MX365947B - Operaciones de cosecha mejoradas para proteinas recombinadas. - Google Patents

Operaciones de cosecha mejoradas para proteinas recombinadas.

Info

Publication number
MX365947B
MX365947B MX2014011558A MX2014011558A MX365947B MX 365947 B MX365947 B MX 365947B MX 2014011558 A MX2014011558 A MX 2014011558A MX 2014011558 A MX2014011558 A MX 2014011558A MX 365947 B MX365947 B MX 365947B
Authority
MX
Mexico
Prior art keywords
recombinant protein
host cell
prokaryotic host
filtered bulk
recombinant proteins
Prior art date
Application number
MX2014011558A
Other languages
English (en)
Spanish (es)
Other versions
MX2014011558A (es
Inventor
Deepa Nadarajah
Michael W Laird
John Richard St
Jane V Gunson
Kim Kaleas
Rachel Adams
Bradley R Snedecor
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2014011558A publication Critical patent/MX2014011558A/es
Publication of MX365947B publication Critical patent/MX365947B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MX2014011558A 2012-03-27 2013-03-14 Operaciones de cosecha mejoradas para proteinas recombinadas. MX365947B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261616297P 2012-03-27 2012-03-27
PCT/US2013/031383 WO2013148249A1 (en) 2012-03-27 2013-03-14 Improved harvest operations for recombinant proteins

Publications (2)

Publication Number Publication Date
MX2014011558A MX2014011558A (es) 2014-11-14
MX365947B true MX365947B (es) 2019-06-19

Family

ID=48040433

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2014011558A MX365947B (es) 2012-03-27 2013-03-14 Operaciones de cosecha mejoradas para proteinas recombinadas.
MX2019007032A MX2019007032A (es) 2012-03-27 2014-09-25 Operaciones de cosecha mejoradas para proteinas recombinadas.
MX2018007677A MX2018007677A (es) 2012-03-27 2014-09-25 Operaciones de cosecha mejoradas para proteinas recombinadas.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2019007032A MX2019007032A (es) 2012-03-27 2014-09-25 Operaciones de cosecha mejoradas para proteinas recombinadas.
MX2018007677A MX2018007677A (es) 2012-03-27 2014-09-25 Operaciones de cosecha mejoradas para proteinas recombinadas.

Country Status (20)

Country Link
US (9) US20140080180A1 (https=)
EP (1) EP2831261B1 (https=)
JP (4) JP6225162B2 (https=)
KR (2) KR102096678B1 (https=)
CN (2) CN109880867A (https=)
AR (2) AR090340A1 (https=)
AU (3) AU2013240280A1 (https=)
BR (1) BR112014023176B1 (https=)
CA (2) CA3086730A1 (https=)
ES (1) ES2654424T3 (https=)
HR (1) HRP20171966T1 (https=)
IL (1) IL234377B (https=)
MX (3) MX365947B (https=)
MY (1) MY171729A (https=)
PL (1) PL2831261T3 (https=)
RU (2) RU2636353C2 (https=)
SG (4) SG10201912877SA (https=)
SI (1) SI2831261T1 (https=)
WO (1) WO2013148249A1 (https=)
ZA (1) ZA201406434B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6201037B1 (en) 1986-01-28 2001-03-13 Ophthalmic Research Group International, Inc. Plastic lens composition and method for the production thereof
IL263342B2 (en) * 2016-06-10 2023-11-01 Lonza Ag Method for stabilizing proteins
CA3041533A1 (en) 2016-11-07 2018-05-11 Seattle Genetics, Inc. Distribution of engineered-cysteine caps
CN120943884A (zh) * 2018-03-27 2025-11-14 百时美施贵宝公司 使用紫外线信号实时监测滴度
WO2020150491A1 (en) * 2019-01-16 2020-07-23 Regeneron Pharmaceuticals, Inc. Methods for characterizing disulfide bonds
CN109725088B (zh) * 2019-03-16 2021-05-18 丁立平 一种测定豆芽中2-萘甲酸及其衍生物的气相色谱-质谱联用法
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113155776A (zh) * 2021-04-29 2021-07-23 华东交通大学 一种柑桔最佳采收期预测方法
FR3146146A1 (fr) 2023-02-24 2024-08-30 Bgene Genetics Production d’acide 1-4-dihydroxy-2-naphtoïque par Escherichia coli

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2036891B (en) 1978-12-05 1983-05-05 Windsor Smith C Change speed gear
US4515893A (en) 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5672347A (en) 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
DE3689123T2 (de) 1985-11-01 1994-03-03 Xoma Corp Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung.
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
DE68919361T2 (de) 1988-06-21 1995-05-24 Genentech Inc Therapeutische zusammensetzungen für die behandlung von myocard-infarkten.
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
ES2193136T3 (es) 1991-08-14 2003-11-01 Genentech Inc Variantes de inmunoglubina para receptores especificos de fc epsilon.
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5288931A (en) 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
CA2140280A1 (en) 1992-08-17 1994-03-03 Avi J. Ashkenazi Bispecific immunoadhesins
AU687755B2 (en) 1992-08-21 1998-03-05 Genentech Inc. Method for treating an LFA-1-mediated disorder
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
ES2108566T3 (es) 1993-12-10 1997-12-16 Genentech Inc Procedimientos para diagnosticar alergias y para seleccionar agentes terapeuticos antialergicos.
WO1995019181A1 (en) 1994-01-18 1995-07-20 Genentech, Inc. A METHOD OF TREATMENT OF PARASITIC INFECTION USING IgE ANTAGONISTS
US5707622A (en) 1994-03-03 1998-01-13 Genentech, Inc. Methods for treating ulcerative colitis
US5639635A (en) 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
JPH11507535A (ja) 1995-06-07 1999-07-06 イムクローン システムズ インコーポレイテッド 腫瘍の成長を抑制する抗体および抗体フラグメント類
CA2242414C (en) 1996-01-23 2012-01-03 Genentech, Inc. Anti-cd18 antibodies for use against stroke
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
EP0941344B1 (en) 1996-11-27 2004-05-19 Genentech, Inc. HUMANIZED ANTI-CD11a ANTIBODIES
KR100816621B1 (ko) 1997-04-07 2008-03-24 제넨테크, 인크. 항-ｖｅｇｆ 항체
ES2293682T5 (es) 1997-05-15 2011-11-17 Genentech, Inc. Anticuerpo anti-apo2.
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
ES2309012T3 (es) 1999-10-29 2008-12-16 Genentech, Inc. Composiciones del anticuerpo anti-psca y a sus procedimientos contra celulas cancerigenas que expresen psca.
US6946271B2 (en) * 2000-09-20 2005-09-20 Degussa Ag Nucleotide sequences which code for the menE gene
US6979556B2 (en) 2000-12-14 2005-12-27 Genentech, Inc. Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
TWI335821B (en) 2002-12-16 2011-01-11 Genentech Inc Immunoglobulin variants and uses thereof
WO2004085364A1 (ja) * 2003-03-26 2004-10-07 Meiji Dairies Corporation １,４−ジヒドロキシ−２−ナフトエ酸の安定化方法
DE602004004796T2 (de) * 2003-08-13 2007-12-06 Sandoz Ag Expressionsvektoren, transformierte wirtszellen und fermentationsverfahren zur herstellung rekombinanter polypeptide
AU2005212237B2 (en) * 2004-02-04 2009-06-11 Merck Sharp & Dohme Llc Process for large scale production of plasmid DNA by E. coli fermentation
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
CN101115832A (zh) * 2004-11-26 2008-01-30 协和发酵工业株式会社 工业上有用的微生物
DK2037946T3 (en) * 2006-05-05 2015-04-27 Gangagen Inc ANTIMICROBIAL ACTIVITIES DERIVED BY PHAGER
JP5305615B2 (ja) * 2006-06-05 2013-10-02 株式会社Ａｄｅｋａ メナキノンの新規生合成経路に関与するタンパク質の遺伝子群を利用したメナキノンの製造方法
AR062069A1 (es) * 2006-07-14 2008-10-15 Genentech Inc Replegado de proteinas recombinantes
KR102055873B1 (ko) * 2007-07-09 2019-12-13 제넨테크, 인크. 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지
CN101665798B (zh) * 2008-09-06 2012-11-21 浙江我武生物科技股份有限公司 一种制备重组人血清白蛋白与干扰素α融合蛋白的方法
CN101503470A (zh) * 2008-09-27 2009-08-12 上海交通大学 rhDSL重组蛋白及其制备方法
JP2010088387A (ja) * 2008-10-10 2010-04-22 Waseda Univ 放線菌内で目的タンパク質を誘導発現可能なプロモーター

Also Published As

Publication number Publication date
JP6225162B2 (ja) 2017-11-01
CN109880867A (zh) 2019-06-14
SI2831261T1 (en) 2018-01-31
PL2831261T3 (pl) 2018-04-30
JP2015512259A (ja) 2015-04-27
EP2831261B1 (en) 2017-10-18
BR112014023176B1 (pt) 2021-09-28
US9765379B2 (en) 2017-09-19
CN104350156B (zh) 2019-04-02
US20160130624A1 (en) 2016-05-12
JP2019141049A (ja) 2019-08-29
AU2017202484B2 (en) 2019-06-13
MX2018007677A (es) 2020-11-12
US20210171997A1 (en) 2021-06-10
ES2654424T3 (es) 2018-02-13
WO2013148249A1 (en) 2013-10-03
US20250137027A1 (en) 2025-05-01
CA2866753C (en) 2020-09-22
AU2019226192A1 (en) 2019-09-26
JP2018046825A (ja) 2018-03-29
US20200199639A1 (en) 2020-06-25
EP2831261A1 (en) 2015-02-04
US20230069966A1 (en) 2023-03-09
AR090340A1 (es) 2014-11-05
SG10201508420VA (en) 2015-11-27
SG10202007206WA (en) 2020-08-28
US20180291411A1 (en) 2018-10-11
ZA201406434B (en) 2017-08-30
RU2017139267A (ru) 2019-02-12
SG10201912877SA (en) 2020-02-27
CA3086730A1 (en) 2013-10-03
HRP20171966T1 (hr) 2018-02-09
US20140080180A1 (en) 2014-03-20
RU2636353C2 (ru) 2017-11-22
MX2019007032A (es) 2019-08-16
BR112014023176A2 (pt) 2017-06-20
AR116615A2 (es) 2021-05-26
AU2013240280A1 (en) 2014-10-16
CN104350156A (zh) 2015-02-11
HK1207120A1 (en) 2016-01-22
KR20200037425A (ko) 2020-04-08
US20240158825A1 (en) 2024-05-16
US20150225760A1 (en) 2015-08-13
MY171729A (en) 2019-10-25
JP2020202849A (ja) 2020-12-24
SG11201406112TA (en) 2014-10-30
AU2017202484A1 (en) 2017-05-04
KR20140148392A (ko) 2014-12-31
MX2014011558A (es) 2014-11-14
IL234377B (en) 2021-01-31
RU2014137554A (ru) 2016-05-20
CA2866753A1 (en) 2013-10-03
KR102096678B1 (ko) 2020-04-02

Similar Documents

Publication Publication Date Title
MX2019007032A (es) Operaciones de cosecha mejoradas para proteinas recombinadas.
EP2536821A4 (en) IMPROVING THE EFFECT OF FE-S-BUNDLE REQUIRING PROTEINS
WO2013152051A3 (en) Improved production of fatty acid derivatives
MX2015017110A (es) Integracion dirigida.
EP3130598A3 (en) Expression sequences
MX351916B (es) Polipeptidos que tienen actividad de lisozima y polinucleotdos que los codifican.
MX2013007853A (es) Polipeptidos que tienen actividad de celobiohidrolasa y polinucleotidos que codifican los mismos.
MY187542A (en) Carbohydrate degrading polypeptide and uses thereof
MX337919B (es) Polipeptidos que tienen actividad de celobiohidrolasa y polinucleotidos que codifican los mismos.
IN2012DN03823A (https=)
NZ742660A (en) Variants of chymosin with improved milk-clotting properties
EA201692359A1 (ru) Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса
WO2013019827A3 (en) Polypeptides having xylanase activity and polynucleotides encoding same
NZ700897A (en) Lowering saturated fatty acid content of plant seeds
GB201003701D0 (en) System for the expression of a protein
MX356647B (es) Polipeptidos que tienen actividad de fosfolipasa c y polinucleotidos que codifican los mismos.
WO2013189972A3 (en) Use of polypeptides having protease activity in animal feed and detergents
WO2014122161A3 (en) Use of polypeptides having protease activity in animal feed
WO2013016724A3 (en) Decarboxylase proteins with high keto-isovalerate decarboxylase activity
MX358963B (es) Polipeptidos con actividad proteasa.
MX2019003360A (es) Vectores de expresion para una secrecion de proteina mejorada.
WO2012175708A3 (en) Polypeptides having protease activity and polynucleotides encoding same
IN2015DN03206A (https=)
MX2015015274A (es) Ruta de ácido organico novedosa.
EA201300057A1 (ru) Полипептид, обладающий углеводдеградирующей активностью, и его применения

Legal Events

Date Code Title Description
FG Grant or registration