PT2370442E - 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina - Google Patents

Info

Publication number

PT2370442E

PT2370442E PT97749394T PT09774939T PT2370442E PT 2370442 E PT2370442 E PT 2370442E PT 97749394 T PT97749394 T PT 97749394T PT 09774939 T PT09774939 T PT 09774939T PT 2370442 E PT2370442 E PT 2370442E

Authority

PT

Portugal

Prior art keywords

amino

trifluoromethyl

diazabicyclo

carbonyl

hept

Prior art date

2008-11-26

Links

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• 102000009410 Chemokine receptor Human genes 0.000 title claims description 49
• 108050000299 Chemokine receptor Proteins 0.000 title claims description 49
• OLHSXPNNEJJDLQ-UHFFFAOYSA-N 3-aminocyclopentane-1-carboxamide Chemical class NC1CCC(C(N)=O)C1 OLHSXPNNEJJDLQ-UHFFFAOYSA-N 0.000 title 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 210
• -1 biphenylyl Chemical group 0.000 claims description 199
• 150000001875 compounds Chemical class 0.000 claims description 198
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• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 99
• 150000003839 salts Chemical class 0.000 claims description 76
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• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 42
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 41
• 125000001475 halogen functional group Chemical group 0.000 claims description 41
• 238000011282 treatment Methods 0.000 claims description 38
• 125000000217 alkyl group Chemical group 0.000 claims description 33
• 239000003814 drug Substances 0.000 claims description 29
• 125000001424 substituent group Chemical group 0.000 claims description 28
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 27
• 125000004778 2,2-difluoroethyl group Chemical group [H]C([H])(*)C([H])(F)F 0.000 claims description 27
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 27
• 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 26
• 125000003118 aryl group Chemical group 0.000 claims description 25
• 230000000694 effects Effects 0.000 claims description 25
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 20
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• MNLVCBKWEVXHGE-UHFFFAOYSA-N [CH]1[CH]CC[CH]1 Chemical group [CH]1[CH]CC[CH]1 MNLVCBKWEVXHGE-UHFFFAOYSA-N 0.000 claims description 17
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• 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 11
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• RQRLGFUJFOPXIL-VSZXSWFZSA-N [(1s,3r)-3-[[(3s,4s)-3-methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[(1s,4s)-5-[3-(trifluoromethyl)phenyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methanone Chemical compound C([C@]1(N(C[C@]2([H])C1)C(=O)[C@@]1(C[C@@H](CC1)N[C@@H]1[C@@H](COCC1)OC)C(C)C)[H])N2C1=CC=CC(C(F)(F)F)=C1 RQRLGFUJFOPXIL-VSZXSWFZSA-N 0.000 claims description 2
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