YU70201A - Estri l-karnitina ili alkanoil l-karnitina korisni kao katjonski lipidi za unutarćelijsko oslobadjanje farmakološki aktivnih jedinjenja - Google Patents
Estri l-karnitina ili alkanoil l-karnitina korisni kao katjonski lipidi za unutarćelijsko oslobadjanje farmakološki aktivnih jedinjenjaInfo
- Publication number
- YU70201A YU70201A YU70201A YUP70201A YU70201A YU 70201 A YU70201 A YU 70201A YU 70201 A YU70201 A YU 70201A YU P70201 A YUP70201 A YU P70201A YU 70201 A YU70201 A YU 70201A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- carnitine
- esters
- active compounds
- pharmacologically active
- carnatines
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 title abstract 3
- 125000002091 cationic group Chemical group 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229960001518 levocarnitine Drugs 0.000 title 1
- -1 alkanoyl L-carnitine Chemical compound 0.000 abstract 2
- 230000003834 intracellular effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Opisani su estri L-karnitina i alkanoil L-kamitina koji se mogu koristiti kao katjonski lipidi za unutarćelijsko oslobadjanje farmakološki aktivnih jedinjenja. Takodje, opisani su novi estri L-karnitina i alkanoil L-karnitina formule (I) gde su grupe R definisane u opisu.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MEP-240/08A MEP24008A (en) | 1999-04-13 | 2000-04-11 | Esters of l-carnitine or alkanoyl l-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999RM000220A IT1306129B1 (it) | 1999-04-13 | 1999-04-13 | Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti |
Publications (2)
Publication Number | Publication Date |
---|---|
YU70201A true YU70201A (sh) | 2004-07-15 |
RS50911B RS50911B (sr) | 2010-08-31 |
Family
ID=11406659
Country Status (34)
Country | Link |
---|---|
US (4) | US6797281B1 (sh) |
EP (3) | EP1426044B1 (sh) |
JP (2) | JP4703855B2 (sh) |
KR (2) | KR100684378B1 (sh) |
CN (2) | CN1263730C (sh) |
AT (2) | ATE286873T1 (sh) |
AU (2) | AU776301B2 (sh) |
BG (3) | BG65501B1 (sh) |
BR (2) | BR0009765B1 (sh) |
CA (2) | CA2650202C (sh) |
CZ (1) | CZ302628B6 (sh) |
DE (2) | DE60025961T2 (sh) |
DK (2) | DK1183228T3 (sh) |
EA (2) | EA006021B1 (sh) |
EE (2) | EE05719B1 (sh) |
ES (2) | ES2234591T3 (sh) |
HK (2) | HK1045145B (sh) |
HR (1) | HRP20010740B1 (sh) |
HU (1) | HU229366B1 (sh) |
IL (4) | IL145765A0 (sh) |
IS (2) | IS2476B (sh) |
IT (1) | IT1306129B1 (sh) |
ME (2) | MEP24008A (sh) |
MX (1) | MXPA01010359A (sh) |
NO (2) | NO327742B1 (sh) |
NZ (2) | NZ515270A (sh) |
PL (2) | PL204418B1 (sh) |
PT (2) | PT1426044E (sh) |
RS (3) | RS20090448A (sh) |
SI (2) | SI1426044T1 (sh) |
SK (2) | SK288246B6 (sh) |
TR (2) | TR200102941T2 (sh) |
WO (1) | WO2000061543A2 (sh) |
ZA (1) | ZA200109291B (sh) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4879433B2 (ja) * | 2000-01-13 | 2012-02-22 | エミスフェアー・テクノロジーズ・インク | 活性剤を送達するための化合物および組成物 |
DE10113446A1 (de) † | 2001-03-19 | 2002-09-26 | Schwarzkopf Gmbh Hans | Haarbehandlungsmittel mit Betainen |
DK2108362T3 (da) * | 2002-06-26 | 2013-09-02 | Medigene Ag | Kationisk liposomal-fremstilling omfattende en taxan |
DK2286795T3 (en) * | 2002-06-26 | 2017-02-06 | Syncore Biotechnology Co Ltd | PROCEDURE FOR PREPARING A Cationic LIPOSOMAL PREPARATION INCLUDING A LIPOPHIL COMPOUND |
ITRM20040288A1 (it) * | 2004-06-11 | 2004-09-11 | Sigma Tau Ind Farmaceuti | Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero. |
GT200500310A (es) | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
US20080095834A1 (en) * | 2005-03-02 | 2008-04-24 | Volkmar Weissig | Mitochondriotropic Phospholipid Vesicles |
SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
CA2617873A1 (en) * | 2005-08-10 | 2007-02-15 | Novartis Ag | Formulations for 7-(t-butoxy)iminomethyl camptothecin |
BRPI0614757A2 (pt) * | 2005-08-10 | 2011-04-12 | Novartis Ag | composição farmacêutica, micropartìcula e seu uso |
US20100178325A1 (en) * | 2006-08-23 | 2010-07-15 | Biodelivery Sciences International, Inc. | Amphiphilic nucleotide cochleate compositions and methods of using the same |
JP2010518012A (ja) * | 2007-02-01 | 2010-05-27 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | カンプトテシン誘導体を含む医薬組成物 |
US20100104625A1 (en) * | 2007-02-16 | 2010-04-29 | Cornell University | Biodegradable compositions and materials |
US20100204432A1 (en) * | 2007-05-28 | 2010-08-12 | Husam Younes | Biodegradable elastomers prepared by the condensation of an organic di-, tri- or tetra-carboxylic acid and an organic diol |
JP4827986B2 (ja) | 2007-06-08 | 2011-11-30 | マンカインド コーポレ−ション | IRE−1αインヒビター |
AU2009223222A1 (en) | 2008-03-13 | 2009-09-17 | Perkinelmer Health Sciences, Inc. | Enzymatic substrates for multiple detection systems |
EP2532649B1 (en) * | 2011-06-07 | 2015-04-08 | Incella GmbH | Amino lipids, their synthesis and uses thereof |
WO2013032643A2 (en) * | 2011-08-31 | 2013-03-07 | Dicerna Pharmaceuticals, Inc. | Lipids capable of conformational change and their use in formulations to deliver therapeutic agents to cells |
WO2014145418A1 (en) | 2013-03-15 | 2014-09-18 | Perkinelmer Health Sciences, Inc. | Compounds and methods relating to testing for lysosomal storage disorders |
KR20180114946A (ko) | 2016-03-02 | 2018-10-19 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 면역요법을 위한 sting 활성화 나노백신 |
US11103588B2 (en) | 2017-06-06 | 2021-08-31 | Wayne State University | Methods and compositions relating to carnitine-derived materials |
CN115177608B (zh) * | 2022-07-26 | 2023-12-05 | 南方医科大学南方医院 | 长链酰基肉碱类化合物在制备预防和/或治疗肝癌的药物中的应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5008288A (en) * | 1986-01-06 | 1991-04-16 | Alfred Stracher | Carnitine directed pharmaceutical agents |
US4866040A (en) * | 1986-01-06 | 1989-09-12 | Alfred Stracher | Aminocarnitine directed pharmaceutical agents |
IT1230142B (it) * | 1989-05-03 | 1991-10-14 | Fidia Spa | Derivati della carnitina, processo per la loro preparazione e impiego in terapia umana |
JPH05507929A (ja) * | 1990-06-15 | 1993-11-11 | ウェイク フォレスト ユニバーシティー | エーテル脂質―ヌクレオシド共有結合体 |
IT1248321B (it) * | 1991-05-15 | 1995-01-05 | Sigma Tau Ind Farmaceuti | Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie |
IT1258370B (it) * | 1992-03-02 | 1996-02-26 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono. |
US5972600A (en) * | 1992-04-03 | 1999-10-26 | The Regents Of The University Of California | Separation of active complexes |
IT1263013B (it) * | 1992-10-20 | 1996-07-23 | Avantgarde Spa | Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee. |
US5552156A (en) * | 1992-10-23 | 1996-09-03 | Ohio State University | Liposomal and micellular stabilization of camptothecin drugs |
US5512671A (en) * | 1993-02-16 | 1996-04-30 | Wake Forest University | Ether lipid-nucleoside covalent conjugates |
IT1261984B (it) * | 1993-06-22 | 1996-06-11 | Avantgarde Spa | Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee. |
EP0706374B1 (en) * | 1993-06-30 | 1997-12-10 | Genentech, Inc. | Method for preparing liposomes |
IT1273987B (it) * | 1994-09-29 | 1997-07-14 | Sigma Tau Ind Farmaceuti | Uso di esteri ftalidilidenici della carnitina e di alcanoil carnitine per il trattamento dello shock endotossico |
US6008202A (en) * | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US6316652B1 (en) * | 1995-06-06 | 2001-11-13 | Kosta Steliou | Drug mitochondrial targeting agents |
US5811406A (en) * | 1995-06-07 | 1998-09-22 | Regents Of The University Of California | Dry powder formulations of polynucleotide complexes |
AU707734B2 (en) * | 1995-06-07 | 1999-07-15 | Regents Of The University Of California, The | Stabilization of polynucleotide complexes |
IT1283955B1 (it) * | 1996-03-20 | 1998-05-07 | Sigma Tau Ind Farmaceuti | Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria. |
US6294378B1 (en) * | 1996-07-26 | 2001-09-25 | Sloan-Kettering Institute For Cancer Research | Method and reagents for genetic immunization |
US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
US6071532A (en) * | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
IT1299172B1 (it) * | 1998-05-06 | 2000-02-29 | Sigma Tau Ind Farmaceuti | Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti |
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1999
- 1999-04-13 IT IT1999RM000220A patent/IT1306129B1/it active
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2000
- 2000-04-11 RS RSP-2009/0448A patent/RS20090448A/sr unknown
- 2000-04-11 JP JP2000610820A patent/JP4703855B2/ja not_active Expired - Fee Related
- 2000-04-11 SI SI200030799T patent/SI1426044T1/sl unknown
- 2000-04-11 DE DE60025961T patent/DE60025961T2/de not_active Expired - Lifetime
- 2000-04-11 DE DE60017388T patent/DE60017388T2/de not_active Expired - Lifetime
- 2000-04-11 KR KR1020017013018A patent/KR100684378B1/ko not_active IP Right Cessation
- 2000-04-11 TR TR2001/02941T patent/TR200102941T2/xx unknown
- 2000-04-11 CZ CZ20013617A patent/CZ302628B6/cs not_active IP Right Cessation
- 2000-04-11 PL PL351112A patent/PL204418B1/pl unknown
- 2000-04-11 EP EP03020049A patent/EP1426044B1/en not_active Expired - Lifetime
- 2000-04-11 CA CA2650202A patent/CA2650202C/en not_active Expired - Fee Related
- 2000-04-11 ME MEP-240/08A patent/MEP24008A/xx unknown
- 2000-04-11 DK DK00922852T patent/DK1183228T3/da active
- 2000-04-11 MX MXPA01010359A patent/MXPA01010359A/es active IP Right Grant
- 2000-04-11 ME MEP-2008-240A patent/ME00113B/me unknown
- 2000-04-11 CN CNB008070539A patent/CN1263730C/zh not_active Expired - Fee Related
- 2000-04-11 SK SK5094-2008A patent/SK288246B6/sk not_active IP Right Cessation
- 2000-04-11 HU HU0201446A patent/HU229366B1/hu not_active IP Right Cessation
- 2000-04-11 CA CA2370143A patent/CA2370143C/en not_active Expired - Fee Related
- 2000-04-11 RS RS20090448A patent/RS52682B/en unknown
- 2000-04-11 EA EA200300745A patent/EA006021B1/ru not_active IP Right Cessation
- 2000-04-11 CN CNB2005101295985A patent/CN100402017C/zh not_active Expired - Fee Related
- 2000-04-11 BR BRPI0009765-9B1A patent/BR0009765B1/pt not_active IP Right Cessation
- 2000-04-11 SK SK1431-2001A patent/SK287253B6/sk not_active IP Right Cessation
- 2000-04-11 AT AT00922852T patent/ATE286873T1/de active
- 2000-04-11 EP EP00922852A patent/EP1183228B1/en not_active Expired - Lifetime
- 2000-04-11 EA EA200101076A patent/EA004459B1/ru not_active IP Right Cessation
- 2000-04-11 KR KR1020067021555A patent/KR100798499B1/ko not_active IP Right Cessation
- 2000-04-11 EP EP04006990A patent/EP1435232A1/en not_active Withdrawn
- 2000-04-11 BG BG109876A patent/BG65501B1/bg unknown
- 2000-04-11 NZ NZ515270A patent/NZ515270A/xx not_active IP Right Cessation
- 2000-04-11 NZ NZ528874A patent/NZ528874A/en not_active IP Right Cessation
- 2000-04-11 AU AU43123/00A patent/AU776301B2/en not_active Ceased
- 2000-04-11 WO PCT/IT2000/000137 patent/WO2000061543A2/en active Application Filing
- 2000-04-11 TR TR2002/02358T patent/TR200202358T2/xx unknown
- 2000-04-11 PT PT03020049T patent/PT1426044E/pt unknown
- 2000-04-11 DK DK03020049T patent/DK1426044T3/da active
- 2000-04-11 ES ES00922852T patent/ES2234591T3/es not_active Expired - Lifetime
- 2000-04-11 BR BRPI0017460A patent/BRPI0017460B1/pt not_active IP Right Cessation
- 2000-04-11 RS YUP-702/01A patent/RS50911B/sr unknown
- 2000-04-11 PL PL386640A patent/PL211710B1/pl unknown
- 2000-04-11 PT PT00922852T patent/PT1183228E/pt unknown
- 2000-04-11 ES ES03020049T patent/ES2258688T3/es not_active Expired - Lifetime
- 2000-04-11 SI SI200030596T patent/SI1183228T1/xx unknown
- 2000-04-11 IL IL14576500A patent/IL145765A0/xx active IP Right Grant
- 2000-04-11 EE EEP201100028A patent/EE05719B1/et not_active IP Right Cessation
- 2000-04-11 AT AT03020049T patent/ATE317257T1/de active
- 2000-04-11 EE EEP200100518A patent/EE05514B1/xx not_active IP Right Cessation
- 2000-11-04 US US09/958,328 patent/US6797281B1/en not_active Expired - Lifetime
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2001
- 2001-09-28 IS IS6095A patent/IS2476B/is unknown
- 2001-10-03 BG BG109876A patent/BG109876A/en unknown
- 2001-10-03 BG BG105971A patent/BG65312B1/bg unknown
- 2001-10-04 IL IL145765A patent/IL145765A/en not_active IP Right Cessation
- 2001-10-12 HR HR20010740A patent/HRP20010740B1/xx not_active IP Right Cessation
- 2001-10-12 NO NO20014985A patent/NO327742B1/no not_active IP Right Cessation
- 2001-11-12 ZA ZA200109291A patent/ZA200109291B/en unknown
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2002
- 2002-06-12 HK HK02104388.0A patent/HK1045145B/zh not_active IP Right Cessation
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2003
- 2003-07-23 US US10/624,645 patent/US7629003B2/en not_active Expired - Fee Related
-
2004
- 2004-01-28 US US10/765,091 patent/US20040186175A1/en not_active Abandoned
- 2004-10-29 AU AU2004224958A patent/AU2004224958B2/en not_active Ceased
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2006
- 2006-05-01 IL IL175366A patent/IL175366A/en not_active IP Right Cessation
- 2006-12-14 HK HK06113747A patent/HK1092732A1/xx not_active IP Right Cessation
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2007
- 2007-03-27 US US11/727,526 patent/US7585519B2/en not_active Expired - Fee Related
- 2007-08-23 IL IL185486A patent/IL185486A0/en not_active IP Right Cessation
-
2008
- 2008-03-07 IS IS8719A patent/IS2539B/is unknown
- 2008-12-30 NO NO20085413A patent/NO336949B1/no not_active IP Right Cessation
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2010
- 2010-09-21 JP JP2010210849A patent/JP5420507B2/ja not_active Expired - Fee Related
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