HRP990287B1 - Stable complexes of poorly soluble compounds - Google Patents

Stable complexes of poorly soluble compounds

Info

Publication number
HRP990287B1
HRP990287B1 HRP990287A HRP990287B1 HR P990287 B1 HRP990287 B1 HR P990287B1 HR P990287 A HRP990287 A HR P990287A HR P990287 B1 HRP990287 B1 HR P990287B1
Authority
HR
Croatia
Prior art keywords
poorly soluble
soluble compounds
stable complexes
complexes
stable
Prior art date
Application number
Other languages
English (en)
Inventor
Antonio A Albano
Phuapradit Wantanee
Harpreet K Sandhu
Shah Navnit Hargovindas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26798138&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP990287(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HRP990287A2 publication Critical patent/HRP990287A2/hr
Publication of HRP990287B1 publication Critical patent/HRP990287B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR990287 1998-09-22 1999-09-20 Stable complexes of poorly soluble compounds HRP990287B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10133698P 1998-09-22 1998-09-22
US13653199P 1999-05-28 1999-05-28

Publications (2)

Publication Number Publication Date
HRP990287A2 HRP990287A2 (en) 2000-06-30
HRP990287B1 true HRP990287B1 (en) 2004-12-31

Family

ID=26798138

Family Applications (1)

Application Number Title Priority Date Filing Date
HR990287 HRP990287B1 (en) 1998-09-22 1999-09-20 Stable complexes of poorly soluble compounds

Country Status (33)

Country Link
US (1) US6350786B1 (de)
EP (1) EP0988863B2 (de)
JP (5) JP2000095708A (de)
KR (1) KR100362019B1 (de)
CN (1) CN1201821C (de)
AR (2) AR022096A1 (de)
AT (1) ATE265232T1 (de)
AU (1) AU770745B2 (de)
BR (1) BR9904283A (de)
CA (1) CA2282906C (de)
CO (1) CO5140077A1 (de)
CZ (1) CZ300215B6 (de)
DE (1) DE69916733T3 (de)
DK (1) DK0988863T4 (de)
ES (1) ES2218918T5 (de)
HK (1) HK1026632A1 (de)
HR (1) HRP990287B1 (de)
HU (1) HU228341B1 (de)
ID (1) ID24034A (de)
IL (1) IL131957A (de)
MA (1) MA26692A1 (de)
MY (1) MY124377A (de)
NO (1) NO326928B1 (de)
NZ (1) NZ337884A (de)
PE (1) PE20001049A1 (de)
PL (1) PL202757B1 (de)
PT (1) PT988863E (de)
RS (1) RS50193B (de)
RU (1) RU2240827C2 (de)
SG (1) SG97131A1 (de)
SI (1) SI0988863T2 (de)
TR (1) TR199902324A3 (de)
TW (1) TWI234465B (de)

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JP2022509965A (ja) 2018-12-03 2022-01-25 ハー・ルンドベック・アクチエゼルスカベット ４－（（１Ｒ，３Ｓ）－６－クロロ－３－フェニル－２，３－ジヒドロ－１Ｈ－インデン－１－イル）－１，２，２－トリメチルピペラジン及び４－（（１Ｒ，３Ｓ）－６－クロロ－３－（フェニル－ｄ５）－２，３－ジヒドロ－１Ｈ－インデン－１－イル）－２，２－ジメチル－１－（メチル－ｄ３）ピペラジンのプロドラッグ
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PE20001049A1 (es) 2000-10-17
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NZ337884A (en) 2001-02-23
RU2240827C2 (ru) 2004-11-27
IL131957A (en) 2005-06-19
EP0988863A3 (de) 2000-08-09
HUP9903189A2 (hu) 2000-06-28
US6350786B1 (en) 2002-02-26
JP6253135B2 (ja) 2017-12-27
ES2218918T5 (es) 2009-06-23
JP2015187170A (ja) 2015-10-29
HK1026632A1 (en) 2000-12-22
AU4880799A (en) 2000-03-23
DE69916733D1 (de) 2004-06-03
DE69916733T2 (de) 2005-03-31
JP2007224048A (ja) 2007-09-06
CA2282906C (en) 2010-07-20
PT988863E (pt) 2004-07-30
BR9904283A (pt) 2000-09-26
CA2282906A1 (en) 2000-03-22
KR20000023426A (ko) 2000-04-25
TR199902324A2 (xx) 2000-04-21
EP0988863B2 (de) 2009-03-18
SI0988863T1 (en) 2004-08-31
EP0988863A2 (de) 2000-03-29
HU228341B1 (en) 2013-03-28
PL202757B1 (pl) 2009-07-31
HRP990287A2 (en) 2000-06-30
HUP9903189A3 (en) 2009-07-28
ATE265232T1 (de) 2004-05-15
SG97131A1 (en) 2003-07-18
IL131957A0 (en) 2001-03-19
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AU770745B2 (en) 2004-03-04
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