BR9815557A - Microrganismo, e, processo para produzir um nucleosìdeo de purina por fermentação - Google Patents

Microrganismo, e, processo para produzir um nucleosìdeo de purina por fermentação

Info

Publication number
BR9815557A
BR9815557A BR9815557-1A BR9815557A BR9815557A BR 9815557 A BR9815557 A BR 9815557A BR 9815557 A BR9815557 A BR 9815557A BR 9815557 A BR9815557 A BR 9815557A
Authority
BR
Brazil
Prior art keywords
enzyme
inactivated
gene encoding
encoded
purine nucleoside
Prior art date
Application number
BR9815557-1A
Other languages
English (en)
Other versions
BR9815557B1 (pt
Inventor
Hiroshi Matsui
Hisashi Kawasaki
Megumi Shimaoka
Yasuhiro Takenaka
Osamu Kurahashi
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BR9815557A publication Critical patent/BR9815557A/pt
Publication of BR9815557B1 publication Critical patent/BR9815557B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"MICRORGANISMO, E, PROCESSO PARA PRODUZIR UM NUCLEOSìDEO DE PURINA POR FERMENTAçãO" Um microrganismo que tem um gene codificando uma enzima em que a inibição de retro-alimentação é dessensibilizada por substituição de um ou dois aminoácidos em amidotransferase de PRPP codificado por purF de Escherichia coli, um gene codificando uma proteína que é um repressor inativado de biossíntese de nucleosídeo de purina codificada por purR, um geneticamente codificando uma enzima que é fosforilase de nucleosídeo de purina inativada codificada por deoD, um gene codificando uma enzima que é sintase de succinil-AMP inativada por purA, um gene codificando uma enzima que é desidrase de 6-fosfogluconato inativada codificada por edd, um gene codificando uma enzima que é isomerase de fosfoglucose inativada codificada por pgi e semelhantes, é criado e um nucleosídeo de purina é produzido por cultivo do microrganismo.
BRPI9815557-1A 1997-07-18 1998-07-17 microrganismo transgênico, e, processo para produzir um nucleosìdeo de purina por fermentação. BR9815557B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19460397 1997-07-18
PCT/JP1998/003239 WO1999003988A1 (fr) 1997-07-18 1998-07-17 Procede de production de nucleosides de purine par fermentation

Publications (2)

Publication Number Publication Date
BR9815557A true BR9815557A (pt) 2001-07-17
BR9815557B1 BR9815557B1 (pt) 2011-10-04

Family

ID=16327302

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9815557-1A BR9815557B1 (pt) 1997-07-18 1998-07-17 microrganismo transgênico, e, processo para produzir um nucleosìdeo de purina por fermentação.

Country Status (9)

Country Link
US (5) US7435560B1 (pt)
EP (3) EP1584679B1 (pt)
JP (1) JP3944916B2 (pt)
KR (3) KR100697552B1 (pt)
CN (1) CN1187446C (pt)
BR (1) BR9815557B1 (pt)
DE (3) DE69840348D1 (pt)
ID (1) ID25613A (pt)
WO (1) WO1999003988A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100697552B1 (ko) 1997-07-18 2007-03-21 아지노모토 가부시키가이샤 발효에 의한 퓨린 뉴클레오사이드의 제조 방법
TWI222464B (en) * 1999-02-08 2004-10-21 Kyowa Hakko Kogyo Kk Process for producing purine nucleotides
CA2377693C (en) * 1999-07-23 2016-11-08 Archer-Daniels-Midland Company Methods for producing l-amino acids
ES2272378T3 (es) 2000-07-05 2007-05-01 Ajinomoto Co., Inc. Metodo para la produccion de nucleotidos por fermentacion.
JP4352716B2 (ja) * 2003-02-17 2009-10-28 味の素株式会社 バチルス属に属するイノシン生産菌及びイノシンの製造法
US7335496B2 (en) 2003-06-05 2008-02-26 Ajinomoto Co., Inc. Method for producing target substance
RU2271391C2 (ru) * 2003-09-03 2006-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ ИНОЗИНА И 5'-ИНОЗИНОВОЙ КИСЛОТЫ МЕТОДОМ ФЕРМЕНТАЦИИ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Escherichia
US20050176033A1 (en) 2003-11-10 2005-08-11 Klyachko Elena V. Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine
KR100664653B1 (ko) * 2005-01-21 2007-01-04 씨제이 주식회사 Ｘｍｐ를 ｇｍｐ로 전환시킬 수 있으면서도, ｇｍｐ의분해에 관련되는 유전자가 불활성화되어 있는 대장균변이주 및 그를 이용하는 방법
US7326546B2 (en) 2005-03-10 2008-02-05 Ajinomoto Co., Inc. Purine-derived substance-producing bacterium and a method for producing purine-derived substance
DE102005019040A1 (de) 2005-04-23 2006-10-26 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung verbesserter Stämme der Familie Enterobacteriaceae
CN101432417B (zh) * 2006-04-24 2014-05-28 味之素株式会社 能够产生嘌呤物质的细菌和用于产生嘌呤物质的方法
BRPI0709635A2 (pt) * 2006-04-24 2011-07-19 Ajinomoto Kk bactéria pertencendo ao gênero bacillus, e, métodos para produzir uma substáncia derivada de purina, e um nucleotìdeo de purina
JP2009165355A (ja) 2006-04-28 2009-07-30 Ajinomoto Co Inc Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
WO2008020595A1 (fr) * 2006-08-15 2008-02-21 Ishihara Sangyo Kaisha, Ltd. Procédé innovant d'utilisation d'un mutant microbien
RU2365622C2 (ru) * 2006-12-22 2009-08-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПРОДУКЦИИ ПУРИНОВЫХ НУКЛЕОЗИДОВ И НУКЛЕОТИДОВ МЕТОДОМ ФЕРМЕНТАЦИИ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Escherichia ИЛИ Bacillus
CN101627110B (zh) 2007-01-22 2014-08-13 味之素株式会社 生产l-氨基酸的微生物和l-氨基酸的生产方法
JP2010130899A (ja) 2007-03-14 2010-06-17 Ajinomoto Co Inc Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法
WO2008133161A1 (ja) 2007-04-17 2008-11-06 Ajinomoto Co., Inc. カルボキシル基を有する酸性物質の製造法
CN101939412B (zh) 2007-09-04 2016-01-20 味之素株式会社 生产氨基酸的微生物以及氨基酸的生产方法
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
BRPI0907542A2 (pt) * 2008-02-25 2015-07-28 Ajinomoto Kk Método para produzir ácido 5'-guanílico, e, microrganismo com uma capacidade de converter ácido inosínico em ácido 5'-guanílico
EP2343371B1 (en) 2008-09-05 2015-10-21 Ajinomoto Co., Inc. Method for producing l-amino acid
CN101492484B (zh) * 2009-03-04 2012-02-29 湖南赛康德生物科技有限公司 一种鸟嘌呤核苷的综合循环生产工艺
KR101166027B1 (ko) 2009-04-01 2012-07-19 씨제이제일제당 (주) 5'-이노신산 생산성이 향상된 코리네박테리움 속 미생물 및 이를 이용한 핵산의 생산방법
EP2451960A2 (en) 2009-07-09 2012-05-16 Verdezyne, Inc. Engineered microorganisms with enhanced fermentation activity
JP2014036576A (ja) 2010-12-10 2014-02-27 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
CN103930557A (zh) 2011-11-11 2014-07-16 味之素株式会社 利用发酵法制造目标物质的方法
JP6519476B2 (ja) 2013-10-23 2019-05-29 味の素株式会社 目的物質の製造法
KR101599800B1 (ko) 2014-03-21 2016-03-04 씨제이제일제당 주식회사 Ｌ-아미노산의 생산능이 향상된 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법
CA2985279A1 (en) 2015-05-19 2016-11-24 Lucite International Uk Limited Process for the biological production of methacrylic acid and derivatives thereof
CN106282220B (zh) * 2015-05-29 2021-03-23 上海市农业科学院 一种提高枯草芽孢杆菌合成肌苷能力的方法
GB201619827D0 (en) 2016-11-23 2017-01-04 Lucite Int Uk Ltd Process for the production of methyl methacrylate
KR102013873B1 (ko) 2018-01-25 2019-08-23 씨제이제일제당 주식회사 퓨린 뉴클레오티드를 생산하는 코리네박테리움 속 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법
CN108753669B (zh) * 2018-05-25 2022-04-08 苏州引航生物科技有限公司 一种腺嘌呤生产菌株及其构建方法和应用
CN110656074B (zh) * 2018-06-28 2022-06-28 中国科学院青岛生物能源与过程研究所 一种合成次黄嘌呤的重组菌及其构建方法与应用
CN110656073B (zh) * 2018-06-28 2022-06-28 中国科学院青岛生物能源与过程研究所 一种生产黄嘌呤的重组菌及其构建方法和应用
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
JP7209977B2 (ja) * 2018-12-18 2023-01-23 帝人株式会社 ニコチンアミド誘導体を製造するための組換え微生物及び方法、並びにそれに用いられるベクター
KR102006976B1 (ko) * 2019-02-26 2019-08-06 씨제이제일제당 주식회사 신규 프로모터 및 이를 이용한 퓨린 뉴클레오티드 제조방법
KR102006977B1 (ko) * 2019-03-28 2019-08-05 씨제이제일제당 주식회사 변이형 포스포리보실피로포스페이트 아미도트랜스퍼라아제 및 이를 이용한 퓨린 뉴클레오티드 제조방법
CN110904063A (zh) * 2019-05-10 2020-03-24 赤峰蒙广生物科技有限公司 一种核苷磷酸化酶的发酵工艺及其应用方法
CN110564660B (zh) * 2019-09-18 2023-03-21 苏州华赛生物工程技术有限公司 生产乳清酸的重组微生物及方法
CN111394268B (zh) * 2019-12-20 2021-06-18 合肥康诺生物制药有限公司 基因工程菌及其构建方法、应用，生产nad+的方法
CN113278596B (zh) * 2021-05-24 2022-07-29 廊坊梅花生物技术开发有限公司 可提高芽孢杆菌核苷产量的突变体及其应用
GB2621337A (en) 2022-08-08 2024-02-14 Mitsubishi Chemical Uk Ltd Process for the biological production of methacrylic acid and derivatives thereof
CN115851693B (zh) * 2022-10-24 2024-05-24 湖北大学 葡萄糖异构酶突变体及其高产葡萄糖异构酶的地衣芽胞杆菌工程菌及应用
CN118086166B (zh) * 2024-04-18 2024-07-09 天津科技大学 一种鸟苷生产菌株及其构建方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3152966A (en) 1961-03-11 1964-10-13 Kyowa Hakko Kogyo Kk Method for producing inosinic acid and adenylic acid by fermentation
US3258408A (en) * 1962-07-07 1966-06-28 Ajinomoto Kk Method of producing xanthosine
DE1442304A1 (de) 1962-08-08 1970-01-15 Takeda Chemical Industries Ltd Verfahren zur Herstellung von Purinderivaten
JPS515075B1 (pt) * 1970-02-05 1976-02-17
JPH0669386B2 (ja) * 1987-03-18 1994-09-07 協和醗酵工業株式会社 ５′−イノシン酸の製造法
JP2545078B2 (ja) * 1987-04-06 1996-10-16 協和醗酵工業株式会社 核酸関連物質の製造法
KR900701999A (ko) * 1988-11-22 1990-12-05 가또 미끼오 5'-이노신산의 제조법
US5876983A (en) 1993-08-24 1999-03-02 Ajinomoto Co., Inc. Mutant phosphoenolpyruvate carboxylase, its gene, and production method of amino acid
JP3783065B2 (ja) 1994-03-04 2006-06-07 味の素株式会社 Ｌ−リジンの製造法
CA2180202A1 (en) 1995-06-30 1996-12-31 Mika Moriya Method of amplifying gene using artificial transposon
KR100697552B1 (ko) 1997-07-18 2007-03-21 아지노모토 가부시키가이샤 발효에 의한 퓨린 뉴클레오사이드의 제조 방법
US20020155556A1 (en) * 2000-12-22 2002-10-24 Ajinomoto Co., Inc Method of producing target substance by fermentation
JP2002345496A (ja) 2001-05-25 2002-12-03 Ajinomoto Co Inc アグマチンの製造方法およびアルギニン脱炭酸酵素の製造方法

Also Published As

Publication number Publication date
EP1004663A4 (en) 2004-09-15
KR20050043978A (ko) 2005-05-11
EP1004663A1 (en) 2000-05-31
EP1584679A1 (en) 2005-10-12
US20070166799A1 (en) 2007-07-19
US7776566B2 (en) 2010-08-17
JP3944916B2 (ja) 2007-07-18
ID25613A (id) 2000-10-19
EP1577386A2 (en) 2005-09-21
CN1270631A (zh) 2000-10-18
US20070161090A1 (en) 2007-07-12
KR100511151B1 (ko) 2005-08-31
CN1187446C (zh) 2005-02-02
EP1004663B1 (en) 2007-02-07
KR100697552B1 (ko) 2007-03-21
DE69837041D1 (de) 2007-03-22
DE69840348D1 (de) 2009-01-22
EP1577386B1 (en) 2009-03-18
WO1999003988A1 (fr) 1999-01-28
DE69837041T2 (de) 2007-11-08
KR20010021986A (ko) 2001-03-15
US7435560B1 (en) 2008-10-14
US20080038781A1 (en) 2008-02-14
EP1584679B1 (en) 2008-12-10
EP1577386A3 (en) 2005-10-12
DE69840678D1 (de) 2009-04-30
KR20050043979A (ko) 2005-05-11
KR100697551B1 (ko) 2007-03-21
US20080044863A1 (en) 2008-02-21
US7601519B2 (en) 2009-10-13
US7608432B2 (en) 2009-10-27
BR9815557B1 (pt) 2011-10-04

Similar Documents

Publication Publication Date Title
BR9815557A (pt) Microrganismo, e, processo para produzir um nucleosìdeo de purina por fermentação
CN100436593C (zh) 复合糖类的制备方法
KR101311571B1 (ko) 시티딘이인산 콜린의 정제 방법
BR0015114A (pt) Sequências de ácido nucléico e de aminoácido, construção de ácido nucleico, vetor, microorganismo, l-pantolactona hidrolase, e, processo para preparar d-pantolactona
CA2317118C (en) Process for producing n-acetylneuraminic acid
HUP9901198A2 (hu) Eljárás L-aminosavak előállítására
BR9609791A (pt) Processo para estabilizar proteínas em um meio ácido com um pectina de elevado teor em éster
WO1997013845A3 (en) Phosphopantetheinyl transferases and uses thereof
Cimini et al. Production of glucuronic acid‐based polysaccharides by microbial fermentation for biomedical applications
CN104974972B (zh) 软骨素的生物技术制备
DK0859848T3 (da) Fremgangsmåde til fremstilling af D-pantoinsyre og D-pantothensyre eller salte deraf
TWI223003B (en) Process for producing GDP-fucose
KR960001113A (ko) 내열성 비환원성 당질 생성 효소와 그 제조방법 및 용도
ATE129016T1 (de) Enzymatisches verfahren zur herstellung von n- acetylneuraminsäure.
PT97397A (pt) Processo para a preparacao de penicilina g acilase e de genes que a codificam
Hottmann et al. Peptidoglycan salvage enables the periodontal pathogen Tannerella forsythia to survive within the oral microbial community
JPWO2003095660A1 (ja) シチジン５’−ジリン酸コリンの製造法
JP4318549B2 (ja) Ｎ−アセチルノイラミン酸の製造法
AU4335496A (en) Lactic bacteria producing exopolysaccharides
ES2272378T3 (es) Metodo para la produccion de nucleotidos por fermentacion.
BR9610848A (pt) Imunidade contra apx de toxinas rtx de actinobacillus pleuropneumoniae
PL312733A1 (en) Genes coding dehydrogenase complex of alpha-keto acids featuring branched chain, originating from streptomyces avermitilis microorganism
CY1105778T1 (el) Γονιδιο του streptomyces avermitilis που κατευθυνει την αναλογια των αβepμεκτινων β2:β1
BR0013093A (pt) Gene de streptomyces avermitilis que regula a proporção de avermectinas b2:b1
HUP0100784A2 (hu) A B2:B1 avermektinek arányát szabályozó Streptomyces avermitilis gén

Legal Events

Date Code Title Description
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/10/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 17A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2315 DE 19-05-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.