PL2831261T3 - Sposób wytwarzania rekombinowanych białek o niskim poziomie DHNA (1,4-dihydroksy-2-naftoesanu) - Google Patents

Sposób wytwarzania rekombinowanych białek o niskim poziomie DHNA (1,4-dihydroksy-2-naftoesanu)

Info

Publication number
PL2831261T3
PL2831261T3 PL13713295T PL13713295T PL2831261T3 PL 2831261 T3 PL2831261 T3 PL 2831261T3 PL 13713295 T PL13713295 T PL 13713295T PL 13713295 T PL13713295 T PL 13713295T PL 2831261 T3 PL2831261 T3 PL 2831261T3
Authority
PL
Poland
Prior art keywords
dhna
naphthoate
dihydroxy
low levels
recombinant proteins
Prior art date
Application number
PL13713295T
Other languages
English (en)
Inventor
Michael W. Laird
Richard St. John
Jane V. GUNSON
Kim KALEAS
Deepa NADARAJAH
Rachel Adams
Bradley R. Snedecor
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of PL2831261T3 publication Critical patent/PL2831261T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
PL13713295T 2012-03-27 2013-03-14 Sposób wytwarzania rekombinowanych białek o niskim poziomie DHNA (1,4-dihydroksy-2-naftoesanu) PL2831261T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261616297P 2012-03-27 2012-03-27
EP13713295.7A EP2831261B1 (en) 2012-03-27 2013-03-14 Method for producing recombinant proteins with low levels of DHNA (1,4-dihydroxy-2-naphthoate)
PCT/US2013/031383 WO2013148249A1 (en) 2012-03-27 2013-03-14 Improved harvest operations for recombinant proteins

Publications (1)

Publication Number Publication Date
PL2831261T3 true PL2831261T3 (pl) 2018-04-30

Family

ID=48040433

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13713295T PL2831261T3 (pl) 2012-03-27 2013-03-14 Sposób wytwarzania rekombinowanych białek o niskim poziomie DHNA (1,4-dihydroksy-2-naftoesanu)

Country Status (21)

Country Link
US (7) US20140080180A1 (pl)
EP (1) EP2831261B1 (pl)
JP (4) JP6225162B2 (pl)
KR (2) KR20200037425A (pl)
CN (2) CN109880867A (pl)
AR (2) AR090340A1 (pl)
AU (3) AU2013240280A1 (pl)
BR (1) BR112014023176B1 (pl)
CA (2) CA3086730A1 (pl)
ES (1) ES2654424T3 (pl)
HK (1) HK1207120A1 (pl)
HR (1) HRP20171966T1 (pl)
IL (1) IL234377B (pl)
MX (3) MX365947B (pl)
MY (1) MY171729A (pl)
PL (1) PL2831261T3 (pl)
RU (2) RU2017139267A (pl)
SG (4) SG10202007206WA (pl)
SI (1) SI2831261T1 (pl)
WO (1) WO2013148249A1 (pl)
ZA (1) ZA201406434B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018075548A2 (pt) * 2016-06-10 2019-04-09 Lonza Ltd método para estabilizar proteínas
WO2018085769A1 (en) * 2016-11-07 2018-05-11 Seattle Genetics, Inc. Distribution of engineered-cysteine caps
US20210024873A1 (en) * 2018-03-27 2021-01-28 Bristol-Myers Squibb Company Real-time monitoring of protein concentration using ultraviolet signal
CN109725088B (zh) * 2019-03-16 2021-05-18 丁立平 一种测定豆芽中2-萘甲酸及其衍生物的气相色谱-质谱联用法
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113155776A (zh) * 2021-04-29 2021-07-23 华东交通大学 一种柑桔最佳采收期预测方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2036891B (en) 1978-12-05 1983-05-05 Windsor Smith C Change speed gear
US4515893A (en) 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5672347A (en) 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
JPS63501765A (ja) 1985-11-01 1988-07-21 インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
DE68919361T2 (de) 1988-06-21 1995-05-24 Genentech Inc Therapeutische zusammensetzungen für die behandlung von myocard-infarkten.
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DK1260521T3 (da) 1991-08-14 2008-03-25 Genentech Inc Immunoglobulinvarianter af specifikke Fc-epsilonreceptorer
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5288931A (en) 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
EP0656064B1 (en) 1992-08-17 1997-03-05 Genentech, Inc. Bispecific immunoadhesins
DE69315847T2 (de) 1992-08-21 1998-06-25 Genentech Inc Verfahren zur behandlung einer durch lfa-1 vermittelten störung
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
JP3507852B2 (ja) 1993-12-10 2004-03-15 ジェネンテク,インコーポレイテッド アレルギー診断法および抗アレルギー性治療剤のスクリーニング法
WO1995019181A1 (en) 1994-01-18 1995-07-20 Genentech, Inc. A METHOD OF TREATMENT OF PARASITIC INFECTION USING IgE ANTAGONISTS
WO1995023865A1 (en) 1994-03-03 1995-09-08 Genentech, Inc. Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders
US5639635A (en) 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
AU6267896A (en) 1995-06-07 1996-12-30 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth oftumors
JP4864175B2 (ja) 1996-01-23 2012-02-01 ジェネンテック, インコーポレイテッド 発作に関する抗―cd18抗体
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
DE69729209T2 (de) 1996-11-27 2005-05-19 Genentech, Inc., South San Francisco Humanisierte anti-koerper gegen cd11a
BRPI9809387B8 (pt) 1997-04-07 2021-05-25 Genentech Inc anticorpo humanizado anti-fator de crescimento endotelial vascular humano e composição que o compreende
DK1860187T3 (da) 1997-05-15 2011-10-31 Genentech Inc Apo-2-receptor
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
AU778199B2 (en) 1999-10-29 2004-11-25 Genentech Inc. Anti-prostate stem cell antigen (PSCA) antibody compositions and methods of use
US6946271B2 (en) * 2000-09-20 2005-09-20 Degussa Ag Nucleotide sequences which code for the menE gene
US6979556B2 (en) 2000-12-14 2005-12-27 Genentech, Inc. Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
JP4351674B2 (ja) 2002-12-16 2009-10-28 ジェネンテック・インコーポレーテッド 免疫グロブリン変異体とその使用法およびその使用
JP4579158B2 (ja) * 2003-03-26 2010-11-10 明治乳業株式会社 1,4−ジヒドロキシ−2−ナフトエ酸の安定化方法
US7785830B2 (en) * 2003-08-13 2010-08-31 Sandoz Ag Expression vectors, transformed host cells and fermentation process for the production of recombinant polypeptides
WO2005078115A1 (en) * 2004-02-04 2005-08-25 Merck & Co., Inc. Process for large scale production of plasmid dna by e. coli fermentation
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
CN101115832A (zh) * 2004-11-26 2008-01-30 协和发酵工业株式会社 工业上有用的微生物
CN101437532B (zh) * 2006-05-05 2013-08-21 冈戈根股份有限公司 噬菌体衍生的抗微生物活性剂
JP5305615B2 (ja) * 2006-06-05 2013-10-02 株式会社Adeka メナキノンの新規生合成経路に関与するタンパク質の遺伝子群を利用したメナキノンの製造方法
BRPI0713252C1 (pt) * 2006-07-14 2021-05-25 Genentech Inc processo para a recuperação de fator de crescimento endotelial vascular (vegf) recombinante reenovelado
CA2691692C (en) * 2007-07-09 2021-05-18 Genentech, Inc. Prevention of disulfide bond reduction during recombinant production of polypeptides
CN101665798B (zh) * 2008-09-06 2012-11-21 浙江我武生物科技股份有限公司 一种制备重组人血清白蛋白与干扰素α融合蛋白的方法
CN101503470A (zh) * 2008-09-27 2009-08-12 上海交通大学 rhDSL重组蛋白及其制备方法
JP2010088387A (ja) * 2008-10-10 2010-04-22 Waseda Univ 放線菌内で目的タンパク質を誘導発現可能なプロモーター

Also Published As

Publication number Publication date
SG10202007206WA (en) 2020-08-28
JP2015512259A (ja) 2015-04-27
RU2636353C2 (ru) 2017-11-22
EP2831261A1 (en) 2015-02-04
EP2831261B1 (en) 2017-10-18
MX365947B (es) 2019-06-19
KR20140148392A (ko) 2014-12-31
SG11201406112TA (en) 2014-10-30
CA2866753A1 (en) 2013-10-03
RU2014137554A (ru) 2016-05-20
US9765379B2 (en) 2017-09-19
ZA201406434B (en) 2017-08-30
AR116615A2 (es) 2021-05-26
KR20200037425A (ko) 2020-04-08
CN104350156A (zh) 2015-02-11
US20150225760A1 (en) 2015-08-13
CA2866753C (en) 2020-09-22
US20210171997A1 (en) 2021-06-10
AU2013240280A1 (en) 2014-10-16
US20230069966A1 (en) 2023-03-09
JP2019141049A (ja) 2019-08-29
JP2018046825A (ja) 2018-03-29
CN104350156B (zh) 2019-04-02
MX2014011558A (es) 2014-11-14
BR112014023176B1 (pt) 2021-09-28
CN109880867A (zh) 2019-06-14
AU2019226192A1 (en) 2019-09-26
KR102096678B1 (ko) 2020-04-02
RU2017139267A (ru) 2019-02-12
SG10201912877SA (en) 2020-02-27
MX2019007032A (es) 2019-08-16
CA3086730A1 (en) 2013-10-03
US20180291411A1 (en) 2018-10-11
JP6225162B2 (ja) 2017-11-01
JP2020202849A (ja) 2020-12-24
MY171729A (en) 2019-10-25
ES2654424T3 (es) 2018-02-13
WO2013148249A1 (en) 2013-10-03
SI2831261T1 (en) 2018-01-31
BR112014023176A2 (pt) 2017-06-20
SG10201508420VA (en) 2015-11-27
HRP20171966T1 (hr) 2018-02-09
MX2018007677A (es) 2020-11-12
US20140080180A1 (en) 2014-03-20
US20160130624A1 (en) 2016-05-12
AU2017202484A1 (en) 2017-05-04
HK1207120A1 (en) 2016-01-22
US20200199639A1 (en) 2020-06-25
AU2017202484B2 (en) 2019-06-13
IL234377B (en) 2021-01-31
AR090340A1 (es) 2014-11-05

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