DE3855333D1 - Therapeutische Nukleoside - Google Patents

Therapeutische Nukleoside

Info

Publication number
DE3855333D1
DE3855333D1 DE3855333T DE3855333T DE3855333D1 DE 3855333 D1 DE3855333 D1 DE 3855333D1 DE 3855333 T DE3855333 T DE 3855333T DE 3855333 T DE3855333 T DE 3855333T DE 3855333 D1 DE3855333 D1 DE 3855333D1
Authority
DE
Germany
Prior art keywords
therapeutic nucleosides
nucleosides
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3855333T
Other languages
English (en)
Other versions
DE3855333T2 (de
Inventor
Thomas Anthony Krenitsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26292613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3855333(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB878719367A external-priority patent/GB8719367D0/en
Priority claimed from GB878725939A external-priority patent/GB8725939D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE3855333D1 publication Critical patent/DE3855333D1/de
Application granted granted Critical
Publication of DE3855333T2 publication Critical patent/DE3855333T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
DE3855333T 1987-08-15 1988-08-12 Therapeutische Nukleoside Expired - Lifetime DE3855333T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878719367A GB8719367D0 (en) 1987-08-15 1987-08-15 Therapeutic compounds
GB878725939A GB8725939D0 (en) 1987-11-05 1987-11-05 Therapeutic compounds

Publications (2)

Publication Number Publication Date
DE3855333D1 true DE3855333D1 (de) 1996-07-04
DE3855333T2 DE3855333T2 (de) 1996-12-05

Family

ID=26292613

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3855333T Expired - Lifetime DE3855333T2 (de) 1987-08-15 1988-08-12 Therapeutische Nukleoside

Country Status (30)

Country Link
EP (2) EP0596542B1 (de)
JP (2) JPH0662623B2 (de)
KR (2) KR960002849B1 (de)
CN (1) CN1033701C (de)
AP (2) AP160A (de)
AT (1) ATE138660T1 (de)
AU (1) AU612393C (de)
CS (1) CS276903B6 (de)
CY (1) CY1833A (de)
DE (1) DE3855333T2 (de)
DK (2) DK170045B1 (de)
ES (1) ES2087639T3 (de)
FI (1) FI89713C (de)
GR (1) GR3020372T3 (de)
HU (1) HU201071B (de)
IE (1) IE65551B1 (de)
IL (1) IL87434A (de)
LU (1) LU88746I2 (de)
LV (1) LV5264A3 (de)
MC (1) MC1968A1 (de)
MX (1) MX9203418A (de)
MY (1) MY103760A (de)
NL (1) NL960001I2 (de)
NO (2) NO167805C (de)
NZ (1) NZ225809A (de)
PL (1) PL158285B1 (de)
PT (1) PT88261B (de)
SA (1) SA95160244B1 (de)
SG (1) SG26346G (de)
SU (1) SU1634138A3 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
GB8816760D0 (en) * 1988-07-14 1988-08-17 Wellcome Found Therapeutic compounds
US5043339A (en) * 1988-12-19 1991-08-27 Burroughs Wellcome Co. Antiviral compounds
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
DE4008858A1 (de) * 1990-03-20 1991-09-26 Hoechst Ag Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
US5831075A (en) * 1993-06-10 1998-11-03 Rolabo Sl Amino acid ester of nucleoside analogues
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9320316D0 (en) * 1993-10-01 1993-11-17 Smithkline Beecham Plc Pharmaceuticals
TW282470B (de) * 1993-11-18 1996-08-01 Ajinomoto Kk
EP0665229B1 (de) * 1994-02-01 1999-11-17 Ajinomoto Co., Inc. Verfahren zur Herstellung von Nukleinsäurebasenderivaten
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
GB9501127D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Tablet
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
GB9501142D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Compounds for use in medicine
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
PT874631E (pt) * 1996-01-19 2004-04-30 Glaxo Group Ltd Utilizacao de valaciclovir para a manufactura de um medicamento para o tratamento de herpes genital por aplicacao diaria unica
ES2180923T5 (es) * 1996-01-26 2005-10-16 F. Hoffmann-La Roche Ag Proceso para la preparacion de derivados de purina.
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
IT1283447B1 (it) * 1996-07-18 1998-04-21 Ind Chimica Srl Processo di preparazione del valaciclovir e relativi intermedi
WO1998031683A1 (fr) * 1997-01-17 1998-07-23 Ajinomoto Co., Inc. Nouveaux cristaux de z-valacyclovir
EP1093364A1 (de) * 1998-05-21 2001-04-25 Magainin Pharmaceuticals Inc. Verfahren zur stimulation der defensinproduktion durch kontakt mit isoleucin
IL160721A0 (en) * 2001-09-07 2004-08-31 Teva Pharma Crystalline forms of valacyclovir hydrochloride
WO2004000265A2 (en) 2002-06-24 2003-12-31 Ranbaxy Laboratories Limited Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
CN1309732C (zh) * 2002-10-28 2007-04-11 南京长澳医药科技有限公司 6－烷氧基－2’，3’－双脱氧鸟嘌呤核苷的制备方法
EP2014660A3 (de) * 2003-06-02 2009-07-15 Teva Pharmaceutical Industries Ltd Neuartige kristalline Formen von Valacyclovir-Hydrochlorid
CN1331471C (zh) * 2003-09-22 2007-08-15 陈云芳 盐酸万乃洛韦软胶囊组合物
JP2007522130A (ja) * 2004-01-21 2007-08-09 テバ ファーマシューティカル インダストリーズ リミティド 塩酸バラシクロビルの調製方法
GB2413017A (en) * 2004-04-06 2005-10-12 Ford Global Tech Llc An electrical connector for a vehicle
WO2006035452A1 (en) * 2004-09-27 2006-04-06 Matrix Laboratories Ltd Novel pseudomorph of valaciclovir hydrochloride
ES2379804T3 (es) 2005-05-25 2012-05-03 Eli Lilly And Company Ésteres de ciclopropanocarboxilato de aciclovir
EP1746098A1 (de) 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir Polymorphe und Verfahren zu deren Herstellung
CN101456859B (zh) * 2009-01-06 2011-07-20 华南理工大学 抗病毒药物缬昔洛韦的制备方法
WO2011158252A1 (en) 2010-06-15 2011-12-22 Matrix Laboratories Ltd Process for the preparation of valacyclovir hydrochloride polymorphic form ii
CN102850354B (zh) * 2012-10-10 2014-07-23 山东金城医药化工股份有限公司 高纯度cbz-万乃洛韦的制备方法
CN106632335A (zh) * 2016-12-27 2017-05-10 河南康达制药有限公司 一种盐酸伐昔洛韦的制备方法
RU2750867C1 (ru) * 2020-05-18 2021-07-05 Александр Сергеевич Самойлов Производные гуанина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
DE3534774A1 (de) * 1985-09-30 1987-04-02 Robugen Gmbh Nucleosid-analoge verbindungen mit antiviraler aktivitaet, verfahren zu deren herstellung sowie arzneimittel mit antiviraler wirkung
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.

Also Published As

Publication number Publication date
JPS6468373A (en) 1989-03-14
FI89713B (fi) 1993-07-30
CS276903B6 (en) 1992-09-16
DK170803B1 (da) 1996-01-22
PT88261A (pt) 1989-06-30
NZ225809A (en) 1991-07-26
DK82694A (da) 1994-07-08
ATE138660T1 (de) 1996-06-15
IE65551B1 (en) 1995-11-01
NL960001I2 (nl) 1996-11-01
AP160A (en) 1991-11-18
AU612393C (en) 2006-08-17
LV5264A3 (lv) 1993-10-10
EP0596542B1 (de) 1996-05-29
AP55A (en) 1989-09-26
DK451388A (da) 1989-02-16
JPH0662623B2 (ja) 1994-08-17
SA95160244B1 (ar) 2006-10-02
PL158285B1 (en) 1992-08-31
NO167805B (no) 1991-09-02
EP0308065B1 (de) 1995-01-04
SU1634138A3 (ru) 1991-03-07
HU201071B (en) 1990-09-28
NL960001I1 (nl) 1996-03-01
MY103760A (en) 1993-09-30
AU612393B2 (en) 1991-07-11
FI883757A0 (fi) 1988-08-12
EP0308065A2 (de) 1989-03-22
JPH07113025B2 (ja) 1995-12-06
EP0308065A3 (en) 1989-09-27
DK451388D0 (da) 1988-08-12
IE882463L (en) 1989-02-15
IL87434A (en) 1993-06-10
CY1833A (en) 1995-12-01
AP8800099A0 (en) 1988-08-01
GR3020372T3 (en) 1996-09-30
AU2097888A (en) 1989-02-16
NO883612D0 (no) 1988-08-12
PT88261B (pt) 1995-03-01
LU88746I2 (fr) 1996-10-04
FI89713C (fi) 1993-11-10
DK170045B1 (da) 1995-05-08
EP0596542A1 (de) 1994-05-11
MC1968A1 (fr) 1989-09-29
IL87434A0 (en) 1989-01-31
PL274215A1 (en) 1990-02-19
ES2087639T3 (es) 1996-07-16
HUT47935A (en) 1989-04-28
MX9203418A (es) 1992-07-01
CN1032538A (zh) 1989-04-26
FI883757A (fi) 1989-02-16
NO883612L (no) 1989-02-16
NO1996015I1 (no) 1996-12-17
DE3855333T2 (de) 1996-12-05
KR960002849B1 (ko) 1996-02-27
JPH03115284A (ja) 1991-05-16
SG26346G (en) 1995-09-01
KR960004940B1 (ko) 1996-04-18
KR890003761A (ko) 1989-04-17
CN1033701C (zh) 1997-01-01
CS8805594A2 (en) 1990-06-13
NO167805C (no) 1991-12-11

Similar Documents

Publication Publication Date Title
DE3855333D1 (de) Therapeutische Nukleoside
DE19575021I2 (de) Therapeutische Nucleoside
KR910002326A (ko) 치료용 뉴클레오시드
DK0434450T3 (da) Terapeutiske nucleosider
DK713488A (da) Adenosinderivater
DK191688D0 (da) Terapeutiske nucleosider
DK564088A (da) Nukleosidderivater
DK406689D0 (da) Terapeutiske nucleosider
MC1914A1 (fr) Nucleosides therapeutiques
GB8706176D0 (en) Therapeutic nucleosides
GB8712691D0 (en) Therapeutic nucleosides
DK725088A (da) Terapeutiske nucleosider
KR880021434U (ko) 지압안대
ATE77386T1 (de) Therapeutische nucleoside.
IT213526Z2 (it) Massaggio idrofacciale
KR880019264U (ko) 개량 침통
GB8708512D0 (en) Therapeutic nucleosides
GB8723013D0 (en) Therapeutic nucleosides
GB8723746D0 (en) Therapeutic nucleosides
GB8723747D0 (en) Therapeutic nucleosides
GB8723793D0 (en) Therapeutic nucleosides

Legal Events

Date Code Title Description
8364 No opposition during term of opposition