ATE509018T1 - Als antimikrobielle mittel geeignete bisindolpyrrole - Google Patents

Als antimikrobielle mittel geeignete bisindolpyrrole

Info

Publication number
ATE509018T1
ATE509018T1 AT05726272T AT05726272T ATE509018T1 AT E509018 T1 ATE509018 T1 AT E509018T1 AT 05726272 T AT05726272 T AT 05726272T AT 05726272 T AT05726272 T AT 05726272T AT E509018 T1 ATE509018 T1 AT E509018T1
Authority
AT
Austria
Prior art keywords
disclosed
compounds
bisindolpyrroles
antimicrobial agent
bis
Prior art date
Application number
AT05726272T
Other languages
English (en)
Inventor
Scott S Mitchell
Kin S Lam
Barbara C Potts
Ginger Tsueng
Jennifer Grodberg
Donald J White
Katherine Anne Reed
Original Assignee
Nereus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nereus Pharmaceuticals Inc filed Critical Nereus Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE509018T1 publication Critical patent/ATE509018T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
AT05726272T 2004-01-23 2005-01-21 Als antimikrobielle mittel geeignete bisindolpyrrole ATE509018T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53905304P 2004-01-23 2004-01-23
US62723504P 2004-11-12 2004-11-12
PCT/US2005/002039 WO2005070922A2 (en) 2004-01-23 2005-01-21 Bis-indole pyrroles useful as antimicrobials agents

Publications (1)

Publication Number Publication Date
ATE509018T1 true ATE509018T1 (de) 2011-05-15

Family

ID=34811361

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05726272T ATE509018T1 (de) 2004-01-23 2005-01-21 Als antimikrobielle mittel geeignete bisindolpyrrole

Country Status (9)

Country Link
US (2) US7166634B2 (de)
EP (1) EP1711486B1 (de)
JP (1) JP2007519727A (de)
KR (1) KR20060132698A (de)
AT (1) ATE509018T1 (de)
AU (1) AU2005206560A1 (de)
BR (1) BRPI0506535A (de)
CA (1) CA2552350A1 (de)
WO (1) WO2005070922A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0506535A (pt) 2004-01-23 2007-02-27 Nereus Pharmaceuticals Inc pirroles bis-indole úteis como agentes anti-microbiais
US8956669B2 (en) * 2009-02-19 2015-02-17 The Uab Research Foundation Anticancer and antimicrobial compounds from antarctic extremophilic microorgansims
US20110008469A1 (en) * 2009-07-09 2011-01-13 Florida Gulf Coast University Antimicrobial composition and methods and apparatus for use thereof
WO2013040528A1 (en) * 2011-09-16 2013-03-21 Microbiotix, Inc. Antimicrobial compounds
WO2013040527A1 (en) * 2011-09-16 2013-03-21 Microbiotix, Inc. Antimicrobial compounds
WO2013040526A1 (en) * 2011-09-16 2013-03-21 Microbiotix, Inc. Antimicrobial compounds
WO2014078294A1 (en) * 2012-11-13 2014-05-22 Memorial Sloan-Kettering Cancer Center Indole compounds and their use as antimicrobials
EP3301096A1 (de) * 2016-09-30 2018-04-04 Heinrich-Heine-Universität Düsseldorf Bis-indole abkömmlinge zur behandlung bakterieller infektionen

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* Cited by examiner, † Cited by third party
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US4970226A (en) * 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
US5276182A (en) 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
DE4039602A1 (de) 1990-12-12 1992-06-17 Bauer Kurt Heinz Prof Dr Pharmazeutische formulierungen
KR100221695B1 (ko) 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
US5653962A (en) 1991-12-12 1997-08-05 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicaments
ES2224200T3 (es) 1992-11-27 2005-03-01 Mayne Pharma (Usa) Inc. Composicion inyectable estable de paclitaxel.
JPH06247964A (ja) * 1993-02-22 1994-09-06 Snow Brand Milk Prod Co Ltd 新規生理活性物質ｈｓ−１及びその製造方法
US5654286A (en) 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
ATE303143T1 (de) 1993-10-01 2005-09-15 Roche Palo Alto Llc Hochdosierte oral anzuwendende suspensionen enthaltendmycophenolat mofetil
US5707641A (en) 1994-10-13 1998-01-13 Pharmaderm Research & Development Ltd. Formulations comprising therapeutically-active proteins or polypeptides
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US5653987A (en) 1995-05-16 1997-08-05 Modi; Pankaj Liquid formulations for proteinic pharmaceuticals
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US5667809A (en) 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
US5874443A (en) 1995-10-19 1999-02-23 Trega Biosciences, Inc. Isoquinoline derivatives and isoquinoline combinatorial libraries
US5886210A (en) 1996-08-22 1999-03-23 Rohm And Haas Company Method for preparing aromatic compounds
US5922683A (en) 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
IL136044A (en) 1997-11-21 2005-08-31 Euro Celtique Sa 2-aminoacetamide derivatives and pharmaceutical compositions containing the same
AU2548699A (en) 1998-02-23 1999-09-06 Rei Asakai Cell death inhibitors
RU2217421C2 (ru) 1998-03-26 2003-11-27 Шионоги & Ко., Лтд. Производные индола, обладающие антивирусной активностью
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
FR2784988B1 (fr) 1998-10-23 2002-09-20 Adir Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2000034255A1 (en) 1998-12-04 2000-06-15 Ontogen Corporation Substituted thiazoles for treatment of human diseases involving modulators of p-, l- and e- selectin
US6589977B1 (en) 1999-02-09 2003-07-08 Sagami Chemical Research Center Pyrrole derivatives and cell death inhibitors
US6569830B1 (en) * 1999-03-05 2003-05-27 Ambi, Inc. Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
EP1341926A2 (de) 2000-11-14 2003-09-10 Phibro-Tech, Inc., doing business as Agtrol International Neue nukleinsäuren, verfahren und transformierte zellen zur modulation der gibberellinproduktion
CN1525968A (zh) 2001-01-18 2004-09-01 三共株式会社 预防或治疗肝病的组合物
DE10109280A1 (de) * 2001-02-26 2002-09-05 Peter Mayser Indolderivate mit inhibitorischer Wirkung auf Proteinkinasen
BRPI0506535A (pt) 2004-01-23 2007-02-27 Nereus Pharmaceuticals Inc pirroles bis-indole úteis como agentes anti-microbiais

Also Published As

Publication number Publication date
AU2005206560A1 (en) 2005-08-04
US20070149601A1 (en) 2007-06-28
JP2007519727A (ja) 2007-07-19
KR20060132698A (ko) 2006-12-21
US7375129B2 (en) 2008-05-20
WO2005070922A3 (en) 2005-09-09
US7166634B2 (en) 2007-01-23
CA2552350A1 (en) 2005-08-04
WO2005070922A2 (en) 2005-08-04
BRPI0506535A (pt) 2007-02-27
EP1711486B1 (de) 2011-05-11
US20050267192A1 (en) 2005-12-01
EP1711486A2 (de) 2006-10-18

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties