HRP20010740B1 - Esters of l-carnitine or alkanoyl l-carnitines use ful as cationic lipids for the intracelular delivery of pharmacologically active compounds - Google Patents

Esters of l-carnitine or alkanoyl l-carnitines use ful as cationic lipids for the intracelular delivery of pharmacologically active compounds

Info

Publication number
HRP20010740B1
HRP20010740B1 HR20010740A HRP20010740A HRP20010740B1 HR P20010740 B1 HRP20010740 B1 HR P20010740B1 HR 20010740 A HR20010740 A HR 20010740A HR P20010740 A HRP20010740 A HR P20010740A HR P20010740 B1 HRP20010740 B1 HR P20010740B1
Authority
HR
Croatia
Prior art keywords
carnitines
carnitine
alkanoyl
esters
active compounds
Prior art date
Application number
HR20010740A
Other languages
English (en)
Inventor
Pisano Claudio
Ornella Tinti Maria
Santaniello Mose
Critelli Luciana
Salvatori Giovanni
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of HRP20010740A2 publication Critical patent/HRP20010740A2/hr
Publication of HRP20010740B1 publication Critical patent/HRP20010740B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HR20010740A 1999-04-13 2001-10-12 Esters of l-carnitine or alkanoyl l-carnitines use ful as cationic lipids for the intracelular delivery of pharmacologically active compounds HRP20010740B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999RM000220A IT1306129B1 (it) 1999-04-13 1999-04-13 Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
PCT/IT2000/000137 WO2000061543A2 (en) 1999-04-13 2000-04-11 Esters of l-carnitine or alkanoyl l-carnitines

Publications (2)

Publication Number Publication Date
HRP20010740A2 HRP20010740A2 (en) 2002-10-31
HRP20010740B1 true HRP20010740B1 (en) 2005-08-31

Family

ID=11406659

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010740A HRP20010740B1 (en) 1999-04-13 2001-10-12 Esters of l-carnitine or alkanoyl l-carnitines use ful as cationic lipids for the intracelular delivery of pharmacologically active compounds

Country Status (34)

Country Link
US (4) US6797281B1 (cs)
EP (3) EP1435232A1 (cs)
JP (2) JP4703855B2 (cs)
KR (2) KR100684378B1 (cs)
CN (2) CN1263730C (cs)
AT (2) ATE286873T1 (cs)
AU (2) AU776301B2 (cs)
BG (3) BG65501B1 (cs)
BR (2) BRPI0017460B1 (cs)
CA (2) CA2650202C (cs)
CZ (1) CZ302628B6 (cs)
DE (2) DE60017388T2 (cs)
DK (2) DK1426044T3 (cs)
EA (2) EA004459B1 (cs)
EE (2) EE05514B1 (cs)
ES (2) ES2258688T3 (cs)
HK (2) HK1045145B (cs)
HR (1) HRP20010740B1 (cs)
HU (1) HU229366B1 (cs)
IL (4) IL145765A0 (cs)
IS (2) IS2476B (cs)
IT (1) IT1306129B1 (cs)
ME (2) ME00113B (cs)
MX (1) MXPA01010359A (cs)
NO (2) NO327742B1 (cs)
NZ (2) NZ515270A (cs)
PL (2) PL204418B1 (cs)
PT (2) PT1183228E (cs)
RS (3) RS52682B (cs)
SI (2) SI1426044T1 (cs)
SK (2) SK288246B6 (cs)
TR (2) TR200202358T2 (cs)
WO (1) WO2000061543A2 (cs)
ZA (1) ZA200109291B (cs)

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US7151191B2 (en) * 2000-01-13 2006-12-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
DE10113446A1 (de) † 2001-03-19 2002-09-26 Schwarzkopf Gmbh Hans Haarbehandlungsmittel mit Betainen
ES2421714T3 (es) * 2002-06-26 2013-09-05 Medigene Ag Una preparación de liposomas catiónicos que comprende un taxano
AU2003280505B2 (en) 2002-06-26 2009-01-15 Syncore Biotechnology Co., Ltd Method of producing a cationic liposomal preparation comprising a lipophilic compound
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
WO2006094203A1 (en) * 2005-03-02 2006-09-08 Northeastern University Mitochondriotropic phospholipid vesicles
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
CA2617873A1 (en) * 2005-08-10 2007-02-15 Novartis Ag Formulations for 7-(t-butoxy)iminomethyl camptothecin
AU2006277879A1 (en) * 2005-08-10 2007-02-15 Novartis Ag Microparticle compositions of the topoisomerase I inhibitor 7-tert-butoxyiminomethylcamptothecin
WO2008024389A2 (en) * 2006-08-23 2008-02-28 Biodelivery Sciences International, Inc. Amphiphilic nucleotide cochleate compositions and methods of using the same
AU2008210511A1 (en) * 2007-02-01 2008-08-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Pharmaceutical composition comprising a campothecin derivative
US20100104625A1 (en) * 2007-02-16 2010-04-29 Cornell University Biodegradable compositions and materials
US20100204432A1 (en) * 2007-05-28 2010-08-12 Husam Younes Biodegradable elastomers prepared by the condensation of an organic di-, tri- or tetra-carboxylic acid and an organic diol
ES2601856T3 (es) 2007-06-08 2017-02-16 Mannkind Corporation Inhibidores de la IRE-1A
WO2009114763A2 (en) 2008-03-13 2009-09-17 Perkinelmer Las, Inc. Enzymatic substrates for multiple detection systems
EP2532649B1 (en) * 2011-06-07 2015-04-08 Incella GmbH Amino lipids, their synthesis and uses thereof
WO2013032643A2 (en) * 2011-08-31 2013-03-07 Dicerna Pharmaceuticals, Inc. Lipids capable of conformational change and their use in formulations to deliver therapeutic agents to cells
TW201525142A (zh) 2013-03-15 2015-07-01 Perkinelmer Health Sci Inc 關於用於溶酶體儲積症之測試的化合物及方法
KR20180114946A (ko) 2016-03-02 2018-10-19 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 면역요법을 위한 sting 활성화 나노백신
US11103588B2 (en) 2017-06-06 2021-08-31 Wayne State University Methods and compositions relating to carnitine-derived materials
CN115177608B (zh) * 2022-07-26 2023-12-05 南方医科大学南方医院 长链酰基肉碱类化合物在制备预防和/或治疗肝癌的药物中的应用

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IT1230142B (it) * 1989-05-03 1991-10-14 Fidia Spa Derivati della carnitina, processo per la loro preparazione e impiego in terapia umana
ATE137242T1 (de) * 1990-06-15 1996-05-15 Univ Wake Forest Kovalente-ther lipidnukleosid-konjugate
IT1248321B (it) * 1991-05-15 1995-01-05 Sigma Tau Ind Farmaceuti Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
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IT1299172B1 (it) * 1998-05-06 2000-02-29 Sigma Tau Ind Farmaceuti Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti

Also Published As

Publication number Publication date
IL175366A (en) 2010-12-30
HK1045145A1 (en) 2002-11-15
EE05514B1 (et) 2012-02-15
DE60017388D1 (de) 2005-02-17
BRPI0017460B1 (pt) 2016-04-19
JP4703855B2 (ja) 2011-06-15
NO20014985L (no) 2001-10-12
PL211710B1 (pl) 2012-06-29
BG105971A (en) 2002-08-30
IS2539B (is) 2009-09-15
AU2004224958B2 (en) 2007-11-22
IL185486A0 (en) 2008-01-06
US6797281B1 (en) 2004-09-28
CA2650202C (en) 2012-12-11
IS6095A (is) 2001-09-28
YU70201A (sh) 2004-07-15
US7629003B2 (en) 2009-12-08
KR100798499B1 (ko) 2008-01-28
CN1823731A (zh) 2006-08-30
ATE286873T1 (de) 2005-01-15
SK287253B6 (sk) 2010-04-07
CZ302628B6 (cs) 2011-08-10
IT1306129B1 (it) 2001-05-30
IL175366A0 (en) 2006-09-05
EE201100028A (et) 2011-08-15
EA200101076A1 (ru) 2002-04-25
JP2011042657A (ja) 2011-03-03
BG109876A (en) 2008-02-29
NZ528874A (en) 2005-09-30
SI1426044T1 (sl) 2006-04-30
EP1435232A1 (en) 2004-07-07
BG65312B1 (bg) 2008-01-31
ZA200109291B (en) 2002-08-16
EE05719B1 (et) 2014-08-15
CA2650202A1 (en) 2000-10-19
HK1045145B (zh) 2006-01-27
SK14312001A3 (sk) 2002-02-05
JP2002541238A (ja) 2002-12-03
EA006021B1 (ru) 2005-08-25
BR0009765B1 (pt) 2013-11-05
HUP0201446A2 (en) 2002-08-28
SK288246B6 (sk) 2015-03-03
EP1183228B1 (en) 2005-01-12
DE60025961T2 (de) 2006-08-17
CN1263730C (zh) 2006-07-12
HK1092732A1 (en) 2007-02-16
CZ20013617A3 (cs) 2002-02-13
EP1426044A1 (en) 2004-06-09
NO20085413L (no) 2001-10-12
NO336949B1 (no) 2015-11-30
ITRM990220A1 (it) 2000-10-13
ES2234591T3 (es) 2005-07-01
HUP0201446A3 (en) 2002-11-28
DE60025961D1 (de) 2006-04-20
NO327742B1 (no) 2009-09-14
CA2370143C (en) 2011-06-21
JP5420507B2 (ja) 2014-02-19
CA2370143A1 (en) 2000-10-19
KR20010113794A (ko) 2001-12-28
RS20090448A (en) 2010-06-30
EA200300745A1 (ru) 2003-12-25
MXPA01010359A (es) 2002-05-06
US20040186175A1 (en) 2004-09-23
AU776301B2 (en) 2004-09-02
RS50911B (sr) 2010-08-31
US20050079209A1 (en) 2005-04-14
EE200100518A (et) 2002-12-16
PL204418B1 (pl) 2010-01-29
ATE317257T1 (de) 2006-02-15
KR20060113799A (ko) 2006-11-02
DE60017388T2 (de) 2006-03-30
SI1183228T1 (en) 2005-04-30
KR100684378B1 (ko) 2007-02-20
HRP20010740A2 (en) 2002-10-31
TR200202358T2 (tr) 2002-12-23
IS8719A (is) 2008-03-07
CN1359370A (zh) 2002-07-17
IL145765A0 (en) 2002-07-25
WO2000061543A3 (en) 2001-01-11
ES2258688T3 (es) 2006-09-01
TR200102941T2 (tr) 2002-05-21
HU229366B1 (en) 2013-11-28
RS52682B (en) 2013-08-30
WO2000061543A2 (en) 2000-10-19
AU4312300A (en) 2000-11-14
NO20014985D0 (no) 2001-10-12
DK1426044T3 (da) 2006-06-12
AU2004224958A1 (en) 2004-11-25
DK1183228T3 (da) 2005-05-17
MEP24008A (en) 2010-06-10
PT1183228E (pt) 2005-04-29
BG65501B1 (bg) 2008-10-31
EP1426044B1 (en) 2006-02-08
EP1183228A2 (en) 2002-03-06
PT1426044E (pt) 2006-06-30
ME00113B (me) 2010-10-10
NZ515270A (en) 2004-02-27
PL351112A1 (en) 2003-03-24
US20070190128A1 (en) 2007-08-16
BR0009765A (pt) 2002-01-02
CN100402017C (zh) 2008-07-16
IL145765A (en) 2007-07-04
IS2476B (is) 2008-12-15
US7585519B2 (en) 2009-09-08
EA004459B1 (ru) 2004-04-29

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