MXPA05010007A - Replicones de alfavirus y construcciones auxiliares mejorados. - Google Patents

Replicones de alfavirus y construcciones auxiliares mejorados.

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Publication number
MXPA05010007A
MXPA05010007A MXPA05010007A MXPA05010007A MXPA05010007A MX PA05010007 A MXPA05010007 A MX PA05010007A MX PA05010007 A MXPA05010007 A MX PA05010007A MX PA05010007 A MXPA05010007 A MX PA05010007A MX PA05010007 A MXPA05010007 A MX PA05010007A
Authority
MX
Mexico
Prior art keywords
nucleic acid
alphavirus
encoding
replication recognition
recognition sequence
Prior art date
Application number
MXPA05010007A
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English (en)
Inventor
Jon O Rayner
Original Assignee
Alphavax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alphavax Inc filed Critical Alphavax Inc
Publication of MXPA05010007A publication Critical patent/MXPA05010007A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2740/10011—Retroviridae
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    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
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    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36161—Methods of inactivation or attenuation
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36161—Methods of inactivation or attenuation
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

La presente invencion provee un acido nucleico recombinante, que comprende: una primera secuencia de acido nucleico que codifica para una secuencia de reconocimiento de replicacion de alfavirus 5'; por lo menos una segunda secuencia de acido nucleico que codifica para una proteina no estructural de alfavirus; por lo menos un promotor subgenomico de alfavirus; por lo menos un elemento de IRES; por lo menos un acido nucleico heterologo; y un tercer acido nucleico que codifica para una secuencia de reconocimiento de replicacion de alfavirus 3'; se proveen ademas metodos para producir particulas de alfavirus que comprenden un acido nucleico recombinante de esta invencion, y metodos de uso de las composiciones de esta invencion; se provee tambien un acido nucleico auxiliar recombinante que comprende: una primera secuencia de acido nucleico que codifica para una secuencia de reconocimiento de replicacion de alfavirus 5'; un promotor subgenomico de alfavirus; un elemento de IRES; un segundo acido nucleico que codifica para una proteina estructural de alfavirus; y un tercer acido nucleico que codifica para una secuencia de reconocimiento de replicacion de alfavirus 3'.
MXPA05010007A 2003-03-20 2004-03-19 Replicones de alfavirus y construcciones auxiliares mejorados. MXPA05010007A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45619603P 2003-03-20 2003-03-20
PCT/US2004/008458 WO2004085660A2 (en) 2003-03-20 2004-03-19 Improved alphavirus replicons and helper constructs

Publications (1)

Publication Number Publication Date
MXPA05010007A true MXPA05010007A (es) 2006-03-10

Family

ID=33098094

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05010007A MXPA05010007A (es) 2003-03-20 2004-03-19 Replicones de alfavirus y construcciones auxiliares mejorados.

Country Status (17)

Country Link
US (1) US7442381B2 (es)
EP (1) EP1608762B1 (es)
JP (2) JP5016305B2 (es)
KR (2) KR101454842B1 (es)
CN (1) CN1791678A (es)
AU (1) AU2004223477B2 (es)
BR (1) BRPI0408424B8 (es)
CA (1) CA2518546C (es)
DK (1) DK1608762T3 (es)
ES (1) ES2453344T3 (es)
HK (1) HK1084692A1 (es)
IL (1) IL170607A (es)
MX (1) MXPA05010007A (es)
NZ (1) NZ542353A (es)
PL (1) PL1608762T3 (es)
WO (1) WO2004085660A2 (es)
ZA (1) ZA200507153B (es)

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