트리즈 리미티드 | 발라시클로비르 히드로클로라이드의 신규한 결정질 형태 |
| JP2007505070A (ja) * | 2003-09-11 | 2007-03-08 | エフ．ホフマン−ラ ロシュ アーゲー | 抗ウイルス性ヌクレオシド誘導体を製造する方法 |
| US20070167353A1 (en) * | 2003-10-24 | 2007-07-19 | John Hilfinger | Prodrug composition |
| US20050137141A1 (en) * | 2003-10-24 | 2005-06-23 | John Hilfinger | Prodrug composition |
| US20060178512A1 (en) * | 2005-02-04 | 2006-08-10 | Cheruthur Govindan | Method for preparing amino acid esters of nucleoside analogues |
| EP1746098A1 (de) * | 2005-07-21 | 2007-01-24 | SOLMAG S.p.A. | Valacyclovir Polymorphe und Verfahren zu deren Herstellung |
| US20080281099A1 (en) * | 2007-05-07 | 2008-11-13 | Mayur Devjibhai Khunt | Process for purifying valacyclovir hydrochloride and intermediates thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8202626A (nl) * | 1982-06-29 | 1984-01-16 | Stichting Rega V Z W | Derivaten van 9-(2-hydroxyethoxymethyl)guanine. |
| AP160A (en) * | 1987-08-15 | 1991-11-18 | The Wellcome Foundation Ltd | Therapeutic acyclic nucleosides. |
| DE68922903T2 (de) * | 1988-12-19 | 1995-11-23 | Wellcome Found | Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate. |
| GB8829571D0 (en) * | 1988-12-19 | 1989-02-08 | Wellcome Found | Antiviral compounds |
-
1994
- 1994-06-09 AT AT94917117T patent/ATE199719T1/de not_active IP Right Cessation
- 1994-06-09 EP EP94917117A patent/EP0702682B1/de not_active Expired - Lifetime
- 1994-06-09 US US08/564,080 patent/US5831075A/en not_active Expired - Fee Related
- 1994-06-09 ES ES94917117T patent/ES2157259T3/es not_active Expired - Lifetime
- 1994-06-09 AU AU68546/94A patent/AU6854694A/en not_active Abandoned
- 1994-06-09 WO PCT/GB1994/001245 patent/WO1994029311A1/en not_active Ceased
- 1994-06-09 DE DE69426880T patent/DE69426880T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0702682B1 (de) | 2001-03-14 |
| DE69426880T2 (de) | 2001-10-31 |
| AU6854694A (en) | 1995-01-03 |
| DE69426880D1 (de) | 2001-04-19 |
| EP0702682A1 (de) | 1996-03-27 |
| ES2157259T3 (es) | 2001-08-16 |
| US5831075A (en) | 1998-11-03 |
| WO1994029311A1 (en) | 1994-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |