HRP20120695T1 - 8-supstituirani benzoazepini kao modulatori toll-u sličnog receptora - Google Patents

8-supstituirani benzoazepini kao modulatori toll-u sličnog receptora Download PDF

Info

Publication number
HRP20120695T1
HRP20120695T1 HRP20120695TT HRP20120695T HRP20120695T1 HR P20120695 T1 HRP20120695 T1 HR P20120695T1 HR P20120695T T HRP20120695T T HR P20120695TT HR P20120695 T HRP20120695 T HR P20120695T HR P20120695 T1 HRP20120695 T1 HR P20120695T1
Authority
HR
Croatia
Prior art keywords
alkyl
compound according
nr6r7
alkynyl
alkenyl
Prior art date
Application number
HRP20120695TT
Other languages
English (en)
Croatian (hr)
Inventor
A. Doherty George
C. Eary Todd
D. Groneberg Robert
Jones Zachary
Original Assignee
Array Biopharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma filed Critical Array Biopharma
Publication of HRP20120695T1 publication Critical patent/HRP20120695T1/hr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HRP20120695TT 2005-08-19 2012-09-04 8-supstituirani benzoazepini kao modulatori toll-u sličnog receptora HRP20120695T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71000405P 2005-08-19 2005-08-19
PCT/US2006/032098 WO2007024612A2 (fr) 2005-08-19 2006-08-17 Benzoazepines substituees en 8, modulatrices du recepteur toll-like

Publications (1)

Publication Number Publication Date
HRP20120695T1 true HRP20120695T1 (hr) 2012-09-30

Family

ID=37623842

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20120695TT HRP20120695T1 (hr) 2005-08-19 2012-09-04 8-supstituirani benzoazepini kao modulatori toll-u sličnog receptora

Country Status (31)

Country Link
US (2) US8153622B2 (fr)
EP (3) EP1940797B1 (fr)
JP (1) JP5138592B2 (fr)
KR (2) KR101442846B1 (fr)
CN (6) CN101309906A (fr)
AP (1) AP2008004386A0 (fr)
AU (1) AU2006283620B2 (fr)
BR (1) BRPI0614941B8 (fr)
CA (3) CA3003143A1 (fr)
CR (2) CR9809A (fr)
DK (1) DK1940797T3 (fr)
EA (1) EA018543B1 (fr)
EC (1) ECSP088292A (fr)
ES (1) ES2391031T3 (fr)
HK (1) HK1122017A1 (fr)
HR (1) HRP20120695T1 (fr)
IL (2) IL189467A (fr)
MA (1) MA29838B1 (fr)
MX (1) MX2008002141A (fr)
MY (1) MY146567A (fr)
NO (1) NO342587B1 (fr)
NZ (1) NZ565907A (fr)
PL (1) PL1940797T3 (fr)
PT (1) PT1940797E (fr)
RS (1) RS52447B (fr)
SI (1) SI1940797T1 (fr)
TN (1) TNSN08076A1 (fr)
TW (2) TWI404537B (fr)
UA (1) UA92754C2 (fr)
WO (1) WO2007024612A2 (fr)
ZA (1) ZA200802496B (fr)

Families Citing this family (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI382019B (zh) * 2005-08-19 2013-01-11 Array Biopharma Inc 作為類鐸受體(toll-like receptor)調節劑之胺基二氮雜呯
AU2009276403B2 (en) * 2008-08-01 2016-03-10 Ventirx Pharmaceuticals, Inc. Toll-like receptor agonist formulations and their use
EP2358683B1 (fr) * 2008-11-06 2015-04-01 VentiRx Pharmaceuticals, Inc. Procédés de synthèse de dérivés de benzazépine
DK2467380T3 (en) * 2009-08-18 2017-03-13 Ventirx Pharmaceuticals Inc SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS
ES2620629T3 (es) 2009-08-18 2017-06-29 Ventirx Pharmaceuticals, Inc. Benzoazepinas sustituidas como moduladores del receptor tipo Toll
CN105640964A (zh) * 2010-04-21 2016-06-08 文蒂雷克斯药品公司 增强抗体依赖性细胞的细胞毒性的方法
CN107080839A (zh) 2010-05-26 2017-08-22 西莱克塔生物科技公司 多价的合成纳米载体疫苗
US9045468B2 (en) 2010-08-17 2015-06-02 Albany Molecular Research, Inc. 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
MX351464B (es) * 2010-10-01 2017-10-16 Ventirx Pharmaceuticals Inc Star El uso de un agonista del receptor 8 tipo toll para el tratamiento de enfermedades alérgicas.
WO2012045090A2 (fr) * 2010-10-01 2012-04-05 Ventirx Pharmaceuticals, Inc. Utilisation thérapeutique d'un agoniste de tlr, et polythérapie
EP2640190A4 (fr) 2010-11-05 2016-05-11 Selecta Biosciences Inc Composés nicotiniques modifiés et procédés associés
GB201022049D0 (en) * 2010-12-29 2011-02-02 Imp Innovations Ltd Methods
BR112013017947A2 (pt) * 2011-01-12 2018-12-18 Array Biopharma Inc benzoazepinas substituídas como moduladores de receptor toll-like
PT2663550T (pt) * 2011-01-12 2017-03-22 Array Biopharma Inc Benzoazepinas substítuidas utilizáveis como moduladores dos recetores tipo toll
RS62254B1 (sr) 2011-04-08 2021-09-30 Janssen Sciences Ireland Unlimited Co Derivati pirimidina za tretman virusnih infekcija
CN112587671A (zh) 2012-07-18 2021-04-02 博笛生物科技有限公司 癌症的靶向免疫治疗
US9228184B2 (en) 2012-09-29 2016-01-05 Dynavax Technologies Corporation Human toll-like receptor inhibitors and methods of use thereof
US9868955B2 (en) 2012-09-29 2018-01-16 Dynavax Technologies Corporation Human toll-like receptor inhibitors and methods of use thereof
WO2014090709A1 (fr) * 2012-12-11 2014-06-19 F. Hoffmann-La Roche Ag Composés dimères
KR101482999B1 (ko) * 2013-06-17 2015-01-14 순천향대학교 산학협력단 톨-유사 수용체(tlr)에 의해 유도되는 trif-의존성 신호전달 경로의 억제제로서의 (e)-1-(2-(2-니트로 비닐)페닐)피롤리딘(nvpp)을 유효성분으로 포함하는 항염증제
WO2015103989A1 (fr) 2014-01-10 2015-07-16 Shanghai Birdie Biotech, Inc. Composés et compositions pour l'immunothérapie
EP3134402B1 (fr) 2014-04-22 2020-05-06 F.Hoffmann-La Roche Ag Composés 4-amino-imidazoquinoline
CN112546230A (zh) 2014-07-09 2021-03-26 博笛生物科技有限公司 用于治疗癌症的联合治疗组合物和联合治疗方法
TWI691335B (zh) 2014-07-09 2020-04-21 英屬開曼群島商博笛生物科技有限公司 用於治療腫瘤的抗pd-l1組合
CN112546238A (zh) 2014-09-01 2021-03-26 博笛生物科技有限公司 用于治疗肿瘤的抗-pd-l1结合物
MX2017007955A (es) 2014-12-16 2018-02-19 Celgene Corp Formas solidas que comprenden (1e, 4e)-2-amino-n,n-dipropil-8-(4-( pirrolidina-1-carbonil)fenil)-3h-benzo[b]azepina-4-carboxamida, composiciones de las mismas y usos de las mismas.
EP3233835B1 (fr) * 2014-12-18 2019-01-23 F.Hoffmann-La Roche Ag Composés sulfonamide de benzazépine
SI3097102T1 (en) 2015-03-04 2018-02-28 Gilead Sciences, Inc. A TOOL RECEPTOR MODULING 4,6-DIAMINO-PYRIDO (3,2-D) PYRIMIDINE COMPOUNDS
MA41625A (fr) * 2015-03-06 2018-01-10 Hoffmann La Roche Composés de benzazépine dicarboxamide
WO2017001307A1 (fr) 2015-06-30 2017-01-05 F. Hoffmann-La Roche Ag Nouvelle aminothiazolopyrimidinedione substituée pour le traitement et la prophylaxie d'une infection virale
CA2995004A1 (fr) 2015-08-26 2017-03-02 Gilead Sciences, Inc. Modulateurs deuteres du recepteur toll
CA2997955A1 (fr) 2015-09-15 2017-03-23 Gilead Sciences, Inc. Modulateurs de recepteurs de type toll pour le traitement du vih
CN108055842B (zh) * 2015-09-17 2021-06-29 豪夫迈·罗氏有限公司 亚磺酰基苯基或磺亚胺酰基苯基苯并氮杂䓬
EP3370726A4 (fr) 2015-11-02 2019-06-12 VentiRx Pharmaceuticals, Inc. Utilisation d'agonistes de tlr8 pour traiter le cancer
KR102165120B1 (ko) 2015-12-15 2020-10-13 길리애드 사이언시즈, 인코포레이티드 인간 면역결핍 바이러스 중화 항체
CN106943596A (zh) 2016-01-07 2017-07-14 博笛生物科技(北京)有限公司 用于治疗肿瘤的抗-cd20组合
CN106943597A (zh) 2016-01-07 2017-07-14 博笛生物科技(北京)有限公司 用于治疗肿瘤的抗-egfr组合
CN115350279A (zh) 2016-01-07 2022-11-18 博笛生物科技有限公司 用于治疗肿瘤的抗-her2组合
EP3464245B1 (fr) 2016-05-23 2020-10-14 H. Hoffnabb-La Roche Ag Composés de benzazépine dicarboxamide à fonction amide tertiaire
WO2017202703A1 (fr) 2016-05-23 2017-11-30 F. Hoffmann-La Roche Ag Composés de benzazépine dicarboxamide à fonction amide secondaire
BR102017010009A2 (pt) 2016-05-27 2017-12-12 Gilead Sciences, Inc. Compounds for the treatment of hepatitis b virus infection
EP3463469B1 (fr) 2016-05-27 2023-12-13 Gilead Sciences, Inc. Combinaision de ledipasvir et sofosbuvir pour l'utilisation dans le traitement de l'hepatite b chez l'homme
JP7012668B2 (ja) 2016-06-12 2022-02-14 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト ジヒドロピリミジニルベンズアゼピンジカルボキサミド化合物
JP7171444B2 (ja) 2016-07-01 2022-11-15 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ウイルス感染治療用のジヒドロピラノピリミジン
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
US10370342B2 (en) 2016-09-02 2019-08-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
ES2912945T3 (es) * 2016-09-29 2022-05-30 Janssen Sciences Ireland Unlimited Co Profármacos de pirimidina para el tratamiento de infecciones virales y otras enfermedades
US10662416B2 (en) 2016-10-14 2020-05-26 Precision Biosciences, Inc. Engineered meganucleases specific for recognition sequences in the hepatitis B virus genome
TWI820984B (zh) 2017-01-31 2023-11-01 美商基利科學股份有限公司 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型
JOP20180008A1 (ar) 2017-02-02 2019-01-30 Gilead Sciences Inc مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b
SG10202110181RA (en) * 2017-03-15 2021-10-28 Silverback Therapeutics Inc Benzazepine compounds, conjugates, and uses thereof
JOP20180040A1 (ar) 2017-04-20 2019-01-30 Gilead Sciences Inc مثبطات pd-1/pd-l1
CN118515666A (zh) 2017-04-27 2024-08-20 博笛生物科技有限公司 2-氨基-喹啉衍生物
RU2020102453A (ru) 2017-06-23 2021-07-23 Бирди Байофармасьютикалз, Инк. Фармацевтические композиции
AR112412A1 (es) 2017-08-17 2019-10-23 Gilead Sciences Inc Formas de sal de colina de un inhibidor de la cápside del vih
TW202024061A (zh) 2017-08-17 2020-07-01 美商基利科學股份有限公司 Hiv蛋白質膜抑制劑之固體形式
CN111051305A (zh) 2017-08-22 2020-04-21 吉利德科学公司 治疗性杂环化合物
CN109694351B (zh) * 2017-10-23 2020-07-28 江苏恒瑞医药股份有限公司 苯并氮杂*衍生物、其制备方法及其在医药上的应用
WO2019084060A1 (fr) 2017-10-24 2019-05-02 Silverback Therapeutics, Inc. Conjugués et leurs procédés d'utilisation pour l'administration sélective d'agents immunomodulateurs
CN109721597B (zh) * 2017-10-30 2021-05-14 上海迪诺医药科技有限公司 吡啶并氮杂卓衍生物、其药物组合物及应用
EP3724222A1 (fr) 2017-12-15 2020-10-21 Silverback Therapeutics, Inc. Conjugué de construction d'anticorps-médicament pour le traitement de l'hépatite
CN111566120B (zh) 2017-12-20 2023-09-29 捷克共和国有机化学与生物化学研究所 活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸
JP7098748B2 (ja) 2017-12-20 2022-07-11 インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. Stingアダプタータンパク質を活性化するホスホン酸結合を有する2’3’環状ジヌクレオチド
PL3752501T3 (pl) 2018-02-13 2023-08-21 Gilead Sciences, Inc. Inhibitory pd-1/pd-l1
US10836746B2 (en) 2018-02-15 2020-11-17 Gilead Sciences, Inc. Therapeutic compounds
CA3175384A1 (fr) 2018-02-16 2019-08-22 Gilead Sciences, Inc. Methodes et intermediaires pour preparer des composes therapeutiques utiles dans le traitement d'une infection virale des retroviridae
PL3759109T3 (pl) 2018-02-26 2024-03-04 Gilead Sciences, Inc. Podstawione związki pirolizyny jako inhibitory replikacji hbv
TW201945003A (zh) 2018-03-01 2019-12-01 愛爾蘭商健生科學愛爾蘭無限公司 2,4-二胺基喹唑啉衍生物及其醫學用途
US10870691B2 (en) 2018-04-05 2020-12-22 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis B virus protein X
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
TW202005654A (zh) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 2,2,─環二核苷酸
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
US11142750B2 (en) 2018-04-12 2021-10-12 Precision Biosciences, Inc. Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome
JP7242702B2 (ja) 2018-04-19 2023-03-20 ギリアード サイエンシーズ, インコーポレイテッド Pd-1/pd-l1阻害剤
WO2019211799A1 (fr) 2018-05-03 2019-11-07 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. Analogue de dinucléotide 2'3'-cyclique comprenant un nucléotide modifié par cyclopentanyle
AU2019299609B9 (en) 2018-07-03 2024-07-11 Jiangsu Hengrui Medicine Co., Ltd. Pyridopyrimidine derivative, preparation method therefor and medical use thereof
PE20210685A1 (es) 2018-07-03 2021-04-08 Gilead Sciences Inc Anticuerpos que se dirigen al gp120 de vih y metodos de uso
EP3818052A1 (fr) 2018-07-06 2021-05-12 Gilead Sciences, Inc. Composés hétérocycliques thérapeutiques
US11186579B2 (en) 2018-07-06 2021-11-30 Gilead Sciences, Inc. Therapeutic heterocyclic compounds
KR20230159715A (ko) 2018-07-13 2023-11-21 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
CN112423750A (zh) 2018-07-16 2021-02-26 吉利德科学公司 用于治疗hiv的衣壳抑制剂
WO2020028097A1 (fr) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Formes solides d'acide (r)-11-(méthoxyméthyl)-12-(3-méthoxypropoxy)-3,3-diméthyl-8-0 x0-2,3,8,13b-tétrahydro-1h-pyrido[2,1-a] pyrrolo[1,2-c]phtalazine-7-carboxylique
CA3111784A1 (fr) 2018-09-12 2020-03-19 Silverback Therapeutics, Inc. Compositions pour le traitement d'une maladie avec des conjugues immunostimulants
EP3860717A1 (fr) 2018-10-03 2021-08-11 Gilead Sciences, Inc. Dérivés d'imidozopyrimidine
KR102635333B1 (ko) 2018-10-24 2024-02-15 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
AU2019373221B2 (en) 2018-10-31 2022-05-26 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having HPK1 inhibitory activity
SG11202103839UA (en) 2018-10-31 2021-05-28 Gilead Sciences Inc Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
MX2021009496A (es) 2019-02-08 2021-09-08 Progeneer Inc Complejo de colesterol-agonista del receptor 7 u 8 tipo larga distancia, y uso del mismo.
WO2020176510A1 (fr) 2019-02-25 2020-09-03 Gilead Sciences, Inc. Agonistes de protéine kinase c
WO2020176505A1 (fr) 2019-02-25 2020-09-03 Gilead Sciences, Inc. Agonistes de protéine kinase c
EP3935066A1 (fr) 2019-03-07 2022-01-12 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. Dinucléotides 3'3'-cycliques et leurs promédicaments
CA3129022C (fr) 2019-03-07 2023-08-01 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. Dinucleotides cycliques en 2'3' et leurs promedicaments
WO2020178768A1 (fr) 2019-03-07 2020-09-10 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. Analogue du dinucléotide 3'3'-cyclique comprenant un nucléotide modifié par cyclopentanyle utilisé en tant que modulateur de sting
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI762925B (zh) 2019-05-21 2022-05-01 美商基利科學股份有限公司 鑑別對使用gp120 v3聚醣導向之抗體的治療敏感之hiv病患的方法
WO2020237025A1 (fr) 2019-05-23 2020-11-26 Gilead Sciences, Inc. Exo-méthylène-oxindoles substitués qui sont des inhibiteurs de hpk1/map4k1
WO2020255019A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (vhb) et d'un dérivé de la quinazoline
CA3140708A1 (fr) 2019-06-18 2020-12-24 Helen Horton Association de vaccins contre le virus de l'hepatite b (vhb) et de derives de pyridopyrimidine
AU2020294920A1 (en) 2019-06-18 2022-02-17 Janssen Sciences Ireland Unlimited Company Quinazoline prodrugs for the treatment of viral infections and further diseases
KR20220035908A (ko) 2019-06-19 2022-03-22 실버백 테라퓨틱스, 인크. 항-메소텔린 항체 및 이의 면역접합체
KR20220032568A (ko) 2019-06-25 2022-03-15 길리애드 사이언시즈, 인코포레이티드 Flt3l-fc 융합 단백질 및 사용 방법
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
AU2020315598A1 (en) 2019-07-16 2022-03-03 Gilead Sciences, Inc. HIV vaccines and methods of making and using
US20220257619A1 (en) 2019-07-18 2022-08-18 Gilead Sciences, Inc. Long-acting formulations of tenofovir alafenamide
CN114667134A (zh) 2019-08-15 2022-06-24 希沃尔拜克治疗公司 苯并氮杂䓬缀合物的制剂及其用途
US20220296619A1 (en) 2019-08-19 2022-09-22 Gilead Sciences, Inc. Pharmaceutical formulations of tenofovir alafenamide
BR112022005687A2 (pt) 2019-09-30 2022-06-21 Gilead Sciences Inc Vacinas contra o hbv e métodos para tratar o hbv
WO2021067644A1 (fr) 2019-10-01 2021-04-08 Silverback Therapeutics, Inc. Polythérapie comprenant des conjugués immunostimulants
KR20220085796A (ko) 2019-10-18 2022-06-22 포티 세븐, 인코포레이티드 골수이형성 증후군 및 급성 골수성 백혈병을 치료하기 위한 조합 치료
US20210147568A1 (en) 2019-10-31 2021-05-20 Forty Seven, Inc. Anti-cd47 based treatment of blood cancer
TWI778443B (zh) 2019-11-12 2022-09-21 美商基利科學股份有限公司 Mcl1抑制劑
EP4065116A1 (fr) 2019-11-26 2022-10-05 Gilead Sciences, Inc. Inhibiteurs de capside pour la prévention du vih
WO2021113765A1 (fr) 2019-12-06 2021-06-10 Precision Biosciences, Inc. Méganucléases modifiées optimisées ayant une spécificité pour une séquence de reconnaissance dans un génome du virus de l'hépatite b
EP4081305B1 (fr) 2019-12-24 2024-09-18 Carna Biosciences, Inc. Composés modulant la diacylglycérol kinase
MX2022008286A (es) 2020-01-02 2022-08-08 Jiangsu Hengrui Medicine Co Forma cristalina del derivado de piridopirimidina y metodo de preparacion de la misma.
CN115087488A (zh) 2020-02-14 2022-09-20 震动疗法股份有限公司 与ccr8结合的抗体和融合蛋白及其用途
JP2023514727A (ja) 2020-02-21 2023-04-07 シルバーバック セラピューティックス インコーポレイテッド ネクチン-4抗体コンジュゲートおよびその使用
JP2023516372A (ja) 2020-03-02 2023-04-19 プロジェニア インコーポレイテッド 病原菌外壁成分基盤の生病原体模倣ナノ粒子及びその製造方法
AR121620A1 (es) 2020-03-20 2022-06-22 Gilead Sciences Inc Profármacos de nucleósidos 4’-c-sustituidos-2-halo-2’-deoxiadenosina y métodos de preparación y uso de los mismos
AU2021264550A1 (en) 2020-05-01 2022-11-17 Gilead Sciences, Inc. CD73 inhibiting 2,4-dioxopyrimidine compounds
EP4153181A1 (fr) 2020-05-21 2023-03-29 Gilead Sciences, Inc. Compositions pharmaceutiques contenant du bictégravir
WO2021262990A1 (fr) 2020-06-25 2021-12-30 Gilead Sciences, Inc. Inhibiteurs de capside pour le traitement du vih
EP4175673A1 (fr) 2020-07-01 2023-05-10 ARS Pharmaceuticals Inc. Conjugués d'anticorps anti-asgr1 et leurs utilisations
EP4194008A1 (fr) 2020-08-04 2023-06-14 Progeneer Inc. Ensemble adjuvant à action cinétique
CN116322751A (zh) 2020-08-04 2023-06-23 蛋白科技先锋 包含能够动力学控制的佐剂的mRNA疫苗
EP4194010A1 (fr) 2020-08-04 2023-06-14 Progeneer Inc. Conjugué d'un médicament fonctionnel et d'un agoniste de récepteur de type toll 7 ou 8, dont le site actif est temporairement inactivé et utilisation associée
BR112023002164A2 (pt) 2020-08-07 2023-03-14 Gilead Sciences Inc Profármacos de análogos de nucleotídeos de fosfonamida e seu uso farmacêutico
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
EP4244396A1 (fr) 2020-11-11 2023-09-20 Gilead Sciences, Inc. Procédés d'identification des patients vih sensibles à la thérapie avec des anticorps visant le site de liaison cd4 de la gp120
TW202304524A (zh) 2021-04-10 2023-02-01 美商普方生物製藥美國公司 Folr1結合劑、其結合物及使用方法
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症
TW202308699A (zh) 2021-04-23 2023-03-01 美商普方生物製藥美國公司 Cd70結合劑、其結合物及其使用方法
KR20240006683A (ko) 2021-05-13 2024-01-15 길리애드 사이언시즈, 인코포레이티드 TLR8 조절 화합물과 항-HBV siRNA 치료제의 조합물
WO2022245671A1 (fr) 2021-05-18 2022-11-24 Gilead Sciences, Inc. Méthodes d'utilisation de protéines de fusion flt3l-fc
EP4359411A1 (fr) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Composés modulant les diacylglycérol kinases
KR20240025616A (ko) 2021-06-23 2024-02-27 길리애드 사이언시즈, 인코포레이티드 다이아실글리세롤 키나제 조절 화합물
EP4359415A1 (fr) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Composés modulant les diacylglycérol kinases
AU2022297367A1 (en) 2021-06-23 2023-12-07 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
KR20240091056A (ko) 2021-10-28 2024-06-21 길리애드 사이언시즈, 인코포레이티드 피리디진-3(2h)-온 유도체
CN118201941A (zh) 2021-10-29 2024-06-14 吉利德科学公司 Cd73化合物
CN118355020A (zh) 2021-12-03 2024-07-16 吉利德科学公司 Hiv病毒感染的治疗性化合物
IL312718A (en) 2021-12-03 2024-07-01 Gilead Sciences Inc Therapeutic compounds for HIV infection
TW202342447A (zh) 2021-12-03 2023-11-01 美商基利科學股份有限公司 用於hiv病毒感染之治療性化合物
US20230220106A1 (en) 2021-12-08 2023-07-13 Dragonfly Therapeutics, Inc. Antibodies targeting 5t4 and uses thereof
WO2023107956A1 (fr) 2021-12-08 2023-06-15 Dragonfly Therapeutics, Inc. Protéines se liant à nkg2d, cd16 et 5t4
CA3239528A1 (fr) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Agents de degradation de doigt de zinc de la famille ikaros et utilisations associees
AU2022417491A1 (en) 2021-12-22 2024-05-23 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
EP4245756A1 (fr) 2022-03-17 2023-09-20 Gilead Sciences, Inc. Agents de dégradation de la famille des doigts de zinc de l'ikaros et leurs utilisations
US20230355796A1 (en) 2022-03-24 2023-11-09 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
TW202345901A (zh) 2022-04-05 2023-12-01 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
TWI843506B (zh) 2022-04-06 2024-05-21 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
WO2023205719A1 (fr) 2022-04-21 2023-10-26 Gilead Sciences, Inc. Composés modulateurs de kras g12d
US20240116928A1 (en) 2022-07-01 2024-04-11 Gilead Sciences, Inc. Cd73 compounds
TW202402280A (zh) 2022-07-01 2024-01-16 美商基利科學股份有限公司 可用於hiv病毒感染之疾病預防性或治療性治療的治療性化合物
WO2024015741A1 (fr) 2022-07-12 2024-01-18 Gilead Sciences, Inc. Polypeptides immunogènes du vih et vaccins et utilisations de ceux-ci
US20240083984A1 (en) 2022-08-26 2024-03-14 Gilead Sciences, Inc. Dosing and scheduling regimen for broadly neutralizing antibodies
US20240091351A1 (en) 2022-09-21 2024-03-21 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY
WO2024076915A1 (fr) 2022-10-04 2024-04-11 Gilead Sciences, Inc. Analogues de 4'-thionucléosides et leur utilisation pharmaceutique
WO2024137852A1 (fr) 2022-12-22 2024-06-27 Gilead Sciences, Inc. Inhibiteurs de prmt5 et leurs utilisations

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US4002610A (en) 1975-09-22 1977-01-11 Mcneil Laboratories, Incorporated 2-Aminobenzodiazepine-5-ones
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
JPS6487631A (en) 1987-09-28 1989-03-31 Idemitsu Petrochemical Co Production of polyarylene sulfide
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
GB8920519D0 (en) 1989-09-11 1989-10-25 Rhone Poulenc Ltd New compositions of matter
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
PT825186E (pt) * 1996-08-16 2002-08-30 Pfizer Derivados de 2-aminobenzazepina e sua utilizacao para o tratamento da imunossupressao
AU2001286405B2 (en) * 2000-07-31 2007-05-10 Yale University Innate immune system-directed vaccines
US20060058288A1 (en) * 2002-04-08 2006-03-16 Masayuki Ii Severe sepsis preventive therapeutic agent
MXPA04012629A (es) * 2002-06-12 2005-10-18 Biogen Idec Inc Metodo para el tratamiento de lesion de reperfusion por isquemia por medio de antagonistas receptores de adenosina.
US20040213264A1 (en) 2003-04-25 2004-10-28 Nortel Networks Limited Service class and destination dominance traffic management
MXPA05013922A (es) * 2003-06-20 2006-02-24 Coley Pharm Group Inc Antagonistas de receptor tipo toll de molecula pequena.
JP2007509987A (ja) 2003-10-31 2007-04-19 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答調節剤化合物による好中球活性化
US20050226878A1 (en) 2003-12-02 2005-10-13 3M Innovative Properties Company Therapeutic combinations and methods including IRM compounds
US8940755B2 (en) 2003-12-02 2015-01-27 3M Innovative Properties Company Therapeutic combinations and methods including IRM compounds
WO2006026760A2 (fr) 2004-09-02 2006-03-09 3M Innovative Properties Company Composes renfermant un 1-amino imidazo et procedes
TWI382019B (zh) 2005-08-19 2013-01-11 Array Biopharma Inc 作為類鐸受體(toll-like receptor)調節劑之胺基二氮雜呯
EP2358683B1 (fr) 2008-11-06 2015-04-01 VentiRx Pharmaceuticals, Inc. Procédés de synthèse de dérivés de benzazépine
ES2620629T3 (es) 2009-08-18 2017-06-29 Ventirx Pharmaceuticals, Inc. Benzoazepinas sustituidas como moduladores del receptor tipo Toll
DK2467380T3 (en) 2009-08-18 2017-03-13 Ventirx Pharmaceuticals Inc SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS

Also Published As

Publication number Publication date
KR20080038413A (ko) 2008-05-06
CA2865331C (fr) 2018-06-12
BRPI0614941B8 (pt) 2021-05-25
EA018543B1 (ru) 2013-08-30
CR20130321A (es) 2013-08-13
US8153622B2 (en) 2012-04-10
IL189467A (en) 2013-04-30
ECSP088292A (es) 2008-05-30
MY146567A (en) 2012-08-30
JP5138592B2 (ja) 2013-02-06
MA29838B1 (fr) 2008-10-03
US8304407B2 (en) 2012-11-06
JP2009504763A (ja) 2009-02-05
DK1940797T3 (da) 2012-09-10
TWI404537B (zh) 2013-08-11
CN101309906A (zh) 2008-11-19
HK1122017A1 (en) 2009-05-08
NZ565907A (en) 2011-05-27
NO20081425L (no) 2008-05-19
CN109096192A (zh) 2018-12-28
ZA200802496B (en) 2009-06-24
CN104803915A (zh) 2015-07-29
EP2322510A3 (fr) 2011-09-07
CN104945323A (zh) 2015-09-30
IL225446A0 (en) 2013-06-27
NO342587B1 (no) 2018-06-18
CN104910072A (zh) 2015-09-16
WO2007024612A3 (fr) 2007-05-10
TW200740759A (en) 2007-11-01
BRPI0614941B1 (pt) 2020-11-17
ES2391031T3 (es) 2012-11-20
US20080234251A1 (en) 2008-09-25
AU2006283620A1 (en) 2007-03-01
KR20130082182A (ko) 2013-07-18
EP1940797A2 (fr) 2008-07-09
WO2007024612A2 (fr) 2007-03-01
CR9809A (es) 2008-06-10
EP1940797B1 (fr) 2012-08-01
RS52447B (en) 2013-02-28
TW201402124A (zh) 2014-01-16
IL189467A0 (en) 2008-08-07
EA200800634A1 (ru) 2008-08-29
AP2008004386A0 (en) 2008-04-30
CA2865331A1 (fr) 2007-03-01
EP2322510A2 (fr) 2011-05-18
CA2619581C (fr) 2014-12-02
CA3003143A1 (fr) 2007-03-01
US20120165317A1 (en) 2012-06-28
UA92754C2 (ru) 2010-12-10
CA2619581A1 (fr) 2007-03-01
BRPI0614941A2 (pt) 2013-01-01
MX2008002141A (es) 2008-04-22
EP3081558A1 (fr) 2016-10-19
CN109096193A (zh) 2018-12-28
SI1940797T1 (sl) 2012-11-30
AU2006283620B2 (en) 2012-05-31
PL1940797T3 (pl) 2012-12-31
PT1940797E (pt) 2012-10-18
TNSN08076A1 (en) 2009-07-14
KR101442846B1 (ko) 2014-10-01

Similar Documents

Publication Publication Date Title
HRP20120695T1 (hr) 8-supstituirani benzoazepini kao modulatori toll-u sličnog receptora
UY29312A1 (es) Piperazin-1-carboxamidas n,4,sustituidas y sus derivados, composiciones que los contienen, procedimientos de preparación y aplicaciones
TW200734322A (en) Indole derivatives exhibiting PGD2 receptor antagonism
TW200744587A (en) Azaindole derivatives exhibiting PGD2 receptor antagonism
AR080878A1 (es) Derivados heterociclicos de ariletinilo, composiciones farmaceuticas que los contienen, metodo para prepararlos y uso de los mismos en el tratamiento de la esquizofrenia y trastornos cognitivos.
AR064319A1 (es) Compuestos y composiciones farmaceuticas derivadas de sulfonamida ciclicos, proceso de preparacion y usos en el tratamiento de trastornos vasomotrices, sexuales, gastrointestinales y otros
MX2009010024A (es) Nuevo compuesto de adenina.
TW200716528A (en) Cyclopropanecarboxamide derivatives
RS107504A (en) Benzofused heteroaryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compostions including the same, and methods for their use
ECSP066760A (es) Derivado de 4-oxopirimidina de anillos condensados
NZ593110A (en) pteridinone derivatives as MODULATORS OF TOLL-LIKE RECEPTORS
ES2626555T3 (es) Pyridone amides como moduladores de canales de sodio
UA97639C2 (ru) ОКТАГИДРОПИРОЛО[3,4-b]ПИРРОЛЬНЫЕ ПРОИЗВОДНЫЕ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ РЕЦЕПТОРОВ ГИСТАМИНА-3
WO2002000650A3 (fr) Nouveaux composes possedant une activite anti-bacterienne, antifongique et anti-tumeur
IN2012DN01325A (fr)
TW200800938A (en) Indole carboxylic acid derivatives exhibiting PGD2 receptor antagonism
PE20020406A1 (es) 7-OXO-PIRIDO[2,3-d]PIRIMIDINAS 2,6-DISUSTITUIDAS COMO INHIBIDORES DE LAS PROTEINAS CINASAS
MXPA06002296A (es) Tienopiridina-fenilacetamidas y sus derivados utiles como nuevos agentes antiangiogenicos.
EA201790713A1 (ru) N-АЛКИЛАРИЛ-5-ОКСОАРИЛОКТАГИДРОЦИКЛОПЕНТА[c]ПИРРОЛЬНЫЕ НЕГАТИВНЫЕ АЛОСТЕРИЧЕСКИЕ МОДУЛЯТОРЫ NR2B
MX2009012885A (es) Nuevo derivado de 1,2,3,4-tetrahidroquinoxalina que tiene, como sustituyente, grupo fenilo que tiene estructura de ester de acido sulfonico o estructura de amida de acido sulfonico introducida en este, y tiene actividad de enlace al receptor de gluco
MX2007005709A (es) Compuestos de n-sulfonilaminobencil-2-fenoxiacetamida sustituidos.
RS49906B (sr) Benzociklohepteni, postupak za njihovo dobijanje, farmaceutski preparati koji ove sadrže kao i njihova primena za izradu lekova
UA100003C2 (ru) Соединения 1,2,4,5-тетрагидро-3н-бензазепина, способ их получения и фармацевтическая композиция, которая их содержит
ECSP14013296A (es) Derivados de etinilo
MX2009013119A (es) Derivados de 2-[2-(fenil)etilamino]alcanamida sustituidos y su uso como moduladores del canal de sodio y/o potasio.