HRP20200492T1 - Bromodomenski inhibitori - Google Patents
Bromodomenski inhibitori Download PDFInfo
- Publication number
- HRP20200492T1 HRP20200492T1 HRP20200492TT HRP20200492T HRP20200492T1 HR P20200492 T1 HRP20200492 T1 HR P20200492T1 HR P20200492T T HRP20200492T T HR P20200492TT HR P20200492 T HRP20200492 T HR P20200492T HR P20200492 T1 HRP20200492 T1 HR P20200492T1
- Authority
- HR
- Croatia
- Prior art keywords
- methyl
- oxopyridin
- phenyl
- difluorophenoxy
- methylsulfonylphenyl
- Prior art date
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- 102000001805 Bromodomains Human genes 0.000 title 1
- 108050009021 Bromodomains Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 24
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 21
- 150000002431 hydrogen Chemical group 0.000 claims 19
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical group 0.000 claims 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 13
- 125000003710 aryl alkyl group Chemical group 0.000 claims 11
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- -1 -OH Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 4
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 3
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- ULCFJZIWNBAUMI-UHFFFAOYSA-N 1,3-dimethyl-5-[3-methylsulfonyl-5-(1-phenylethoxy)phenyl]pyridin-2-one Chemical compound CC(Oc1cc(cc(c1)S(C)(=O)=O)-c1cc(C)c(=O)n(C)c1)c1ccccc1 ULCFJZIWNBAUMI-UHFFFAOYSA-N 0.000 claims 2
- GQDKFEKWEKWYFA-UHFFFAOYSA-N 5-(2-ethoxy-5-ethylsulfonylphenyl)-1,4-dimethylpyridin-2-one Chemical compound CCOc1ccc(cc1-c1cn(C)c(=O)cc1C)S(=O)(=O)CC GQDKFEKWEKWYFA-UHFFFAOYSA-N 0.000 claims 2
- AQIAUSFIHLCAAE-UHFFFAOYSA-N 5-[2-(2,4-difluorophenoxy)-5-(methylsulfonylmethyl)phenyl]-1,3-dimethylpyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(CS(C)(=O)=O)ccc1Oc1ccc(F)cc1F AQIAUSFIHLCAAE-UHFFFAOYSA-N 0.000 claims 2
- NLUVMQLLCWZXEX-UHFFFAOYSA-N 5-[2-(4-aminocyclohexyl)oxy-5-methylsulfonylphenyl]-1,3-dimethylpyridin-2-one Chemical compound NC1CCC(CC1)OC1=C(C=C(C=C1)S(=O)(=O)C)C=1C=C(C(N(C1)C)=O)C NLUVMQLLCWZXEX-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- MYRKCCRWKSPYFD-UHFFFAOYSA-N N-[3-(1,5-dimethyl-6-oxopyridin-3-yl)-4-(4-hydroxycyclohexyl)oxyphenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(OC2CCC(O)CC2)c(c1)-c1cc(C)c(=O)n(C)c1 MYRKCCRWKSPYFD-UHFFFAOYSA-N 0.000 claims 2
- ZEBCOVBATPLOOU-UHFFFAOYSA-N N-[3-(1,5-dimethyl-6-oxopyridin-3-yl)-4-(4-hydroxycyclohexyl)oxyphenyl]methanesulfonamide Chemical compound Cc1cc(cn(C)c1=O)-c1cc(NS(C)(=O)=O)ccc1OC1CCC(O)CC1 ZEBCOVBATPLOOU-UHFFFAOYSA-N 0.000 claims 2
- OBAIHAQZJYIHQU-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(1,5-dimethyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(C)c(=O)n(C)c1 OBAIHAQZJYIHQU-UHFFFAOYSA-N 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000005133 alkynyloxy group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- SUPVVDIFWWAVAL-UHFFFAOYSA-N n-[4-(2,4-difluorophenoxy)-3-(1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide Chemical compound C1=CC(=O)N(C)C=C1C1=CC(NS(=O)(=O)CC)=CC=C1OC1=CC=C(F)C=C1F SUPVVDIFWWAVAL-UHFFFAOYSA-N 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- HCPXFQKSYYNHFD-UHFFFAOYSA-N 1,3-dimethyl-5-(2-methylsulfonyl-5-propylpyrimidin-4-yl)pyridin-2-one Chemical compound CCCc1cnc(nc1-c1cc(C)c(=O)n(C)c1)S(C)(=O)=O HCPXFQKSYYNHFD-UHFFFAOYSA-N 0.000 claims 1
- MUTDVUIWBNUADB-UHFFFAOYSA-N 1,3-dimethyl-5-(3-methylsulfonyl-5-phenylmethoxyphenyl)pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(OCc2ccccc2)cc(c1)S(C)(=O)=O MUTDVUIWBNUADB-UHFFFAOYSA-N 0.000 claims 1
- HQIZTOPCDNQQPN-UHFFFAOYSA-N 1,3-dimethyl-5-[3-[(3-methyloxetan-3-yl)methoxy]-5-methylsulfonylphenyl]pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(OCC2(C)COC2)cc(c1)S(C)(=O)=O HQIZTOPCDNQQPN-UHFFFAOYSA-N 0.000 claims 1
- SOERVUPXXNBLAF-UHFFFAOYSA-N 1,3-dimethyl-5-[3-methylsulfonyl-5-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(OCC(F)(F)F)cc(c1)S(C)(=O)=O SOERVUPXXNBLAF-UHFFFAOYSA-N 0.000 claims 1
- LMBQRUXOSAOOPX-UHFFFAOYSA-N 1,3-dimethyl-5-[3-methylsulfonyl-5-(2-phenylethoxy)phenyl]pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(OCCc2ccccc2)cc(c1)S(C)(=O)=O LMBQRUXOSAOOPX-UHFFFAOYSA-N 0.000 claims 1
- LRZHIMAYJUNZNR-UHFFFAOYSA-N 1,3-dimethyl-5-[3-methylsulfonyl-5-(pyridin-2-ylmethoxy)phenyl]pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(OCc2ccccn2)cc(c1)S(C)(=O)=O LRZHIMAYJUNZNR-UHFFFAOYSA-N 0.000 claims 1
- IQHUKDCFSMXODB-UHFFFAOYSA-N 1,3-dimethyl-5-[3-methylsulfonyl-5-(pyridin-3-ylmethoxy)phenyl]pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(OCc2cccnc2)cc(c1)S(C)(=O)=O IQHUKDCFSMXODB-UHFFFAOYSA-N 0.000 claims 1
- BSWVPYBKQCWSFB-UHFFFAOYSA-N 1,3-dimethyl-5-[5-(methylsulfonylmethyl)-2-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(CS(C)(=O)=O)ccc1OCC(F)(F)F BSWVPYBKQCWSFB-UHFFFAOYSA-N 0.000 claims 1
- RDPCTGHNKAWSSN-UHFFFAOYSA-N 1,3-dimethyl-5-[5-methylsulfonyl-2-(3,3,3-trifluoropropoxy)phenyl]pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(ccc1OCCC(F)(F)F)S(C)(=O)=O RDPCTGHNKAWSSN-UHFFFAOYSA-N 0.000 claims 1
- GLJZUWSPZHLHNL-UHFFFAOYSA-N 1,3-dimethyl-5-[5-methylsulfonyl-2-(oxan-4-ylamino)phenyl]pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(ccc1NC1CCOCC1)S(C)(=O)=O GLJZUWSPZHLHNL-UHFFFAOYSA-N 0.000 claims 1
- CWCXJCAJOMUQIJ-UHFFFAOYSA-N 1,3-dimethyl-5-[5-methylsulfonyl-2-(oxan-4-yloxy)phenyl]pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(ccc1OC1CCOCC1)S(C)(=O)=O CWCXJCAJOMUQIJ-UHFFFAOYSA-N 0.000 claims 1
- FWERCUQNCPLSTF-UHFFFAOYSA-N 1,3-dimethyl-5-[5-methylsulfonyl-2-(oxolan-3-ylamino)phenyl]pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(ccc1NC1CCOC1)S(C)(=O)=O FWERCUQNCPLSTF-UHFFFAOYSA-N 0.000 claims 1
- RYGWEWCXEFYURJ-UHFFFAOYSA-N 1,3-dimethyl-5-[5-methylsulfonyl-2-(oxolan-3-yloxy)phenyl]pyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(ccc1OC1CCOC1)S(C)(=O)=O RYGWEWCXEFYURJ-UHFFFAOYSA-N 0.000 claims 1
- FPDQKNLZBATDJI-UHFFFAOYSA-N 1-(cyclopropylmethyl)-5-[4-(2,4-difluorophenoxy)-1-(methylsulfonylmethyl)-6-oxopyridin-3-yl]-3-methylpyridin-2-one Chemical compound Cc1cc(cn(CC2CC2)c1=O)-c1cn(CS(C)(=O)=O)c(=O)cc1Oc1ccc(F)cc1F FPDQKNLZBATDJI-UHFFFAOYSA-N 0.000 claims 1
- SROUHQSDVWURIW-UHFFFAOYSA-N 1-benzyl-5-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-3-methylpyridin-2-one Chemical compound Cc1cc(cn(Cc2ccccc2)c1=O)-c1cc(ccc1OCC1CC1)S(C)(=O)=O SROUHQSDVWURIW-UHFFFAOYSA-N 0.000 claims 1
- ZOILCGKVSYSULJ-UHFFFAOYSA-N 1-cyclobutyl-5-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-3-methylpyridin-2-one Chemical compound Cc1cc(cn(C2CCC2)c1=O)-c1cc(ccc1OCC1CC1)S(C)(=O)=O ZOILCGKVSYSULJ-UHFFFAOYSA-N 0.000 claims 1
- ATXUGZLOOZFSMI-UHFFFAOYSA-N 1-cyclopropyl-5-[2-(cyclopropylmethoxy)-5-ethylsulfonylphenyl]-3-methylpyridin-2-one Chemical compound CCS(=O)(=O)c1ccc(OCC2CC2)c(c1)-c1cc(C)c(=O)n(c1)C1CC1 ATXUGZLOOZFSMI-UHFFFAOYSA-N 0.000 claims 1
- KSLMWKWAOIDDHL-UHFFFAOYSA-N 1-methyl-5-(2-methylsulfonyl-5-propylpyrimidin-4-yl)pyridin-2-one Chemical compound CCCc1cnc(nc1-c1ccc(=O)n(C)c1)S(C)(=O)=O KSLMWKWAOIDDHL-UHFFFAOYSA-N 0.000 claims 1
- SJONSEWAQNJGJM-UHFFFAOYSA-N 1-methyl-5-(5-methylsulfonyl-2-propylphenyl)pyridin-2-one Chemical compound CCCc1ccc(cc1-c1ccc(=O)n(C)c1)S(C)(=O)=O SJONSEWAQNJGJM-UHFFFAOYSA-N 0.000 claims 1
- JFWHIYWRVFGTSR-UHFFFAOYSA-N 2-[[3-(1,5-dimethyl-6-oxopyridin-3-yl)-5-methylsulfonylphenoxy]methyl]benzonitrile Chemical compound Cc1cc(cn(C)c1=O)-c1cc(OCc2ccccc2C#N)cc(c1)S(C)(=O)=O JFWHIYWRVFGTSR-UHFFFAOYSA-N 0.000 claims 1
- FKWDUYPFNXYDTJ-UHFFFAOYSA-N 2-methyl-4-(3-methylsulfonyl-5-phenylmethoxyphenyl)isoquinolin-1-one Chemical compound Cn1cc(-c2cc(OCc3ccccc3)cc(c2)S(C)(=O)=O)c2ccccc2c1=O FKWDUYPFNXYDTJ-UHFFFAOYSA-N 0.000 claims 1
- DSZWOKHPTSBEJO-UHFFFAOYSA-N 3-(difluoromethoxy)-5-[2-(2,4-difluorophenoxy)-5-(ethylsulfonylmethyl)phenyl]-1-methylpyridin-2-one Chemical compound CCS(=O)(=O)Cc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(OC(F)F)c(=O)n(C)c1 DSZWOKHPTSBEJO-UHFFFAOYSA-N 0.000 claims 1
- HAZMIJIKTRRBFM-UHFFFAOYSA-N 3-(dimethylamino)-5-(2-ethoxy-5-ethylsulfonylphenyl)-1-methylpyridin-2-one Chemical compound CCOc1ccc(cc1-c1cc(N(C)C)c(=O)n(C)c1)S(=O)(=O)CC HAZMIJIKTRRBFM-UHFFFAOYSA-N 0.000 claims 1
- XVYAYMDOJNAGLN-UHFFFAOYSA-N 3-[[3-(1,5-dimethyl-6-oxopyridin-3-yl)-5-methylsulfonylphenoxy]methyl]benzonitrile Chemical compound Cc1cc(cn(C)c1=O)-c1cc(OCc2cccc(c2)C#N)cc(c1)S(C)(=O)=O XVYAYMDOJNAGLN-UHFFFAOYSA-N 0.000 claims 1
- BZJVXVIIADXSEJ-UHFFFAOYSA-N 3-amino-1-methyl-5-(3-methylsulfonylphenyl)pyrazin-2-one Chemical compound Cn1cc(nc(N)c1=O)-c1cccc(c1)S(C)(=O)=O BZJVXVIIADXSEJ-UHFFFAOYSA-N 0.000 claims 1
- YGUMCEDDFVYQNX-UHFFFAOYSA-N 3-amino-1-methyl-5-(3-methylsulfonylphenyl)pyridin-2-one Chemical compound Cn1cc(cc(N)c1=O)-c1cccc(c1)S(C)(=O)=O YGUMCEDDFVYQNX-UHFFFAOYSA-N 0.000 claims 1
- WWJKRDCHVRNFLE-UHFFFAOYSA-N 3-amino-5-(3-ethylsulfonylphenyl)-1-methylpyrazin-2-one Chemical compound CCS(=O)(=O)c1cccc(c1)-c1cn(C)c(=O)c(N)n1 WWJKRDCHVRNFLE-UHFFFAOYSA-N 0.000 claims 1
- OETITKLZKXGWDG-UHFFFAOYSA-N 3-amino-5-(3-ethylsulfonylphenyl)-1-methylpyridin-2-one Chemical compound CCS(=O)(=O)c1cccc(c1)-c1cc(N)c(=O)n(C)c1 OETITKLZKXGWDG-UHFFFAOYSA-N 0.000 claims 1
- BKMRBHGBWCRLHX-UHFFFAOYSA-N 3-amino-5-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-1-methylpyridin-2-one Chemical compound Cn1cc(cc(N)c1=O)-c1cc(ccc1OCC1CC1)S(C)(=O)=O BKMRBHGBWCRLHX-UHFFFAOYSA-N 0.000 claims 1
- OZIIHWQRRKWIKY-UHFFFAOYSA-N 3-chloro-1-methyl-5-(2-methylsulfonyl-5-propylpyrimidin-4-yl)pyridin-2-one Chemical compound CCCc1cnc(nc1-c1cc(Cl)c(=O)n(C)c1)S(C)(=O)=O OZIIHWQRRKWIKY-UHFFFAOYSA-N 0.000 claims 1
- NVJHSZWCYGYFIC-UHFFFAOYSA-N 3-chloro-1-methyl-5-[5-(methylsulfonylmethyl)-2-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-one Chemical compound Cn1cc(cc(Cl)c1=O)-c1cc(CS(C)(=O)=O)ccc1OCC(F)(F)F NVJHSZWCYGYFIC-UHFFFAOYSA-N 0.000 claims 1
- FRZDYQLBFWXADP-UHFFFAOYSA-N 3-chloro-5-[2-(cyclopropylmethoxy)-5-ethylsulfonylphenyl]-1-methylpyridin-2-one Chemical compound CCS(=O)(=O)c1ccc(OCC2CC2)c(c1)-c1cc(Cl)c(=O)n(C)c1 FRZDYQLBFWXADP-UHFFFAOYSA-N 0.000 claims 1
- MAUXRLZYCYBHEZ-UHFFFAOYSA-N 3-chloro-5-[2-(cyclopropylmethylamino)-5-ethylsulfonylphenyl]-1-methylpyridin-2-one Chemical compound CCS(=O)(=O)c1ccc(NCC2CC2)c(c1)-c1cc(Cl)c(=O)n(C)c1 MAUXRLZYCYBHEZ-UHFFFAOYSA-N 0.000 claims 1
- KSBDPTZDKIMISA-UHFFFAOYSA-N 3-cyclopropyl-5-[2-(cyclopropylmethoxy)-5-ethylsulfonylphenyl]-1-methylpyridin-2-one Chemical compound CCS(=O)(=O)c1ccc(OCC2CC2)c(c1)-c1cc(C2CC2)c(=O)n(C)c1 KSBDPTZDKIMISA-UHFFFAOYSA-N 0.000 claims 1
- JWJMAWXJTOADOL-UHFFFAOYSA-N 3-fluoro-1-methyl-5-[5-(methylsulfonylmethyl)-2-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-one Chemical compound Cn1cc(cc(F)c1=O)-c1cc(CS(C)(=O)=O)ccc1OCC(F)(F)F JWJMAWXJTOADOL-UHFFFAOYSA-N 0.000 claims 1
- PEAGEMGKICIDRI-UHFFFAOYSA-N 3-methoxy-1-methyl-5-(2-methylsulfonyl-5-propylpyrimidin-4-yl)pyridin-2-one Chemical compound CCCc1cnc(nc1-c1cc(OC)c(=O)n(C)c1)S(C)(=O)=O PEAGEMGKICIDRI-UHFFFAOYSA-N 0.000 claims 1
- NOWXCDVCWUYJTR-UHFFFAOYSA-N 4-(2,4-difluorophenoxy)-3-(1-methyl-6-oxopyridin-3-yl)benzenesulfonamide Chemical compound Cn1cc(ccc1=O)-c1cc(ccc1Oc1ccc(F)cc1F)S(N)(=O)=O NOWXCDVCWUYJTR-UHFFFAOYSA-N 0.000 claims 1
- TVQJYUMWFAOFPY-UHFFFAOYSA-N 4-(cyclopropylmethylamino)-3-(1,5-dimethyl-6-oxopyridin-3-yl)benzenesulfonamide Chemical compound Cc1cc(cn(C)c1=O)-c1cc(ccc1NCC1CC1)S(N)(=O)=O TVQJYUMWFAOFPY-UHFFFAOYSA-N 0.000 claims 1
- ZFLIMTXVDFXDBH-UHFFFAOYSA-N 4-(cyclopropylmethylamino)-3-(1-methyl-6-oxopyridin-3-yl)benzenesulfonamide Chemical compound Cn1cc(ccc1=O)-c1cc(ccc1NCC1CC1)S(N)(=O)=O ZFLIMTXVDFXDBH-UHFFFAOYSA-N 0.000 claims 1
- VSGRJDVHZXVIOJ-UHFFFAOYSA-N 4-[3-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one Chemical compound Cn1cc(-c2cc(OCC3CC3)cc(c2)S(C)(=O)=O)c2ccccc2c1=O VSGRJDVHZXVIOJ-UHFFFAOYSA-N 0.000 claims 1
- YRYBIHFYVRSCOW-UHFFFAOYSA-N 4-[3-[(4-methoxyphenyl)methoxy]-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one Chemical compound COc1ccc(COc2cc(cc(c2)S(C)(=O)=O)-c2cn(C)c(=O)c3ccccc23)cc1 YRYBIHFYVRSCOW-UHFFFAOYSA-N 0.000 claims 1
- WPDZIMRSBFCSBT-UHFFFAOYSA-N 4-ethoxy-3-(1-methyl-6-oxopyridin-3-yl)benzenesulfonamide Chemical compound CCOc1ccc(cc1-c1ccc(=O)n(C)c1)S(N)(=O)=O WPDZIMRSBFCSBT-UHFFFAOYSA-N 0.000 claims 1
- JWGKRAXDBCRUDU-UHFFFAOYSA-N 5-(2-but-2-ynoxy-5-ethylsulfonylphenyl)-3-methoxy-1-methylpyridin-2-one Chemical compound CCS(=O)(=O)c1ccc(OCC#CC)c(c1)-c1cc(OC)c(=O)n(C)c1 JWGKRAXDBCRUDU-UHFFFAOYSA-N 0.000 claims 1
- GFLPXIDBPLJCRF-UHFFFAOYSA-N 5-(2-but-2-ynoxy-5-methylsulfonylphenyl)-1,3-dimethylpyridin-2-one Chemical compound CC#CCOc1ccc(cc1-c1cc(C)c(=O)n(C)c1)S(C)(=O)=O GFLPXIDBPLJCRF-UHFFFAOYSA-N 0.000 claims 1
- RGYMGNASNJIACV-UHFFFAOYSA-N 5-(2-butyl-5-methylsulfonylphenyl)-1-methylpyridin-2-one Chemical compound CCCCc1ccc(cc1-c1ccc(=O)n(C)c1)S(C)(=O)=O RGYMGNASNJIACV-UHFFFAOYSA-N 0.000 claims 1
- BBZJVFYLQXGXFH-UHFFFAOYSA-N 5-(2-cyclopentyloxy-5-methylsulfonylphenyl)-1,3-dimethylpyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(ccc1OC1CCCC1)S(C)(=O)=O BBZJVFYLQXGXFH-UHFFFAOYSA-N 0.000 claims 1
- WYGGBIKMGXOHPG-UHFFFAOYSA-N 5-(2-ethyl-5-methylsulfonylphenyl)-1-methylpyridin-2-one Chemical compound CCc1ccc(cc1-c1ccc(=O)n(C)c1)S(C)(=O)=O WYGGBIKMGXOHPG-UHFFFAOYSA-N 0.000 claims 1
- SDCQIFQDDJKRKX-UHFFFAOYSA-N 5-(3-but-2-ynoxy-5-methylsulfonylphenyl)-1,3-dimethylpyridin-2-one Chemical compound CC#CCOc1cc(cc(c1)S(C)(=O)=O)-c1cc(C)c(=O)n(C)c1 SDCQIFQDDJKRKX-UHFFFAOYSA-N 0.000 claims 1
- GIHRAFQGFRCVKC-UHFFFAOYSA-N 5-(5-butyl-2-methylsulfonylpyrimidin-4-yl)-1,3-dimethylpyridin-2-one Chemical compound CCCCc1cnc(nc1-c1cc(C)c(=O)n(C)c1)S(C)(=O)=O GIHRAFQGFRCVKC-UHFFFAOYSA-N 0.000 claims 1
- IPBFTDRLQOGXNX-UHFFFAOYSA-N 5-(5-butyl-2-methylsulfonylpyrimidin-4-yl)-3-chloro-1-methylpyridin-2-one Chemical compound CCCCc1cnc(nc1-c1cc(Cl)c(=O)n(C)c1)S(C)(=O)=O IPBFTDRLQOGXNX-UHFFFAOYSA-N 0.000 claims 1
- HAGFCIVWYUNLNH-UHFFFAOYSA-N 5-(5-butyl-2-methylsulfonylpyrimidin-4-yl)-3-methoxy-1-methylpyridin-2-one Chemical compound CCCCc1cnc(nc1-c1cc(OC)c(=O)n(C)c1)S(C)(=O)=O HAGFCIVWYUNLNH-UHFFFAOYSA-N 0.000 claims 1
- ICMSRIZZWKKGSV-UHFFFAOYSA-N 5-(5-butyl-2-methylsulfonylpyrimidin-4-yl)-3-methyl-1-propan-2-ylpyridin-2-one Chemical compound CCCCc1cnc(nc1-c1cc(C)c(=O)n(c1)C(C)C)S(C)(=O)=O ICMSRIZZWKKGSV-UHFFFAOYSA-N 0.000 claims 1
- LNZHMXUIYQOPQF-UHFFFAOYSA-N 5-(5-ethyl-2-methylsulfonylpyrimidin-4-yl)-1,3-dimethylpyridin-2-one Chemical compound CCc1cnc(nc1-c1cc(C)c(=O)n(C)c1)S(C)(=O)=O LNZHMXUIYQOPQF-UHFFFAOYSA-N 0.000 claims 1
- OKZKGDXKKZVMQN-UHFFFAOYSA-N 5-(5-ethylsulfonyl-2-methoxyphenyl)-3-hydroxy-1-methylpyridin-2-one Chemical compound CCS(=O)(=O)c1ccc(OC)c(c1)-c1cc(O)c(=O)n(C)c1 OKZKGDXKKZVMQN-UHFFFAOYSA-N 0.000 claims 1
- GSBQKAUXASYAHX-UHFFFAOYSA-N 5-(5-ethylsulfonyl-2-pent-2-ynoxyphenyl)-3-methoxy-1-methylpyridin-2-one Chemical compound CCC#CCOc1ccc(cc1-c1cc(OC)c(=O)n(C)c1)S(=O)(=O)CC GSBQKAUXASYAHX-UHFFFAOYSA-N 0.000 claims 1
- QYSCYBVWXGVQSV-UHFFFAOYSA-N 5-[2-(2,4-difluoroanilino)-5-ethylsulfonylphenyl]-1,3-dimethylpyridin-2-one Chemical compound CCS(=O)(=O)c1ccc(Nc2ccc(F)cc2F)c(c1)-c1cc(C)c(=O)n(C)c1 QYSCYBVWXGVQSV-UHFFFAOYSA-N 0.000 claims 1
- GWQQRQJBAXNBKT-UHFFFAOYSA-N 5-[2-(2,4-difluoroanilino)-5-methylsulfonylphenyl]-1,3-dimethylpyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1cc(ccc1Nc1ccc(F)cc1F)S(C)(=O)=O GWQQRQJBAXNBKT-UHFFFAOYSA-N 0.000 claims 1
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- PLNKCJHTASWURV-UHFFFAOYSA-N 5-[5-(2,4-difluorophenoxy)-2-methylsulfonylpyrimidin-4-yl]-1,3-dimethylpyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1nc(ncc1Oc1ccc(F)cc1F)S(C)(=O)=O PLNKCJHTASWURV-UHFFFAOYSA-N 0.000 claims 1
- MZCXNKOEMCXMDJ-UHFFFAOYSA-N 5-[5-(2,4-difluorophenoxy)-2-methylsulfonylpyrimidin-4-yl]-1-methyl-3-propan-2-ylpyridin-2-one Chemical compound CC(C)c1cc(cn(C)c1=O)-c1nc(ncc1Oc1ccc(F)cc1F)S(C)(=O)=O MZCXNKOEMCXMDJ-UHFFFAOYSA-N 0.000 claims 1
- NBTHFQNNVZQPIZ-UHFFFAOYSA-N 5-[5-(2,4-difluorophenoxy)-2-methylsulfonylpyrimidin-4-yl]-3-methoxy-1-methylpyridin-2-one Chemical compound COc1cc(cn(C)c1=O)-c1nc(ncc1Oc1ccc(F)cc1F)S(C)(=O)=O NBTHFQNNVZQPIZ-UHFFFAOYSA-N 0.000 claims 1
- QKRSRGXZDBBGJX-UHFFFAOYSA-N 5-[5-(2,4-difluorophenoxy)-2-methylsulfonylpyrimidin-4-yl]-3-methyl-1-propan-2-ylpyridin-2-one Chemical compound CC(C)n1cc(cc(C)c1=O)-c1nc(ncc1Oc1ccc(F)cc1F)S(C)(=O)=O QKRSRGXZDBBGJX-UHFFFAOYSA-N 0.000 claims 1
- CIXNHMLVJFDJTC-UHFFFAOYSA-N 5-[5-(cyclopropylmethoxy)-2-(methylsulfonylmethyl)pyrimidin-4-yl]-1,3-dimethylpyridin-2-one Chemical compound Cc1cc(cn(C)c1=O)-c1nc(CS(C)(=O)=O)ncc1OCC1CC1 CIXNHMLVJFDJTC-UHFFFAOYSA-N 0.000 claims 1
- GJJHICQLPCENEF-UHFFFAOYSA-N 5-[5-(ethylsulfonylmethyl)-2-(2,2,2-trifluoroethoxy)phenyl]-1,3-dimethylpyridin-2-one Chemical compound CCS(=O)(=O)Cc1ccc(OCC(F)(F)F)c(c1)-c1cc(C)c(=O)n(C)c1 GJJHICQLPCENEF-UHFFFAOYSA-N 0.000 claims 1
- SSANVONWZZCBTN-UHFFFAOYSA-N 5-[5-(ethylsulfonylmethyl)-2-(2,2,2-trifluoroethoxy)phenyl]-1-(2-hydroxyethyl)-3-methylpyridin-2-one Chemical compound CCS(=O)(=O)Cc1ccc(OCC(F)(F)F)c(c1)-c1cc(C)c(=O)n(CCO)c1 SSANVONWZZCBTN-UHFFFAOYSA-N 0.000 claims 1
- NXWZSAYQJBQUCC-UHFFFAOYSA-N 6-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2,4-dimethylpyridazin-3-one Chemical compound Cc1cc(nn(C)c1=O)-c1cc(ccc1OCC1CC1)S(C)(=O)=O NXWZSAYQJBQUCC-UHFFFAOYSA-N 0.000 claims 1
- QHHVIDLQOKJQPT-UHFFFAOYSA-N 6-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2,5-dimethylpyridazin-3-one Chemical compound Cc1cc(=O)n(C)nc1-c1cc(ccc1OCC1CC1)S(C)(=O)=O QHHVIDLQOKJQPT-UHFFFAOYSA-N 0.000 claims 1
- VQRIHCBEYAIYRW-UHFFFAOYSA-N N-[2-(2,4-difluorophenoxy)-6-(1,5-dimethyl-6-oxopyridin-3-yl)pyrimidin-4-yl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1cc(nc(Oc2ccc(F)cc2F)n1)-c1cc(C)c(=O)n(C)c1 VQRIHCBEYAIYRW-UHFFFAOYSA-N 0.000 claims 1
- SDWBQFMSJOOXCA-UHFFFAOYSA-N N-[2-methoxy-5-[1-methyl-5-(methylamino)-6-oxopyridin-3-yl]phenyl]methanesulfonamide Chemical compound CNc1cc(cn(C)c1=O)-c1ccc(OC)c(NS(C)(=O)=O)c1 SDWBQFMSJOOXCA-UHFFFAOYSA-N 0.000 claims 1
- FTNIEJOFMMWKDD-UHFFFAOYSA-N N-[3-(1,4,5-trimethyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cc1c(C)c(=O)n(C)cc1-c1cccc(NS(C)(=O)=O)c1 FTNIEJOFMMWKDD-UHFFFAOYSA-N 0.000 claims 1
- VVYZQRYIBDZYKW-UHFFFAOYSA-N N-[3-(1,4-dimethyl-6-oxopyridazin-3-yl)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1cccc(c1)-c1nn(C)c(=O)cc1C VVYZQRYIBDZYKW-UHFFFAOYSA-N 0.000 claims 1
- WGBOHEXRUPAQOX-UHFFFAOYSA-N N-[3-(1,4-dimethyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cc1cc(=O)n(C)cc1-c1cccc(NS(C)(=O)=O)c1 WGBOHEXRUPAQOX-UHFFFAOYSA-N 0.000 claims 1
- SLAPSWPNFURCDP-UHFFFAOYSA-N N-[3-(1,5-dimethyl-6-oxopyridazin-3-yl)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1cccc(c1)-c1cc(C)c(=O)n(C)n1 SLAPSWPNFURCDP-UHFFFAOYSA-N 0.000 claims 1
- INWSGXXRSLUJLS-UHFFFAOYSA-N N-[3-(1,5-dimethyl-6-oxopyridin-3-yl)-4-(oxan-3-yloxy)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(OC2CCCOC2)c(c1)-c1cc(C)c(=O)n(C)c1 INWSGXXRSLUJLS-UHFFFAOYSA-N 0.000 claims 1
- GDZREEXMPAGLJL-UHFFFAOYSA-N N-[3-(1,5-dimethyl-6-oxopyridin-3-yl)-4-(oxan-3-yloxy)phenyl]methanesulfonamide Chemical compound Cc1cc(cn(C)c1=O)-c1cc(NS(C)(=O)=O)ccc1OC1CCCOC1 GDZREEXMPAGLJL-UHFFFAOYSA-N 0.000 claims 1
- PJJIDMXLOGDSNQ-UHFFFAOYSA-N N-[3-(1,5-dimethyl-6-oxopyridin-3-yl)-4-(oxan-4-yloxy)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(OC2CCOCC2)c(c1)-c1cc(C)c(=O)n(C)c1 PJJIDMXLOGDSNQ-UHFFFAOYSA-N 0.000 claims 1
- HRMPOYZNAUWFGC-UHFFFAOYSA-N N-[3-(1,5-dimethyl-6-oxopyridin-3-yl)-4-(oxan-4-yloxy)phenyl]methanesulfonamide Chemical compound Cc1cc(cn(C)c1=O)-c1cc(NS(C)(=O)=O)ccc1OC1CCOCC1 HRMPOYZNAUWFGC-UHFFFAOYSA-N 0.000 claims 1
- OMKACMAUXSKDLZ-UHFFFAOYSA-N N-[3-(1,5-dimethyl-6-oxopyridin-3-yl)-4-(oxolan-3-yloxy)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(OC2CCOC2)c(c1)-c1cc(C)c(=O)n(C)c1 OMKACMAUXSKDLZ-UHFFFAOYSA-N 0.000 claims 1
- ZCKVXUUKABKBIR-UHFFFAOYSA-N N-[3-(1,5-dimethyl-6-oxopyridin-3-yl)-4-(oxolan-3-yloxy)phenyl]methanesulfonamide Chemical compound Cc1cc(cn(C)c1=O)-c1cc(NS(C)(=O)=O)ccc1OC1CCOC1 ZCKVXUUKABKBIR-UHFFFAOYSA-N 0.000 claims 1
- FIONOWOTYABCNH-UHFFFAOYSA-N N-[3-(1,5-dimethyl-6-oxopyridin-3-yl)-5-phenylmethoxyphenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1cc(OCc2ccccc2)cc(c1)-c1cc(C)c(=O)n(C)c1 FIONOWOTYABCNH-UHFFFAOYSA-N 0.000 claims 1
- MPRSVAFCQHCEJW-UHFFFAOYSA-N N-[3-(1,5-dimethyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cc1cc(cn(C)c1=O)-c1cccc(NS(C)(=O)=O)c1 MPRSVAFCQHCEJW-UHFFFAOYSA-N 0.000 claims 1
- WWXNMJKYTZBMOL-UHFFFAOYSA-N N-[3-(1-cyclobutyl-5-methyl-6-oxopyridin-3-yl)-4-(2,4-difluorophenoxy)phenyl]methanesulfonamide Chemical compound Cc1cc(cn(C2CCC2)c1=O)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F WWXNMJKYTZBMOL-UHFFFAOYSA-N 0.000 claims 1
- QOSTWOZJVWHSML-UHFFFAOYSA-N N-[3-(1-methyl-6-oxo-5-phenylmethoxypyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cn1cc(cc(OCc2ccccc2)c1=O)-c1cccc(NS(C)(=O)=O)c1 QOSTWOZJVWHSML-UHFFFAOYSA-N 0.000 claims 1
- XGMNDDLVXPHJHM-UHFFFAOYSA-N N-[3-(1-methyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cn1cc(ccc1=O)-c1cccc(NS(C)(=O)=O)c1 XGMNDDLVXPHJHM-UHFFFAOYSA-N 0.000 claims 1
- FMNWTIKNQGHQGB-UHFFFAOYSA-N N-[3-(2,4-difluorophenoxy)-5-(1,5-dimethyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1cc(Oc2ccc(F)cc2F)cc(c1)-c1cc(C)c(=O)n(C)c1 FMNWTIKNQGHQGB-UHFFFAOYSA-N 0.000 claims 1
- IJDIHJBIGIIGNA-UHFFFAOYSA-N N-[3-(5-amino-1-methyl-6-oxopyridin-3-yl)-4-(2,4-difluorophenoxy)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(N)c(=O)n(C)c1 IJDIHJBIGIIGNA-UHFFFAOYSA-N 0.000 claims 1
- UYUYRWKFGFWUKO-UHFFFAOYSA-N N-[3-(5-cyclopropyl-1-methyl-6-oxopyridin-3-yl)-4-(2,4-difluorophenoxy)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(C2CC2)c(=O)n(C)c1 UYUYRWKFGFWUKO-UHFFFAOYSA-N 0.000 claims 1
- DNOOQCMNOFZGCL-UHFFFAOYSA-N N-[3-(5-cyclopropyl-1-methyl-6-oxopyridin-3-yl)-4-(2,4-difluorophenoxy)phenyl]methanesulfonamide Chemical compound Cn1cc(cc(C2CC2)c1=O)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F DNOOQCMNOFZGCL-UHFFFAOYSA-N 0.000 claims 1
- POJLUPKVSKYQAH-UHFFFAOYSA-N N-[3-(5-hydroxy-1-methyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cn1cc(cc(O)c1=O)-c1cccc(NS(C)(=O)=O)c1 POJLUPKVSKYQAH-UHFFFAOYSA-N 0.000 claims 1
- TZIKTTLNBPRMQA-UHFFFAOYSA-N N-[3-[1-(cyclopropylmethyl)-5-methyl-6-oxopyridin-3-yl]-4-(2,4-difluorophenoxy)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(C)c(=O)n(CC2CC2)c1 TZIKTTLNBPRMQA-UHFFFAOYSA-N 0.000 claims 1
- ZLMKVBSMJXPVAC-UHFFFAOYSA-N N-[3-[5-(difluoromethoxy)-1-methyl-6-oxopyridin-3-yl]-4-(2,4-difluorophenoxy)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(OC(F)F)c(=O)n(C)c1 ZLMKVBSMJXPVAC-UHFFFAOYSA-N 0.000 claims 1
- BCKFOFZYBKHHMM-UHFFFAOYSA-N N-[4-(1,5-dimethyl-6-oxopyridin-3-yl)-5-ethylpyrimidin-2-yl]ethanesulfonamide Chemical compound CCc1cnc(NS(=O)(=O)CC)nc1-c1cc(C)c(=O)n(C)c1 BCKFOFZYBKHHMM-UHFFFAOYSA-N 0.000 claims 1
- CXDYKYWPPBOKFM-UHFFFAOYSA-N N-[4-(1,5-dimethyl-6-oxopyridin-3-yl)-5-propylpyrimidin-2-yl]ethanesulfonamide Chemical compound CCCc1cnc(NS(=O)(=O)CC)nc1-c1cc(C)c(=O)n(C)c1 CXDYKYWPPBOKFM-UHFFFAOYSA-N 0.000 claims 1
- ZBOJZQWRXHUZDX-UHFFFAOYSA-N N-[4-(1-butyl-5-methyl-6-oxopyridin-3-yl)-5-(2,4-difluorophenoxy)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCCCn1cc(cc(C)c1=O)-c1nc(NS(=O)(=O)CC)ncc1Oc1ccc(F)cc1F ZBOJZQWRXHUZDX-UHFFFAOYSA-N 0.000 claims 1
- QTFXJHFLVBPOLG-UHFFFAOYSA-N N-[4-(1-butyl-5-methyl-6-oxopyridin-3-yl)-5-(2,4-difluorophenoxy)pyrimidin-2-yl]methanesulfonamide Chemical compound CCCCn1cc(cc(C)c1=O)-c1nc(NS(C)(=O)=O)ncc1Oc1ccc(F)cc1F QTFXJHFLVBPOLG-UHFFFAOYSA-N 0.000 claims 1
- DILHIEWTHGIJER-UHFFFAOYSA-N N-[4-(1-methyl-6-oxopyridin-3-yl)-5-propylpyrimidin-2-yl]ethanesulfonamide Chemical compound CCCc1cnc(NS(=O)(=O)CC)nc1-c1ccc(=O)n(C)c1 DILHIEWTHGIJER-UHFFFAOYSA-N 0.000 claims 1
- BCPPFUYPUYTUEA-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(1,4,5-trimethyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cc1c(C)c(=O)n(C)cc1-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F BCPPFUYPUYTUEA-UHFFFAOYSA-N 0.000 claims 1
- FQQVEHQFZSGKHI-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(1,4-dimethyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cc1cc(=O)n(C)cc1-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F FQQVEHQFZSGKHI-UHFFFAOYSA-N 0.000 claims 1
- ZRAQQZPRBJVBBS-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(1,5-dimethyl-6-oxopyridin-3-yl)phenyl]-N-(oxetan-3-yl)methanesulfonamide Chemical compound Cc1cc(cn(C)c1=O)-c1cc(ccc1Oc1ccc(F)cc1F)N(C1COC1)S(C)(=O)=O ZRAQQZPRBJVBBS-UHFFFAOYSA-N 0.000 claims 1
- WTMYLMRXTWFEHP-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(1,5-dimethyl-6-oxopyridin-3-yl)phenyl]-N-methylmethanesulfonamide Chemical compound CN(c1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(C)c(=O)n(C)c1)S(C)(=O)=O WTMYLMRXTWFEHP-UHFFFAOYSA-N 0.000 claims 1
- HCYZEVDMLQPGMC-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(1,5-dimethyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cc1cc(cn(C)c1=O)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F HCYZEVDMLQPGMC-UHFFFAOYSA-N 0.000 claims 1
- SSNAIUPTUONSTO-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(1-methyl-5-methylsulfanyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(SC)c(=O)n(C)c1 SSNAIUPTUONSTO-UHFFFAOYSA-N 0.000 claims 1
- XELPHWNFWQJAGU-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(1-methyl-6-oxo-5-pyrrolidin-1-ylpyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cn1cc(cc(N2CCCC2)c1=O)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F XELPHWNFWQJAGU-UHFFFAOYSA-N 0.000 claims 1
- WUONGQJTWIXWPB-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(4-fluoro-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cn(C)c(=O)cc1F WUONGQJTWIXWPB-UHFFFAOYSA-N 0.000 claims 1
- ACKCSFHDSWGMOQ-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(5-ethynyl-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(C#C)c(=O)n(C)c1 ACKCSFHDSWGMOQ-UHFFFAOYSA-N 0.000 claims 1
- UVMGOAHIYVVHOY-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(5-ethynyl-1-methyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cn1cc(cc(C#C)c1=O)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F UVMGOAHIYVVHOY-UHFFFAOYSA-N 0.000 claims 1
- YCFQVKUOYCMBKB-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(5-fluoro-1-methyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cn1cc(cc(F)c1=O)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F YCFQVKUOYCMBKB-UHFFFAOYSA-N 0.000 claims 1
- WNQCVWSGWOOTFZ-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(5-hydroxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(O)c(=O)n(C)c1 WNQCVWSGWOOTFZ-UHFFFAOYSA-N 0.000 claims 1
- TUIRELQBQBNZNX-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(5-methoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(OC)c(=O)n(C)c1 TUIRELQBQBNZNX-UHFFFAOYSA-N 0.000 claims 1
- PEBAQHBFGXVROJ-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-(5-methoxy-1-methyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound COc1cc(cn(C)c1=O)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F PEBAQHBFGXVROJ-UHFFFAOYSA-N 0.000 claims 1
- DHODFNMTPFOZNY-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-[1-methyl-5-(methylamino)-6-oxopyridin-3-yl]phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(NC)c(=O)n(C)c1 DHODFNMTPFOZNY-UHFFFAOYSA-N 0.000 claims 1
- BFLAIQQOVPVKTB-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-[1-methyl-5-(methylamino)-6-oxopyridin-3-yl]phenyl]methanesulfonamide Chemical compound CNc1cc(cn(C)c1=O)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F BFLAIQQOVPVKTB-UHFFFAOYSA-N 0.000 claims 1
- XOCHOYQVEHLGMN-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-[1-methyl-6-oxo-5-(2,2,2-trifluoroethoxy)pyridin-3-yl]phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(OCC(F)(F)F)c(=O)n(C)c1 XOCHOYQVEHLGMN-UHFFFAOYSA-N 0.000 claims 1
- HCYZEVDMLQPGMC-FIBGUPNXSA-N N-[4-(2,4-difluorophenoxy)-3-[1-methyl-6-oxo-5-(trideuteriomethyl)pyridin-3-yl]phenyl]methanesulfonamide Chemical compound FC1=C(OC2=C(C=C(C=C2)NS(=O)(=O)C)C2=CN(C(C(=C2)C([2H])([2H])[2H])=O)C)C=CC(=C1)F HCYZEVDMLQPGMC-FIBGUPNXSA-N 0.000 claims 1
- FZZPNODNZCQBQD-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-[1-methyl-6-oxo-5-(trifluoromethyl)pyridin-3-yl]phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(c(=O)n(C)c1)C(F)(F)F FZZPNODNZCQBQD-UHFFFAOYSA-N 0.000 claims 1
- WXSNAPTWEZWCAX-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-[5-(dimethylamino)-1-methyl-6-oxopyridin-3-yl]phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(N(C)C)c(=O)n(C)c1 WXSNAPTWEZWCAX-UHFFFAOYSA-N 0.000 claims 1
- ZSQHKTNJIIYBEL-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-3-[5-(dimethylamino)-1-methyl-6-oxopyridin-3-yl]phenyl]methanesulfonamide Chemical compound CN(C)c1cc(cn(C)c1=O)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F ZSQHKTNJIIYBEL-UHFFFAOYSA-N 0.000 claims 1
- QXXQXGRLLBUIIP-UHFFFAOYSA-N N-[4-(2,4-difluorophenoxy)-6-(1,5-dimethyl-6-oxopyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1nc(Oc2ccc(F)cc2F)cc(n1)-c1cc(C)c(=O)n(C)c1 QXXQXGRLLBUIIP-UHFFFAOYSA-N 0.000 claims 1
- PVXPLEOBAKNBRW-UHFFFAOYSA-N N-[4-(4,4-difluorocyclohexyl)oxy-3-(1,5-dimethyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ccc(OC2CCC(F)(F)CC2)c(c1)-c1cc(C)c(=O)n(C)c1 PVXPLEOBAKNBRW-UHFFFAOYSA-N 0.000 claims 1
- ALSIECKYYMKGIS-UHFFFAOYSA-N N-[4-(4,4-difluorocyclohexyl)oxy-3-(1,5-dimethyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound Cc1cc(cn(C)c1=O)-c1cc(NS(C)(=O)=O)ccc1OC1CCC(F)(F)CC1 ALSIECKYYMKGIS-UHFFFAOYSA-N 0.000 claims 1
- BZMMWGCCTAMXOK-UHFFFAOYSA-N N-[4-(5-chloro-1-methyl-6-oxopyridin-3-yl)-5-propylpyrimidin-2-yl]ethanesulfonamide Chemical compound CCCc1cnc(NS(=O)(=O)CC)nc1-c1cc(Cl)c(=O)n(C)c1 BZMMWGCCTAMXOK-UHFFFAOYSA-N 0.000 claims 1
- HYEKLYMBFWZUDG-UHFFFAOYSA-N N-[4-(5-methoxy-1-methyl-6-oxopyridin-3-yl)-5-propylpyrimidin-2-yl]ethanesulfonamide Chemical compound CCCc1cnc(NS(=O)(=O)CC)nc1-c1cc(OC)c(=O)n(C)c1 HYEKLYMBFWZUDG-UHFFFAOYSA-N 0.000 claims 1
- GUTLFPOBCGMRJL-UHFFFAOYSA-N N-[4-[1-(cyclobutylmethyl)-5-methyl-6-oxopyridin-3-yl]-5-(2,4-difluorophenoxy)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ncc(Oc2ccc(F)cc2F)c(n1)-c1cc(C)c(=O)n(CC2CCC2)c1 GUTLFPOBCGMRJL-UHFFFAOYSA-N 0.000 claims 1
- KYIGOBDTDBBCBO-UHFFFAOYSA-N N-[4-[1-(cyclobutylmethyl)-5-methyl-6-oxopyridin-3-yl]-5-(2,4-difluorophenoxy)pyrimidin-2-yl]methanesulfonamide Chemical compound Cc1cc(cn(CC2CCC2)c1=O)-c1nc(NS(C)(=O)=O)ncc1Oc1ccc(F)cc1F KYIGOBDTDBBCBO-UHFFFAOYSA-N 0.000 claims 1
- RDQFLEIDENCMAE-UHFFFAOYSA-N N-[4-[1-(cyclopropylmethyl)-5-methyl-6-oxopyridin-3-yl]-5-(2,4-difluorophenoxy)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ncc(Oc2ccc(F)cc2F)c(n1)-c1cc(C)c(=O)n(CC2CC2)c1 RDQFLEIDENCMAE-UHFFFAOYSA-N 0.000 claims 1
- SYYQEGWITDFXDD-UHFFFAOYSA-N N-[4-[1-(cyclopropylmethyl)-5-methyl-6-oxopyridin-3-yl]-5-(2,4-difluorophenoxy)pyrimidin-2-yl]methanesulfonamide Chemical compound Cc1cc(cn(CC2CC2)c1=O)-c1nc(NS(C)(=O)=O)ncc1Oc1ccc(F)cc1F SYYQEGWITDFXDD-UHFFFAOYSA-N 0.000 claims 1
- JFVBWKGVPXIMRW-UHFFFAOYSA-N N-[5-(2,4-difluorophenoxy)-4-(1,5-dimethyl-6-oxopyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ncc(Oc2ccc(F)cc2F)c(n1)-c1cc(C)c(=O)n(C)c1 JFVBWKGVPXIMRW-UHFFFAOYSA-N 0.000 claims 1
- LOGRPTBALCDGHH-UHFFFAOYSA-N N-[5-(2,4-difluorophenoxy)-4-(1,5-dimethyl-6-oxopyridin-3-yl)pyrimidin-2-yl]methanesulfonamide Chemical compound Cc1cc(cn(C)c1=O)-c1nc(NS(C)(=O)=O)ncc1Oc1ccc(F)cc1F LOGRPTBALCDGHH-UHFFFAOYSA-N 0.000 claims 1
- NNDUBQWNNFHNCO-UHFFFAOYSA-N N-[5-(2,4-difluorophenoxy)-4-(1-methyl-6-oxo-5-propan-2-ylpyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ncc(Oc2ccc(F)cc2F)c(n1)-c1cc(C(C)C)c(=O)n(C)c1 NNDUBQWNNFHNCO-UHFFFAOYSA-N 0.000 claims 1
- YMGZRKQFEYGMQM-UHFFFAOYSA-N N-[5-(2,4-difluorophenoxy)-4-(5-methoxy-1-methyl-6-oxopyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ncc(Oc2ccc(F)cc2F)c(n1)-c1cc(OC)c(=O)n(C)c1 YMGZRKQFEYGMQM-UHFFFAOYSA-N 0.000 claims 1
- WQOPYKYSKJWWCM-UHFFFAOYSA-N N-[5-(2,4-difluorophenoxy)-4-(5-methoxy-1-methyl-6-oxopyridin-3-yl)pyrimidin-2-yl]methanesulfonamide Chemical compound COc1cc(cn(C)c1=O)-c1nc(NS(C)(=O)=O)ncc1Oc1ccc(F)cc1F WQOPYKYSKJWWCM-UHFFFAOYSA-N 0.000 claims 1
- AYCRJLSDLOMMPJ-UHFFFAOYSA-N N-[5-(2,4-difluorophenoxy)-4-(5-methyl-6-oxo-1-propan-2-ylpyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCS(=O)(=O)Nc1ncc(Oc2ccc(F)cc2F)c(n1)-c1cc(C)c(=O)n(c1)C(C)C AYCRJLSDLOMMPJ-UHFFFAOYSA-N 0.000 claims 1
- IXKHTLKKEDXCEF-UHFFFAOYSA-N N-[5-(5-amino-1-methyl-6-oxopyridin-3-yl)-2-methoxyphenyl]methanesulfonamide Chemical compound COc1ccc(cc1NS(C)(=O)=O)-c1cc(N)c(=O)n(C)c1 IXKHTLKKEDXCEF-UHFFFAOYSA-N 0.000 claims 1
- MUJLMORXVWXUNR-UHFFFAOYSA-N N-[5-(6-amino-4-methyl-5-oxopyrazin-2-yl)-2-methoxyphenyl]methanesulfonamide Chemical compound COc1ccc(cc1NS(C)(=O)=O)-c1cn(C)c(=O)c(N)n1 MUJLMORXVWXUNR-UHFFFAOYSA-N 0.000 claims 1
- BFDIHPLJAPVZEE-UHFFFAOYSA-N N-[5-(cyclopropylmethoxy)-4-(1,5-dimethyl-6-oxopyridin-3-yl)pyrimidin-2-yl]-N-ethylmethanesulfonamide Chemical compound CCN(c1ncc(OCC2CC2)c(n1)-c1cc(C)c(=O)n(C)c1)S(C)(=O)=O BFDIHPLJAPVZEE-UHFFFAOYSA-N 0.000 claims 1
- BSYSBWVNKXYCOI-UHFFFAOYSA-N N-[5-(cyclopropylmethoxy)-4-(1,5-dimethyl-6-oxopyridin-3-yl)pyrimidin-2-yl]methanesulfonamide Chemical compound Cc1cc(cn(C)c1=O)-c1nc(NS(C)(=O)=O)ncc1OCC1CC1 BSYSBWVNKXYCOI-UHFFFAOYSA-N 0.000 claims 1
- JPZAAGFNKWCAFH-UHFFFAOYSA-N N-[5-[3-(methanesulfonamido)phenyl]-1-methyl-2-oxopyridin-3-yl]acetamide Chemical compound CC(=O)Nc1cc(cn(C)c1=O)-c1cccc(NS(C)(=O)=O)c1 JPZAAGFNKWCAFH-UHFFFAOYSA-N 0.000 claims 1
- TUDDHALDLORDMK-UHFFFAOYSA-N N-[5-[3-(methanesulfonamido)phenyl]-1-methyl-2-oxopyridin-3-yl]propanamide Chemical compound CCC(=O)Nc1cc(cn(C)c1=O)-c1cccc(NS(C)(=O)=O)c1 TUDDHALDLORDMK-UHFFFAOYSA-N 0.000 claims 1
- SBFCSXKFAVQLJE-UHFFFAOYSA-N N-[5-[5-(cyclopropylmethylamino)-1-methyl-6-oxopyridin-3-yl]-2-methoxyphenyl]methanesulfonamide Chemical compound COc1ccc(cc1NS(C)(=O)=O)-c1cc(NCC2CC2)c(=O)n(C)c1 SBFCSXKFAVQLJE-UHFFFAOYSA-N 0.000 claims 1
- WQTODVFYKXMSRE-UHFFFAOYSA-N N-[5-[5-(diethylamino)-1-methyl-6-oxopyridin-3-yl]-2-methoxyphenyl]methanesulfonamide Chemical compound CCN(CC)c1cc(cn(C)c1=O)-c1ccc(OC)c(NS(C)(=O)=O)c1 WQTODVFYKXMSRE-UHFFFAOYSA-N 0.000 claims 1
- YKUGJYLPXYAKAY-UHFFFAOYSA-N N-[5-[5-(dimethylamino)-1-methyl-6-oxopyridin-3-yl]-2-methoxyphenyl]methanesulfonamide Chemical compound COc1ccc(cc1NS(C)(=O)=O)-c1cc(N(C)C)c(=O)n(C)c1 YKUGJYLPXYAKAY-UHFFFAOYSA-N 0.000 claims 1
- YGBWQWRCQWHWJB-UHFFFAOYSA-N N-[5-[5-(ethylamino)-1-methyl-6-oxopyridin-3-yl]-2-methoxyphenyl]methanesulfonamide Chemical compound CCNc1cc(cn(C)c1=O)-c1ccc(OC)c(NS(C)(=O)=O)c1 YGBWQWRCQWHWJB-UHFFFAOYSA-N 0.000 claims 1
- KOAHYGSWEOFGQG-UHFFFAOYSA-N N-[5-butyl-4-(1,5-dimethyl-6-oxopyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCCCc1cnc(NS(=O)(=O)CC)nc1-c1cc(C)c(=O)n(C)c1 KOAHYGSWEOFGQG-UHFFFAOYSA-N 0.000 claims 1
- XWDCXVQMONIRLU-UHFFFAOYSA-N N-[5-butyl-4-(1,5-dimethyl-6-oxopyridin-3-yl)pyrimidin-2-yl]methanesulfonamide Chemical compound CCCCc1cnc(NS(C)(=O)=O)nc1-c1cc(C)c(=O)n(C)c1 XWDCXVQMONIRLU-UHFFFAOYSA-N 0.000 claims 1
- AJIKTXPXHBIWCL-UHFFFAOYSA-N N-[5-butyl-4-(1-methyl-6-oxo-5-propan-2-ylpyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCCCc1cnc(NS(=O)(=O)CC)nc1-c1cc(C(C)C)c(=O)n(C)c1 AJIKTXPXHBIWCL-UHFFFAOYSA-N 0.000 claims 1
- FRJBUXIWNLWSPG-UHFFFAOYSA-N N-[5-butyl-4-(1-methyl-6-oxopyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCCCc1cnc(NS(=O)(=O)CC)nc1-c1ccc(=O)n(C)c1 FRJBUXIWNLWSPG-UHFFFAOYSA-N 0.000 claims 1
- UMFJTSFWDQQUDC-UHFFFAOYSA-N N-[5-butyl-4-(5-chloro-1-methyl-6-oxopyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCCCc1cnc(NS(=O)(=O)CC)nc1-c1cc(Cl)c(=O)n(C)c1 UMFJTSFWDQQUDC-UHFFFAOYSA-N 0.000 claims 1
- OCBZFDHWKDMBFH-UHFFFAOYSA-N N-[5-butyl-4-(5-methoxy-1-methyl-6-oxopyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCCCc1cnc(NS(=O)(=O)CC)nc1-c1cc(OC)c(=O)n(C)c1 OCBZFDHWKDMBFH-UHFFFAOYSA-N 0.000 claims 1
- QRWWAIHIHGIKPK-UHFFFAOYSA-N N-[5-butyl-4-(5-methyl-6-oxo-1-propan-2-ylpyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide Chemical compound CCCCc1cnc(NS(=O)(=O)CC)nc1-c1cc(C)c(=O)n(c1)C(C)C QRWWAIHIHGIKPK-UHFFFAOYSA-N 0.000 claims 1
- XOIKXFPYVKNPCP-UHFFFAOYSA-N N-[6-[3-(methanesulfonamido)phenyl]-4-methyl-3-oxopyrazin-2-yl]acetamide Chemical compound CC(=O)Nc1nc(cn(C)c1=O)-c1cccc(NS(C)(=O)=O)c1 XOIKXFPYVKNPCP-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- WQJZQUFCIKXUIP-HPRDVNIFSA-N [2H]C([2H])([2H])N(C=CC(C)=C1C(C=C(C=C2)S(CC)(=O)=O)=C2OCC2CC2)C1=O Chemical compound [2H]C([2H])([2H])N(C=CC(C)=C1C(C=C(C=C2)S(CC)(=O)=O)=C2OCC2CC2)C1=O WQJZQUFCIKXUIP-HPRDVNIFSA-N 0.000 claims 1
- KWAUUCSKGSPHFP-UHFFFAOYSA-N [4-(cyclopropylmethoxy)-3-(1,5-dimethyl-6-oxopyridin-3-yl)phenyl] sulfamate Chemical compound Cc1cc(cn(C)c1=O)-c1cc(OS(N)(=O)=O)ccc1OCC1CC1 KWAUUCSKGSPHFP-UHFFFAOYSA-N 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 claims 1
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- WUPMBWLQPRRRAR-UHFFFAOYSA-N n-[3-(5-chloro-1-methyl-6-oxopyridin-3-yl)-4-(2,4-difluorophenoxy)phenyl]ethanesulfonamide Chemical compound C1=C(Cl)C(=O)N(C)C=C1C1=CC(NS(=O)(=O)CC)=CC=C1OC1=CC=C(F)C=C1F WUPMBWLQPRRRAR-UHFFFAOYSA-N 0.000 claims 1
- OWVZWSUUKSDCQT-UHFFFAOYSA-N n-[4-(2,4-difluorophenoxy)-3-(1-methyl-6-oxopyridin-3-yl)phenyl]methanesulfonamide Chemical compound C1=CC(=O)N(C)C=C1C1=CC(NS(C)(=O)=O)=CC=C1OC1=CC=C(F)C=C1F OWVZWSUUKSDCQT-UHFFFAOYSA-N 0.000 claims 1
- OMWANJCPZZONED-UHFFFAOYSA-N n-[4-(2,4-difluorophenoxy)-3-(5-fluoro-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide Chemical compound C1=C(F)C(=O)N(C)C=C1C1=CC(NS(=O)(=O)CC)=CC=C1OC1=CC=C(F)C=C1F OMWANJCPZZONED-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
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Claims (21)
1. Spoj Formule (II) ili njegova farmaceutski prihvatljiva sol,
[image]
naznačen time, da
R2 je alkil, cikloalkil, cikloalkilalkil, heterociklilalkil, aralkil ili heteroarilalkil;
X6 je C-H ili N;
X5 je C-R5 ili N; pod uvjetom da ako X6 je N, tada X5 je C-R5 i ako X5 je N, tada X6 je CH;
R5 je vodik, halogen, -OH, -CN, -OR61, -NHR61, -N(R61)2, alkil, cikloalkil, cikloalkilalkil, aril, aralkil, heterociklil, heterociklilalkil, heteroaril ili heteroarilalkil, gdje je svaki R61 neovisno odabran od alkila, cikloalkila, cikloalkilalkila, arila, aralkila, heterociklila, heterociklilalkila, heteroarila ili heteroarilalkila;
R6 je vodik, halogen, -OH, -CN, alkil, cikloalkil, cikloalkilalkil, amino, alkilamino, dialkilamino, cikloalkilalkilamino, alkoksi, -S-alkil, cikloalkilalkoksi, heterociklil, araloksi, heteroariloksi, ariloksi, alkiniloksi ili -N(H)CO alkil;
RA je
[image]
X2 je N ili C-R12, gdje je R12 vodik, halogen, alkil ili alkoksi;
R13 je -Y-Z;
Y je odabran od veze, -CH2- ili -CH(C1-C4 alkil)-;
Z je odabran od -SO2R21, -N(R22)SO2R21, -SO2N(R22)2, -N(R22)SO2N(R22)2,-CON(R22)2, -N(R22)CO2R21, -N(R22)CON(R22)2, -N(R22)COR21, -COR21, -OC(O)N(R22)2, -OSO2N(R22)2 ili -N(R22)SO3R21;
X3 je N ili C-R14, pri čemu je R14 vodik, halogen, -CN, alkil, cikloalkil ili alkoksi;
X4 je N ili C-R15, pri čemu je R15 vodik, halogen, -CN, alkil, alkoksi, ariloksi, aralkiloksi, cikloalkilalkiloksi, heterocikliloksi, heteroarilalkiloksi ili alkiniloksi;
R16 je vodik, halogen, -N(H)COX ili -W-X, u kojem W je veza, -O-, -S- ili - NH-, a X je odabran od alkila, arila, aralkila, cikloalkila, cikloalkilalkila, alkinila, cikloalkilalkinila, heterociklila, heterociklilalkila, heteroarila ili heteroarilalkila;
svaki R21 je neovisno odabran od alkila, cikloalkila, cikloalkilalkila, arila, aralkila, heterociklila, heterociklilalkila, heteroarila ili heteroarilalkila; i
svaki R22 je neovisno odabran od vodika, alkila, cikloalkila, cikloalkilalkila, arila, aralkila, heterociklila, heterociklilalkila, heteroarila ili heteroarilalkila.; te pod uvjetom da kada X6 je N, tada R5 i R6 nisu vodik.
2. Spoj u skladu s patentnim zahtjevom 1 ili njegova farmaceutski prihvatljiva sol kako je predstavljeno Formulom (IIa)
[image]
naznačen time, da
R2 je CH3, CH2CH3, CH2CF3, CH2F, CHF2, CF3, CH2D, CHD2 ili CD3;
X6 je C-H ili N; 55
X5 je C-R5 ili N; pod uvjetom da ako X6 je N, tada X5 je C-R5 i ako X5 je N, tada X6 je CH;
R5 je vodik, halogen, -OH,-CN, -OR61, -NHR61, -N(R61)2, alkil, cikloalkil, cikloalkilalkil, aril, aralkil, heterociklil, heterociklilalkil, heteroaril ili heteroarilalkil, gdje je svaki R61 neovisno odabran od alkila, cikloalkila, cikloalkilalkila, arila, aralkila, heterociklila, heterociklilalkila, heteroarila ili heteroarilalkila;
R6 je vodik, halogen, -OH, -CN, alkil, cikloalkil, cikloalkilalkil, amino, alkilamino, dialkilamino, cikloalkilalkilamino, alkoksi ili cikloalkilalkoksi;
RA je
[image]
X2 je N ili C-R12, gdje R12 je vodik, halogen, alkil ili alkoksi;
R13 je -Y-Z;
Y je odabran od veze ili -CH2-;
Z je odabran od -SO2R21, -N(R22)SO2R21, -SO2N(R22)2, -N(R22)SO2N(R22)2, - CON(R22)2, -N(R22)CO2R21, -N(R22)CON(R22)2, -N(R22)COR21, -OC(O)N(R22)2, - OSO2N(R22)2 ili -N(R22)SO3R21; X3 je N ili C-R14, gdje je R14 vodik, halogen, -CN, alkil, cikloalkil ili akoksi;
X4 je N ili C-R15, gdje je R15 vodik, halogen, -CN, alkil ili akoksi;
R16 je vodik, halogen ili -W-X, gdje W je veza, -O-, -S- ili -NH-, a X je odabran od alkila, arila, aralkila, cikloalkila, cikloalkilalkila, heterociklila, heterociklilalkila, heteroarila ili heteroarilalkila;
svaki R21 je neovisno odabran od alkila, cikloalkila, cikloalkilalkila, arila, aralkila, heterociklila, heterociklilalkila, heteroarila ili heteroarilalkila; i
svaki R22 je neovisno odabran od vodika, alkila, cikloalkila, cikloalkilalkila, arila, aralkila, heterociklila, heterociklilalkila, heteroarila ili heteroarilalkila; i pod uvjetom da kada X6 je N, tada R5 i R6 nisu vodik.
3. Spoj u skladu s patentnim zahtjevom 1 ili 2, naznačen time, da R2 je CH3 i/ili pri čemu X6 je C-H ili u kojem X6 je N.
4. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-3, naznačen time, da X5 je C-R5.
5. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-3, naznačen time, da X5 je N.
6. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-4, naznačen time, da je R5 vodik, halogen ili alkil ili u kojem je R6 vodik, halogen, alkil ili akoksi ili u kojem je R5 vodik, halogen ili alkil i R6 je vodik, halogen, alkil, ili alkoksi.
7. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-6, naznačen time, da je Y veza ili u kojem je Y - CH2-.
8. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-7, naznačen time, da je Z odabran iz skupine koja se sastoji od -SO2R21, -N(R22)SO2R21, -SO2N(R22)2, -N(R22)SO2N(R22)2, -CON(R22)2, -N(R22CO2R21 i -N(R22)CON(R22)2.
9. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-8, naznačen time, da R21 je alkil, cikloalkil ili cikloalkilalkil.
10. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-9, naznačen time, da R14 je vodik, halogen ili alkil.
11. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-10, naznačen time, da X4 je C-R15.
12. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-9 ili 11, naznačen time, da X3 je N.
13. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-12, naznačen time, da X2 je N.
14. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-9, naznačen time, da X2 i X3 si N, a X4 je C-H ili u kojem R21 je alkil X2 i X3 su N, a X4 je C-H.
15. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-14, naznačen time, da W je -O- ili pri čemu W je - NH- ili u kojem W je veza ili u kojem W je -O- i X je alkil ili u kojem W je -O- i X je aril ili u kojem W je -O- i X je cikloalkilalkil ili u kojem W je veza i X je alkil ili u kojem W je veza i X je aril ili u kojem W je veza i X je cikloalkilalkil.
16. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-15, naznačen time, da je X odabran iz skupine koja se sastoji od alkila, arila i cikloalkilalkila.
17. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-16, naznačen time, da R6 je CD3.
18. Spoj sukladno patentnom zahtjevu 1 ili njegova farmaceutski prihvatljiva sol, naznačen time, da je odabran od:
N-[3-(1-metil-6-oksopiridin-3-il)fenil]metansulfonamida;
N-[3-(1,4-dimetil-6-oksopiridin-3-il)fenil]metansulfonamida;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)fenil]metansulfonamida;
N-[3-(1,4,5-trimetil-6-oksopiridin-3-il)fenil]metansulfonamida;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-1-metilpiridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-(1-metil-6-oksopiridin-3-il)fenil]etansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-(1-metil-6-oksopiridin-3-il)fenil]metansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-(1,4-dimetil-6-oksopiridin-3-il)fenil]metansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-(1,5-dimetil-6-oksopiridin-3-il)fenil]metansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-(1,4,5-trimetil-6-oksopiridin-3-il)fenil]metansulfonamida;
3-amino-1-metil-5-(3-metilsulfonilfenil)pirazin-2-ona;
3-amino-5-(3-etilsulfonilfenil)-1-metilpirazin-2-ona;
N-[5-(6-amino-4-metil-5-oksopirazin-2-il)-2-metoksifenil]metansulfonamida;
3-amino-1-metil-5-(3-metilsulfonilfenil)piridin-2-ona;
3-amino-5-(3-etilsulfonilfenil)-1-metilpiridin-2-ona;
N-[5-(5-amino-1-metil-6-oksopiridin-3-il)-2-metoksifenil]metansulfonamida;
N-[2-metoksi-5-[1-metil-5-(metilamino)-6-oksopiridin-3-il]fenil]metansulfonamida;
N-[5-[5-(etilamino)-1-metil-6-oksopiridin-3-il]-2-metoksifenil]metansulfonamida;
N-[5-[5-(ciklopropilmetilamino)-1-metil-6-oksopiridin-3-il]-2-metoksifenil]metansulfonamida;
N-[5-[5-(dimetilamino)-1-metil-6-oksopiridin-3-il]-2-metoksifenil]metansulfonamida;
N-[5-[5-(dietilamino)-1-metil-6-oksopiridin-3-il]-2-metoksifenil]metansulfonamida;
N-[3-(5-amino-1-metil-6-oksopiridin-3-il)-4-(2,4-difluorofenoksi)fenil]etansulfonamida;
3-amino-5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-1-metilpiridin-2-ona;
4-etoksi-3-(1-metil-6-oksopiridin-3-il)benzensulfonamida;
4-(2,4-difluorofenoksi)-3-(1-metil-6-oksopiridin-3-il)benzensulfonamida;
5 - [2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-3-fluoro-1-metilpiridin-2-ona;
5 - [2-(2,4-difluorofenoksi)-5 -metilsulfonilfenil]-3-fluoro-1-metilpiridin-2-ona;
5-[2-(2,4-difluorofenoksi)-5-etilsulfonilfenil]-3-fluoro-1-metilpiridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-(5-fluoro-1-metil-6-oksopiridin-3-il)fenil]etansulfonamida;
N-[3-(5-kloro-1-metil-6-oksopiridin-3-il)-4-(2,4-difluorofenoksi)fenil]etansulfonamida;
6-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-2,4-dimetilpiridazin-3-ona;
6-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-2,5-dimetilpiridazin-3-ona;
N-[4-(2,4-difluorofenoksi)-3-[1-metil-6-okso-5-(trifluorometil)piridin-3-il]fenil]etansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-(4-fluoro-1-metil-6-oksopiridin-3-il)fenil]etansulfonamida;
N-[3-(5-ciklopropil-1-metil-6-oksopiridin-3-il)-4-(2,4-difluorofenoksi)fenil]etansulfonamida;
N-{4-(2,4-difluorofenoksi)-3-[1-(2H3)metil-6-oksopiridin-3-il]fenil}etansulfonamida;
5-[5-(ciklopropilmetoksi)-2-(metilsulfonilmetil)pirimidin-4-il]-1,3-dimetilpiridin-2-ona;
5-[5-(2,4-difluorofenoksi)-2-(metilsulfonilmetil)pirimidin-4-il]-3-metoksi-1-metilpiridin-2-ona;
5-[5-(2,4-difluorofenoksi)-2-(metilsulfonilmetil)pirimidin-4-il]-1,3-dimetilpiridin-2-ona;
5-[5-(2,4-difluorofenoksi)-2-metilsulfonilpirimidin-4-il]-1,3-dimetilpiridin-2-ona;
5-[5-(2,4-difluorofenoksi)-2-metilsulfonilpirimidin-4-il]-3-metoksi-1-metilpiridin-2-ona;
N-[5-(ciklopropilmetoksi)-4-(1,5-dimetil-6-oksopiridin-3-il)pirimidin-2-il]metansulfonamida;
N-[5-(ciklopropilmetoksi)-4-(1,5-dimetil-6-oksopiridin-3-il)pirimidin-2-il]-N-etilmetansulfonamida;
N-[5-(2,4-difluorofenoksi)-4-(1,5-dimetil-6-oksopiridin-3-il)pirimidin-2-il]metansulfonamida;
N-[5-(2,4-difluorofenoksi)-4-(5-metoksi-1-metil-6-oksopiridin-3-il)pirimidin-2-il]metansulfonamida;
N-[5-(2,4-difluorofenoksi)-4-(5-metoksi-1-metil-6-oksopiridin-3-il)pirimidin-2-il]etansulfonamida;
N-[5-(2,4-difluorofenoksi)-4-(1,5-dimetil-6-oksopiridin-3-il)pirimidin-2-il]etansulfonamida;
[4-(ciklopropilmetoksi)-3-(1,5-dimetil-6-oksopiridin-3-il)fenil]sulfamata;
N-[4-(2,4-difluorofenoksi)-3-(1,5-dimetil-6-oksopiridin-3-il)fenil]-N-metilmetansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-(1,5-dimetil-6-oksopiridin-3-il)fenil]-N-(oksetan-3-il)metansulfonamida;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-1-(ciklopropilmetil)-3-metilpiridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-3-metil-1-(2-metilpropil)piridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-1-(2-metoksietil)-3-metilpiridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-3-metil-1-(oksetan-3-ilmetil)piridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-3-metil-1-(1,3-oksazol-4-ilmetil)piridin-2-ona;
N-[3-[1-(ciklopropilmetil)-5-metil-6-oksopiridin-3-il]-4-(2,4-difluorofenoksi)fenil]etansulfonamida;
N-[4-[1-(ciklopropilmetil)-5-metil-6-oksopiridin-3-il]-5-(2,4-difluorofenoksi)pirimidin-2- il]metansulfonamida;
N-[4-[1-(ciklopropilmetil)-5-metil-6-oksopiridin-3-il]-5-(2,4-difluorofenoksi)pirimidin-2-il]etansulfonamida;
1-(ciklopropilmetil)-5-[4-(2,4-difluorofenoksi)-1-(metilsulfonilmetil)-6-oksopiridin-3-il]-3-metilpiridin-2- ona;
1-ciklopropil-5-[2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-3-metilpiridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-(5-fluoro-1-metil-6-oksopiridin-3-il)fenil]metansulfonamida;
3-kloro-5-[2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-1-metilpiridin-2-ona;
5 - [2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-3-fluoro-1 -metilpiridin-2-ona;
3-kloro-5-[2-(ciklopropilmetilamino)-5-etilsulfonilfenil]-1-metilpiridin-2-ona;
5-[2-(2,4-difluorofenoksi)-5-(methanesulfonilmetil)fenil]-3-(2H3)metil-1-metil-1,2-dihidropiridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-[5-(2H3)metil-1-metil-6-okso-1,6-dihidropiridin-3-il]fenil]metansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-[5-(2H3)metil-1-metil-6-okso-1,6-dihidropiridin-3-il]fenil]etan-1-sulfonamida;
N-[3-(5-ciklopropil-1-metil-6-oksopiridin-3-il)-4-(2,4-difluorofenoksi)fenil]metansulfonamida;
3-ciklopropil-5-[2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-1-metilpiridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-(1-metil-6-okso-5-pirolidin-1-ilpiridin-3-il)fenil]metansulfonamida;
5-[2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-1-metil-3-pirolidin-1-ilpiridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-(5-etinil-1-metil-6-oksopiridin-3-il)fenil]etansulfonamida;
5-[2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-3-etinil-1-metilpiridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-3-etinil-1-metilpiridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-(5-etinil-1-metil-6-oksopiridin-3-il)fenil]metansulfonamida;
5-[2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-3-(difluorometoksi)-1-metilpiridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-1-metil-3-(2,2,2-trifluoroetoksi)piridin-2-ona;
N-[3-[5-(difluorometoksi)-1-metil-6-oksopiridin-3-il]-4-(2,4-difluorofenoksi)fenil]etansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-[1-metil-6-okso-5-(2,2,2-trifluoroetoksi)piridin-3-il]fenil]etansulfonamida;
3-(difluorometoksi)-5-[2-(2,4-difluorofenoksi)-5-(etilsulfonilmetil)fenil]-1-metilpiridin-2-ona;
5-[2-(2,4-difluorofenoksi)-5-(etilsulfonilmetil)fenil]-1-metil-3-(2,2,2-trifluoroetoksi)piridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-1-metil-3-(1-metilpirazol-4-il)oksipiridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-1-metil-3-(1-propan-2-ilpirazol-4-il)oksipiridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-1-metil-3-fenoksipiridin-2-ona;
N-[4-(1-butil-5-metil-6-oksopiridin-3-il)-5-(2,4-difluorofenoksi)pirimidin-2-il]metansulfonamida;
N-[4-(1-butil-5-metil-6-oksopiridin-3-il)-5-(2,4-difluorofenoksi)pirimidin-2-il]etansulfonamida;
N-[4-[1-(ciklobutilmetil)-5-metil-6-oksopiridin-3-il]-5-(2,4-difluorofenoksi)pirimidin-2- il]metansulfonamida;
N-[4-[1-(ciklobutilmetil)-5-metil-6-oksopiridin-3-il]-5-(2,4-difluorofenoksi)pirimidin-2-il]etansulfonamida;
5-(5-etil-2-metilsulfonilpirimidin-4-il)-1,3-dimetilpiridin-2-ona;
1,3-dimetil-5-(2-metilsulfonil-5-propilpirimidin-4-il)piridin-2-ona;
5-(5-butil-2-metilsulfonilpirimidin-4-il)-1,3-dimetilpiridin-2-ona;
N-[4-(1,5-dimetil-6-oksopiridin-3-il)-5-etilpirimidin-2-il]etansulfonamida;
N-[4-(1,5-dimetil-6-oksopiridin-3-il)-5-propilpirimidin-2-il]etansulfonamida;
N-[5-butil-4-(1,5-dimetil-6-oksopiridin-3-il)pirimidin-2-il]etansulfonamida;
5-(2-etil-5-metilsulfonilfenil)-1-metilpiridin-2-ona;
1-metil-5-(5-metilsulfonil-2-propilfenil)piridin-2-ona;
5-[2-(2-ciklopropiletil)-5-metilsulfonilfenil]-1-metilpiridin-2-ona;
5-(2-butil-5-metilsulfonilfenil)-1-metilpiridin-2-ona;
5-[3-[(4-metoksifenil)metoksi]-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
1,3-dimetil-5-(3-metilsulfonil-5-fenilmetoksifenil)piridin-2-ona;
5-[3-(ciklopropilmetoksi)-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
1,3-dimetil-5-[3-metilsulfonil-5-(2-feniletoksi)fenil]piridin-2-ona;
5-[3-(2-ciklopropiletoksi)-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
1,3-dimetil-5-[3-metilsulfonil-5-(2,2,2-trifluoroetoksi)fenil]piridin-2-ona;
1,3-dimetil-5-[3-[(3-metiloksetan-3-il)metoksi]-5-metilsulfonilfenil]piridin-2-ona;
1,3-dimetil-5-[3-metilsulfonil-5-(piridin-2-ilmetoksi)fenil]piridin-2-ona;
5-[3-[(2,6-dimetilfenil)metoksi]-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5-[3-[(2-klorofenil)metoksi]-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5-[3-[[2-(difluorometoksi)fenil]metoksi]-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
2-[[3-(1,5-dimetil-6-oksopiridin-3-il)-5-metilsulfonilfenoksi]metil]benzonitrila;
5-[3-[(2,4-difluorofenil)metoksi]-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
1,3-dimetil-5-[3-metilsulfonil-5-(1-feniletoksi)fenil]piridin-2-ona;
5-[3-[(2,3-diklorofenil)metoksi]-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
1,3-dimetil-5-[3-metilsulfonil-5-(piridin-3-ilmetoksi)fenil]piridin-2-ona;
3-[[3-(1,5-dimetil-6-oksopiridin-3-il)-5-metilsulfonilfenoksi]metil]benzonitrila;
5-(3-but-2-inoksi-5-metilsulfonilfenil)-1,3-dimetilpiridin-2-ona;
1,3-dimetil-5-[3-metilsulfonil-5-(1-feniletoksi)fenil]piridin-2-ona;
N-[3-(2,4-difluorofenoksi)-5-(1,5-dimetil-6-oksopiridin-3-il)fenil]etansulfonamida;
4-[3 - [(4-metoksifenil)metoksi]-5-metilsulfonilfenil] -2-metilizokinolin-1-ona;
2-metil-4-(3-metilsulfonil-5-fenilmetoksifenil)izokinolin-1-ona;
4-[3-(ciklopropilmetoksi)-5-metilsulfonilfenil]-2-metilizokinolin-1-ona;
N-[4-(2,4-difluorofenoksi)-6-(1,5-dimetil-6-oksopiridin-3-il)pirimidin-2-il]etansulfonamida;
N-[2-(2,4-difluorofenoksi)-6-(1,5-dimetil-6-oksopiridin-3-il)pirimidin-4-il]etansulfonamida;
1-metil-5-(2-metilsulfonil-5-propilpirimidin-4-il)piridin-2-ona;
5-(5-butil-2-metilsulfonilpirimidin-4-il)-il)-1-metilpiridin-2-ona;
3-kloro-1-metil-5-(2-metilsulfonil-5-propilpirimidin-4-il)piridin-2-ona;
5-(5-butil-2-metilsulfonilpirimidin-4-il)-3-kloro-1-metilpiridin-2-ona;
3-metoksi-1-metil-5-(2-metilsulfonil-5-propilpirimidin-4-il)piridin-2-ona;
5-(5-butil-2-metilsulfonilpirimidin-4-il)-3-metoksi-1 -metilpiridin-2-ona;
N-[4-(1-metil-6-oksopiridin-3-il)-5-propilpirimidin-2-il]etansulfonamida;
N-[5-butil-4-(1-metil-6-oksopiridin-3-il)pirimidin-2-il]etansulfonamida;
N-[4-(5-kloro-1-metil-6-oksopiridin-3-il)-5-propilpirimidin-2-il]etansulfonamida;
N-[5-butil-4-(5-kloro-1-metil-6-oksopiridin-3-il)pirimidin-2-il]etansulfonamida;
N-[4-(5-metoksi-1-metil-6-oksopiridin-3-il)-5-propilpirimidin-2-il]etansulfonamida;
N-[5-butil-4-(5-metoksi-1-metil-6-oksopiridin-3-il)pirimidin-2-il]etansulfonamida;
N-[5-butil-4-(1,5-dimetil-6-oksopiridin-3-il)pirimidin-2-il]metansulfonamida;
5-(2-but-2-inoksi-5-metilsulfonilfenil)-1,3-dimetilpiridin-2-ona;
5-(2-but-2-inoksi-5-etilsulfonilfenil)-3-metoksi-1-metilpiridin-2-ona;
5-(5-etilsulfonil-2-pent-2-inoksifenil)-3-metoksi-1 -metilpiridin-2-ona;
5-[2-(3-ciklopropilprop-2-inoksi)-5-etilsulfonilfenil]-3-metoksi-1-metilpiridin-2-ona;
5-[2-(2,4-difluorofenoksi)-5-etilsulfonilfenil]-1-metil-3-(trifluorometil)piridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-propan-2-ilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)-5-fenilmetoksifenil]etansulfonamida;
5-[2-(2,4-difluoroanilino)-5-etilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5-[2-[(4,4-difluorocikloheksil)amino]-5-etilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5-[2-(2,4-difluoroanilino)-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-3-metoksi-1-metilpiridin-2-ona;
5-[2-(2,4-difluorofenoksi)-5-(metilsulfonilmetil)fenil]-3-metoksi-1-metilpiridin-2-ona;
5-[2-(4-hidroksicikloheksil)oksi-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-(1-metil-5-metilsulfanil-6-oksopiridin-3-il)fenil]etansulfonamida;
5-[2-(4-aminocikloheksil)oksi-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5-[2-(4-aminocikloheksil)oksi-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
1,3-dimetil-5-[5-metilsulfonil-2-(3,3,3-trifluoropropoksi)fenil]piridin-2-ona;
5-[2-(2,4-difluorofenoksi)-5-(metilsulfonilmetil)fenil]-1-(2-hidroksietil)-3-metilpiridin-2-ona;
5-[5-(etilsulfonilmetil)-2-(2,2,2-trifluoroetoksi)fenil]-1-(2-hidroksietil)-3 -metilpiridin-2-ona;
5-[2-(ciklopropilmetilamino)-5-etilsulfonilfenil]-1-metil-3-(metilamino)piridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-1-metil-3-(metilamino)piridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-[1-metil-5-(metilamino)-6-oksopiridin-3-il]fenil]etansulfonamida;
5-[5-(etilsulfonilmetil)-2-(2,2,2-trifluoroetoksi)fenil]-1,3-dimetilpiridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-[1-metil-5-(metilamino)-6-oksopiridin-3-il]fenil]metansulfonamida;
5-[2-[(4,4-difluorocikloheksil)amino]-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5-[2-(ciklopropilmetilamino)-5-etilsulfonilfenil]-3-metoksi-1-metilpiridin-2-ona;
5-[2-(4,4-difluorocikloheksil)oksi-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5-[2-(ciklopentilamino)-5-etilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5-[2-(ciklopentilamino)-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
3-kloro-1-metil-5-[5-(metilsulfonilmetil)-2-(2,2,2-trifluoroetoksi)fenil]piridin-2-ona;
5-(2-ciklopentiloksi-5-metilsulfonilfenil)-1,3-dimetilpiridin-2-ona;
1.3-dimetil-5-[5-metilsulfonil-2-(oksan-4-iloksi)fenil]piridin-2-ona;
3-fluoro-1-metil-5-[5-(metilsulfonilmetil)-2-(2,2,2-trifluoroetoksi)fenil]piridin-2-ona;
5-[2-(ciklopropilmetilamino)-5-metilsulfonilfenil]-1,4-dimetilpiridin-2-ona;
5-[2-(ciklopropilmetilamino)-5-etilsulfonilfenil]-1,4-dimetilpiridin-2-ona;
1.3-dimetil-5-[5-metilsulfonil-2-(oksolan-3-ilamino)fenil]piridin-2-ona;
1.3-dimetil-5-[5-metilsulfonil-2-(oksolan-3-iloksi)fenil]piridin-2-ona;
1.3-dimetil-5-[5-(metilsulfonilmetil)-2-(2,2,2-trifluoroetoksi)fenil]piridin-2-ona;
5-[2-(ciklopropilmetilamino)-5-metilsulfonilfenil]-1-etil-3-metilpiridin-2-ona;
5-[2-(2,4-difluorofenoksi)-5-(metilsulfonilmetil)fenil]-1-etil-3-metilpiridin-2-ona;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)-4-(4-hidroksicikloheksil)oksifenil]etansulfonamida;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)-4-(4-hidroksicikloheksil)oksifenil]etansulfonamida;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)-4-(4-hidroksicikloheksil)oksifenil]metansulfonamida;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)-4-(4-hidroksicikloheksil)oksifenil]metansulfonamida;
1.3-dimetil-5-[5-metilsulfonil-2-(oksan-4-ilamino)fenil]piridin-2-ona;
5-[2-(2,4-difluorofenoksi)-5-(metilsulfonilmetil)fenil]-3-fluoro-1-metilpiridin-2-ona;
5-[2-(ciklopropilmetilamino)-5-metilsulfonilfenil]-3-(dimetilamino)-1-metilpiridin-2-ona;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)-4-(oksan-4-iloksi)fenil]metansulfonamida;
5-[2-(ciklopropilmetilamino)-5-etilsulfonilfenil]-3-(dimetilamino)-1-metilpiridin-2-ona;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)-4-(oksan-4-iloksi)fenil]etansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-(5-metoksi-1-metil-6-oksopiridin-3-il)fenil]metansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-(5-metoksi-1-metil-6-oksopiridin-3-il)fenil]etansulfonamida;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)-4-(oksolan-3-iloksi)fenil]metansulfonamida;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)-4-(oksolan-3-iloksi)fenil]etansulfonamida;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)-4-(oksan-3-iloksi)fenil]metansulfonamida;
N-[4-(4,4-difluorocikloheksil)oksi-3-(1,5-dimetil-6-oksopiridin-3-il)fenil]metansulfonamida;
N-[3-(1,5-dimetil-6-oksopiridin-3-il)-4-(oksan-3-iloksi)fenil]etansulfonamida;
N-[4-(4,4-difluorocikloheksil)oksi-3-(1,5-dimetil-6-oksopiridin-3-il)fenil]etansulfonamida;
5 - [2-(ciklopropilmetoksi)-5-etilsulfonilfenil] -1,3-dimetilpiridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-(5-hidroksi-1-metil-6-oksopiridin-3-il)fenil]etansulfonamida;
4-(ciklopropilmetilamino)-3-(1,5-dimetil-6-oksopiridin-3-il)benzenesulfonamida;
4-(ciklopropilmetilamino)-3-(1-metil-6-oksopiridin-3-il)benzenesulfonamida;
5-[2-(2,4-difluorofenoksi)-5-(metilsulfonilmetil)fenil]-1,4-dimetilpiridin-2-ona;
5-[2-(2,4-difluorofenoksi)-5-(metilsulfonilmetil)fenil]-1,3-dimetilpiridin-2-ona;
5-(2-etoksi-5-etilsulfonilfenil)-1-(2H3)metil-4-metilpiridin-2-one;
5 - [2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-1-(2H3)metil-4-metilpiridin-2-ona;
5-(2-etoksi-5-etilsulfonilfenil)-1,4-dimetilpiridin-2-ona;
5-[2-(ciklobutilmetoksi)-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5-[2-(ciklobutilmetoksi)-5-metilsulfonilfenil]-1-metilpiridin-2-ona;
5-(5-etilsulfonil-2-metoksifenil)-3-hidroksi-1-metilpiridin-2-ona;
5 - [2-(ciklopropilmetilamino)-5 -metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
N-[4-(2,4-difluorofenoksi)-3-[5-(dimetilamino)-1-metil-6-oksopiridin-3-il]fenil]metansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-[5-(dimetilamino)-1-metil-6-oksopiridin-3-il]fenil]etansulfonamida;
5 - [2-(ciklopropilmetilamino)-5-etilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5 - [2-(ciklopropilmetoksi)-5-etilsulfonilfenil]-1,4-dimetilpiridin-2-ona;
N-[3-(5-hidroksi-1-metil-6-oksopiridin-3-il)fenil]metansulfonamida;
5 - [2-(ciklopropilmetilamino)-5-metilsulfonilfenil]-1-metilpiridin-2-ona;
3 -(dimetilamino)-5 -(2-etoksi-5-etilsulfonilfenil)-1-metilpiridin-2-ona;
5 - [2-(2,4-difluorofenoksi)-5 -(metilsulfonilmetil)fenil]-1-metilpiridin-2-ona;
N-[3-(1-metil-6-okso-5-fenilmetoksipiridin-3-il)fenil]metansulfonamida;
N-[4-(2,4-difluorofenoksi)-3-(1,5-dimetil-6-oksopiridin-3-il)fenil]etansulfonamida;
5 - [2-(ciklopropilmetilamino)-5-etilsulfonilfenil]-1-metilpiridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-3-(dimetilamino)-1-metilpiridin-2-ona;
5 - [4-fluoro-2-metoksi-5-(metilsulfonilmetil)fenil]-1-metilpiridin-2-ona;
5 - [2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-1,3-dimetilpiridin-2-ona;
5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-1,4-dimetilpiridin-2-ona;
N-[6-[3-(metansulfonamido)fenil]-4-metil-3-oksopirazin-2-il]acetamida;
N-[3-(1,4-dimetil-6-oksopiridazin-3-il)fenil]etansulfonamida;
N-[3-(1,5-dimetil-6-oksopiridazin-3-il)fenil]etansulfonamida;
N-[5-[3-(metansulfonamido)fenil]-1-metil-2-oksopiridin-3-il]propanamida;
N-[5-[3-(metansulfonamido)pheny1]-1-metil-2-oksopiridin-3-il]acetamida;
1-ciklobutil-5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-3-metilpiridin-2-ona;
N-[3-(1-ciklobutil-5-metil-6-oksopiridin-3-il)-4-(2,4-difluorofenoksi)fenil]metansulfonamida;
1-benzil-5-[2-(ciklopropilmetoksi)-5-metilsulfonilfenil]-3-metilpiridin-2-ona;
5-(5-butil-2-metilsulfonilpirimidin-4-il)-3-metil-1-propan-2-ilpiridin-2-ona;
N-[5-(2,4-difluorofenoksi)-4-(5-metil-6-okso-1-propan-2-ilpiridin-3-il)pirimidin-2-il]etansulfonamida;
5-[5-(2,4-difluorofenoksi)-2-metilsulfonilpirimidin-4-il]-3-metil-1-propan-2-ilpiridin-2-ona;
N-[5-butil-4-(5-metil-6-okso-1-propan-2-ilpiridin-3-il)pirimidin-2-il]etansulfonamida;
N-[5-butil-4-(1-metil-6-okso-5-propan-2-ilpiridin-3-il)pirimidin-2-il]etansulfonamida;
5-(5-butil-2-metilsulfonilpirimidin-4-il)-il)-1-metil-3-propan-2-ilpiridin-2-ona;
N-[5-(2,4-difluorofenoksi)-4-(1-metil-6-okso-5-propan-2-ilpiridin-3-il)pirimidin-2-il]etansulfonamida; ili 5-[5-(2,4-difluorofenoksi)-2-metilsulfonilpirimidin-4-il]-1-metil-3-propan-2-ilpiridin-2-ona.
19. Farmaceutski pripravak, naznačen time, da sadrži spoj Formule (II) ili spoj prema patentnom zahtjevu 18 ili njegovu farmaceutski prihvatljivu sol i farmaceutski prihvatljivu pomoćnu tvar.
20. Spoj Formule (II) ili spoj iz patentnog zahtjeva 18 ili farmaceutski pripravak u skladu s patentnim zahtjevom 19, naznačen time, da se koristi kao lijek.
21. Spoj Formule (II) ili spoj iz patentnog zahtjeva 18 ili farmaceutski pripravak u skladu s patentnim zahtjevom 19, naznačen time, da se koristi kao lijek za liječenje karcinoma.
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