HRP20130409T2 - 3-aminociklopentankarboksamidi kao modulatori kemokinskih receptora - Google Patents

3-aminociklopentankarboksamidi kao modulatori kemokinskih receptora Download PDF

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Publication number
HRP20130409T2
HRP20130409T2 HRP20130409AT HRP20130409T HRP20130409T2 HR P20130409 T2 HRP20130409 T2 HR P20130409T2 HR P20130409A T HRP20130409A T HR P20130409AT HR P20130409 T HRP20130409 T HR P20130409T HR P20130409 T2 HRP20130409 T2 HR P20130409T2
Authority
HR
Croatia
Prior art keywords
amino
anhydro
dideoxy
hept
diazabicyclo
Prior art date
Application number
HRP20130409AT
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English (en)
Croatian (hr)
Inventor
Rajesh Venkateswaran Devraj
Wei Huang
Robert Owen Hughes
Donald Joseph Rogier Jr.
John Isidro Trujillo
Steve Ronald Turner
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HRP20130409T1 publication Critical patent/HRP20130409T1/hr
Publication of HRP20130409T2 publication Critical patent/HRP20130409T2/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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HRP20130409AT 2008-11-26 2009-11-20 3-aminociklopentankarboksamidi kao modulatori kemokinskih receptora HRP20130409T2 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11805308P 2008-11-26 2008-11-26
PCT/IB2009/055232 WO2010061329A1 (en) 2008-11-26 2009-11-20 3-aminocyclopentanecarboxamides as chemokine receptor modulators

Publications (2)

Publication Number Publication Date
HRP20130409T1 HRP20130409T1 (en) 2013-06-30
HRP20130409T2 true HRP20130409T2 (hr) 2013-11-22

Family

ID=41693100

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HRP20130409AT HRP20130409T2 (hr) 2008-11-26 2009-11-20 3-aminociklopentankarboksamidi kao modulatori kemokinskih receptora

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EP (1) EP2370442B9 (enExample)
JP (1) JP5108153B2 (enExample)
KR (1) KR101374412B1 (enExample)
CN (1) CN102227429B (enExample)
AP (1) AP3113A (enExample)
AU (1) AU2009321221B2 (enExample)
BR (1) BRPI0920936A2 (enExample)
CA (1) CA2743030C (enExample)
CL (1) CL2011001223A1 (enExample)
CO (1) CO6361921A2 (enExample)
CR (1) CR20110275A (enExample)
CU (1) CU24022B1 (enExample)
CY (1) CY1114020T1 (enExample)
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DO (1) DOP2011000154A (enExample)
EA (1) EA020470B1 (enExample)
EC (1) ECSP11011081A (enExample)
ES (1) ES2415430T3 (enExample)
GE (1) GEP20146064B (enExample)
HR (1) HRP20130409T2 (enExample)
IL (1) IL212732A (enExample)
MA (1) MA32834B1 (enExample)
ME (1) ME01144B (enExample)
MX (1) MX2011005526A (enExample)
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NI (1) NI201100102A (enExample)
NZ (1) NZ592919A (enExample)
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PL (1) PL2370442T3 (enExample)
PT (1) PT2370442E (enExample)
RS (2) RS52810B9 (enExample)
SI (1) SI2370442T1 (enExample)
SV (1) SV2011003923A (enExample)
TN (1) TN2011000254A1 (enExample)
UA (1) UA99978C2 (enExample)
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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0920936A2 (pt) * 2008-11-26 2020-08-11 Pfizer Inc 3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas
KR101303963B1 (ko) * 2011-04-08 2013-09-05 재단법인 경기과학기술진흥원 (1ｒ,2ｒ,3ｒ)-3-아미노사이클로펜탄-1,2-디올을 포함하는 항알러지용 조성물
KR102456088B1 (ko) 2014-04-04 2022-10-19 델 마 파마슈티컬스 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체
TW201605451A (zh) * 2014-07-17 2016-02-16 參天製藥股份有限公司 老年性黃斑部病變之預防或治療劑
JOP20190040A1 (ar) * 2016-09-14 2019-03-10 Novartis Ag توليفة من ناهضات fxr
TWI830733B (zh) * 2018-05-11 2024-02-01 中國大陸商迪哲（江蘇）醫藥有限公司 環戊烷化合物

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU693143B2 (en) 1993-12-06 1998-06-25 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
US5510332A (en) 1994-07-07 1996-04-23 Texas Biotechnology Corporation Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor
ATE237342T1 (de) 1994-07-11 2003-05-15 Athena Neurosciences Inc Inhibitoren der leukozytenadhäsion
US5462208A (en) 1994-08-01 1995-10-31 The Procter & Gamble Company Two-phase dispensing systems utilizing bellows pumps
US5811391A (en) 1994-08-25 1998-09-22 Cytel Corporation Cyclic CS-1 peptidomimetics, compositions and methods of using same
GB9524630D0 (en) 1994-12-24 1996-01-31 Zeneca Ltd Chemical compounds
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
AU5259296A (en) 1995-04-07 1996-10-23 Warner-Lambert Company Flavones and coumarins as agents for the treatment of athero sclerosis
US5704960A (en) 1995-12-20 1998-01-06 Corning, Inc. Method of forming an optical fiber for reduced polarization effects in amplifiers
GB9603741D0 (en) 1996-02-22 1996-04-24 Lin Mei Treatment of water by electrolysis
US6281212B1 (en) 1996-07-12 2001-08-28 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO1998042656A1 (en) 1997-03-21 1998-10-01 Cytel Corporation Novel compounds
EP1017382B1 (en) 1997-05-29 2006-03-01 Merck & Co., Inc. (a New Jersey corp.) Biarylalkanoic acids as cell adhesion inhibitors
JP2002512625A (ja) 1997-05-29 2002-04-23 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としての複素環アミド化合物
WO1998053818A1 (en) 1997-05-29 1998-12-03 Merck & Co., Inc. Sulfonamides as cell adhesion inhibitors
AU7667498A (en) 1997-05-30 1998-12-30 Celltech Therapeutics Limited Anti-inflammatory tyrosine derivatives
ES2206953T3 (es) 1997-06-23 2004-05-16 Tanabe Seiyaku Co., Ltd. Inhibidores de la adherencia celular mediada por alfa 4-beta 1.
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
MY129850A (en) * 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
SI1501507T1 (sl) * 2002-04-29 2008-12-31 Merck & Co Inc Tetrahidropiranil ciklopentil tetrahidropiridopiridin modulatorji s kemokinsko receptorsko aktivnostjo
MXPA06007000A (es) * 2003-12-18 2006-08-31 Incyte Corp Derivados de 3-cicloalquilaminopirrolidina como moduladores de receptores de quimiocina.
US7435830B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7566726B2 (en) 2004-04-28 2009-07-28 Merck & Co. Inc. 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity
WO2006004741A2 (en) * 2004-06-28 2006-01-12 Incyte Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
CN1976702A (zh) * 2004-06-28 2007-06-06 因赛特公司 作为趋化因子受体调节剂的3－氨基环戊烷甲酰胺类
GEP20094843B (en) * 2004-06-28 2009-11-25 Incyte Corp 3-aminocyclopentane carboxamides as modulators of chemokine receptors
MEP1008A (xx) 2005-12-21 2010-02-10 Incyte Corp 3-aminociklopentankarboksamidi kao modulatori receptora hemokina
BRPI0920936A2 (pt) * 2008-11-26 2020-08-11 Pfizer Inc 3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas

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KR101374412B1 (ko) 2014-03-17
CA2743030C (en) 2013-10-22
PT2370442E (pt) 2013-06-27
CL2011001223A1 (es) 2011-09-02
AP3113A (en) 2015-01-31
BRPI0920936A2 (pt) 2020-08-11
DK2370442T5 (da) 2013-09-23
NZ592919A (en) 2013-05-31
SI2370442T1 (sl) 2013-06-28
EA201170721A1 (ru) 2011-12-30
AU2009321221B2 (en) 2013-04-04
CR20110275A (es) 2011-07-01
NI201100102A (es) 2011-09-27
RS52810B (sr) 2013-10-31
TN2011000254A1 (fr) 2012-12-17
CU20110121A7 (es) 2013-05-31
CO6361921A2 (es) 2012-01-20
WO2010061329A1 (en) 2010-06-03
CA2743030A1 (en) 2010-06-03
AU2009321221A1 (en) 2010-06-03
EP2370442B9 (en) 2013-09-04
MY152557A (en) 2014-10-31
ES2415430T9 (es) 2013-11-25
MA32834B1 (fr) 2011-11-01
GEP20146064B (en) 2014-03-25
RS52810B8 (sr) 2019-08-30
US20110144129A1 (en) 2011-06-16
DK2370442T3 (da) 2013-06-17
KR20110075036A (ko) 2011-07-05
JP2012509931A (ja) 2012-04-26
JP5108153B2 (ja) 2012-12-26
ES2415430T3 (es) 2013-07-25
US20130197008A1 (en) 2013-08-01
PL2370442T3 (pl) 2013-08-30
PE20110831A1 (es) 2011-11-20
IL212732A (en) 2016-06-30
ECSP11011081A (es) 2011-12-30
EA020470B1 (ru) 2014-11-28
ME01144B (me) 2013-03-20
UA99978C2 (en) 2012-10-25
US8946413B2 (en) 2015-02-03
EP2370442B1 (en) 2013-04-24
DOP2011000154A (es) 2011-07-31
IL212732A0 (en) 2011-07-31
EP2370442A1 (en) 2011-10-05
CU24022B1 (es) 2014-07-30
CN102227429A (zh) 2011-10-26
CN102227429B (zh) 2014-05-28
ZA201104069B (en) 2012-02-29
CY1114020T1 (el) 2016-07-27
RS52810B9 (sr) 2019-06-28
US8293903B2 (en) 2012-10-23
HRP20130409T1 (en) 2013-06-30
HK1161261A1 (en) 2012-08-24
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SV2011003923A (es) 2011-07-28

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