CR10986A - 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional) - Google Patents

6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)

Info

Publication number
CR10986A
CR10986A CR10986A CR10986A CR10986A CR 10986 A CR10986 A CR 10986A CR 10986 A CR10986 A CR 10986A CR 10986 A CR10986 A CR 10986A CR 10986 A CR10986 A CR 10986A
Authority
CR
Costa Rica
Prior art keywords
penems
alquiliden
divisional
bicycle
lactamases
Prior art date
Application number
CR10986A
Other languages
English (en)
Inventor
Mudumbai Vekatesan Aranapakam
Abe Takao
Mansour Suhayl Tarek
Yamamura Itsuki
Takasaki Tsuyoshi
Santos Dos Osvaldo
Sum Fuk-Wah
Lin Yang-I
Atul Agarwal
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR10986A publication Critical patent/CR10986A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se refiere a ciertos 6-alquilidem-penems triciclicos que actuan como inhibidores de B-lactamasa de espectro amplio. Las B-Lactamasas hidrolizan los antibioticos de B-lactamasa y como tales sirven como la causa principal de la resistencia bacteriana. Los compuestos de la invencion, cuando combinan con antibioticos de B-lactama, proporcionaran un tratamiento efectivo contra infecciones bacterianas que atentan contra la vida.
CR10986A 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional) CR10986A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37705202P 2002-05-01 2002-05-01

Publications (1)

Publication Number Publication Date
CR10986A true CR10986A (es) 2009-09-09

Family

ID=29401437

Family Applications (3)

Application Number Title Priority Date Filing Date
CR7508A CR7508A (es) 2002-05-01 2004-10-06 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas
CR10983A CR10983A (es) 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)
CR10986A CR10986A (es) 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CR7508A CR7508A (es) 2002-05-01 2004-10-06 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas
CR10983A CR10983A (es) 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)

Country Status (21)

Country Link
US (3) US7112582B2 (es)
EP (2) EP1988093A1 (es)
JP (2) JP4602759B2 (es)
KR (1) KR20050007368A (es)
CN (2) CN1649883B (es)
AR (1) AR039774A1 (es)
AU (1) AU2003231205A1 (es)
BR (1) BR0309757A (es)
CA (1) CA2483538A1 (es)
CR (3) CR7508A (es)
EC (1) ECSP045397A (es)
IL (1) IL164899A0 (es)
MX (1) MXPA04010663A (es)
NO (1) NO20044549L (es)
NZ (1) NZ536182A (es)
RU (1) RU2339640C2 (es)
SG (1) SG162614A1 (es)
TW (1) TW200307687A (es)
UA (1) UA79117C2 (es)
WO (1) WO2003093279A1 (es)
ZA (1) ZA200409686B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AU2004268593B2 (en) * 2003-08-25 2012-02-02 Revaax Pharmaceuticals, Llc Oral neurotherapeutic cefazolin compositions
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
WO2007027323A2 (en) * 2005-07-27 2007-03-08 Wyeth TRICYCLIC 6-ALKYLIDENE-PENEM β-LACTAMASE INHIBITORS AND β-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC
KR20080032637A (ko) * 2005-07-27 2008-04-15 와이어쓰 이환식 6-알킬리덴-페넴 β-락타마제 저해제 및 β-락탐항생제 조합: 광범위 항생제
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
CN104119857A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
CN104119858A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
KR102148587B1 (ko) 2016-02-23 2020-08-26 화이자 인코포레이티드 6,7-디히드로-5H-피라졸로[5,1-b][1,3]옥사진-2-카르복스아미드 화합물
CN108473510B (zh) * 2016-04-28 2021-10-29 豪夫迈·罗氏有限公司 制备2-吡唑并[1,5-a]吡嗪-2-基吡啶并[1,2-a]嘧啶-4-酮的方法
US10660334B2 (en) 2016-08-15 2020-05-26 Bayer Cropscience Aktiengesellschaft Fused bicyclic heterocycle derivatives as pesticides

Family Cites Families (37)

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US2004A (en) * 1841-03-12 Improvement in the manner of constructing and propelling steam-vessels
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EP0041768B1 (en) 1980-04-24 1987-11-11 Beecham Group Plc Beta-lactam compounds, their preparation and use
EP0120613A1 (en) 1983-03-02 1984-10-03 Beecham Group Plc Penem derivatives and precursors
FI82471C (fi) 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
GB8402086D0 (en) 1984-01-26 1984-02-29 Beecham Group Plc Compounds
DE3584015D1 (de) 1984-01-30 1991-10-17 Pfizer 6-(substituierte) methylen-penicillansaeure und 6-(substituierte) hydroxymethyl-penicillansaeure und deren derivate.
EP0167050A1 (en) * 1984-06-21 1986-01-08 Beecham Group Plc Clavulanate compounds, their preparation and use and intermediates thereof
GB8518421D0 (en) 1985-07-22 1985-08-29 Beecham Group Plc Compounds
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EP0232966B1 (en) 1986-01-17 1997-10-08 Beecham Group Plc Process for the preparation of penem compounds and intermediates for this preparation
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
GB8724566D0 (en) 1987-10-20 1987-11-25 Roussel Lab Ltd Chemical compounds
GB8729614D0 (en) 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
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NZ237202A (en) 1990-02-23 1994-01-26 Bristol Myers Squibb Co Composition containing beta-lactam antibiotic and cationic oligopeptide
EP0447704A1 (en) 1990-03-21 1991-09-25 Smithkline Beecham Farmaceutici S.p.A. N-Acylated azacyclic compounds, processes for their preparations and their use as medications
GB9116236D0 (en) 1991-07-27 1991-09-11 Smithkline Beecham Plc Novel compounds
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AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
KR20080032637A (ko) * 2005-07-27 2008-04-15 와이어쓰 이환식 6-알킬리덴-페넴 β-락타마제 저해제 및 β-락탐항생제 조합: 광범위 항생제

Also Published As

Publication number Publication date
CN101570545A (zh) 2009-11-04
IL164899A0 (en) 2005-12-18
NZ536182A (en) 2006-10-27
US20040077622A1 (en) 2004-04-22
TW200307687A (en) 2003-12-16
EP1988093A1 (en) 2008-11-05
AR039774A1 (es) 2005-03-02
KR20050007368A (ko) 2005-01-17
ECSP045397A (es) 2005-01-03
RU2339640C2 (ru) 2008-11-27
US7812014B2 (en) 2010-10-12
EP1499621A1 (en) 2005-01-26
NO20044549L (no) 2005-01-25
US7112582B2 (en) 2006-09-26
BR0309757A (pt) 2005-03-08
UA79117C2 (en) 2007-05-25
JP2010215652A (ja) 2010-09-30
MXPA04010663A (es) 2005-04-20
CR7508A (es) 2005-01-05
CA2483538A1 (en) 2003-11-13
CN1649883A (zh) 2005-08-03
JP4602759B2 (ja) 2010-12-22
ZA200409686B (en) 2007-09-26
JP2005533017A (ja) 2005-11-04
RU2004135082A (ru) 2006-01-20
WO2003093279A1 (en) 2003-11-13
US20080312203A1 (en) 2008-12-18
SG162614A1 (en) 2010-07-29
US20060217361A1 (en) 2006-09-28
AU2003231205A1 (en) 2003-11-17
CN1649883B (zh) 2010-05-26
CR10983A (es) 2009-09-09

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)