EA200600280A1 - Композиции на основе производных липопептидных антибиотиков и способы их применения - Google Patents

Композиции на основе производных липопептидных антибиотиков и способы их применения

Info

Publication number
EA200600280A1
EA200600280A1 EA200600280A EA200600280A EA200600280A1 EA 200600280 A1 EA200600280 A1 EA 200600280A1 EA 200600280 A EA200600280 A EA 200600280A EA 200600280 A EA200600280 A EA 200600280A EA 200600280 A1 EA200600280 A1 EA 200600280A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
derivatives
lipopeptid
antibiotics
application
Prior art date
Application number
EA200600280A
Other languages
English (en)
Other versions
EA010294B1 (ru
Inventor
Дэйл Р. Камерон
Винсент А. Бойд
Ричард А. Лиз
Вильям В. Курран
Дональд Б. Бордерс
Паоло В.М. Сгарби
Ширли А. Вакович-Сгарби
Мэтью Нодвелл
Юхен Чен
Кьюи Джиа
Доминик Дугорд
Original Assignee
Майджиникс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Майджиникс, Инк. filed Critical Майджиникс, Инк.
Publication of EA200600280A1 publication Critical patent/EA200600280A1/ru
Publication of EA010294B1 publication Critical patent/EA010294B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В настоящем изобретении предложены производные липопептидных антибиотиков, проявляющие противомикробную активность по отношению к микроорганизмам, способы синтеза и соединения для синтеза подобных противомикробных производных и их аналогов, способы применения соединений в различных контекстах, в том числе для лечения и профилактики микробных инфекций.
EA200600280A 2003-07-17 2004-06-28 Композиции на основе производных липопептидных антибиотиков и способы их применения EA010294B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48833103P 2003-07-17 2003-07-17
US56491204P 2004-04-23 2004-04-23
PCT/US2004/021039 WO2005000878A2 (en) 2003-06-26 2004-06-28 Compositions of lipopeptide antibiotic derivatives and methods of use thereof

Publications (2)

Publication Number Publication Date
EA200600280A1 true EA200600280A1 (ru) 2006-10-27
EA010294B1 EA010294B1 (ru) 2008-08-29

Family

ID=36203969

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600280A EA010294B1 (ru) 2003-07-17 2004-06-28 Композиции на основе производных липопептидных антибиотиков и способы их применения

Country Status (11)

Country Link
US (1) US7868135B2 (ru)
EP (2) EP1656390A2 (ru)
JP (1) JP2007536200A (ru)
CN (1) CN1839150A (ru)
AU (1) AU2004252174A1 (ru)
CA (1) CA2530063A1 (ru)
EA (1) EA010294B1 (ru)
IL (1) IL172647A0 (ru)
NZ (1) NZ544750A (ru)
WO (1) WO2005000878A2 (ru)
ZA (1) ZA200600008B (ru)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2641991A1 (en) * 2006-02-09 2007-08-16 Elevance Renewable Sciences, Inc. Antimicrobial compositions, methods and systems
WO2007092632A2 (en) * 2006-02-09 2007-08-16 Elevance Renawable Sciences, Inc. Surface coating compositions and methods
GB0821540D0 (en) 2008-11-25 2008-12-31 Merlion Pharmaceuticals Pte Ltd Lipopeptide compounds and their use
RU2532222C2 (ru) * 2009-02-16 2014-10-27 Серенис Терапьютикс Холдинг С.А, Миметики аполипопротеина а-i
DE102009060102A1 (de) * 2009-12-21 2011-06-22 Martin-Luther-Universität Halle-Wittenberg, 06108 Derivatisierungsreagenzien zur tandem-massenspektrometrischen Quantifizierung von Proteinen
JP2013522204A (ja) * 2010-03-09 2013-06-13 メルク・シャープ・エンド・ドーム・コーポレイション β−ラクタム系抗菌薬の活性を増強する橋かけ型リポ糖ペプチド関連出願の相互参照該当なし
ES2374779B1 (es) * 2010-03-10 2012-12-27 Universidad De Barcelona Compuestos péptidicos útiles como agentes antibacterianos.
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
US20140249073A1 (en) * 2011-05-27 2014-09-04 Rqx Pharmaceuticals, Inc Broad spectrum antibiotics
EP2703410B1 (en) * 2012-08-28 2015-10-14 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie Jagaricin, derivatives, and uses thereof
CN104903302B (zh) 2012-11-21 2019-03-29 阿奇克斯制药公司 大环广谱抗生素
WO2015179441A2 (en) 2014-05-20 2015-11-26 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
US9856292B2 (en) * 2014-11-14 2018-01-02 Bristol-Myers Squibb Company Immunomodulators
CN104557743A (zh) * 2014-12-02 2015-04-29 南京邮电大学 一类包含不饱和脂肪酸结构的抗白色念珠菌药物及其制备方法
EP4289950A3 (en) 2015-01-09 2024-01-24 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
CN104817619B (zh) * 2015-04-23 2018-07-17 浙江大学 抗菌化合物及其应用
CN105231000B (zh) * 2015-09-25 2020-01-07 广东海洋大学 一种利用水产品下脚料生产抗菌营养复合型饲料添加剂的方法
KR20180109858A (ko) 2015-11-20 2018-10-08 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
CA3058953A1 (en) * 2017-04-05 2018-10-11 Revolution Medicines, Inc. Compounds that participate in cooperative binding and uses thereof
CN109593808B (zh) * 2017-09-30 2022-10-04 上海医药工业研究院 达托霉素发酵培养基及其制备方法
JP7296636B2 (ja) * 2018-07-20 2023-06-23 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
JP6770553B2 (ja) * 2018-07-20 2020-10-14 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
US11872240B2 (en) * 2018-08-06 2024-01-16 Chander SHEKHAR Antimicrobial formulations comprising vancomycin or tobramycin
CN111434775B (zh) * 2019-01-11 2022-12-06 上海医药工业研究院 一种发酵制备达托霉素的方法
ES2961566T3 (es) 2019-05-28 2024-03-12 Hoffmann La Roche Antibióticos macrocíclicos de amplio espectro
RU2762182C1 (ru) * 2020-12-08 2021-12-16 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения
CN112625106B (zh) * 2021-01-13 2023-03-31 兰州大学 一种抗菌多肽化合物、合成方法及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB923544A (en) 1959-07-21 1963-04-10 Takeda Pharmaceutical A new antibiotic-glumamycin
US3057779A (en) 1960-03-14 1962-10-09 American Cyanamid Co Antibiotic and production thereof
US3639582A (en) 1967-04-14 1972-02-01 Zaidan Hojin Biseibutsu Antibiotic laspartomycin
DE1800363A1 (de) 1967-10-04 1969-07-03 Shionogi & Co Tsushimycin und seine Herstellung
FR2124060B1 (ru) 1971-02-02 1974-04-12 Rhone Poulenc Sa
IL61604A (en) 1977-07-22 1981-10-30 Baxter Travenol Lab Flexible collapsible containers
US4524135A (en) 1982-05-21 1985-06-18 Eli Lilly And Company A-21978C cyclic peptides
CA1315229C (en) 1987-06-10 1993-03-30 Patrick J. Baker Chromatographic purification process
US4994270A (en) 1988-04-11 1991-02-19 Eli Lilly And Company A54145 antibiotics and process for their production
US5028590A (en) 1988-04-11 1991-07-02 Eli Lilly And Company Derivatives of A54145 cyclic peptides
US5039789A (en) 1988-04-11 1991-08-13 Eli Lilly And Company A54145 cyclic peptides
US4977083A (en) 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
TW455591B (en) * 1993-06-08 2001-09-21 Hoechst Ag Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof
DE4411025A1 (de) * 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US6146872A (en) 1996-06-13 2000-11-14 Fukisawa Pharmaceutical Co., Ltd. Cyclic lipopeptide acylase
DE19807972A1 (de) 1998-02-25 1999-08-26 Hoechst Marion Roussel De Gmbh Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
WO2002005837A1 (en) * 2000-07-17 2002-01-24 Intrabiotics Pharmaceuticals, Inc. Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
US6716962B2 (en) 2000-07-17 2004-04-06 Micrologix Biotech Inc. Extractive purification of lipopeptide antibiotics
US6750199B2 (en) 2000-07-17 2004-06-15 Micrologix Biotech Inc. Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
AU2003202878B2 (en) 2002-01-03 2008-07-31 Migenix Inc. Dab9 derivatives of lipopeptide antibiotics and methods of making and using the same

Also Published As

Publication number Publication date
IL172647A0 (en) 2006-04-10
ZA200600008B (en) 2007-09-26
EP1656390A2 (en) 2006-05-17
WO2005000878A3 (en) 2005-06-16
US20050153876A1 (en) 2005-07-14
WO2005000878A2 (en) 2005-01-06
CN1839150A (zh) 2006-09-27
CA2530063A1 (en) 2005-01-06
WO2005000878A8 (en) 2006-06-08
NZ544750A (en) 2009-06-26
EA010294B1 (ru) 2008-08-29
JP2007536200A (ja) 2007-12-13
AU2004252174A1 (en) 2005-01-06
EP2147925A1 (en) 2010-01-27
US7868135B2 (en) 2011-01-11

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU