AP55A - Therapeutic Acyclic Nucleosides - Google Patents

Therapeutic Acyclic Nucleosides Download PDF

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Publication number
AP55A
AP55A APAP/P/1988/000099A AP8800099A AP55A AP 55 A AP55 A AP 55A AP 8800099 A AP8800099 A AP 8800099A AP 55 A AP55 A AP 55A
Authority
AP
ARIPO
Prior art keywords
compound
formula
group
salt
pharmaceutically acceptable
Prior art date
Application number
APAP/P/1988/000099A
Other languages
English (en)
Other versions
AP8800099A0 (en
Inventor
Thomas Anthony Krenitsky
Lilia Marie Beauchamp
Original Assignee
The Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26292613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP55(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB878719367A external-priority patent/GB8719367D0/en
Priority claimed from GB878725939A external-priority patent/GB8725939D0/en
Publication of AP8800099A0 publication Critical patent/AP8800099A0/xx
Application filed by The Wellcome Foundation Ltd filed Critical The Wellcome Foundation Ltd
Application granted granted Critical
Publication of AP55A publication Critical patent/AP55A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
APAP/P/1988/000099A 1987-08-15 1988-08-10 Therapeutic Acyclic Nucleosides AP55A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878719367A GB8719367D0 (en) 1987-08-15 1987-08-15 Therapeutic compounds
GB878725939A GB8725939D0 (en) 1987-11-05 1987-11-05 Therapeutic compounds

Publications (2)

Publication Number Publication Date
AP8800099A0 AP8800099A0 (en) 1988-08-01
AP55A true AP55A (en) 1989-09-26

Family

ID=26292613

Family Applications (2)

Application Number Title Priority Date Filing Date
APAP/P/1991/000238A AP160A (en) 1987-08-15 1988-08-10 Therapeutic acyclic nucleosides.
APAP/P/1988/000099A AP55A (en) 1987-08-15 1988-08-10 Therapeutic Acyclic Nucleosides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
APAP/P/1991/000238A AP160A (en) 1987-08-15 1988-08-10 Therapeutic acyclic nucleosides.

Country Status (30)

Country Link
EP (2) EP0596542B1 (fi)
JP (2) JPH0662623B2 (fi)
KR (2) KR960002849B1 (fi)
CN (1) CN1033701C (fi)
AP (2) AP160A (fi)
AT (1) ATE138660T1 (fi)
AU (1) AU612393C (fi)
CS (1) CS276903B6 (fi)
CY (1) CY1833A (fi)
DE (1) DE3855333T2 (fi)
DK (2) DK170045B1 (fi)
ES (1) ES2087639T3 (fi)
FI (1) FI89713C (fi)
GR (1) GR3020372T3 (fi)
HU (1) HU201071B (fi)
IE (1) IE65551B1 (fi)
IL (1) IL87434A (fi)
LU (1) LU88746I2 (fi)
LV (1) LV5264A3 (fi)
MC (1) MC1968A1 (fi)
MX (1) MX9203418A (fi)
MY (1) MY103760A (fi)
NL (1) NL960001I2 (fi)
NO (2) NO167805C (fi)
NZ (1) NZ225809A (fi)
PL (1) PL158285B1 (fi)
PT (1) PT88261B (fi)
SA (1) SA95160244B1 (fi)
SG (1) SG26346G (fi)
SU (1) SU1634138A3 (fi)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8816760D0 (en) * 1988-07-14 1988-08-17 Wellcome Found Therapeutic compounds
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
DE4008858A1 (de) * 1990-03-20 1991-09-26 Hoechst Ag Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
DE69426880T2 (de) * 1993-06-10 2001-10-31 Rolabo S.L., Zaragoza Verfahren zur herstellung von aminosäureester von nukleosid analogen
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9320316D0 (en) * 1993-10-01 1993-11-17 Smithkline Beecham Plc Pharmaceuticals
TW282470B (fi) * 1993-11-18 1996-08-01 Ajinomoto Kk
DE69513313T2 (de) * 1994-02-01 2000-07-13 Ajinomoto Co., Inc. Verfahren zur Herstellung von Nukleinsäurebasenderivaten
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5856481A (en) * 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
GB9501142D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Compounds for use in medicine
GB9501127D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Tablet
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
DK0874631T3 (da) * 1996-01-19 2004-03-22 Glaxo Group Ltd Anvendelse af valaciclovir til fremstilling af et medikament til behandling af genital herpes ved en enkelt daglig anvendelse
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
ATE222909T1 (de) * 1996-01-26 2002-09-15 Hoffmann La Roche Verfahren zur herstellung von purin-derivaten
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
IT1283447B1 (it) * 1996-07-18 1998-04-21 Ind Chimica Srl Processo di preparazione del valaciclovir e relativi intermedi
CN1250449A (zh) * 1997-01-17 2000-04-12 味之素株式会社 新型z－伐昔洛韦结晶
AU4007699A (en) * 1998-05-21 1999-12-06 Mark Anderson A method for stimulation of defensin production by exposure to isoleucin
EP1436295A4 (en) * 2001-09-07 2007-07-11 Teva Pharma CRISTALLINE FORMS OF VALACYCLOVIR HYDROCHLORIDE
US20060147519A1 (en) 2002-06-24 2006-07-06 Ashish Gogia Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
CN1309732C (zh) * 2002-10-28 2007-04-11 南京长澳医药科技有限公司 6－烷氧基－2’，3’－双脱氧鸟嘌呤核苷的制备方法
EP2014660A3 (en) * 2003-06-02 2009-07-15 Teva Pharmaceutical Industries Ltd Novel crystalline forms of valacyclovir hydrochloride
CN1331471C (zh) * 2003-09-22 2007-08-15 陈云芳 盐酸万乃洛韦软胶囊组合物
WO2005073233A1 (en) * 2004-01-21 2005-08-11 Teva Pharmaceutical Industries Ltd. Process for the preparation of valacyclovir hydrochloride
GB2413017A (en) * 2004-04-06 2005-10-12 Ford Global Tech Llc An electrical connector for a vehicle
WO2006035452A1 (en) * 2004-09-27 2006-04-06 Matrix Laboratories Ltd Novel pseudomorph of valaciclovir hydrochloride
ATE546451T1 (de) 2005-05-25 2012-03-15 Lilly Co Eli Cyclopropancarbonsäureester von acyclovir
EP1746098A1 (en) 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir polymorphs and a process for the preparation thereof
CN101456859B (zh) * 2009-01-06 2011-07-20 华南理工大学 抗病毒药物缬昔洛韦的制备方法
WO2011158252A1 (en) 2010-06-15 2011-12-22 Matrix Laboratories Ltd Process for the preparation of valacyclovir hydrochloride polymorphic form ii
CN102850354B (zh) * 2012-10-10 2014-07-23 山东金城医药化工股份有限公司 高纯度cbz-万乃洛韦的制备方法
CN106632335A (zh) * 2016-12-27 2017-05-10 河南康达制药有限公司 一种盐酸伐昔洛韦的制备方法
RU2750867C1 (ru) * 2020-05-18 2021-07-05 Александр Сергеевич Самойлов Производные гуанина

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3534774A1 (de) * 1985-09-30 1987-04-02 Robugen Gmbh Nucleosid-analoge verbindungen mit antiviraler aktivitaet, verfahren zu deren herstellung sowie arzneimittel mit antiviraler wirkung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3534774A1 (de) * 1985-09-30 1987-04-02 Robugen Gmbh Nucleosid-analoge verbindungen mit antiviraler aktivitaet, verfahren zu deren herstellung sowie arzneimittel mit antiviraler wirkung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.

Also Published As

Publication number Publication date
IL87434A0 (en) 1989-01-31
AP8800099A0 (en) 1988-08-01
DK170803B1 (da) 1996-01-22
NO167805B (no) 1991-09-02
ATE138660T1 (de) 1996-06-15
EP0596542B1 (en) 1996-05-29
NO1996015I1 (no) 1996-12-17
NO167805C (no) 1991-12-11
CS276903B6 (en) 1992-09-16
EP0308065B1 (en) 1995-01-04
HUT47935A (en) 1989-04-28
JPH07113025B2 (ja) 1995-12-06
NO883612D0 (no) 1988-08-12
CY1833A (en) 1995-12-01
FI89713B (fi) 1993-07-30
FI89713C (fi) 1993-11-10
PT88261B (pt) 1995-03-01
DE3855333D1 (de) 1996-07-04
JPH03115284A (ja) 1991-05-16
DE3855333T2 (de) 1996-12-05
KR960002849B1 (ko) 1996-02-27
NL960001I2 (nl) 1996-11-01
EP0596542A1 (en) 1994-05-11
SU1634138A3 (ru) 1991-03-07
AP160A (en) 1991-11-18
DK451388D0 (da) 1988-08-12
NO883612L (no) 1989-02-16
EP0308065A3 (en) 1989-09-27
DK451388A (da) 1989-02-16
IE65551B1 (en) 1995-11-01
PL274215A1 (en) 1990-02-19
PL158285B1 (en) 1992-08-31
PT88261A (pt) 1989-06-30
AU612393C (en) 2006-08-17
JPH0662623B2 (ja) 1994-08-17
CN1033701C (zh) 1997-01-01
ES2087639T3 (es) 1996-07-16
HU201071B (en) 1990-09-28
CN1032538A (zh) 1989-04-26
KR890003761A (ko) 1989-04-17
IE882463L (en) 1989-02-15
IL87434A (en) 1993-06-10
FI883757A0 (fi) 1988-08-12
MY103760A (en) 1993-09-30
JPS6468373A (en) 1989-03-14
LV5264A3 (lv) 1993-10-10
AU612393B2 (en) 1991-07-11
DK82694A (da) 1994-07-08
CS8805594A2 (en) 1990-06-13
SA95160244B1 (ar) 2006-10-02
LU88746I2 (fr) 1996-10-04
MC1968A1 (fr) 1989-09-29
AU2097888A (en) 1989-02-16
NZ225809A (en) 1991-07-26
SG26346G (en) 1995-09-01
FI883757A (fi) 1989-02-16
GR3020372T3 (en) 1996-09-30
KR960004940B1 (ko) 1996-04-18
EP0308065A2 (en) 1989-03-22
DK170045B1 (da) 1995-05-08
MX9203418A (es) 1992-07-01
NL960001I1 (nl) 1996-03-01

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