DE69837041D1 - Verfahren und mikroorganism zur herstellung von purin-nukleosiden durch fermentation - Google Patents

Verfahren und mikroorganism zur herstellung von purin-nukleosiden durch fermentation

Info

Publication number
DE69837041D1
DE69837041D1 DE69837041T DE69837041T DE69837041D1 DE 69837041 D1 DE69837041 D1 DE 69837041D1 DE 69837041 T DE69837041 T DE 69837041T DE 69837041 T DE69837041 T DE 69837041T DE 69837041 D1 DE69837041 D1 DE 69837041D1
Authority
DE
Germany
Prior art keywords
purin
nucleosides
microorganism
fermentation
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69837041T
Other languages
English (en)
Other versions
DE69837041T2 (de
Inventor
Hiroshi Matsui
Hisashi Kawasaki
Megumi Shimaoka
Yasuhiro Takenaka
Osamu Kurahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of DE69837041D1 publication Critical patent/DE69837041D1/de
Application granted granted Critical
Publication of DE69837041T2 publication Critical patent/DE69837041T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69837041T 1997-07-18 1998-07-17 Verfahren und Mikroorganismus zur Herstellung von Purin-Nukleosiden durch Fermentation Expired - Lifetime DE69837041T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP19460397 1997-07-18
JP19460397 1997-07-18
PCT/JP1998/003239 WO1999003988A1 (fr) 1997-07-18 1998-07-17 Procede de production de nucleosides de purine par fermentation

Publications (2)

Publication Number Publication Date
DE69837041D1 true DE69837041D1 (de) 2007-03-22
DE69837041T2 DE69837041T2 (de) 2007-11-08

Family

ID=16327302

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69837041T Expired - Lifetime DE69837041T2 (de) 1997-07-18 1998-07-17 Verfahren und Mikroorganismus zur Herstellung von Purin-Nukleosiden durch Fermentation
DE69840678T Expired - Lifetime DE69840678D1 (de) 1997-07-18 1998-07-17 Verfahren zur produktion von purinnukleosiden durch fermentation
DE69840348T Expired - Lifetime DE69840348D1 (de) 1997-07-18 1998-07-17 Verfahren zur Produktion von Purinnukleosiden durch Fermentation

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69840678T Expired - Lifetime DE69840678D1 (de) 1997-07-18 1998-07-17 Verfahren zur produktion von purinnukleosiden durch fermentation
DE69840348T Expired - Lifetime DE69840348D1 (de) 1997-07-18 1998-07-17 Verfahren zur Produktion von Purinnukleosiden durch Fermentation

Country Status (9)

Country Link
US (5) US7435560B1 (de)
EP (3) EP1004663B1 (de)
JP (1) JP3944916B2 (de)
KR (3) KR100697551B1 (de)
CN (1) CN1187446C (de)
BR (1) BR9815557B1 (de)
DE (3) DE69837041T2 (de)
ID (1) ID25613A (de)
WO (1) WO1999003988A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100697551B1 (ko) 1997-07-18 2007-03-21 아지노모토 가부시키가이샤 발효에 의한 퓨린 뉴클레오사이드의 제조 방법
TWI222464B (en) * 1999-02-08 2004-10-21 Kyowa Hakko Kogyo Kk Process for producing purine nucleotides
NZ517295A (en) * 1999-07-23 2004-04-30 Archer Daniels Midland Co Methods for producing bacterial cells with increased L-amino acid yield by disrupting the pgi gene
ES2272378T3 (es) 2000-07-05 2007-05-01 Ajinomoto Co., Inc. Metodo para la produccion de nucleotidos por fermentacion.
JP4352716B2 (ja) * 2003-02-17 2009-10-28 味の素株式会社 バチルス属に属するイノシン生産菌及びイノシンの製造法
US7335496B2 (en) 2003-06-05 2008-02-26 Ajinomoto Co., Inc. Method for producing target substance
RU2271391C2 (ru) * 2003-09-03 2006-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ ИНОЗИНА И 5'-ИНОЗИНОВОЙ КИСЛОТЫ МЕТОДОМ ФЕРМЕНТАЦИИ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Escherichia
US20050176033A1 (en) 2003-11-10 2005-08-11 Klyachko Elena V. Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine
KR100664653B1 (ko) * 2005-01-21 2007-01-04 씨제이 주식회사 Ｘｍｐ를 ｇｍｐ로 전환시킬 수 있으면서도, ｇｍｐ의분해에 관련되는 유전자가 불활성화되어 있는 대장균변이주 및 그를 이용하는 방법
US7326546B2 (en) 2005-03-10 2008-02-05 Ajinomoto Co., Inc. Purine-derived substance-producing bacterium and a method for producing purine-derived substance
DE102005019040A1 (de) 2005-04-23 2006-10-26 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung verbesserter Stämme der Familie Enterobacteriaceae
KR101250826B1 (ko) * 2006-04-24 2013-04-11 아지노모토 가부시키가이샤 퓨린계 물질 생산균 및 퓨린계 물질의 제조법
EP2011861A1 (de) * 2006-04-24 2009-01-07 Ajinomoto Co., Inc. Bakterium mit fähigkeit zur produktion einer purinsubstanz und verfahren zur produktion der purinsubstanz
JP2009165355A (ja) 2006-04-28 2009-07-30 Ajinomoto Co Inc Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
WO2008020595A1 (fr) * 2006-08-15 2008-02-21 Ishihara Sangyo Kaisha, Ltd. Procédé innovant d'utilisation d'un mutant microbien
RU2365622C2 (ru) 2006-12-22 2009-08-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПРОДУКЦИИ ПУРИНОВЫХ НУКЛЕОЗИДОВ И НУКЛЕОТИДОВ МЕТОДОМ ФЕРМЕНТАЦИИ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Escherichia ИЛИ Bacillus
WO2008090770A1 (ja) 2007-01-22 2008-07-31 Ajinomoto Co., Inc. Ｌ－アミノ酸を生産する微生物及びｌ－アミノ酸の製造法
JP2010130899A (ja) 2007-03-14 2010-06-17 Ajinomoto Co Inc Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法
WO2008133161A1 (ja) 2007-04-17 2008-11-06 Ajinomoto Co., Inc. カルボキシル基を有する酸性物質の製造法
EP2192170B1 (de) 2007-09-04 2017-02-15 Ajinomoto Co., Inc. Aminosäureproduzierender mikroorganismus und verfahren zur aminosäureproduktion
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
EP2264144A4 (de) * 2008-02-25 2012-11-07 Ajinomoto Kk Verfahren zur herstellung von 5'-guanylsäure
WO2010027022A1 (ja) 2008-09-05 2010-03-11 味の素株式会社 Ｌ－アミノ酸生産菌及びｌ－アミノ酸の製造法
CN101492484B (zh) * 2009-03-04 2012-02-29 湖南赛康德生物科技有限公司 一种鸟嘌呤核苷的综合循环生产工艺
KR101166027B1 (ko) 2009-04-01 2012-07-19 씨제이제일제당 (주) 5'-이노신산 생산성이 향상된 코리네박테리움 속 미생물 및 이를 이용한 핵산의 생산방법
EP2451960A2 (de) 2009-07-09 2012-05-16 Verdezyne, Inc. Manipulierte mikroorganismen mit erhöhter gärungsaktivität
JP2014036576A (ja) 2010-12-10 2014-02-27 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
BR112013016373B1 (pt) 2011-11-11 2021-05-18 Ajinomoto Co., Inc método para produzir uma substância alvo
EP3061828A4 (de) 2013-10-23 2017-03-15 Ajinomoto Co., Inc. Verfahren zur herstellung einer zielsubstanz
KR101599800B1 (ko) 2014-03-21 2016-03-04 씨제이제일제당 주식회사 Ｌ-아미노산의 생산능이 향상된 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법
JP7203496B2 (ja) 2015-05-19 2023-01-13 ミツビシ ケミカル ユーケー リミテッド メタクリル酸およびその誘導体の生物学的製造方法
CN106282220B (zh) * 2015-05-29 2021-03-23 上海市农业科学院 一种提高枯草芽孢杆菌合成肌苷能力的方法
GB201619827D0 (en) 2016-11-23 2017-01-04 Lucite Int Uk Ltd Process for the production of methyl methacrylate
KR102013873B1 (ko) 2018-01-25 2019-08-23 씨제이제일제당 주식회사 퓨린 뉴클레오티드를 생산하는 코리네박테리움 속 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법
CN108753669B (zh) * 2018-05-25 2022-04-08 苏州引航生物科技有限公司 一种腺嘌呤生产菌株及其构建方法和应用
CN110656073B (zh) * 2018-06-28 2022-06-28 中国科学院青岛生物能源与过程研究所 一种生产黄嘌呤的重组菌及其构建方法和应用
CN110656074B (zh) * 2018-06-28 2022-06-28 中国科学院青岛生物能源与过程研究所 一种合成次黄嘌呤的重组菌及其构建方法与应用
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
EP3901272A4 (de) * 2018-12-18 2022-12-21 Teijin Limited Genetisch modifizierter mikroorganismus und verfahren zur herstellung eines nikotinamidderivats sowie vektor zur verwendung darin
KR102006976B1 (ko) * 2019-02-26 2019-08-06 씨제이제일제당 주식회사 신규 프로모터 및 이를 이용한 퓨린 뉴클레오티드 제조방법
KR102006977B1 (ko) * 2019-03-28 2019-08-05 씨제이제일제당 주식회사 변이형 포스포리보실피로포스페이트 아미도트랜스퍼라아제 및 이를 이용한 퓨린 뉴클레오티드 제조방법
CN110904063A (zh) * 2019-05-10 2020-03-24 赤峰蒙广生物科技有限公司 一种核苷磷酸化酶的发酵工艺及其应用方法
CN110564660B (zh) * 2019-09-18 2023-03-21 苏州华赛生物工程技术有限公司 生产乳清酸的重组微生物及方法
CN111394268B (zh) * 2019-12-20 2021-06-18 合肥康诺生物制药有限公司 基因工程菌及其构建方法、应用，生产nad+的方法
CN113278596B (zh) * 2021-05-24 2022-07-29 廊坊梅花生物技术开发有限公司 可提高芽孢杆菌核苷产量的突变体及其应用
GB2621337A (en) 2022-08-08 2024-02-14 Mitsubishi Chemical Uk Ltd Process for the biological production of methacrylic acid and derivatives thereof
CN115851693B (zh) * 2022-10-24 2024-05-24 湖北大学 葡萄糖异构酶突变体及其高产葡萄糖异构酶的地衣芽胞杆菌工程菌及应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3152966A (en) 1961-03-11 1964-10-13 Kyowa Hakko Kogyo Kk Method for producing inosinic acid and adenylic acid by fermentation
US3258408A (en) * 1962-07-07 1966-06-28 Ajinomoto Kk Method of producing xanthosine
DE1442304A1 (de) 1962-08-08 1970-01-15 Takeda Chemical Industries Ltd Verfahren zur Herstellung von Purinderivaten
JPS515075B1 (de) * 1970-02-05 1976-02-17
JPH0669386B2 (ja) * 1987-03-18 1994-09-07 協和醗酵工業株式会社 ５′−イノシン酸の製造法
JP2545078B2 (ja) * 1987-04-06 1996-10-16 協和醗酵工業株式会社 核酸関連物質の製造法
EP0406436A4 (en) * 1988-11-22 1992-04-22 Kyowa Hakko Kogyo Co., Ltd. Process for preparing 5'-inosinic acid
WO1995006114A1 (fr) 1993-08-24 1995-03-02 Ajinomoto Co., Inc. Allele de phosphenolpyruvate carboxylase, gene de cet allele et procede de production de l'acide amine
CN1117152C (zh) 1994-03-04 2003-08-06 味之素株式会社 生产l－赖氨酸的方法
CA2180202A1 (en) 1995-06-30 1996-12-31 Mika Moriya Method of amplifying gene using artificial transposon
KR100697551B1 (ko) * 1997-07-18 2007-03-21 아지노모토 가부시키가이샤 발효에 의한 퓨린 뉴클레오사이드의 제조 방법
ATE330022T1 (de) * 2000-12-22 2006-07-15 Ajinomoto Kk Verfahren zur herstellung einer zielsubstanz durch fermentation
JP2002345496A (ja) 2001-05-25 2002-12-03 Ajinomoto Co Inc アグマチンの製造方法およびアルギニン脱炭酸酵素の製造方法

Also Published As

Publication number Publication date
KR100697551B1 (ko) 2007-03-21
KR20010021986A (ko) 2001-03-15
EP1577386A3 (de) 2005-10-12
EP1004663A4 (de) 2004-09-15
EP1577386A2 (de) 2005-09-21
US20080044863A1 (en) 2008-02-21
CN1187446C (zh) 2005-02-02
US20070161090A1 (en) 2007-07-12
EP1584679B1 (de) 2008-12-10
EP1577386B1 (de) 2009-03-18
DE69840678D1 (de) 2009-04-30
BR9815557B1 (pt) 2011-10-04
KR20050043978A (ko) 2005-05-11
EP1584679A1 (de) 2005-10-12
WO1999003988A1 (fr) 1999-01-28
DE69840348D1 (de) 2009-01-22
ID25613A (id) 2000-10-19
KR100697552B1 (ko) 2007-03-21
KR20050043979A (ko) 2005-05-11
BR9815557A (pt) 2001-07-17
CN1270631A (zh) 2000-10-18
US20070166799A1 (en) 2007-07-19
US7601519B2 (en) 2009-10-13
US7776566B2 (en) 2010-08-17
EP1004663A1 (de) 2000-05-31
EP1004663B1 (de) 2007-02-07
JP3944916B2 (ja) 2007-07-18
US7608432B2 (en) 2009-10-27
KR100511151B1 (ko) 2005-08-31
US7435560B1 (en) 2008-10-14
DE69837041T2 (de) 2007-11-08
US20080038781A1 (en) 2008-02-14

Similar Documents

Publication Publication Date Title
DE69837041D1 (de) Verfahren und mikroorganism zur herstellung von purin-nukleosiden durch fermentation
DE69826592D1 (de) Verfahren zur Herstellung von Stanolestern
DE69628565D1 (de) Verfahren zur herstellung von monokristallinen materialien
DE69535120D1 (de) L-Isoleucin produzierendes Bacterium und Verfahren zur Herstellung von L-Isoleucin durch Fermentation
DE69418851T2 (de) Verfahren zur Herstellung von Befestigungsvorrichtungen
DE69836227D1 (de) Verfahren zur herstellung egiii-ähnlicher enzyme
DE69530242D1 (de) Verfahren zur Herstellung von Glutaminsäure durch Fermentation
DE69702354D1 (de) Verfahren zur Herstellung von Acrylsäure
DE69628312D1 (de) Verfahren zur herstellung von getraenkedosenblech
DE59609850D1 (de) Verfahren zur Herstellung von Vanillin und dafür geeignete Mikroorganismen
DE59609854D1 (de) Verfahren zur herstellung von verkappten polyarylenethern
DE59608641D1 (de) Verfahren zur Herstellung von Nikotinsäureamid
DE69727977D1 (de) Verfahren zur simultanen herstellung von acrylnitril und acrylsäure
DE3789833D1 (de) Isoliertes Phenylalanindehydrogenase-Gen und Verfahren zur Herstellung von Phenylalanindeshydrogenase.
DE69630038D1 (de) Verfahren zur herstellung und aufreinigung von enzymen
DE69637616D1 (de) Verfahren zur herstellung von nukleinsäuren
DE3672920D1 (de) Verfahren zur herstellung immobilisierter enzyme und vorrichtung zur durchfuehrung des verfahrens.
DE59606220D1 (de) Verfahren zur Herstellung von Hohlkörpern
DE59813598D1 (de) Enzymatisches Verfahren zur Herstellung von (S)-Cyanhydrinen
DE3575743D1 (de) Verfahren zur gewinnung von phenylalanin-dehydrogenase enthaltenden mikroorganismen und deren verwendung zur herstellung von l-alpha-aminosaeuren.
ATE204023T1 (de) Enzymatische verfahren zur herstellung von (s)- cyanhydrinen
DE69321885D1 (de) Verfahren zur fermentativen Herstellung von 10-Hydroxy-C18-Carbonsäure und Gamma-Dodekalaktonderivaten
DE69610837T2 (de) Verfahren zur herstellung von laubholzelementen
DE69225050T2 (de) Uricase kodierende DNA und Verfahren zur Herstellung von Uricase
DE69511747D1 (de) Verfahren zur Herstellung von Wabenkörpern

Legal Events

Date Code Title Description
8364 No opposition during term of opposition