HRP20200091T1 - Unos rna za okidanje više imunosnih puteva - Google Patents

Unos rna za okidanje više imunosnih puteva Download PDF

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Publication number
HRP20200091T1
HRP20200091T1 HRP20200091TT HRP20200091T HRP20200091T1 HR P20200091 T1 HRP20200091 T1 HR P20200091T1 HR P20200091T T HRP20200091T T HR P20200091TT HR P20200091 T HRP20200091 T HR P20200091T HR P20200091 T1 HRP20200091 T1 HR P20200091T1
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HR
Croatia
Prior art keywords
rna
self
intended
immunogens
cap
Prior art date
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HRP20200091TT
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English (en)
Inventor
Andrew Geall
Katrin Ramsauer
Gillis Otten
Christian Mandl
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Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of HRP20200091T1 publication Critical patent/HRP20200091T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (7)

1. Samoreplicirajuća RNA koja kodira imunogene, naznačena time što je namijenjena upotrebi u profilaktičnom ili terapijskom postupku postizanja imunosnog odgovora kod kralježnjaka, gdje RNA ima 5’ kapu, gdje imunogen izaziva imunosni odgovor protiv bakterije, virusa, gljivice ili parazita, gdje se navedeni postupak sastoji u primjeni RNA koja kodira imunogene na kralježnjaku u kombinaciji sa submikrometarskom kationskom emulzijom ulja u vodi tako da RNA: (i) stimulira endosomski receptor TLR7 vezan uz prirođenu imunost; (ii) stimulira citoplazmatski receptor RIG-1 ili MDA5 vezan uz prirođenu imunost; i (iii) translatira se kako bi se omogućilo eksprimiranje imunogena, uz uvjet da RNA ne sadrži modificirane nukleotide osim 5’ kape.
2. Samoreplicirajuća RNA koja kodira imunogene namijenjena upotrebi u skladu s patentnim zahtjevom 1, naznačena time što se RNA primjenjuje na skeletno mišićno tkivo.
3. Samoreplicirajuća RNA koja kodira imunogene namijenjena upotrebi u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što se RNA primjenjuje injiciranjem.
4. Samoreplicirajuća RNA koja kodira imunogene namijenjena upotrebi u skladu s patentnim zahtjevom 3, naznačena time što se injiciranje provodi iglom.
5. Samoreplicirajuća RNA koja kodira imunogene namijenjena upotrebi u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što je RNA +-lančana.
6. Farmaceutski pripravak, naznačen time što sadrži samoreplicirajuću RNA koja kodira imunogene namijenjenu upotrebi u profilaktičnom ili terapijskom postupku postizanja imunosnog odgovora kod kralježnjaka, gdje RNA ima 5’ kapu, gdje imunogen izaziva imunosni odgovor protiv bakterije, virusa, gljivice ili parazita, gdje se navedeni postupak sastoji u primjeni RNA koja kodira imunogene na kralježnjaku u kombinaciji sa submikrometarskom kationskom emulzijom ulja u vodi tako da RNA: (i) stimulira endosomski receptor TLR7 vezan uz prirođenu imunost; (ii) stimulira citoplazmatski receptor RIG-1 ili MDA5 vezan uz prirođenu imunost; i (iii) translatira se kako bi se omogućilo eksprimiranje imunogena, uz uvjet da RNA ne sadrži modificirane nukleotide osim 5’ kape.
7. Samoreplicirajuća RNA koja kodira imunogene namijenjena upotrebi u skladu s bilo kojim od patentnih zahtjeva 1-5, ili farmaceutski pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 6, naznačeni time što 5’ kapa sadrži 7-metilgvanozin.
HRP20200091TT 2010-07-06 2020-01-20 Unos rna za okidanje više imunosnih puteva HRP20200091T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36178910P 2010-07-06 2010-07-06
EP17177123.1A EP3243526B1 (en) 2010-07-06 2011-07-06 Delivery of rna to trigger multiple immune pathways

Publications (1)

Publication Number Publication Date
HRP20200091T1 true HRP20200091T1 (hr) 2020-04-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20200091TT HRP20200091T1 (hr) 2010-07-06 2020-01-20 Unos rna za okidanje više imunosnih puteva

Country Status (12)

Country Link
US (18) US9801897B2 (hr)
EP (2) EP2590670B1 (hr)
CY (1) CY1122515T1 (hr)
DK (1) DK3243526T3 (hr)
ES (2) ES2646669T3 (hr)
HR (1) HRP20200091T1 (hr)
HU (1) HUE047796T2 (hr)
LT (1) LT3243526T (hr)
PL (1) PL3243526T3 (hr)
PT (1) PT3243526T (hr)
SI (1) SI3243526T1 (hr)
WO (1) WO2012006377A2 (hr)

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