MX2007007598A - Macrolidos. - Google Patents

Macrolidos.

Info

Publication number
MX2007007598A
MX2007007598A MX2007007598A MX2007007598A MX2007007598A MX 2007007598 A MX2007007598 A MX 2007007598A MX 2007007598 A MX2007007598 A MX 2007007598A MX 2007007598 A MX2007007598 A MX 2007007598A MX 2007007598 A MX2007007598 A MX 2007007598A
Authority
MX
Mexico
Prior art keywords
compounds
methods
macrolides
excerptand
diseaseby
Prior art date
Application number
MX2007007598A
Other languages
English (en)
Inventor
Louis Stanley Chupak
Mark Edward Flanagan
Takushi Kaneko
Thomas Victor Magee
Mark Carl Noe
Usa Reilly
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35809765&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2007007598(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MX2007007598A publication Critical patent/MX2007007598A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Tires In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos macrolidos per se, como se muestran a continuacion y se definen en esta memoria, y su uso, p. ej., como agentes antibacterianos y antiprotozoarios en animales, incluyendo seres humanos: (ver formula) tambien se describen metodos para preparar los compuestos, productos intermedios y sus composiciones farmaceuticas, y metodos para tratar o prevenir la enfermedad por administracion de los compuestos a los sujetos que lo necesiten; este resumen es solo un extracto y no limita la invencion.
MX2007007598A 2004-12-21 2005-12-12 Macrolidos. MX2007007598A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63809704P 2004-12-21 2004-12-21
US71753005P 2005-09-14 2005-09-14
PCT/IB2005/003829 WO2006067589A1 (en) 2004-12-21 2005-12-12 Macrolides

Publications (1)

Publication Number Publication Date
MX2007007598A true MX2007007598A (es) 2007-07-25

Family

ID=35809765

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007007598A MX2007007598A (es) 2004-12-21 2005-12-12 Macrolidos.

Country Status (35)

Country Link
US (1) US7462600B2 (es)
EP (2) EP1836211B1 (es)
JP (1) JP4111994B1 (es)
KR (1) KR100897678B1 (es)
CN (1) CN101120011A (es)
AP (1) AP2007004026A0 (es)
AR (1) AR052824A1 (es)
AT (1) ATE459633T1 (es)
AU (1) AU2005317735B2 (es)
BR (1) BRPI0519135A2 (es)
CA (1) CA2591746A1 (es)
CR (1) CR9202A (es)
DE (1) DE602005019786D1 (es)
DK (1) DK1836211T3 (es)
EA (1) EA011281B1 (es)
ES (1) ES2339871T3 (es)
GE (1) GEP20094834B (es)
GT (1) GT200500378A (es)
HN (1) HN2005036113A (es)
HR (1) HRP20100253T1 (es)
IL (1) IL183661A0 (es)
MA (1) MA29108B1 (es)
MX (1) MX2007007598A (es)
NL (1) NL1030713C2 (es)
NO (1) NO20073367L (es)
PE (1) PE20060948A1 (es)
PL (1) PL1836211T3 (es)
PT (1) PT1836211E (es)
SI (1) SI1836211T1 (es)
TN (1) TNSN07233A1 (es)
TW (1) TW200626608A (es)
UA (1) UA85937C2 (es)
UY (1) UY29285A1 (es)
WO (1) WO2006067589A1 (es)
ZA (1) ZA200705108B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8367669B2 (en) * 2005-06-15 2013-02-05 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
US9133212B1 (en) 2005-06-15 2015-09-15 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
JP5395432B2 (ja) 2005-08-24 2014-01-22 リブ−エックス ファーマシューティカルズ，インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
DE602008001611D1 (en) * 2007-03-13 2010-08-05 Pfizer Prod Inc Makrolide auf erythromycinbasis
WO2008115118A1 (en) * 2007-03-21 2008-09-25 Innate Pharmaceuticals Ab Method and means for preventing and inhibiting type iii secretion in infections caused by gram-negative bacteria
EP2220104A1 (en) * 2007-10-25 2010-08-25 Sandoz AG Process for the production of telithromycin
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
RU2495878C2 (ru) 2007-12-21 2013-10-20 Ф.Хоффманн-Ля Рош Аг Гетероциклические антивирусные соединения
EP2464651B1 (en) 2009-08-13 2016-04-20 Basilea Pharmaceutica AG New macrolides and their use
CA2793884C (en) * 2010-03-22 2019-09-10 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
WO2012142125A2 (en) 2011-04-12 2012-10-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria
CN102558047B (zh) * 2011-12-14 2013-10-30 天津药物研究院药业有限责任公司 3-甲基喹啉的制备方法
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
RU2015103119A (ru) 2012-07-13 2016-08-27 Ф. Хоффманн-Ля Рош Аг Антипролиферативные бензо[в]азепин-2-оны
KR101612179B1 (ko) * 2013-04-19 2016-04-12 영남대학교 산학협력단 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 암질환 예방 또는 치료용 약학조성물
TW201534586A (zh) 2013-06-11 2015-09-16 Orion Corp 新穎ｃｙｐ１７抑制劑／抗雄激素劑
CN103739643A (zh) * 2013-12-30 2014-04-23 华东理工大学 利用分子印迹技术对红霉素进行回收分离纯化的方法
CN104230891B (zh) * 2014-08-27 2016-03-30 于宗光 一种托匹司他的制备方法
CN110234323A (zh) 2016-10-04 2019-09-13 Ti生物制药有限公司 具有抗菌活性的酮内酯
EP3972587A4 (en) * 2019-06-04 2023-01-18 Hager Biosciences, LLC PYRAZOLE AND IMIDAZOLE DERIVATIVES, COMPOSITIONS AND METHODS AS OREXIN ANTAGONISTS
CN111793022A (zh) * 2020-04-27 2020-10-20 滁州拜奥生物科技有限公司 一种3-甲基喹啉的制备方法
WO2024050061A2 (en) * 2022-09-01 2024-03-07 Hager Biosciences, Llc Pyrazole and imidazole derivatives as dual orexin and kappa-opioid receptors modulators, composition, methods for treating neurological and psychiatric disorders

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653899A (en) 1952-04-14 1953-09-29 Lilly Co Eli Erythromycin, its salts, and method of preparation
US2823203A (en) 1954-06-24 1958-02-11 Abbott Lab Method of producing substantially pure erythromycin a
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4742049A (en) 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
US5075289A (en) 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
IE70593B1 (en) 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
US5523399A (en) 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
FR2697524B1 (fr) 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
FR2727969B1 (fr) 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5747466A (en) 1995-11-08 1998-05-05 Abbott Laboratories 3-deoxy-3-descladinose derivatives of erythromycins A and B
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
EP0918783A1 (en) 1996-05-07 1999-06-02 Abbott Laboratories 6-o-substituted erythromycins and method for making them
US5750510A (en) 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (fr) 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
FR2751656B1 (fr) 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
ATE296832T1 (de) 1996-09-04 2005-06-15 Abbott Lab 6-o-substituierte ketoliden mit antibakteriellen wirkung
US5804565A (en) 1996-09-24 1998-09-08 Taisho Pharmaceutical Co., Ltd. Erythromycin A derivatives
US6191118B1 (en) 1996-11-27 2001-02-20 Taisho Pharmaceutical Co., Ltd. Erythromycin A derivatives
US6140479A (en) 1997-03-24 2000-10-31 Taisho Pharmaceuticals Co., Ltd. Erythromycin a derivatives
AU6932098A (en) 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
US20020025937A1 (en) 2000-03-20 2002-02-28 Yong-Jin Wu 9-oxime erythromycin derivatives
EP0895999A1 (en) 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
ZA987689B (en) 1997-09-02 1999-02-24 Abbott Lab 3-descladinose 6-O substituted erythromycin derivatives
US6034069A (en) 1997-09-30 2000-03-07 Abbott Laboratories 3-'N-modified 6-O-substituted erythromycin ketolide derivatives having antibacterial activity
AU9649598A (en) 1997-10-29 1999-05-17 Taisho Pharmaceutical Co., Ltd. Erythromycin a, 11,12-carbamate derivatives
HN1998000159A (es) 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
PA8461401A1 (es) 1997-10-29 2000-05-24 Pfizer Prod Inc Derivados de eritromicina triciclicos
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AP9801420A0 (en) 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
ES2226282T3 (es) 1998-03-03 2005-03-16 Pfizer Products Inc. Antibioticos macrilidos de 3,6-cetal.
US5955440A (en) 1998-03-27 1999-09-21 Abbott Laboratories Macrolide LHRH antagonists
AU3439899A (en) 1998-06-03 1999-12-20 Pfizer Products Inc. Tricyclic 3-keto derivatives of 6-o-methylerythromycin
JP4573925B2 (ja) 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
US6020521A (en) 1998-08-26 2000-02-01 Abbott Laboratories Macrolide LHRH antagonists
US6387885B1 (en) 1998-08-26 2002-05-14 Abbott Laboratories 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists
US6262030B1 (en) 1998-11-03 2001-07-17 Pfizer Inc. Erythromycin derivatives
SK5812001A3 (en) 1998-11-03 2001-12-03 Pfizer Prod Inc Novel macrolide antibiotics
TR200102129T2 (tr) 1998-12-10 2002-01-21 Pfizer Products Inc. Karbamat ve karbazat ketolid antibiyotikleri.
CZ20012675A3 (cs) 1999-01-27 2002-04-17 Pfizer Products Inc. Ketolidová antibiotika
US6054435A (en) 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
MXPA01010521A (es) 1999-04-16 2003-08-19 Johnson & Johnson Antibacteriales de cetolidos.
US6395710B1 (en) 1999-04-16 2002-05-28 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US20020077302A1 (en) 1999-04-23 2002-06-20 Yong-Jin Wu Tricyclic erythromycin derivatives
US20020061857A1 (en) 1999-04-23 2002-05-23 Yong-Jin Wu 9-amino-3-oxo erythromycin derivatives
US6355620B1 (en) 1999-05-14 2002-03-12 Abbott Laboratories C-2 modified erythromycin derivatives
WO2000071557A1 (en) 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
JP2001072669A (ja) 1999-09-07 2001-03-21 Showa Kako Kk ７−クロロ−２，４（１ｈ，３ｈ）−キナゾリンジオンの製造方法
US6569836B2 (en) 1999-12-02 2003-05-27 Abbott Laboratories 6-O-alkyl-2-nor-2-substituted ketolide derivatives
EP1114826A3 (en) 1999-12-29 2001-10-31 Pfizer Products Inc. Novel antibacterial and prokinetic macrolides
EP1122261A3 (en) 2000-01-31 2001-09-26 Pfizer Products Inc. 13 and 14-membered antibacterial macrolides
JP2001261694A (ja) 2000-03-06 2001-09-26 Pfizer Prod Inc ケトライド抗生物質
EP1146051A3 (en) 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
US20020061856A1 (en) 2000-04-24 2002-05-23 Yong-Jin Wu Novel tricyclic erythromycin derivatives
ATE271062T1 (de) 2000-06-30 2004-07-15 Pfizer Prod Inc Makrolid-antibiotika
US20020115621A1 (en) 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
HUP0302526A2 (hu) 2000-12-21 2003-11-28 Glaxo Group Limited Makrolid vegyületek, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
US20020132782A1 (en) 2001-01-18 2002-09-19 Zhenkun Ma 9-amino erythromycin derivatives with antibacterial activity
WO2003004509A2 (en) 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US7064110B2 (en) 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
WO2005070918A1 (en) 2002-05-13 2005-08-04 Enanta Pharmaceuticals, Inc. Process for the preparation of t-11 bicyclic erythromycin derivatives
WO2004094407A1 (ja) 2003-04-21 2004-11-04 Daiichi Pharmaceutical Co. Ltd. ５員複素環誘導体
EP1794171A2 (en) 2004-07-28 2007-06-13 Ranbaxy Laboratories, Ltd. Ketolide derivatives as antibacterial agents
WO2006046112A2 (en) 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
GB0424951D0 (en) 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
US7419962B2 (en) 2004-12-07 2008-09-02 Enanta Pharmaceuticals, Inc. 3,6-bicyclolides
WO2006065743A2 (en) 2004-12-13 2006-06-22 Enanta Pharmaceuticals, Inc. Tetracylic bicyclolides
WO2006065721A2 (en) 2004-12-13 2006-06-22 Enanta Pharmaceuticals, Inc. 11, 12-lactone bicyclolides

Also Published As

Publication number Publication date
BRPI0519135A2 (pt) 2008-12-23
AR052824A1 (es) 2007-04-04
DE602005019786D1 (de) 2010-04-15
CN101120011A (zh) 2008-02-06
CA2591746A1 (en) 2006-06-29
HRP20100253T1 (hr) 2010-06-30
ATE459633T1 (de) 2010-03-15
PL1836211T3 (pl) 2010-07-30
TW200626608A (en) 2006-08-01
EA200701113A1 (ru) 2007-12-28
PE20060948A1 (es) 2006-10-11
JP4111994B1 (ja) 2008-07-02
UY29285A1 (es) 2006-07-31
AU2005317735B2 (en) 2009-06-04
TNSN07233A1 (fr) 2008-11-21
NL1030713A1 (nl) 2006-06-22
PT1836211E (pt) 2010-04-08
DK1836211T3 (da) 2010-05-17
US7462600B2 (en) 2008-12-09
JP2008524319A (ja) 2008-07-10
KR20070089191A (ko) 2007-08-30
US20060135447A1 (en) 2006-06-22
EA011281B1 (ru) 2009-02-27
EP1836211A1 (en) 2007-09-26
EP2233493A1 (en) 2010-09-29
ES2339871T3 (es) 2010-05-26
AU2005317735A1 (en) 2006-06-29
CR9202A (es) 2007-07-16
NO20073367L (no) 2007-09-05
KR100897678B1 (ko) 2009-05-14
HN2005036113A (es) 2010-12-06
NL1030713C2 (nl) 2006-12-12
GEP20094834B (en) 2009-11-25
SI1836211T1 (sl) 2010-04-30
UA85937C2 (uk) 2009-03-10
AP2007004026A0 (en) 2007-06-30
IL183661A0 (en) 2007-09-20
MA29108B1 (fr) 2007-12-03
ZA200705108B (en) 2009-01-28
EP1836211B1 (en) 2010-03-03
GT200500378A (es) 2006-11-28
WO2006067589A1 (en) 2006-06-29

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