FI883757A0 - Terapeutiska nukleosider. - Google Patents

Terapeutiska nukleosider.

Info

Publication number
FI883757A0
FI883757A0 FI883757A FI883757A FI883757A0 FI 883757 A0 FI883757 A0 FI 883757A0 FI 883757 A FI883757 A FI 883757A FI 883757 A FI883757 A FI 883757A FI 883757 A0 FI883757 A0 FI 883757A0
Authority
FI
Finland
Prior art keywords
nucleosider
therapeutic
therapeutic nucleosider
Prior art date
Application number
FI883757A
Other languages
English (en)
Other versions
FI89713C (fi
FI883757A (fi
FI89713B (fi
Inventor
Thomas Anthony Krenitsky
Lilia Marie Beauchamp
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26292613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI883757(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB878719367A external-priority patent/GB8719367D0/en
Priority claimed from GB878725939A external-priority patent/GB8725939D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI883757A0 publication Critical patent/FI883757A0/fi
Publication of FI883757A publication Critical patent/FI883757A/fi
Application granted granted Critical
Publication of FI89713B publication Critical patent/FI89713B/fi
Publication of FI89713C publication Critical patent/FI89713C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
FI883757A 1987-08-15 1988-08-12 Foerfarande foer framstaellning av terapeutiskt aktivt 2-(2-amino-1,6-dihydro-6-oxo-9h(purin-9-yl)metoxi)etyl-l-valinat eller l-isoleucinat eller deras salt FI89713C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB878719367A GB8719367D0 (en) 1987-08-15 1987-08-15 Therapeutic compounds
GB878725939A GB8725939D0 (en) 1987-11-05 1987-11-05 Therapeutic compounds
GB8719367 1987-11-05
GB8725939 1987-11-05

Publications (4)

Publication Number Publication Date
FI883757A0 true FI883757A0 (fi) 1988-08-12
FI883757A FI883757A (fi) 1989-02-16
FI89713B FI89713B (fi) 1993-07-30
FI89713C FI89713C (fi) 1993-11-10

Family

ID=26292613

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883757A FI89713C (fi) 1987-08-15 1988-08-12 Foerfarande foer framstaellning av terapeutiskt aktivt 2-(2-amino-1,6-dihydro-6-oxo-9h(purin-9-yl)metoxi)etyl-l-valinat eller l-isoleucinat eller deras salt

Country Status (30)

Country Link
EP (2) EP0308065B1 (fi)
JP (2) JPH0662623B2 (fi)
KR (2) KR960002849B1 (fi)
CN (1) CN1033701C (fi)
AP (2) AP55A (fi)
AT (1) ATE138660T1 (fi)
AU (1) AU612393C (fi)
CS (1) CS276903B6 (fi)
CY (1) CY1833A (fi)
DE (1) DE3855333T2 (fi)
DK (2) DK170045B1 (fi)
ES (1) ES2087639T3 (fi)
FI (1) FI89713C (fi)
GR (1) GR3020372T3 (fi)
HU (1) HU201071B (fi)
IE (1) IE65551B1 (fi)
IL (1) IL87434A (fi)
LU (1) LU88746I2 (fi)
LV (1) LV5264A3 (fi)
MC (1) MC1968A1 (fi)
MX (1) MX9203418A (fi)
MY (1) MY103760A (fi)
NL (1) NL960001I2 (fi)
NO (2) NO167805C (fi)
NZ (1) NZ225809A (fi)
PL (1) PL158285B1 (fi)
PT (1) PT88261B (fi)
SA (1) SA95160244B1 (fi)
SG (1) SG26346G (fi)
SU (1) SU1634138A3 (fi)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
GB8816760D0 (en) * 1988-07-14 1988-08-17 Wellcome Found Therapeutic compounds
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
JP2788084B2 (ja) * 1988-12-19 1998-08-20 ザ ウエルカム フアウンデーシヨン リミテツド 抗ウイルス化合物
DE4008858A1 (de) * 1990-03-20 1991-09-26 Hoechst Ag Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
US5831075A (en) * 1993-06-10 1998-11-03 Rolabo Sl Amino acid ester of nucleoside analogues
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9320316D0 (en) * 1993-10-01 1993-11-17 Smithkline Beecham Plc Pharmaceuticals
TW282470B (fi) * 1993-11-18 1996-08-01 Ajinomoto Kk
EP0665229B1 (en) * 1994-02-01 1999-11-17 Ajinomoto Co., Inc. Process for the production of nucleic acid base derivatives
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
GB9501142D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Compounds for use in medicine
GB9501127D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Tablet
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
DK0874631T3 (da) * 1996-01-19 2004-03-22 Glaxo Group Ltd Anvendelse af valaciclovir til fremstilling af et medikament til behandling af genital herpes ved en enkelt daglig anvendelse
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
ATE222909T1 (de) * 1996-01-26 2002-09-15 Hoffmann La Roche Verfahren zur herstellung von purin-derivaten
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
IT1283447B1 (it) * 1996-07-18 1998-04-21 Ind Chimica Srl Processo di preparazione del valaciclovir e relativi intermedi
EP0976750A4 (en) * 1997-01-17 2001-05-30 Ajinomoto Kk NEW Z-VALACYCLOVIR CRYSTALS
CA2332961A1 (en) * 1998-05-21 1999-11-25 Michael Zasloff A method for stimulation of defensin production by exposure to isoleucine
US6849736B2 (en) * 2001-09-07 2005-02-01 Teva Pharmaceutical Industries Ltd. Crystalline forms of valacyclovir hydrochloride
WO2004000265A2 (en) 2002-06-24 2003-12-31 Ranbaxy Laboratories Limited Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
CN1309732C (zh) * 2002-10-28 2007-04-11 南京长澳医药科技有限公司 6－烷氧基－2’，3’－双脱氧鸟嘌呤核苷的制备方法
EP1638972A2 (en) * 2003-06-02 2006-03-29 Teva Pharmaceutical Industries Limited Novel crystalline forms of valacyclovir hydrochloride
CN1331471C (zh) * 2003-09-22 2007-08-15 陈云芳 盐酸万乃洛韦软胶囊组合物
JP2007522130A (ja) * 2004-01-21 2007-08-09 テバ ファーマシューティカル インダストリーズ リミティド 塩酸バラシクロビルの調製方法
GB2413017A (en) * 2004-04-06 2005-10-12 Ford Global Tech Llc An electrical connector for a vehicle
WO2006035452A1 (en) * 2004-09-27 2006-04-06 Matrix Laboratories Ltd Novel pseudomorph of valaciclovir hydrochloride
WO2006127217A2 (en) 2005-05-25 2006-11-30 Eli Lilly And Company Cyclopropanecarboxylate esters of acyclovir
EP1746098A1 (en) 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir polymorphs and a process for the preparation thereof
CN101456859B (zh) * 2009-01-06 2011-07-20 华南理工大学 抗病毒药物缬昔洛韦的制备方法
WO2011158252A1 (en) 2010-06-15 2011-12-22 Matrix Laboratories Ltd Process for the preparation of valacyclovir hydrochloride polymorphic form ii
CN102850354B (zh) * 2012-10-10 2014-07-23 山东金城医药化工股份有限公司 高纯度cbz-万乃洛韦的制备方法
CN106632335A (zh) * 2016-12-27 2017-05-10 河南康达制药有限公司 一种盐酸伐昔洛韦的制备方法
RU2750867C1 (ru) * 2020-05-18 2021-07-05 Александр Сергеевич Самойлов Производные гуанина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
DE3534774A1 (de) * 1985-09-30 1987-04-02 Robugen Gmbh Nucleosid-analoge verbindungen mit antiviraler aktivitaet, verfahren zu deren herstellung sowie arzneimittel mit antiviraler wirkung
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides

Also Published As

Publication number Publication date
EP0596542A1 (en) 1994-05-11
DK170803B1 (da) 1996-01-22
SG26346G (en) 1995-09-01
FI89713C (fi) 1993-11-10
NO1996015I1 (no) 1996-12-17
HU201071B (en) 1990-09-28
JPS6468373A (en) 1989-03-14
DK170045B1 (da) 1995-05-08
SU1634138A3 (ru) 1991-03-07
FI883757A (fi) 1989-02-16
JPH0662623B2 (ja) 1994-08-17
KR890003761A (ko) 1989-04-17
LU88746I2 (fr) 1996-10-04
ES2087639T3 (es) 1996-07-16
EP0308065B1 (en) 1995-01-04
PT88261A (pt) 1989-06-30
NL960001I1 (nl) 1996-03-01
AP8800099A0 (en) 1988-08-01
NL960001I2 (nl) 1996-11-01
KR960002849B1 (ko) 1996-02-27
PL158285B1 (en) 1992-08-31
DK82694A (da) 1994-07-08
IE65551B1 (en) 1995-11-01
NO883612D0 (no) 1988-08-12
GR3020372T3 (en) 1996-09-30
EP0308065A3 (en) 1989-09-27
NO167805C (no) 1991-12-11
PL274215A1 (en) 1990-02-19
MC1968A1 (fr) 1989-09-29
PT88261B (pt) 1995-03-01
EP0596542B1 (en) 1996-05-29
AP55A (en) 1989-09-26
AU2097888A (en) 1989-02-16
FI89713B (fi) 1993-07-30
CY1833A (en) 1995-12-01
MY103760A (en) 1993-09-30
JPH03115284A (ja) 1991-05-16
HUT47935A (en) 1989-04-28
CN1033701C (zh) 1997-01-01
AP160A (en) 1991-11-18
CN1032538A (zh) 1989-04-26
EP0308065A2 (en) 1989-03-22
IL87434A0 (en) 1989-01-31
SA95160244B1 (ar) 2006-10-02
NO883612L (no) 1989-02-16
AU612393B2 (en) 1991-07-11
CS8805594A2 (en) 1990-06-13
MX9203418A (es) 1992-07-01
DK451388A (da) 1989-02-16
NZ225809A (en) 1991-07-26
DE3855333T2 (de) 1996-12-05
LV5264A3 (lv) 1993-10-10
DE3855333D1 (de) 1996-07-04
DK451388D0 (da) 1988-08-12
AU612393C (en) 2006-08-17
ATE138660T1 (de) 1996-06-15
KR960004940B1 (ko) 1996-04-18
CS276903B6 (en) 1992-09-16
NO167805B (no) 1991-09-02
JPH07113025B2 (ja) 1995-12-06
IE882463L (en) 1989-02-15
IL87434A (en) 1993-06-10

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Legal Events

Date Code Title Description
BB Publication of examined application
ND Supplementary protection certificate (spc) granted
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L52

Extension date: 20091220

FG Patent granted

Owner name: THE WELLCOME FOUNDATION LIMITED

MA Patent expired