KR101374412B1 - 케모카인 수용체 조절제로서의 3-아미노시클로펜탄카르복스아미드 - Google Patents
케모카인 수용체 조절제로서의 3-아미노시클로펜탄카르복스아미드 Download PDFInfo
- Publication number
- KR101374412B1 KR101374412B1 KR1020117011887A KR20117011887A KR101374412B1 KR 101374412 B1 KR101374412 B1 KR 101374412B1 KR 1020117011887 A KR1020117011887 A KR 1020117011887A KR 20117011887 A KR20117011887 A KR 20117011887A KR 101374412 B1 KR101374412 B1 KR 101374412B1
- Authority
- KR
- South Korea
- Prior art keywords
- amino
- trifluoromethyl
- carbonyl
- diazabicyclo
- dideoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 C*(C)c1ncnc(C(F)(F)F)c1 Chemical compound C*(C)c1ncnc(C(F)(F)F)c1 0.000 description 2
- DNRAIXKDBWKUJX-UHFFFAOYSA-N CC(c1nncc(C(F)(F)F)c1)S Chemical compound CC(c1nncc(C(F)(F)F)c1)S DNRAIXKDBWKUJX-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Virology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11805308P | 2008-11-26 | 2008-11-26 | |
| US61/118,053 | 2008-11-26 | ||
| PCT/IB2009/055232 WO2010061329A1 (en) | 2008-11-26 | 2009-11-20 | 3-aminocyclopentanecarboxamides as chemokine receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20110075036A KR20110075036A (ko) | 2011-07-05 |
| KR101374412B1 true KR101374412B1 (ko) | 2014-03-17 |
Family
ID=41693100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117011887A Expired - Fee Related KR101374412B1 (ko) | 2008-11-26 | 2009-11-20 | 케모카인 수용체 조절제로서의 3-아미노시클로펜탄카르복스아미드 |
Country Status (38)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2370442E (pt) * | 2008-11-26 | 2013-06-27 | Pfizer | 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina |
| KR101303963B1 (ko) * | 2011-04-08 | 2013-09-05 | 재단법인 경기과학기술진흥원 | (1r,2r,3r)-3-아미노사이클로펜탄-1,2-디올을 포함하는 항알러지용 조성물 |
| EP3125920B1 (en) | 2014-04-04 | 2020-12-23 | Del Mar Pharmaceuticals | Dianhydrogalactitol, diacetyldianhydrogalactitol or dibromodulcitol to treat non-small-cell carcinoma of the lung and ovarian cancer |
| WO2016010131A1 (ja) * | 2014-07-17 | 2016-01-21 | 参天製薬株式会社 | 加齢黄斑変性の予防または治療剤 |
| JOP20190040A1 (ar) * | 2016-09-14 | 2019-03-10 | Novartis Ag | توليفة من ناهضات fxr |
| TWI830733B (zh) * | 2018-05-11 | 2024-02-01 | 中國大陸商迪哲(江蘇)醫藥有限公司 | 環戊烷化合物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050234034A1 (en) | 2004-03-03 | 2005-10-20 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US20060020133A1 (en) | 2004-06-28 | 2006-01-26 | Chu-Biao Xue | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995015973A1 (en) | 1993-12-06 | 1995-06-15 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| US5510332A (en) | 1994-07-07 | 1996-04-23 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor |
| ATE237342T1 (de) | 1994-07-11 | 2003-05-15 | Athena Neurosciences Inc | Inhibitoren der leukozytenadhäsion |
| US5462208A (en) | 1994-08-01 | 1995-10-31 | The Procter & Gamble Company | Two-phase dispensing systems utilizing bellows pumps |
| US5811391A (en) | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
| GB9524630D0 (en) | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| WO1996031206A2 (en) | 1995-04-07 | 1996-10-10 | Warner-Lambert Company | Flavones and coumarins as agents for the treatment of atherosclerosis |
| US5704960A (en) | 1995-12-20 | 1998-01-06 | Corning, Inc. | Method of forming an optical fiber for reduced polarization effects in amplifiers |
| GB9603741D0 (en) | 1996-02-22 | 1996-04-24 | Lin Mei | Treatment of water by electrolysis |
| JP2000516210A (ja) | 1996-07-12 | 2000-12-05 | ロイコサイト,インコーポレーテッド | ケモカインレセプターアンタゴニストとその使用方法 |
| WO1998042656A1 (en) | 1997-03-21 | 1998-10-01 | Cytel Corporation | Novel compounds |
| EP1001764A4 (en) | 1997-05-29 | 2005-08-24 | Merck & Co Inc | HETEROCYCLIC AMIDE COMPOUNDS AS INHIBITORS OF CELL ADHESION |
| ATE318841T1 (de) | 1997-05-29 | 2006-03-15 | Merck & Co Inc | Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren |
| AU728435B2 (en) | 1997-05-29 | 2001-01-11 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
| WO1998054207A1 (en) | 1997-05-30 | 1998-12-03 | Celltech Therapeutics Limited | Anti-inflammatory tyrosine derivatives |
| DE69818049T2 (de) | 1997-06-23 | 2004-07-15 | Tanabe Seiyaku Co., Ltd. | Inhibitoren der alpha4-beta1 vermittelten zelladhäsion |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| MY129850A (en) | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| PT1501507E (pt) * | 2002-04-29 | 2008-08-12 | Merck Sharp & Dohme | Tetrahidropiranil ciclopentil tetrahidropiridopiridinas moduladoras da actividade dos receptores de quimioquinas |
| JP4740151B2 (ja) | 2003-12-18 | 2011-08-03 | インサイト コーポレイション | ケモカイン受容体のモジュレーターとしての3‐シクロアルキルアミノピロリジン誘導体 |
| EP1755603A4 (en) | 2004-04-28 | 2009-03-11 | Merck & Co Inc | 3,3-DISUBSTITUTED TETRAHYDROPYRANYL CYCLOPENTYL AMIDE MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY |
| WO2006004684A2 (en) | 2004-06-28 | 2006-01-12 | Incyte Corporation | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| CN1976707A (zh) * | 2004-06-28 | 2007-06-06 | 因赛特公司 | 作为趋化因子受体调节剂的3-氨基环戊烷甲酰胺类 |
| MEP1008A (xx) | 2005-12-21 | 2010-02-10 | Incyte Corp | 3-aminociklopentankarboksamidi kao modulatori receptora hemokina |
| PT2370442E (pt) * | 2008-11-26 | 2013-06-27 | Pfizer | 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina |
-
2009
- 2009-11-20 PT PT97749394T patent/PT2370442E/pt unknown
- 2009-11-20 CN CN200980147183.7A patent/CN102227429B/zh not_active Expired - Fee Related
- 2009-11-20 BR BRPI0920936-0A patent/BRPI0920936A2/pt not_active Application Discontinuation
- 2009-11-20 UA UAA201106571A patent/UA99978C2/uk unknown
- 2009-11-20 SI SI200930601T patent/SI2370442T1/sl unknown
- 2009-11-20 NZ NZ592919A patent/NZ592919A/xx not_active IP Right Cessation
- 2009-11-20 PL PL09774939T patent/PL2370442T3/pl unknown
- 2009-11-20 MY MYPI20112377 patent/MY152557A/en unknown
- 2009-11-20 AP AP2011005732A patent/AP3113A/xx active
- 2009-11-20 ES ES09774939T patent/ES2415430T3/es active Active
- 2009-11-20 WO PCT/IB2009/055232 patent/WO2010061329A1/en not_active Ceased
- 2009-11-20 KR KR1020117011887A patent/KR101374412B1/ko not_active Expired - Fee Related
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- 2009-11-20 JP JP2011538083A patent/JP5108153B2/ja active Active
- 2009-11-20 HR HRP20130409AT patent/HRP20130409T2/hr unknown
- 2009-11-20 PE PE2011001105A patent/PE20110831A1/es active IP Right Grant
- 2009-11-20 DK DK09774939.4T patent/DK2370442T5/da active
- 2009-11-20 EP EP09774939.4A patent/EP2370442B9/en active Active
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- 2009-11-20 RS RS20130260A patent/RS52810B9/sr unknown
- 2009-11-20 GE GEAP200912239A patent/GEP20146064B/en unknown
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050234034A1 (en) | 2004-03-03 | 2005-10-20 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US20060020133A1 (en) | 2004-06-28 | 2006-01-26 | Chu-Biao Xue | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
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