ATE222909T1 - Verfahren zur herstellung von purin-derivaten - Google Patents

Verfahren zur herstellung von purin-derivaten

Info

Publication number
ATE222909T1
ATE222909T1 AT97901569T AT97901569T ATE222909T1 AT E222909 T1 ATE222909 T1 AT E222909T1 AT 97901569 T AT97901569 T AT 97901569T AT 97901569 T AT97901569 T AT 97901569T AT E222909 T1 ATE222909 T1 AT E222909T1
Authority
AT
Austria
Prior art keywords
purine derivatives
intermediates
producing purine
purin
propanediol
Prior art date
Application number
AT97901569T
Other languages
English (en)
Inventor
Humberto B Arzeno
Steven D Axt
Colin C Beard
Charles A Dvorak
Paul R Fatheree
Lawrence E Fisher
Yeun-Kwei Han
Eric R Humphreys
Jan P Lund
Sam Linh Nguyen
Douglas Leslie Wren
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE222909T1 publication Critical patent/ATE222909T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97901569T 1996-01-26 1997-01-21 Verfahren zur herstellung von purin-derivaten ATE222909T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59207996A 1996-01-26 1996-01-26
PCT/EP1997/000262 WO1997027198A1 (en) 1996-01-26 1997-01-21 Process for preparing purine derivatives

Publications (1)

Publication Number Publication Date
ATE222909T1 true ATE222909T1 (de) 2002-09-15

Family

ID=24369197

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97901569T ATE222909T1 (de) 1996-01-26 1997-01-21 Verfahren zur herstellung von purin-derivaten

Country Status (10)

Country Link
JP (1) JP4094667B2 (de)
KR (1) KR100491941B1 (de)
CN (1) CN1064683C (de)
AT (1) ATE222909T1 (de)
AU (1) AU1543797A (de)
CA (1) CA2243650C (de)
DE (1) DE69714971T3 (de)
ES (1) ES2180923T5 (de)
MX (1) MX9805935A (de)
WO (1) WO1997027198A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
JP2007505070A (ja) * 2003-09-11 2007-03-08 エフ．ホフマン−ラ　ロシュ　アーゲー 抗ウイルス性ヌクレオシド誘導体を製造する方法
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
CN103562207B (zh) * 2011-05-31 2016-08-17 法尔玛赞公司 用于制备缬更昔洛韦的2-氨基-9-((2-苯基-1，3-二噁烷-5-基氧基)甲基)-1h-嘌呤-6(9h)-酮化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
JP3225545B2 (ja) * 1991-09-18 2001-11-05 味の素株式会社 非環状ヌクレオシド類の製造法
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables

Also Published As

Publication number Publication date
WO1997027198A1 (en) 1997-07-31
DE69714971T3 (de) 2005-12-15
CN1212693A (zh) 1999-03-31
JP4094667B2 (ja) 2008-06-04
DE69714971D1 (de) 2002-10-02
KR19990081991A (ko) 1999-11-15
AU1543797A (en) 1997-08-20
DE69714971T2 (de) 2003-05-28
MX9805935A (es) 1998-11-30
CN1064683C (zh) 2001-04-18
ES2180923T5 (es) 2005-10-16
ES2180923T3 (es) 2003-02-16
KR100491941B1 (ko) 2005-08-05
CA2243650C (en) 2006-08-15
CA2243650A1 (en) 1997-07-31
JP2000503977A (ja) 2000-04-04

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