HRP20230185T1 - Pegilirani liposomi za isporuku rna koja kodira imunogen - Google Patents

Pegilirani liposomi za isporuku rna koja kodira imunogen Download PDF

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Publication number
HRP20230185T1
HRP20230185T1 HRP20230185TT HRP20230185T HRP20230185T1 HR P20230185 T1 HRP20230185 T1 HR P20230185T1 HR P20230185T T HRP20230185T T HR P20230185TT HR P20230185 T HRP20230185 T HR P20230185T HR P20230185 T1 HRP20230185 T1 HR P20230185T1
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liposome
rna
polyethylene glycol
immunogen
human herpesvirus
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HRP20230185TT
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Andrew Geall
Ayush Verma
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Glaxosmithkline Biologicals Sa
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Publication of HRP20230185T1 publication Critical patent/HRP20230185T1/hr
Publication of HRP20230185T8 publication Critical patent/HRP20230185T8/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36171—Demonstrated in vivo effect
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Claims (11)

1. Liposom unutar kojeg je inkapsulirana RNK koja kodira imunogen od interesa, pri čemu liposom sadrži najmanje jedan lipid koji uključuje polietilen glikolni dio, tako da je polietilen glikol prisutan na vanjskoj strani liposoma; pri čemu je prosječna molekularna masa polietilen glikola između 1 kDa i 3 kDa; pri čemu je imunogen izveden iz humanog herpesvirusa i izaziva imunološki odgovor protiv herpesvirusa.
2. Liposom prema zahtjevu 1, naznačen time što je prosječna molekularna masa polietilen glikola 2 kDa.
3. Liposom prema bilo kojem prethodnom zahtjevu, naznačen time što liposom ima promjer u rasponu od 80-160 nm.
4. Liposom prema bilo kojem prethodnom zahtjevu, naznačen time što liposom sadrži lipid s kationskom glavnom skupinom.
5. Liposom prema bilo kojem prethodnom zahtjevu, naznačen time što liposom sadrži lipid s zwitterionskom glavnom skupinom.
6. Liposom prema bilo kojem prethodnom zahtjevu, naznačen time što je imunogen izveden iz humanog herpesvirusa koji je Herpes Simplex virus (HSV) (npr. HSV tip 1 ili 2), Varicella-zoster virus (VZV), Epstein-Barr virus (EBV), citomegalovirus (CMV), humani herpesvirus 6 (HHV6), humani herpesvirus 7 (HHV7), ili humani herpesvirus 8 (HHV8).
7. Liposom prema bilo kojem prethodnom zahtjevu, naznačen time što je RNA samo-replicirajuća RNA.
8. Farmaceutski pripravak koji sadrži liposom prema bilo kojem prethodnom zahtjevu, naznačen time što farmaceutski pripravak sadrži više takvih liposoma.
9. Liposom prema zahtjevima 1-7, ili farmaceutski pripravak prema zahtjevu 8, za uporabu u postupku za podizanje zaštitnog imunološkog odgovora kod kralježnjaka, koji sadrži korak davanja kralježnjaku učinkovite količine navedenog liposoma, ili navedenog farmaceutskog pripravka.
10. Proces za pripremu liposoma koji sadrži RNA, koji sadrži korak miješanja RNA s jednim ili više lipida, pod takvim uvjetima da lipidi tvore liposom u kojem je RNA inkapsulirana, pri čemu najmanje jedan lipid uključuje polietilen glikolni dio koji postaje lociran na vanjskoj strani liposoma tijekom procesa, i pri čemu je prosječna molekularna masa polietilen glikola između 1kDa i 3kDa; pri čemu RNA kodira imunogen koji je izveden iz humanog herpesvirusa i izaziva imunološki odgovor protiv herpesvirusa; izborno pri čemu je postupak za pripremu liposoma prema bilo kojem od zahtjeva 2-7.
11. Postupak prema patentnom zahtjevu 10, koji nadalje sadrži pripremu farmaceutskog pripravka koji sadrži farmaceutski prihvatljiv nosač uz liposom.
HRP20230185TT 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rna koja kodira imunogen HRP20230185T8 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37882610P 2010-08-31 2010-08-31
EP22174932.8A EP4066857B1 (en) 2010-08-31 2011-08-31 Pegylated liposomes for delivery of immunogen-encoding rna

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HRP20230185T1 true HRP20230185T1 (hr) 2023-03-31
HRP20230185T8 HRP20230185T8 (hr) 2023-07-21

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Family Applications (6)

Application Number Title Priority Date Filing Date
HRP20220695TT HRP20220695T1 (hr) 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rnk kodirane za imunogen
HRP20230226TT HRP20230226T1 (hr) 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rna koja kodira imunogen
HRP20221023TT HRP20221023T1 (hr) 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rna koja kodira imunogen
HRP20230185TT HRP20230185T8 (hr) 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rna koja kodira imunogen
HRP20221533TT HRP20221533T1 (hr) 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rna koja kodira imunogen
HRP20220835TT HRP20220835T8 (hr) 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rna koja kodira imunogen

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Application Number Title Priority Date Filing Date
HRP20220695TT HRP20220695T1 (hr) 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rnk kodirane za imunogen
HRP20230226TT HRP20230226T1 (hr) 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rna koja kodira imunogen
HRP20221023TT HRP20221023T1 (hr) 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rna koja kodira imunogen

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Application Number Title Priority Date Filing Date
HRP20221533TT HRP20221533T1 (hr) 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rna koja kodira imunogen
HRP20220835TT HRP20220835T8 (hr) 2010-08-31 2011-08-31 Pegilirani liposomi za isporuku rna koja kodira imunogen

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US (3) US20130202684A1 (hr)
EP (11) EP4226941B1 (hr)
JP (1) JP5911870B2 (hr)
CN (1) CN103179984A (hr)
AU (1) AU2011295935B2 (hr)
BR (1) BR112013004866A2 (hr)
CA (1) CA2809851A1 (hr)
DK (6) DK2611461T3 (hr)
ES (6) ES2918192T3 (hr)
FI (2) FI4066855T3 (hr)
HR (6) HRP20220695T1 (hr)
HU (6) HUE058361T2 (hr)
LT (6) LT3981427T (hr)
MX (1) MX2013002336A (hr)
PL (6) PL3970742T3 (hr)
PT (6) PT4066857T (hr)
RS (6) RS63315B1 (hr)
RU (1) RU2013114362A (hr)
SI (6) SI4066856T1 (hr)
WO (1) WO2012031043A1 (hr)

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