HRP20100253T1 - Makrolidi - Google Patents
Makrolidi Download PDFInfo
- Publication number
- HRP20100253T1 HRP20100253T1 HR20100253T HRP20100253T HRP20100253T1 HR P20100253 T1 HRP20100253 T1 HR P20100253T1 HR 20100253 T HR20100253 T HR 20100253T HR P20100253 T HRP20100253 T HR P20100253T HR P20100253 T1 HRP20100253 T1 HR P20100253T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- diradical
- substituted
- methyl
- oxo
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title 1
- 229940041033 macrolides Drugs 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 38
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 32
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 23
- 150000001875 compounds Chemical class 0.000 claims abstract 21
- 125000000217 alkyl group Chemical group 0.000 claims abstract 15
- 125000001424 substituent group Chemical group 0.000 claims abstract 14
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract 12
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract 11
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims abstract 11
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims abstract 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 7
- 229910052799 carbon Inorganic materials 0.000 claims abstract 7
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims abstract 6
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims abstract 6
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims abstract 4
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims abstract 2
- 125000003627 8 membered carbocyclic group Chemical group 0.000 claims abstract 2
- 101100495917 Arabidopsis thaliana ATRX gene Proteins 0.000 claims abstract 2
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
- -1 hydrocarbon radical Chemical class 0.000 claims 64
- 229960003276 erythromycin Drugs 0.000 claims 23
- 229910020008 S(O) Inorganic materials 0.000 claims 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 claims 7
- 108010081348 HRT1 protein Hairy Proteins 0.000 claims 7
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 claims 7
- 125000001589 carboacyl group Chemical group 0.000 claims 7
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 7
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 7
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 229930006677 Erythromycin A Natural products 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 2
- 125000005862 (C1-C6)alkanoyl group Chemical group 0.000 claims 2
- 125000006592 (C2-C3) alkenyl group Chemical group 0.000 claims 2
- 125000006593 (C2-C3) alkynyl group Chemical group 0.000 claims 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229930195733 hydrocarbon Natural products 0.000 claims 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 2
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000004209 (C1-C8) alkyl group Chemical class 0.000 claims 1
- 125000005955 1H-indazolyl group Chemical group 0.000 claims 1
- 125000002471 4H-quinolizinyl group Chemical group C=1(C=CCN2C=CC=CC12)* 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000005873 benzo[d]thiazolyl group Chemical group 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 1
- 229960002626 clarithromycin Drugs 0.000 claims 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Tires In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63809704P | 2004-12-21 | 2004-12-21 | |
| US71753005P | 2005-09-14 | 2005-09-14 | |
| PCT/IB2005/003829 WO2006067589A1 (en) | 2004-12-21 | 2005-12-12 | Macrolides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100253T1 true HRP20100253T1 (hr) | 2010-06-30 |
Family
ID=35809765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100253T HRP20100253T1 (hr) | 2004-12-21 | 2010-05-04 | Makrolidi |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7462600B2 (de) |
| EP (2) | EP2233493A1 (de) |
| JP (1) | JP4111994B1 (de) |
| KR (1) | KR100897678B1 (de) |
| CN (1) | CN101120011A (de) |
| AP (1) | AP2007004026A0 (de) |
| AR (1) | AR052824A1 (de) |
| AT (1) | ATE459633T1 (de) |
| AU (1) | AU2005317735B2 (de) |
| BR (1) | BRPI0519135A2 (de) |
| CA (1) | CA2591746A1 (de) |
| CR (1) | CR9202A (de) |
| DE (1) | DE602005019786D1 (de) |
| DK (1) | DK1836211T3 (de) |
| EA (1) | EA011281B1 (de) |
| ES (1) | ES2339871T3 (de) |
| GE (1) | GEP20094834B (de) |
| GT (1) | GT200500378A (de) |
| HN (1) | HN2005036113A (de) |
| HR (1) | HRP20100253T1 (de) |
| IL (1) | IL183661A0 (de) |
| MA (1) | MA29108B1 (de) |
| MX (1) | MX2007007598A (de) |
| NL (1) | NL1030713C2 (de) |
| NO (1) | NO20073367L (de) |
| PE (1) | PE20060948A1 (de) |
| PL (1) | PL1836211T3 (de) |
| PT (1) | PT1836211E (de) |
| SI (1) | SI1836211T1 (de) |
| TN (1) | TNSN07233A1 (de) |
| TW (1) | TW200626608A (de) |
| UA (1) | UA85937C2 (de) |
| UY (1) | UY29285A1 (de) |
| WO (1) | WO2006067589A1 (de) |
| ZA (1) | ZA200705108B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8367669B2 (en) * | 2005-06-15 | 2013-02-05 | Vanderbilt University | Inhibitors of hemeprotein-catalyzed lipid peroxidation |
| US9133212B1 (en) | 2005-06-15 | 2015-09-15 | Vanderbilt University | Inhibitors of hemeprotein-catalyzed lipid peroxidation |
| ES2638427T3 (es) | 2005-08-24 | 2017-10-20 | Melinta Therapeutics, Inc. | Compuestos de triazol y procedimientos de preparación y uso del mismo |
| AP2009004985A0 (en) * | 2007-03-13 | 2009-10-31 | Pfizer Prod Inc | Erythromycin-based macrolides |
| WO2008115118A1 (en) * | 2007-03-21 | 2008-09-25 | Innate Pharmaceuticals Ab | Method and means for preventing and inhibiting type iii secretion in infections caused by gram-negative bacteria |
| US20110040078A1 (en) * | 2007-10-25 | 2011-02-17 | Siegfried Wolf | Process for the production of telithromycin |
| CN101917850B (zh) | 2007-10-25 | 2016-01-13 | 森普拉制药公司 | 大环内酯类抗菌剂的制备方法 |
| KR101610415B1 (ko) | 2007-12-21 | 2016-04-07 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 항바이러스 화합물 |
| CA2769551A1 (en) | 2009-08-13 | 2011-02-17 | Basilea Pharmaceutica Ag | New macrolides and their use |
| CN103080122A (zh) * | 2010-03-22 | 2013-05-01 | 森普拉制药公司 | 大环内脂的结晶形式及其用途 |
| US9320786B2 (en) | 2011-04-12 | 2016-04-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria |
| CN102558047B (zh) * | 2011-12-14 | 2013-10-30 | 天津药物研究院药业有限责任公司 | 3-甲基喹啉的制备方法 |
| KR20140139083A (ko) | 2012-03-27 | 2014-12-04 | 셈프라 파마슈티컬스, 인크. | 마크롤라이드계 항생제를 투여하기 위한 비경구 제제 |
| RU2015103119A (ru) | 2012-07-13 | 2016-08-27 | Ф. Хоффманн-Ля Рош Аг | Антипролиферативные бензо[в]азепин-2-оны |
| KR101612179B1 (ko) * | 2013-04-19 | 2016-04-12 | 영남대학교 산학협력단 | 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 암질환 예방 또는 치료용 약학조성물 |
| TW201534586A (zh) | 2013-06-11 | 2015-09-16 | Orion Corp | 新穎ｃｙｐ１７抑制劑／抗雄激素劑 |
| CN103739643A (zh) * | 2013-12-30 | 2014-04-23 | 华东理工大学 | 利用分子印迹技术对红霉素进行回收分离纯化的方法 |
| CN104230891B (zh) * | 2014-08-27 | 2016-03-30 | 于宗光 | 一种托匹司他的制备方法 |
| JP2019533669A (ja) | 2016-10-04 | 2019-11-21 | バイオファーマティ ソシエテ アノニム | 抗菌活性を有するケトライド |
| US20220315602A1 (en) * | 2019-06-04 | 2022-10-06 | Hager Biosciences, Llc | Pyrazole and imidazole derivatives, compositions and methods as orexin antagonists |
| CN111793022A (zh) * | 2020-04-27 | 2020-10-20 | 滁州拜奥生物科技有限公司 | 一种3-甲基喹啉的制备方法 |
| WO2024050061A2 (en) * | 2022-09-01 | 2024-03-07 | Hager Biosciences, Llc | Pyrazole and imidazole derivatives as dual orexin and kappa-opioid receptors modulators, composition, methods for treating neurological and psychiatric disorders |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2653899A (en) | 1952-04-14 | 1953-09-29 | Lilly Co Eli | Erythromycin, its salts, and method of preparation |
| US2823203A (en) | 1954-06-24 | 1958-02-11 | Abbott Lab | Method of producing substantially pure erythromycin a |
| US4331803A (en) | 1980-06-04 | 1982-05-25 | Taisho Pharmaceutical Co., Ltd. | Novel erythromycin compounds |
| SI8110592A8 (en) | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
| US4474768A (en) | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| US4742049A (en) * | 1986-06-04 | 1988-05-03 | Abbott Laboratories | Semisynthetic erythromycin antibiotics |
| US5075289A (en) | 1988-06-07 | 1991-12-24 | Abbott Laboratories | 9-r-azacyclic erythromycin antibiotics |
| IE70593B1 (en) | 1989-09-29 | 1996-12-11 | Eisai Co Ltd | Biphenylmethane derivative the use of it and pharmacological compositions containing same |
| US5523399A (en) | 1991-12-27 | 1996-06-04 | Taisho Pharmaceutical Co., Ltd. | 5-O-desosaminylerythronolide derivatives |
| US5527780A (en) | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| FR2697524B1 (fr) * | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2719587B1 (fr) | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| US5629322A (en) | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
| FR2727969B1 (fr) * | 1994-12-09 | 1997-01-17 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US5747466A (en) * | 1995-11-08 | 1998-05-05 | Abbott Laboratories | 3-deoxy-3-descladinose derivatives of erythromycins A and B |
| FR2742757B1 (fr) | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| JP2000509712A (ja) * | 1996-05-07 | 2000-08-02 | アボツト・ラボラトリーズ | ６―ｏ―置換エリスロマイシン及びその製造方法 |
| US5750510A (en) * | 1997-04-04 | 1998-05-12 | Abbott Laboratories | 3-descladinose-2,3-anhydroerythromycin derivatives |
| FR2748746B1 (fr) * | 1996-05-14 | 1998-08-14 | Hoechst Marion Roussel Inc | Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine |
| US6271255B1 (en) | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
| FR2751656B1 (fr) * | 1996-07-24 | 1998-10-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| KR100523679B1 (ko) | 1996-09-04 | 2005-10-26 | 아보트 러보러터리즈 | 항균 활성을 지닌 6-ｏ-치환된 케톨라이드 |
| US5804565A (en) | 1996-09-24 | 1998-09-08 | Taisho Pharmaceutical Co., Ltd. | Erythromycin A derivatives |
| HUP0000198A3 (en) | 1996-11-27 | 2000-09-28 | Taisho Pharmaceutical Co Ltd | Erythromycin a derivatives |
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| JP4043191B2 (ja) | 1998-11-03 | 2008-02-06 | ファイザー・プロダクツ・インク | 新規なマクロライド抗生物質 |
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| HUP0105190A3 (en) | 1999-01-27 | 2003-03-28 | Pfizer Prod Inc | Ketolide antibiotics, medicaments containing them and their use |
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| ATE340183T1 (de) * | 1999-04-16 | 2006-10-15 | Kosan Biosciences Inc | Antiinfektiöse makrolidderivate |
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2005
- 2005-12-12 PT PT05813939T patent/PT1836211E/pt unknown
- 2005-12-12 ES ES05813939T patent/ES2339871T3/es active Active
- 2005-12-12 JP JP2007547694A patent/JP4111994B1/ja not_active Expired - Fee Related
- 2005-12-12 WO PCT/IB2005/003829 patent/WO2006067589A1/en active Application Filing
- 2005-12-12 CA CA002591746A patent/CA2591746A1/en not_active Abandoned
- 2005-12-12 EP EP10154783A patent/EP2233493A1/de not_active Withdrawn
- 2005-12-12 DE DE602005019786T patent/DE602005019786D1/de active Active
- 2005-12-12 AP AP2007004026A patent/AP2007004026A0/xx unknown
- 2005-12-12 DK DK05813939.5T patent/DK1836211T3/da active
- 2005-12-12 UA UAA200706959A patent/UA85937C2/uk unknown
- 2005-12-12 AT AT05813939T patent/ATE459633T1/de not_active IP Right Cessation
- 2005-12-12 CN CNA2005800482465A patent/CN101120011A/zh active Pending
- 2005-12-12 AU AU2005317735A patent/AU2005317735B2/en not_active Ceased
- 2005-12-12 MX MX2007007598A patent/MX2007007598A/es active IP Right Grant
- 2005-12-12 GE GEAP200510142A patent/GEP20094834B/en unknown
- 2005-12-12 PL PL05813939T patent/PL1836211T3/pl unknown
- 2005-12-12 BR BRPI0519135-1A patent/BRPI0519135A2/pt not_active IP Right Cessation
- 2005-12-12 EP EP05813939A patent/EP1836211B1/de active Active
- 2005-12-12 EA EA200701113A patent/EA011281B1/ru not_active IP Right Cessation
- 2005-12-12 KR KR1020077014160A patent/KR100897678B1/ko not_active IP Right Cessation
- 2005-12-12 SI SI200530941T patent/SI1836211T1/sl unknown
- 2005-12-14 PE PE2005001462A patent/PE20060948A1/es not_active Application Discontinuation
- 2005-12-19 HN HN2005036113A patent/HN2005036113A/es unknown
- 2005-12-20 GT GT200500378A patent/GT200500378A/es unknown
- 2005-12-20 AR ARP050105370A patent/AR052824A1/es unknown
- 2005-12-20 TW TW094145385A patent/TW200626608A/zh unknown
- 2005-12-20 NL NL1030713A patent/NL1030713C2/nl not_active IP Right Cessation
- 2005-12-21 US US11/313,523 patent/US7462600B2/en not_active Expired - Fee Related
- 2005-12-21 UY UY29285A patent/UY29285A1/es not_active Application Discontinuation
-
2007
- 2007-06-04 IL IL183661A patent/IL183661A0/en unknown
- 2007-06-15 ZA ZA200705108A patent/ZA200705108B/xx unknown
- 2007-06-20 TN TNP2007000233A patent/TNSN07233A1/fr unknown
- 2007-06-21 CR CR9202A patent/CR9202A/es not_active Application Discontinuation
- 2007-06-21 MA MA30024A patent/MA29108B1/fr unknown
- 2007-06-29 NO NO20073367A patent/NO20073367L/no not_active Application Discontinuation
-
2010
- 2010-05-04 HR HR20100253T patent/HRP20100253T1/hr unknown
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