ECSP045397A - 6-ALQUILIDEN-PENEMS BICÍCLICOS COMO INHIBIDORES DE LAS b-LACTAMASAS - Google Patents

6-ALQUILIDEN-PENEMS BICÍCLICOS COMO INHIBIDORES DE LAS b-LACTAMASAS

Info

Publication number
ECSP045397A
ECSP045397A EC2004005397A ECSP045397A ECSP045397A EC SP045397 A ECSP045397 A EC SP045397A EC 2004005397 A EC2004005397 A EC 2004005397A EC SP045397 A ECSP045397 A EC SP045397A EC SP045397 A ECSP045397 A EC SP045397A
Authority
EC
Ecuador
Prior art keywords
alquiliden
penems
lactamases
bicyclic
inhibitors
Prior art date
Application number
EC2004005397A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ECSP045397A publication Critical patent/ECSP045397A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención provee un compuesto de la Fórmula (I), composiciones farmacéuticas y el uso de las mismas para el tratamiento de la infección bacterial o enfermedad en un paciente que necesita del mismo.
EC2004005397A 2002-05-01 2004-10-29 6-ALQUILIDEN-PENEMS BICÍCLICOS COMO INHIBIDORES DE LAS b-LACTAMASAS ECSP045397A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37705202P 2002-05-01 2002-05-01

Publications (1)

Publication Number Publication Date
ECSP045397A true ECSP045397A (es) 2005-01-03

Family

ID=29401437

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005397A ECSP045397A (es) 2002-05-01 2004-10-29 6-ALQUILIDEN-PENEMS BICÍCLICOS COMO INHIBIDORES DE LAS b-LACTAMASAS

Country Status (21)

Country Link
US (3) US7112582B2 (es)
EP (2) EP1988093A1 (es)
JP (2) JP4602759B2 (es)
KR (1) KR20050007368A (es)
CN (2) CN101570545A (es)
AR (1) AR039774A1 (es)
AU (1) AU2003231205A1 (es)
BR (1) BR0309757A (es)
CA (1) CA2483538A1 (es)
CR (3) CR7508A (es)
EC (1) ECSP045397A (es)
IL (1) IL164899A0 (es)
MX (1) MXPA04010663A (es)
NO (1) NO20044549L (es)
NZ (1) NZ536182A (es)
RU (1) RU2339640C2 (es)
SG (1) SG162614A1 (es)
TW (1) TW200307687A (es)
UA (1) UA79117C2 (es)
WO (1) WO2003093279A1 (es)
ZA (1) ZA200409686B (es)

Families Citing this family (18)

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AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
US7833998B2 (en) * 2003-08-25 2010-11-16 Revaax Pharmaceuticals, Llc Oral neurotherapeutic cephalosporin sulfoxide and sulfone-containing compositions
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
JP2009502932A (ja) * 2005-07-27 2009-01-29 ワイス 三環式６−アルキリデンペネムβ−ラクタマーゼ阻害剤およびβ−ラクタム抗生物質の組み合わせ：広範なスペクトルの抗生物質
EP1906954A1 (en) * 2005-07-27 2008-04-09 Wyeth Incoporated Bicyclic 6-alkylidene-penem b-lactamase inhibitors and -lactam antibiotic combination: a broad spectrum antibiotic
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
CN104119858A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
CN104119857A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
CA3015166C (en) 2016-02-23 2021-08-03 Pfizer Inc. 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
EP3448861B1 (en) * 2016-04-28 2021-04-21 F. Hoffmann-La Roche AG A process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one
KR102419244B1 (ko) 2016-08-15 2022-07-08 바이엘 크롭사이언스 악티엔게젤샤프트 해충 방제제로서의 축합 바이시클릭 헤테로사이클 유도체
CN114957258A (zh) * 2021-02-25 2022-08-30 华东理工大学 基于碳青霉烯结构的广谱丝氨酸β-内酰胺酶抑制剂的合成及其在耐药细菌抑制中的应用
BR112023023866A2 (pt) * 2021-05-21 2024-02-06 Chengdu Baiyu Pharmaceutical Co Ltd Derivado de piperazina e seu uso na medicina

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US2004A (en) * 1841-03-12 Improvement in the manner of constructing and propelling steam-vessels
US4206067A (en) * 1978-10-02 1980-06-03 Chevron Research Company Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base
DE3176517D1 (en) 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
EP0120613A1 (en) 1983-03-02 1984-10-03 Beecham Group Plc Penem derivatives and precursors
FI82471C (fi) 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
GB8402086D0 (en) 1984-01-26 1984-02-29 Beecham Group Plc Compounds
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GB9116236D0 (en) 1991-07-27 1991-09-11 Smithkline Beecham Plc Novel compounds
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AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
EP1906954A1 (en) * 2005-07-27 2008-04-09 Wyeth Incoporated Bicyclic 6-alkylidene-penem b-lactamase inhibitors and -lactam antibiotic combination: a broad spectrum antibiotic

Also Published As

Publication number Publication date
CR7508A (es) 2005-01-05
CR10983A (es) 2009-09-09
US20040077622A1 (en) 2004-04-22
US20060217361A1 (en) 2006-09-28
WO2003093279A1 (en) 2003-11-13
NO20044549L (no) 2005-01-25
SG162614A1 (en) 2010-07-29
JP2005533017A (ja) 2005-11-04
AR039774A1 (es) 2005-03-02
TW200307687A (en) 2003-12-16
KR20050007368A (ko) 2005-01-17
RU2004135082A (ru) 2006-01-20
EP1499621A1 (en) 2005-01-26
RU2339640C2 (ru) 2008-11-27
US7812014B2 (en) 2010-10-12
CR10986A (es) 2009-09-09
JP2010215652A (ja) 2010-09-30
BR0309757A (pt) 2005-03-08
IL164899A0 (en) 2005-12-18
EP1988093A1 (en) 2008-11-05
MXPA04010663A (es) 2005-04-20
AU2003231205A1 (en) 2003-11-17
JP4602759B2 (ja) 2010-12-22
CA2483538A1 (en) 2003-11-13
ZA200409686B (en) 2007-09-26
NZ536182A (en) 2006-10-27
CN101570545A (zh) 2009-11-04
CN1649883A (zh) 2005-08-03
US20080312203A1 (en) 2008-12-18
US7112582B2 (en) 2006-09-26
CN1649883B (zh) 2010-05-26
UA79117C2 (en) 2007-05-25

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