KR100605466B1 - 바소프레신 작용제로서의 축합 아제핀 - Google Patents

바소프레신 작용제로서의 축합 아제핀 Download PDF

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Publication number
KR100605466B1
KR100605466B1 KR1020027006382A KR20027006382A KR100605466B1 KR 100605466 B1 KR100605466 B1 KR 100605466B1 KR 1020027006382 A KR1020027006382 A KR 1020027006382A KR 20027006382 A KR20027006382 A KR 20027006382A KR 100605466 B1 KR100605466 B1 KR 100605466B1
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South Korea
Prior art keywords
pharmaceutically acceptable
methyl
acceptable salt
proline
ylcarbonyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020027006382A
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English (en)
Korean (ko)
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KR20020063191A (ko
Inventor
도린마리 애쉬워스
게리로버트윌리엄 피트
피터 허드슨
크리스토퍼마르틴 예이
리차드제레미 프랭클린
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훼링 비.브이.
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Publication of KR100605466B1 publication Critical patent/KR100605466B1/ko
Assigned to 밴티아 리미티드 reassignment 밴티아 리미티드 권리의 전부이전등록 Assignors: 훼링 비.브이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020027006382A 2000-01-05 2001-01-04 바소프레신 작용제로서의 축합 아제핀 Expired - Fee Related KR100605466B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0000079.4A GB0000079D0 (en) 2000-01-05 2000-01-05 Novel antidiuretic agents
GB0000079.4 2000-01-05

Publications (2)

Publication Number Publication Date
KR20020063191A KR20020063191A (ko) 2002-08-01
KR100605466B1 true KR100605466B1 (ko) 2006-07-28

Family

ID=9883168

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027006382A Expired - Fee Related KR100605466B1 (ko) 2000-01-05 2001-01-04 바소프레신 작용제로서의 축합 아제핀

Country Status (34)

Country Link
US (3) US7074781B2 (https=)
EP (1) EP1248784B1 (https=)
JP (2) JP3869723B2 (https=)
KR (1) KR100605466B1 (https=)
CN (1) CN1183129C (https=)
AR (1) AR035327A1 (https=)
AT (1) ATE366730T1 (https=)
AU (1) AU777538B2 (https=)
BR (1) BR0107414B1 (https=)
CA (1) CA2396277C (https=)
CY (1) CY1108034T1 (https=)
CZ (1) CZ303444B6 (https=)
DE (1) DE60129298T2 (https=)
DK (1) DK1248784T3 (https=)
EE (1) EE200200367A (https=)
ES (1) ES2288923T3 (https=)
GB (1) GB0000079D0 (https=)
HK (1) HK1046910B (https=)
HR (1) HRP20020481B1 (https=)
HU (1) HU229937B1 (https=)
IL (1) IL149528A0 (https=)
MX (1) MXPA02006546A (https=)
MY (1) MY140467A (https=)
NO (1) NO322571B1 (https=)
NZ (1) NZ518803A (https=)
PL (1) PL211341B1 (https=)
PT (1) PT1248784E (https=)
RU (1) RU2259367C2 (https=)
SI (1) SI1248784T1 (https=)
SK (1) SK287005B6 (https=)
UA (1) UA73152C2 (https=)
UY (1) UY26521A1 (https=)
WO (1) WO2001049682A1 (https=)
ZA (1) ZA200205180B (https=)

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US7138393B2 (en) 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
ATE329899T1 (de) * 2000-03-27 2006-07-15 Applied Research Systems Pharmazeutisch wirksame pyrrolidin-derivate als bax-inhibitoren
AU2001256209B2 (en) * 2000-03-27 2006-02-16 Merck Serono Sa Pharmaceutically active pyrrolidine derivatives
GB0015601D0 (en) * 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
GB0115515D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Oxytocin agonisys
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
EP1619185B1 (en) 2003-04-28 2011-06-15 Astellas Pharma Inc. 4,4-difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivative or salt thereof
DK1530967T3 (da) * 2003-11-13 2006-07-03 Ferring Bv Blisterpakning og dertil hörende fast dosisform
WO2006054560A1 (ja) * 2004-11-17 2006-05-26 Kissei Pharmaceutical Co., Ltd. 芳香族アミド誘導体、それを含有する医薬組成物およびそれらの医薬用途
WO2006104008A1 (ja) * 2005-03-25 2006-10-05 Kissei Pharmaceutical Co., Ltd. ウレア誘導体、それを含有する医薬組成物およびそれらの医薬用途
WO2007052517A1 (ja) * 2005-10-31 2007-05-10 Sumitomo Chemical Company, Limited ヒドロキシ－２－ピロリジンカルボキシアミド化合物の製法
TW200820976A (en) * 2006-09-25 2008-05-16 Kissei Pharmaceutical 1,4-benzodiazepine derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes
US9096546B2 (en) * 2007-05-10 2015-08-04 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
JP5451613B2 (ja) 2007-08-06 2014-03-26 アラーガン、インコーポレイテッド デスモプレシン薬物送達のための方法及びデバイス
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
NO3085381T3 (https=) * 2008-05-21 2018-09-15
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
GB201005623D0 (en) * 2010-04-01 2010-05-19 Vantia Ltd New polymorph
GB201105537D0 (en) * 2011-03-31 2011-05-18 Vantia Ltd New process
WO2020154581A1 (en) 2019-01-24 2020-07-30 Assia Chemical Industries Ltd Solid state forms of fedovapagon-salicyclic acid co-crystal

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GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
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US7341963B2 (en) * 2005-05-17 2008-03-11 Milliken & Company Non-woven material with barrier skin

Also Published As

Publication number Publication date
HRP20020481B1 (hr) 2009-03-31
US20080261951A1 (en) 2008-10-23
EP1248784B1 (en) 2007-07-11
JP2006137767A (ja) 2006-06-01
HUP0203917A2 (hu) 2003-03-28
AR035327A1 (es) 2004-05-12
CN1183129C (zh) 2005-01-05
BR0107414A (pt) 2002-10-08
HU229937B1 (hu) 2015-01-28
AU2384601A (en) 2001-07-16
ES2288923T3 (es) 2008-02-01
AU777538B2 (en) 2004-10-21
CY1108034T1 (el) 2013-09-04
NZ518803A (en) 2003-03-28
SK9112002A3 (en) 2003-01-09
CZ303444B6 (cs) 2012-09-19
CN1392875A (zh) 2003-01-22
JP3869723B2 (ja) 2007-01-17
RU2259367C2 (ru) 2005-08-27
US20030087892A1 (en) 2003-05-08
CA2396277A1 (en) 2001-07-12
GB0000079D0 (en) 2000-02-23
UY26521A1 (es) 2001-03-16
HK1046910A1 (en) 2003-01-30
DK1248784T3 (da) 2007-10-29
PL355808A1 (en) 2004-05-17
PT1248784E (pt) 2007-10-02
EE200200367A (et) 2003-12-15
UA73152C2 (en) 2005-06-15
US20060154916A1 (en) 2006-07-13
SK287005B6 (sk) 2009-09-07
CA2396277C (en) 2012-03-20
ATE366730T1 (de) 2007-08-15
IL149528A0 (en) 2002-11-10
JP2003519228A (ja) 2003-06-17
MXPA02006546A (es) 2002-12-09
NO20023137L (no) 2002-06-27
HK1046910B (en) 2007-08-31
PL211341B1 (pl) 2012-05-31
CZ20022305A3 (cs) 2002-10-16
NO20023137D0 (no) 2002-06-27
NO322571B1 (no) 2006-10-30
JP3813629B2 (ja) 2006-08-23
EP1248784A1 (en) 2002-10-16
DE60129298T2 (de) 2008-01-03
MY140467A (en) 2009-12-31
US7560454B2 (en) 2009-07-14
KR20020063191A (ko) 2002-08-01
HUP0203917A3 (en) 2004-07-28
RU2002120798A (ru) 2004-01-10
DE60129298D1 (de) 2007-08-23
WO2001049682A1 (en) 2001-07-12
US7074781B2 (en) 2006-07-11
BR0107414B1 (pt) 2014-09-16
SI1248784T1 (sl) 2007-12-31
ZA200205180B (en) 2004-02-05
HRP20020481A2 (en) 2004-08-31

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