HRP20171966T1 - Postupak za proizvodnju rekombinantnih proteina s niskim razinama dhna (1,4-dihidroksi-2-naftoata) - Google Patents

Postupak za proizvodnju rekombinantnih proteina s niskim razinama dhna (1,4-dihidroksi-2-naftoata) Download PDF

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Publication number
HRP20171966T1
HRP20171966T1 HRP20171966TT HRP20171966T HRP20171966T1 HR P20171966 T1 HRP20171966 T1 HR P20171966T1 HR P20171966T T HRP20171966T T HR P20171966TT HR P20171966 T HRP20171966 T HR P20171966T HR P20171966 T1 HRP20171966 T1 HR P20171966T1
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HR
Croatia
Prior art keywords
recombinant protein
maintained
dhna
homogenization
levels
Prior art date
Application number
HRP20171966TT
Other languages
English (en)
Croatian (hr)
Inventor
Michael W. Laird
Richard St. John
Jane V. GUNSON
Kim KALEAS
Deepa NADARAJAH
Rachel Adams
Bradley R. Snedecor
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of HRP20171966T1 publication Critical patent/HRP20171966T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HRP20171966TT 2012-03-27 2013-03-14 Postupak za proizvodnju rekombinantnih proteina s niskim razinama dhna (1,4-dihidroksi-2-naftoata) HRP20171966T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261616297P 2012-03-27 2012-03-27
PCT/US2013/031383 WO2013148249A1 (en) 2012-03-27 2013-03-14 Improved harvest operations for recombinant proteins
EP13713295.7A EP2831261B1 (en) 2012-03-27 2013-03-14 Method for producing recombinant proteins with low levels of DHNA (1,4-dihydroxy-2-naphthoate)

Publications (1)

Publication Number Publication Date
HRP20171966T1 true HRP20171966T1 (hr) 2018-02-09

Family

ID=48040433

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20171966TT HRP20171966T1 (hr) 2012-03-27 2013-03-14 Postupak za proizvodnju rekombinantnih proteina s niskim razinama dhna (1,4-dihidroksi-2-naftoata)

Country Status (20)

Country Link
US (9) US20140080180A1 (https=)
EP (1) EP2831261B1 (https=)
JP (4) JP6225162B2 (https=)
KR (2) KR102096678B1 (https=)
CN (2) CN109880867A (https=)
AR (2) AR090340A1 (https=)
AU (3) AU2013240280A1 (https=)
BR (1) BR112014023176B1 (https=)
CA (2) CA3086730A1 (https=)
ES (1) ES2654424T3 (https=)
HR (1) HRP20171966T1 (https=)
IL (1) IL234377B (https=)
MX (3) MX365947B (https=)
MY (1) MY171729A (https=)
PL (1) PL2831261T3 (https=)
RU (2) RU2636353C2 (https=)
SG (4) SG10201912877SA (https=)
SI (1) SI2831261T1 (https=)
WO (1) WO2013148249A1 (https=)
ZA (1) ZA201406434B (https=)

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CN120943884A (zh) * 2018-03-27 2025-11-14 百时美施贵宝公司 使用紫外线信号实时监测滴度
WO2020150491A1 (en) * 2019-01-16 2020-07-23 Regeneron Pharmaceuticals, Inc. Methods for characterizing disulfide bonds
CN109725088B (zh) * 2019-03-16 2021-05-18 丁立平 一种测定豆芽中2-萘甲酸及其衍生物的气相色谱-质谱联用法
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113155776A (zh) * 2021-04-29 2021-07-23 华东交通大学 一种柑桔最佳采收期预测方法
FR3146146A1 (fr) 2023-02-24 2024-08-30 Bgene Genetics Production d’acide 1-4-dihydroxy-2-naphtoïque par Escherichia coli

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Publication number Publication date
JP6225162B2 (ja) 2017-11-01
CN109880867A (zh) 2019-06-14
SI2831261T1 (en) 2018-01-31
PL2831261T3 (pl) 2018-04-30
JP2015512259A (ja) 2015-04-27
EP2831261B1 (en) 2017-10-18
BR112014023176B1 (pt) 2021-09-28
US9765379B2 (en) 2017-09-19
CN104350156B (zh) 2019-04-02
US20160130624A1 (en) 2016-05-12
JP2019141049A (ja) 2019-08-29
AU2017202484B2 (en) 2019-06-13
MX2018007677A (es) 2020-11-12
US20210171997A1 (en) 2021-06-10
ES2654424T3 (es) 2018-02-13
WO2013148249A1 (en) 2013-10-03
US20250137027A1 (en) 2025-05-01
CA2866753C (en) 2020-09-22
AU2019226192A1 (en) 2019-09-26
JP2018046825A (ja) 2018-03-29
US20200199639A1 (en) 2020-06-25
EP2831261A1 (en) 2015-02-04
US20230069966A1 (en) 2023-03-09
AR090340A1 (es) 2014-11-05
SG10201508420VA (en) 2015-11-27
SG10202007206WA (en) 2020-08-28
US20180291411A1 (en) 2018-10-11
ZA201406434B (en) 2017-08-30
RU2017139267A (ru) 2019-02-12
SG10201912877SA (en) 2020-02-27
CA3086730A1 (en) 2013-10-03
US20140080180A1 (en) 2014-03-20
RU2636353C2 (ru) 2017-11-22
MX2019007032A (es) 2019-08-16
BR112014023176A2 (pt) 2017-06-20
AR116615A2 (es) 2021-05-26
AU2013240280A1 (en) 2014-10-16
CN104350156A (zh) 2015-02-11
HK1207120A1 (en) 2016-01-22
KR20200037425A (ko) 2020-04-08
US20240158825A1 (en) 2024-05-16
US20150225760A1 (en) 2015-08-13
MY171729A (en) 2019-10-25
JP2020202849A (ja) 2020-12-24
SG11201406112TA (en) 2014-10-30
AU2017202484A1 (en) 2017-05-04
KR20140148392A (ko) 2014-12-31
MX2014011558A (es) 2014-11-14
IL234377B (en) 2021-01-31
RU2014137554A (ru) 2016-05-20
MX365947B (es) 2019-06-19
CA2866753A1 (en) 2013-10-03
KR102096678B1 (ko) 2020-04-02

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