ATE420191T1 - Promotoren zur expression im modifizierten vacciniavirus ankara - Google Patents
Promotoren zur expression im modifizierten vacciniavirus ankaraInfo
- Publication number
- ATE420191T1 ATE420191T1 AT04790902T AT04790902T ATE420191T1 AT E420191 T1 ATE420191 T1 AT E420191T1 AT 04790902 T AT04790902 T AT 04790902T AT 04790902 T AT04790902 T AT 04790902T AT E420191 T1 ATE420191 T1 AT E420191T1
- Authority
- AT
- Austria
- Prior art keywords
- expression
- ankara
- promotors
- modified
- vacciniavirus
- Prior art date
Links
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 title abstract 3
- 241000700618 Vaccinia virus Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
- A61K39/285—Vaccinia virus or variola virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301730 | 2003-11-24 | ||
| EP04000943A EP1536015B1 (de) | 2003-11-24 | 2004-01-17 | Promotoren zur Expression in modifiziertem Vaccinia Virus Ankara |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE420191T1 true ATE420191T1 (de) | 2009-01-15 |
Family
ID=34442836
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04000943T ATE377088T1 (de) | 2003-11-24 | 2004-01-17 | Promotoren zur expression in modifiziertem vaccinia virus ankara |
| AT07014231T ATE471383T1 (de) | 2003-11-24 | 2004-01-17 | Promotoren zur expression in modifiziertem vaccinia virus ankara |
| AT04790902T ATE420191T1 (de) | 2003-11-24 | 2004-10-27 | Promotoren zur expression im modifizierten vacciniavirus ankara |
| AT08008470T ATE504654T1 (de) | 2003-11-24 | 2004-10-27 | Promotoren zur expression in modifiziertem vaccinia virus ankara |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04000943T ATE377088T1 (de) | 2003-11-24 | 2004-01-17 | Promotoren zur expression in modifiziertem vaccinia virus ankara |
| AT07014231T ATE471383T1 (de) | 2003-11-24 | 2004-01-17 | Promotoren zur expression in modifiziertem vaccinia virus ankara |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08008470T ATE504654T1 (de) | 2003-11-24 | 2004-10-27 | Promotoren zur expression in modifiziertem vaccinia virus ankara |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US7816508B2 (de) |
| EP (4) | EP1845164B1 (de) |
| JP (2) | JP2007512009A (de) |
| KR (1) | KR20060109873A (de) |
| CN (1) | CN1898390A (de) |
| AT (4) | ATE377088T1 (de) |
| AU (1) | AU2004295382A1 (de) |
| BR (1) | BRPI0416916A (de) |
| CA (1) | CA2546680A1 (de) |
| DE (4) | DE602004009743T2 (de) |
| DK (3) | DK1536015T3 (de) |
| EA (1) | EA012846B1 (de) |
| IL (4) | IL174653A0 (de) |
| NO (1) | NO20062948L (de) |
| NZ (1) | NZ547405A (de) |
| SG (2) | SG142300A1 (de) |
| UA (1) | UA90098C2 (de) |
| WO (1) | WO2005054484A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101676389A (zh) * | 2000-11-23 | 2010-03-24 | 巴法里安诺迪克有限公司 | 改良安卡拉痘苗病毒变体 |
| DE602004009743T2 (de) * | 2003-11-24 | 2008-08-28 | Bavarian Nordic A/S | Promotoren zur Expression in modifiziertem Vaccinia Virus Ankara |
| EP2042604A1 (de) * | 2007-09-26 | 2009-04-01 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | VV-Promotergesteuerte Überexpression von rekombinanten Antigenen |
| WO2010060632A1 (en) * | 2008-11-27 | 2010-06-03 | Bavarian Nordic A/S | Promoters for recombinant viral expression |
| US8613936B2 (en) | 2009-03-13 | 2013-12-24 | Bavarian Nordic A/S | Replication deficient recombinant viruses expressing antigens regulated by transcriptional control elements comprising multiple elements |
| US8394385B2 (en) * | 2009-03-13 | 2013-03-12 | Bavarian Nordic A/S | Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines |
| GB201006405D0 (en) | 2010-04-16 | 2010-06-02 | Isis Innovation | Poxvirus expression system |
| WO2012048817A2 (en) | 2010-10-15 | 2012-04-19 | Bavarian Nordic A/S | Recombinant modified vaccinia virus ankara influenza vaccine |
| DK2788021T3 (en) | 2011-12-09 | 2017-04-10 | Bavarian Nordic As | POXVIRUS VECTOR FOR EXPRESSION OF BACTERIAL ANTIGENES CONNECTED TO TETANANOX INFRAGMENT C |
| DE102013004595A1 (de) | 2013-03-15 | 2014-09-18 | Emergent Product Development Germany Gmbh | RSV-Impfstoffe |
| FR3042121A1 (fr) | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| CN106754921A (zh) * | 2016-12-12 | 2017-05-31 | 孙浩 | 哺乳动物细胞表达启动子及其制造和使用方法 |
| US11242509B2 (en) * | 2017-05-12 | 2022-02-08 | Memorial Sloan Kettering Cancer Center | Vaccinia virus mutants useful for cancer immunotherapy |
| AU2024241503A1 (en) | 2023-03-17 | 2025-08-14 | Albert-Ludwigs-Universität Freiburg | Hbv antigen formulation for treating hepatitis b |
| WO2025172435A1 (en) | 2024-02-13 | 2025-08-21 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Hbv antigen formulation for treating hepatitis b |
| FR3160186A1 (fr) | 2024-03-13 | 2025-09-19 | Odimma Therapeutics | Vecteur non-viral pour transcription augmentee |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA68327C2 (en) | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
| RU2280075C2 (ru) | 2000-03-14 | 2006-07-20 | Бавариан Нордик А/С | Измененный штамм модифицированного вируса коровьей оспы ankara (mva) |
| CN101676389A (zh) * | 2000-11-23 | 2010-03-24 | 巴法里安诺迪克有限公司 | 改良安卡拉痘苗病毒变体 |
| PT1372710E (pt) * | 2001-03-08 | 2009-12-21 | Us Gov Health & Human Serv | Vam modificado que expressa os genes gag e pol do envelope de vih |
| CA2481783A1 (en) | 2002-05-16 | 2003-11-27 | Bavarian Nordic A/S | Expression of genes in modified vaccinia virus ankara by using the cowpox ati promoter |
| DE60336653D1 (de) * | 2002-08-07 | 2011-05-19 | Bavarian Nordic As | Vaccinia virus wirtspektrum gene zur erhöhung des titers von avipoxviren |
| DE602004009743T2 (de) * | 2003-11-24 | 2008-08-28 | Bavarian Nordic A/S | Promotoren zur Expression in modifiziertem Vaccinia Virus Ankara |
-
2004
- 2004-01-17 DE DE602004009743T patent/DE602004009743T2/de not_active Expired - Lifetime
- 2004-01-17 AT AT04000943T patent/ATE377088T1/de active
- 2004-01-17 EP EP07014231A patent/EP1845164B1/de not_active Expired - Lifetime
- 2004-01-17 DK DK04000943T patent/DK1536015T3/da active
- 2004-01-17 AT AT07014231T patent/ATE471383T1/de active
- 2004-01-17 DE DE602004027767T patent/DE602004027767D1/de not_active Expired - Lifetime
- 2004-01-17 DK DK07014231.0T patent/DK1845164T3/da active
- 2004-01-17 EP EP04000943A patent/EP1536015B1/de not_active Expired - Lifetime
- 2004-10-27 SG SG200802660-1A patent/SG142300A1/en unknown
- 2004-10-27 AT AT04790902T patent/ATE420191T1/de active
- 2004-10-27 SG SG201100204-5A patent/SG169325A1/en unknown
- 2004-10-27 EA EA200601043A patent/EA012846B1/ru not_active IP Right Cessation
- 2004-10-27 EP EP08008470A patent/EP1956094B1/de not_active Expired - Lifetime
- 2004-10-27 NZ NZ547405A patent/NZ547405A/en unknown
- 2004-10-27 KR KR1020067007781A patent/KR20060109873A/ko not_active Ceased
- 2004-10-27 UA UAA200607039A patent/UA90098C2/ru unknown
- 2004-10-27 BR BRPI0416916-6A patent/BRPI0416916A/pt not_active Application Discontinuation
- 2004-10-27 CN CNA2004800347488A patent/CN1898390A/zh active Pending
- 2004-10-27 EP EP04790902A patent/EP1689872B1/de not_active Expired - Lifetime
- 2004-10-27 AU AU2004295382A patent/AU2004295382A1/en not_active Abandoned
- 2004-10-27 JP JP2006540219A patent/JP2007512009A/ja active Pending
- 2004-10-27 WO PCT/EP2004/012125 patent/WO2005054484A1/en not_active Ceased
- 2004-10-27 CA CA002546680A patent/CA2546680A1/en not_active Abandoned
- 2004-10-27 DE DE602004032187T patent/DE602004032187D1/de not_active Expired - Lifetime
- 2004-10-27 US US10/580,206 patent/US7816508B2/en not_active Expired - Fee Related
- 2004-10-27 DE DE602004018975T patent/DE602004018975D1/de not_active Expired - Lifetime
- 2004-10-27 AT AT08008470T patent/ATE504654T1/de active
- 2004-10-27 DK DK04790902T patent/DK1689872T3/da active
-
2006
- 2006-03-30 IL IL174653A patent/IL174653A0/en not_active IP Right Cessation
- 2006-06-23 NO NO20062948A patent/NO20062948L/no not_active Application Discontinuation
-
2009
- 2009-06-03 IL IL199127A patent/IL199127A/en not_active IP Right Cessation
- 2009-06-03 IL IL199128A patent/IL199128A/en not_active IP Right Cessation
- 2009-06-03 IL IL199126A patent/IL199126A/en not_active IP Right Cessation
-
2010
- 2010-09-10 US US12/879,119 patent/US20110008792A1/en not_active Abandoned
- 2010-09-10 US US12/879,101 patent/US20110014242A1/en not_active Abandoned
- 2010-12-22 JP JP2010285881A patent/JP2011067219A/ja not_active Withdrawn
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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