RU2636353C2 - Усовершенствованные способы выделения рекобинантных белков - Google Patents

Усовершенствованные способы выделения рекобинантных белков Download PDF

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Publication number
RU2636353C2
RU2636353C2 RU2014137554A RU2014137554A RU2636353C2 RU 2636353 C2 RU2636353 C2 RU 2636353C2 RU 2014137554 A RU2014137554 A RU 2014137554A RU 2014137554 A RU2014137554 A RU 2014137554A RU 2636353 C2 RU2636353 C2 RU 2636353C2
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recombinant protein
host cell
prokaryotic host
antibodies
recombinant
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RU2014137554A
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Russian (ru)
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RU2014137554A (ru
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Майкл У. ЛЕЙРД
ДЖОН Ричард СТ.
Джейн В. ГАНСОН
Ким КАЛЕАС
Дипа НАДАРАДЖА
Рэйчел АДАМС
Брэдли Р. СНЕДЕКОР
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Дженентек, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2014137554A 2012-03-27 2013-03-14 Усовершенствованные способы выделения рекобинантных белков RU2636353C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261616297P 2012-03-27 2012-03-27
US61/616,297 2012-03-27
PCT/US2013/031383 WO2013148249A1 (en) 2012-03-27 2013-03-14 Improved harvest operations for recombinant proteins

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RU2017139267A Division RU2017139267A (ru) 2012-03-27 2013-03-14 Усовершенствованные способы выделения рекомбинантных белков

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RU2014137554A RU2014137554A (ru) 2016-05-20
RU2636353C2 true RU2636353C2 (ru) 2017-11-22

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RU2014137554A RU2636353C2 (ru) 2012-03-27 2013-03-14 Усовершенствованные способы выделения рекобинантных белков
RU2017139267A RU2017139267A (ru) 2012-03-27 2013-03-14 Усовершенствованные способы выделения рекомбинантных белков

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US (9) US20140080180A1 (https=)
EP (1) EP2831261B1 (https=)
JP (4) JP6225162B2 (https=)
KR (2) KR102096678B1 (https=)
CN (2) CN109880867A (https=)
AR (2) AR090340A1 (https=)
AU (3) AU2013240280A1 (https=)
BR (1) BR112014023176B1 (https=)
CA (2) CA3086730A1 (https=)
ES (1) ES2654424T3 (https=)
HR (1) HRP20171966T1 (https=)
IL (1) IL234377B (https=)
MX (3) MX365947B (https=)
MY (1) MY171729A (https=)
PL (1) PL2831261T3 (https=)
RU (2) RU2636353C2 (https=)
SG (4) SG10201912877SA (https=)
SI (1) SI2831261T1 (https=)
WO (1) WO2013148249A1 (https=)
ZA (1) ZA201406434B (https=)

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CN120943884A (zh) * 2018-03-27 2025-11-14 百时美施贵宝公司 使用紫外线信号实时监测滴度
WO2020150491A1 (en) * 2019-01-16 2020-07-23 Regeneron Pharmaceuticals, Inc. Methods for characterizing disulfide bonds
CN109725088B (zh) * 2019-03-16 2021-05-18 丁立平 一种测定豆芽中2-萘甲酸及其衍生物的气相色谱-质谱联用法
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113155776A (zh) * 2021-04-29 2021-07-23 华东交通大学 一种柑桔最佳采收期预测方法
FR3146146A1 (fr) 2023-02-24 2024-08-30 Bgene Genetics Production d’acide 1-4-dihydroxy-2-naphtoïque par Escherichia coli

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JP6225162B2 (ja) 2017-11-01
CN109880867A (zh) 2019-06-14
SI2831261T1 (en) 2018-01-31
PL2831261T3 (pl) 2018-04-30
JP2015512259A (ja) 2015-04-27
EP2831261B1 (en) 2017-10-18
BR112014023176B1 (pt) 2021-09-28
US9765379B2 (en) 2017-09-19
CN104350156B (zh) 2019-04-02
US20160130624A1 (en) 2016-05-12
JP2019141049A (ja) 2019-08-29
AU2017202484B2 (en) 2019-06-13
MX2018007677A (es) 2020-11-12
US20210171997A1 (en) 2021-06-10
ES2654424T3 (es) 2018-02-13
WO2013148249A1 (en) 2013-10-03
US20250137027A1 (en) 2025-05-01
CA2866753C (en) 2020-09-22
AU2019226192A1 (en) 2019-09-26
JP2018046825A (ja) 2018-03-29
US20200199639A1 (en) 2020-06-25
EP2831261A1 (en) 2015-02-04
US20230069966A1 (en) 2023-03-09
AR090340A1 (es) 2014-11-05
SG10201508420VA (en) 2015-11-27
SG10202007206WA (en) 2020-08-28
US20180291411A1 (en) 2018-10-11
ZA201406434B (en) 2017-08-30
RU2017139267A (ru) 2019-02-12
SG10201912877SA (en) 2020-02-27
CA3086730A1 (en) 2013-10-03
HRP20171966T1 (hr) 2018-02-09
US20140080180A1 (en) 2014-03-20
MX2019007032A (es) 2019-08-16
BR112014023176A2 (pt) 2017-06-20
AR116615A2 (es) 2021-05-26
AU2013240280A1 (en) 2014-10-16
CN104350156A (zh) 2015-02-11
HK1207120A1 (en) 2016-01-22
KR20200037425A (ko) 2020-04-08
US20240158825A1 (en) 2024-05-16
US20150225760A1 (en) 2015-08-13
MY171729A (en) 2019-10-25
JP2020202849A (ja) 2020-12-24
SG11201406112TA (en) 2014-10-30
AU2017202484A1 (en) 2017-05-04
KR20140148392A (ko) 2014-12-31
MX2014011558A (es) 2014-11-14
IL234377B (en) 2021-01-31
RU2014137554A (ru) 2016-05-20
MX365947B (es) 2019-06-19
CA2866753A1 (en) 2013-10-03
KR102096678B1 (ko) 2020-04-02

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