HRP20020481B1 - Kondenzirani azepini kao agonisti vazopresina - Google Patents

Kondenzirani azepini kao agonisti vazopresina

Info

Publication number
HRP20020481B1
HRP20020481B1 HR20020481A HRP20020481A HRP20020481B1 HR P20020481 B1 HRP20020481 B1 HR P20020481B1 HR 20020481 A HR20020481 A HR 20020481A HR P20020481 A HRP20020481 A HR P20020481A HR P20020481 B1 HRP20020481 B1 HR P20020481B1
Authority
HR
Croatia
Prior art keywords
independently selected
lower alkyl
azepins
vasopresin
agonists
Prior art date
Application number
HR20020481A
Other languages
English (en)
Croatian (hr)
Inventor
Doreen Ashworth Mary
William Gary Pitt Robert
Hudson Peter
Christopher Yea Martyn
Richard Franklin Jeremy
Original Assignee
Vantia Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vantia Limited filed Critical Vantia Limited
Publication of HRP20020481A2 publication Critical patent/HRP20020481A2/hr
Publication of HRP20020481B1 publication Critical patent/HRP20020481B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20020481A 2000-01-05 2001-01-04 Kondenzirani azepini kao agonisti vazopresina HRP20020481B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0000079.4A GB0000079D0 (en) 2000-01-05 2000-01-05 Novel antidiuretic agents
PCT/GB2001/000023 WO2001049682A1 (en) 2000-01-05 2001-01-04 Condensed azepines as vasopressin agonists

Publications (2)

Publication Number Publication Date
HRP20020481A2 HRP20020481A2 (en) 2004-08-31
HRP20020481B1 true HRP20020481B1 (hr) 2009-03-31

Family

ID=9883168

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020481A HRP20020481B1 (hr) 2000-01-05 2001-01-04 Kondenzirani azepini kao agonisti vazopresina

Country Status (34)

Country Link
US (3) US7074781B2 (https=)
EP (1) EP1248784B1 (https=)
JP (2) JP3869723B2 (https=)
KR (1) KR100605466B1 (https=)
CN (1) CN1183129C (https=)
AR (1) AR035327A1 (https=)
AT (1) ATE366730T1 (https=)
AU (1) AU777538B2 (https=)
BR (1) BR0107414B1 (https=)
CA (1) CA2396277C (https=)
CY (1) CY1108034T1 (https=)
CZ (1) CZ303444B6 (https=)
DE (1) DE60129298T2 (https=)
DK (1) DK1248784T3 (https=)
EE (1) EE200200367A (https=)
ES (1) ES2288923T3 (https=)
GB (1) GB0000079D0 (https=)
HK (1) HK1046910B (https=)
HR (1) HRP20020481B1 (https=)
HU (1) HU229937B1 (https=)
IL (1) IL149528A0 (https=)
MX (1) MXPA02006546A (https=)
MY (1) MY140467A (https=)
NO (1) NO322571B1 (https=)
NZ (1) NZ518803A (https=)
PL (1) PL211341B1 (https=)
PT (1) PT1248784E (https=)
RU (1) RU2259367C2 (https=)
SI (1) SI1248784T1 (https=)
SK (1) SK287005B6 (https=)
UA (1) UA73152C2 (https=)
UY (1) UY26521A1 (https=)
WO (1) WO2001049682A1 (https=)
ZA (1) ZA200205180B (https=)

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US7138393B2 (en) 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
ATE329899T1 (de) * 2000-03-27 2006-07-15 Applied Research Systems Pharmazeutisch wirksame pyrrolidin-derivate als bax-inhibitoren
AU2001256209B2 (en) * 2000-03-27 2006-02-16 Merck Serono Sa Pharmaceutically active pyrrolidine derivatives
GB0015601D0 (en) * 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
GB0115515D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Oxytocin agonisys
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
EP1619185B1 (en) 2003-04-28 2011-06-15 Astellas Pharma Inc. 4,4-difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivative or salt thereof
DK1530967T3 (da) * 2003-11-13 2006-07-03 Ferring Bv Blisterpakning og dertil hörende fast dosisform
WO2006054560A1 (ja) * 2004-11-17 2006-05-26 Kissei Pharmaceutical Co., Ltd. 芳香族アミド誘導体、それを含有する医薬組成物およびそれらの医薬用途
WO2006104008A1 (ja) * 2005-03-25 2006-10-05 Kissei Pharmaceutical Co., Ltd. ウレア誘導体、それを含有する医薬組成物およびそれらの医薬用途
WO2007052517A1 (ja) * 2005-10-31 2007-05-10 Sumitomo Chemical Company, Limited ヒドロキシ－２－ピロリジンカルボキシアミド化合物の製法
TW200820976A (en) * 2006-09-25 2008-05-16 Kissei Pharmaceutical 1,4-benzodiazepine derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes
US9096546B2 (en) * 2007-05-10 2015-08-04 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
JP5451613B2 (ja) 2007-08-06 2014-03-26 アラーガン、インコーポレイテッド デスモプレシン薬物送達のための方法及びデバイス
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
NO3085381T3 (https=) * 2008-05-21 2018-09-15
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
GB201005623D0 (en) * 2010-04-01 2010-05-19 Vantia Ltd New polymorph
GB201105537D0 (en) * 2011-03-31 2011-05-18 Vantia Ltd New process
WO2020154581A1 (en) 2019-01-24 2020-07-30 Assia Chemical Industries Ltd Solid state forms of fedovapagon-salicyclic acid co-crystal

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EP0514667A1 (en) * 1991-04-19 1992-11-25 Otsuka Pharmaceutical Co., Ltd. Benzazepin derivatives as vasopressin antagonists
WO1994012476A1 (fr) * 1992-11-25 1994-06-09 Yamanouchi Pharmaceutical Co., Ltd. Derive de benzanilide
WO1994020473A1 (fr) * 1993-03-11 1994-09-15 Yamanouchi Pharmaceutical Co., Ltd. Compose avec action antagoniste de la vasopressine
US5753644A (en) * 1992-10-16 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Vasopressin antagonist and oxytocin antagonist
WO1999006403A1 (en) * 1997-07-30 1999-02-11 American Home Products Corporation Tricyclic vasopressin agonists
WO1999006409A1 (en) * 1997-07-30 1999-02-11 American Home Products Corporation Tricyclic vasopressin agonists

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GB2355454A (en) 1999-10-20 2001-04-25 Ferring Bv Antidiuretic agents
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0015601D0 (en) 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
DE10033337A1 (de) 2000-07-08 2002-01-17 Boehringer Ingelheim Pharma Biphenylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
GB0120051D0 (en) 2001-08-16 2001-10-10 Ferring Bv Oxytocin agonists
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
EP1449844A1 (en) 2003-02-14 2004-08-25 Ferring B.V. benzamide derivatives as oxytocin agonists and vasopressin antagonists
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514667A1 (en) * 1991-04-19 1992-11-25 Otsuka Pharmaceutical Co., Ltd. Benzazepin derivatives as vasopressin antagonists
US5753644A (en) * 1992-10-16 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Vasopressin antagonist and oxytocin antagonist
WO1994012476A1 (fr) * 1992-11-25 1994-06-09 Yamanouchi Pharmaceutical Co., Ltd. Derive de benzanilide
WO1994020473A1 (fr) * 1993-03-11 1994-09-15 Yamanouchi Pharmaceutical Co., Ltd. Compose avec action antagoniste de la vasopressine
WO1999006403A1 (en) * 1997-07-30 1999-02-11 American Home Products Corporation Tricyclic vasopressin agonists
WO1999006409A1 (en) * 1997-07-30 1999-02-11 American Home Products Corporation Tricyclic vasopressin agonists

Also Published As

Publication number Publication date
US20080261951A1 (en) 2008-10-23
EP1248784B1 (en) 2007-07-11
JP2006137767A (ja) 2006-06-01
HUP0203917A2 (hu) 2003-03-28
AR035327A1 (es) 2004-05-12
CN1183129C (zh) 2005-01-05
BR0107414A (pt) 2002-10-08
HU229937B1 (hu) 2015-01-28
AU2384601A (en) 2001-07-16
ES2288923T3 (es) 2008-02-01
AU777538B2 (en) 2004-10-21
CY1108034T1 (el) 2013-09-04
NZ518803A (en) 2003-03-28
SK9112002A3 (en) 2003-01-09
CZ303444B6 (cs) 2012-09-19
CN1392875A (zh) 2003-01-22
JP3869723B2 (ja) 2007-01-17
RU2259367C2 (ru) 2005-08-27
US20030087892A1 (en) 2003-05-08
CA2396277A1 (en) 2001-07-12
GB0000079D0 (en) 2000-02-23
UY26521A1 (es) 2001-03-16
HK1046910A1 (en) 2003-01-30
DK1248784T3 (da) 2007-10-29
PL355808A1 (en) 2004-05-17
PT1248784E (pt) 2007-10-02
EE200200367A (et) 2003-12-15
UA73152C2 (en) 2005-06-15
US20060154916A1 (en) 2006-07-13
SK287005B6 (sk) 2009-09-07
CA2396277C (en) 2012-03-20
ATE366730T1 (de) 2007-08-15
IL149528A0 (en) 2002-11-10
JP2003519228A (ja) 2003-06-17
MXPA02006546A (es) 2002-12-09
NO20023137L (no) 2002-06-27
HK1046910B (en) 2007-08-31
PL211341B1 (pl) 2012-05-31
CZ20022305A3 (cs) 2002-10-16
NO20023137D0 (no) 2002-06-27
NO322571B1 (no) 2006-10-30
JP3813629B2 (ja) 2006-08-23
EP1248784A1 (en) 2002-10-16
KR100605466B1 (ko) 2006-07-28
DE60129298T2 (de) 2008-01-03
MY140467A (en) 2009-12-31
US7560454B2 (en) 2009-07-14
KR20020063191A (ko) 2002-08-01
HUP0203917A3 (en) 2004-07-28
RU2002120798A (ru) 2004-01-10
DE60129298D1 (de) 2007-08-23
WO2001049682A1 (en) 2001-07-12
US7074781B2 (en) 2006-07-11
BR0107414B1 (pt) 2014-09-16
SI1248784T1 (sl) 2007-12-31
ZA200205180B (en) 2004-02-05
HRP20020481A2 (en) 2004-08-31

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