PE20060948A1 - Derivados de eritromicina a como agentes antibacterianos y antiprotozoarios - Google Patents
Derivados de eritromicina a como agentes antibacterianos y antiprotozoariosInfo
- Publication number
- PE20060948A1 PE20060948A1 PE2005001462A PE2005001462A PE20060948A1 PE 20060948 A1 PE20060948 A1 PE 20060948A1 PE 2005001462 A PE2005001462 A PE 2005001462A PE 2005001462 A PE2005001462 A PE 2005001462A PE 20060948 A1 PE20060948 A1 PE 20060948A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- radical
- erythromycin
- antibacterial
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Tires In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO MACROLIDO DE FORMULA I, DONDE 1 ESTA AUSENTE CH2 O C(CH3)H; EL RADICAL 2 ES C(O)(CH2)m, -S(O)2(CH2)m, ENTRE OTROS; EL RADICAL 3 ES C(O), CH(OC(O)R14), ENTRE OTROS; EL RADICAL 4 ES O O NR10; EL RADICAL 4 ES O; EL RADICAL 5 ES C(O), C(O)NH, ENTRE OTROS; EL RADICAL 6 ES -(C(Rc)(Rd))x; x ES UN ENTERO DE 0 A 5; EL RADICAL 7 ES -(C(Rc)(Re))y-; y ES UN ENTERO DE 0 A 5, CON LA CONDICION QUE LA SUMA DE x+y SEA DE 1 A 5; R1 ES H, OH, F O ALQUILO C1-C6; R3 ES ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R6 Y R7 SON H, ALQUILO C1-C12, ENTRE OTROS; R6 ES H, ALQUILO C1-C6, ENTRE OTROS; R9 ES H, ALQUILO C1-C6, ENTRE OTROS; R10 ES H O ALQUILO C1-C6; R13 Y R16 SON H, C(O)(ALQUILO C1-C6), ENTRE OTROS; R14 Y R15 SON H, ALQUILO C1-C10, ENTRE OTROS; R17 ES C(O)(ALQUILO C1-C6), ENTRE OTROS; R19 ES H, ALQUILO C1-C6, ENTRE OTROS; Ra Y Rb SON H, ALQUILO C1-C6, ENTRE OTROS; Rc ES H, F, Cl, ENTRE OTROS; Rd Y Re SON H; Ar ES HETEROCICLO DE 9 A 10 MIEMBROS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-DESCLADINOSIL-11,12-DIDESOXI-6-O-METIL-3-OXO-12,11-(OXICARBONIL-81-((QUINOLIN-5-IL)-METIL9-AZETIDIN-3-IL)-IMINO)-ERITROMICINA A, 3-DESCLADINOSIL-11,12-DIDESOXI-6-O-METIL-3-OXO-12,11-(OXICARBONIL-(1-((QUINOLIN-4-IL)-AZETIDIN-3-IL)-IMINO-ERITROMICINA A, ENTRE OTROS. DICHOS COMPUESTOS SON ANTIBACTERIANOS Y ANTIPROTOZOARIOS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63809704P | 2004-12-21 | 2004-12-21 | |
| US71753005P | 2005-09-14 | 2005-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060948A1 true PE20060948A1 (es) | 2006-10-11 |
Family
ID=35809765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001462A PE20060948A1 (es) | 2004-12-21 | 2005-12-14 | Derivados de eritromicina a como agentes antibacterianos y antiprotozoarios |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7462600B2 (es) |
| EP (2) | EP2233493A1 (es) |
| JP (1) | JP4111994B1 (es) |
| KR (1) | KR100897678B1 (es) |
| CN (1) | CN101120011A (es) |
| AP (1) | AP2007004026A0 (es) |
| AR (1) | AR052824A1 (es) |
| AT (1) | ATE459633T1 (es) |
| AU (1) | AU2005317735B2 (es) |
| BR (1) | BRPI0519135A2 (es) |
| CA (1) | CA2591746A1 (es) |
| CR (1) | CR9202A (es) |
| DE (1) | DE602005019786D1 (es) |
| DK (1) | DK1836211T3 (es) |
| EA (1) | EA011281B1 (es) |
| ES (1) | ES2339871T3 (es) |
| GE (1) | GEP20094834B (es) |
| GT (1) | GT200500378A (es) |
| HN (1) | HN2005036113A (es) |
| HR (1) | HRP20100253T1 (es) |
| IL (1) | IL183661A0 (es) |
| MA (1) | MA29108B1 (es) |
| MX (1) | MX2007007598A (es) |
| NL (1) | NL1030713C2 (es) |
| NO (1) | NO20073367L (es) |
| PE (1) | PE20060948A1 (es) |
| PL (1) | PL1836211T3 (es) |
| PT (1) | PT1836211E (es) |
| SI (1) | SI1836211T1 (es) |
| TN (1) | TNSN07233A1 (es) |
| TW (1) | TW200626608A (es) |
| UA (1) | UA85937C2 (es) |
| UY (1) | UY29285A1 (es) |
| WO (1) | WO2006067589A1 (es) |
| ZA (1) | ZA200705108B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8367669B2 (en) * | 2005-06-15 | 2013-02-05 | Vanderbilt University | Inhibitors of hemeprotein-catalyzed lipid peroxidation |
| US9133212B1 (en) | 2005-06-15 | 2015-09-15 | Vanderbilt University | Inhibitors of hemeprotein-catalyzed lipid peroxidation |
| EP1928893A2 (en) | 2005-08-24 | 2008-06-11 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
| EP2125851B1 (en) * | 2007-03-13 | 2010-06-23 | Pfizer Products Inc. | Erythromycin-based macrolides |
| EP2136806A4 (en) * | 2007-03-21 | 2011-11-23 | Creative Antibiotics Sweden Ab | METHOD AND MEANS FOR PREVENTING AND SUPPRESSING TYPE III SECRETION IN INFECTIONS BY GRAM-NEGATIVE BACTERIA |
| WO2009055557A1 (en) | 2007-10-25 | 2009-04-30 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| EP2220104A1 (en) * | 2007-10-25 | 2010-08-25 | Sandoz AG | Process for the production of telithromycin |
| WO2009080534A1 (en) | 2007-12-21 | 2009-07-02 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| JP5662445B2 (ja) * | 2009-08-13 | 2015-01-28 | バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ | 新規マクロライド及びその使用 |
| SI2550286T1 (sl) * | 2010-03-22 | 2016-04-29 | Cempra Pharmaceuticals, Inc. | Kristalne oblike makrolida in njihove uporabe |
| CN106974913A (zh) | 2011-04-12 | 2017-07-25 | 美国卫生和人力服务部 | 用于治疗或预防疟疾的疟原虫表面阴离子通道抑制剂 |
| CN102558047B (zh) * | 2011-12-14 | 2013-10-30 | 天津药物研究院药业有限责任公司 | 3-甲基喹啉的制备方法 |
| RU2658050C2 (ru) | 2012-03-27 | 2018-06-19 | Семпра Фармасьютикалз, Инк. | Парентеральные составы для введения макролидных антибиотиков |
| MX2015000362A (es) | 2012-07-13 | 2015-04-14 | Hoffmann La Roche | Benzo(b)-azepin-2-onas antiproliferativas. |
| KR101612179B1 (ko) * | 2013-04-19 | 2016-04-12 | 영남대학교 산학협력단 | 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 암질환 예방 또는 치료용 약학조성물 |
| TW201534586A (zh) | 2013-06-11 | 2015-09-16 | Orion Corp | 新穎ｃｙｐ１７抑制劑／抗雄激素劑 |
| CN103739643A (zh) * | 2013-12-30 | 2014-04-23 | 华东理工大学 | 利用分子印迹技术对红霉素进行回收分离纯化的方法 |
| CN104230891B (zh) * | 2014-08-27 | 2016-03-30 | 于宗光 | 一种托匹司他的制备方法 |
| CN110234323A (zh) | 2016-10-04 | 2019-09-13 | Ti生物制药有限公司 | 具有抗菌活性的酮内酯 |
| WO2020247447A1 (en) * | 2019-06-04 | 2020-12-10 | Hager Biosciences, Llc | Pyrazole and imidazole derivatives, compositions and methods as orexin antagonists |
| CN111793022A (zh) * | 2020-04-27 | 2020-10-20 | 滁州拜奥生物科技有限公司 | 一种3-甲基喹啉的制备方法 |
| WO2024050061A2 (en) * | 2022-09-01 | 2024-03-07 | Hager Biosciences, Llc | Pyrazole and imidazole derivatives as dual orexin and kappa-opioid receptors modulators, composition, methods for treating neurological and psychiatric disorders |
Family Cites Families (74)
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-
2005
- 2005-12-12 BR BRPI0519135-1A patent/BRPI0519135A2/pt not_active IP Right Cessation
- 2005-12-12 EA EA200701113A patent/EA011281B1/ru not_active IP Right Cessation
- 2005-12-12 GE GEAP200510142A patent/GEP20094834B/en unknown
- 2005-12-12 PL PL05813939T patent/PL1836211T3/pl unknown
- 2005-12-12 AT AT05813939T patent/ATE459633T1/de not_active IP Right Cessation
- 2005-12-12 MX MX2007007598A patent/MX2007007598A/es active IP Right Grant
- 2005-12-12 PT PT05813939T patent/PT1836211E/pt unknown
- 2005-12-12 ES ES05813939T patent/ES2339871T3/es active Active
- 2005-12-12 AU AU2005317735A patent/AU2005317735B2/en not_active Ceased
- 2005-12-12 JP JP2007547694A patent/JP4111994B1/ja not_active Expired - Fee Related
- 2005-12-12 EP EP10154783A patent/EP2233493A1/en not_active Withdrawn
- 2005-12-12 SI SI200530941T patent/SI1836211T1/sl unknown
- 2005-12-12 WO PCT/IB2005/003829 patent/WO2006067589A1/en active Application Filing
- 2005-12-12 UA UAA200706959A patent/UA85937C2/uk unknown
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- 2005-12-12 CN CNA2005800482465A patent/CN101120011A/zh active Pending
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- 2005-12-14 PE PE2005001462A patent/PE20060948A1/es not_active Application Discontinuation
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