EE201100028A - L-karnitiini v?i alkanol-L-karnitiinide estrite kasutamine katioonsete lipiididena farmakoloogiliselt aktiivsete komponentide intratsellulaarseks kohaletoimetamiseks - Google Patents
L-karnitiini v?i alkanol-L-karnitiinide estrite kasutamine katioonsete lipiididena farmakoloogiliselt aktiivsete komponentide intratsellulaarseks kohaletoimetamiseksInfo
- Publication number
- EE201100028A EE201100028A EEP201100028A EEP201100028A EE201100028A EE 201100028 A EE201100028 A EE 201100028A EE P201100028 A EEP201100028 A EE P201100028A EE P201100028 A EEP201100028 A EE P201100028A EE 201100028 A EE201100028 A EE 201100028A
- Authority
- EE
- Estonia
- Prior art keywords
- carnitine
- pharmacologically active
- alkanoic
- cationic lipids
- intracellular delivery
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 3
- 125000002091 cationic group Chemical group 0.000 title abstract 2
- 230000003834 intracellular effect Effects 0.000 title abstract 2
- -1 alkanoyl L-carnitines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999RM000220A IT1306129B1 (it) | 1999-04-13 | 1999-04-13 | Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti |
| EEP200100518A EE05514B1 (et) | 1999-04-13 | 2000-04-11 | L karnitiini v i alkanol L karnitiinide estrid katioonsete lipiididena farmakoloogiliselt aktiivsete komponentidena intratsellulaarseks kohaletoimetamiseks |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE201100028A true EE201100028A (et) | 2011-08-15 |
| EE05719B1 EE05719B1 (et) | 2014-08-15 |
Family
ID=11406659
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200100518A EE05514B1 (et) | 1999-04-13 | 2000-04-11 | L karnitiini v i alkanol L karnitiinide estrid katioonsete lipiididena farmakoloogiliselt aktiivsete komponentidena intratsellulaarseks kohaletoimetamiseks |
| EEP201100028A EE05719B1 (et) | 1999-04-13 | 2000-04-11 | L-karnitiini või alkanoüül-L-karnitiinide estrite kasutamine katioonsete lipiididena farmakoloogiliselt aktiivsete komponentide intratsellulaarseks kohaletoimetamiseks |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200100518A EE05514B1 (et) | 1999-04-13 | 2000-04-11 | L karnitiini v i alkanol L karnitiinide estrid katioonsete lipiididena farmakoloogiliselt aktiivsete komponentidena intratsellulaarseks kohaletoimetamiseks |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US6797281B1 (et) |
| EP (3) | EP1435232A1 (et) |
| JP (2) | JP4703855B2 (et) |
| KR (2) | KR100684378B1 (et) |
| CN (2) | CN1263730C (et) |
| AT (2) | ATE317257T1 (et) |
| AU (2) | AU776301B2 (et) |
| BG (3) | BG65501B1 (et) |
| BR (2) | BRPI0017460B1 (et) |
| CA (2) | CA2650202C (et) |
| CZ (1) | CZ302628B6 (et) |
| DE (2) | DE60025961T2 (et) |
| DK (2) | DK1183228T3 (et) |
| EA (2) | EA006021B1 (et) |
| EE (2) | EE05514B1 (et) |
| ES (2) | ES2258688T3 (et) |
| HK (2) | HK1045145B (et) |
| HR (1) | HRP20010740B1 (et) |
| HU (1) | HU229366B1 (et) |
| IL (4) | IL145765A0 (et) |
| IS (2) | IS2476B (et) |
| IT (1) | IT1306129B1 (et) |
| ME (2) | ME00113B (et) |
| MX (1) | MXPA01010359A (et) |
| NO (2) | NO327742B1 (et) |
| NZ (2) | NZ515270A (et) |
| PL (2) | PL204418B1 (et) |
| PT (2) | PT1426044E (et) |
| RS (3) | RS52682B (et) |
| SI (2) | SI1426044T1 (et) |
| SK (2) | SK287253B6 (et) |
| TR (2) | TR200202358T2 (et) |
| WO (1) | WO2000061543A2 (et) |
| ZA (1) | ZA200109291B (et) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1246792B1 (en) * | 2000-01-13 | 2014-08-13 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| DE10113446A1 (de) † | 2001-03-19 | 2002-09-26 | Schwarzkopf Gmbh Hans | Haarbehandlungsmittel mit Betainen |
| PT2108362E (pt) * | 2002-06-26 | 2013-07-11 | Medigene Ag | Preparação lipossomal catiónica que compreende um taxano |
| ES2331791T5 (es) | 2002-06-26 | 2016-01-21 | Medigene Ag | Método de producción de una preparación catiónica de liposomas que comprende un compuesto lipófilo |
| ITRM20040288A1 (it) * | 2004-06-11 | 2004-09-11 | Sigma Tau Ind Farmaceuti | Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero. |
| GT200500310A (es) | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
| WO2006094203A1 (en) * | 2005-03-02 | 2006-09-08 | Northeastern University | Mitochondriotropic phospholipid vesicles |
| SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
| EP1915132A1 (en) * | 2005-08-10 | 2008-04-30 | Novartis AG | Microparticle compositions of the topoisomerase i inhibitor 7-tert-butoxyiminomethylcamptothecin |
| MX2008001970A (es) * | 2005-08-10 | 2008-03-24 | Novartis Ag | Formulaciones para 7-(t-butoxi)iminometil camptotecin. |
| US20100178325A1 (en) * | 2006-08-23 | 2010-07-15 | Biodelivery Sciences International, Inc. | Amphiphilic nucleotide cochleate compositions and methods of using the same |
| KR20090115856A (ko) * | 2007-02-01 | 2009-11-09 | 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. | 캄포테신 유도체를 함유하는 약학적 조성물 |
| WO2008101173A2 (en) * | 2007-02-16 | 2008-08-21 | Cornell University | Biodegradable compositions and materials |
| US20100204432A1 (en) * | 2007-05-28 | 2010-08-12 | Husam Younes | Biodegradable elastomers prepared by the condensation of an organic di-, tri- or tetra-carboxylic acid and an organic diol |
| CN103450077B (zh) | 2007-06-08 | 2016-07-06 | 满康德股份有限公司 | IRE-1α抑制剂 |
| EP2265645A4 (en) * | 2008-03-13 | 2011-03-23 | Perkinelmer Health Sci Inc | ENZYMATIC SUBSTRATES FOR MULTIPLE DETECTION SYSTEMS |
| EP2532649B1 (en) * | 2011-06-07 | 2015-04-08 | Incella GmbH | Amino lipids, their synthesis and uses thereof |
| WO2013032643A2 (en) * | 2011-08-31 | 2013-03-07 | Dicerna Pharmaceuticals, Inc. | Lipids capable of conformational change and their use in formulations to deliver therapeutic agents to cells |
| US20140274798A1 (en) | 2013-03-15 | 2014-09-18 | University Of Washington Through Its Center For Commercialization | Compounds and methods relating to lysosomal storage disorders |
| MX2018010586A (es) | 2016-03-02 | 2019-03-28 | Univ Texas | Nanovacuna de activacion de "sting" para inmunoterapia. |
| US11103588B2 (en) | 2017-06-06 | 2021-08-31 | Wayne State University | Methods and compositions relating to carnitine-derived materials |
| CN115177608B (zh) * | 2022-07-26 | 2023-12-05 | 南方医科大学南方医院 | 长链酰基肉碱类化合物在制备预防和/或治疗肝癌的药物中的应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4866040A (en) * | 1986-01-06 | 1989-09-12 | Alfred Stracher | Aminocarnitine directed pharmaceutical agents |
| US5008288A (en) * | 1986-01-06 | 1991-04-16 | Alfred Stracher | Carnitine directed pharmaceutical agents |
| IT1230142B (it) * | 1989-05-03 | 1991-10-14 | Fidia Spa | Derivati della carnitina, processo per la loro preparazione e impiego in terapia umana |
| AU660417B2 (en) * | 1990-06-15 | 1995-06-29 | University Of North Carolina At Chapel Hill, The | Ether lipid-nucleoside covalent conjugates |
| IT1248321B (it) * | 1991-05-15 | 1995-01-05 | Sigma Tau Ind Farmaceuti | Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie |
| IT1258370B (it) * | 1992-03-02 | 1996-02-26 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono. |
| US5972600A (en) * | 1992-04-03 | 1999-10-26 | The Regents Of The University Of California | Separation of active complexes |
| IT1263013B (it) * | 1992-10-20 | 1996-07-23 | Avantgarde Spa | Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee. |
| US5552156A (en) * | 1992-10-23 | 1996-09-03 | Ohio State University | Liposomal and micellular stabilization of camptothecin drugs |
| US5512671A (en) * | 1993-02-16 | 1996-04-30 | Wake Forest University | Ether lipid-nucleoside covalent conjugates |
| IT1261984B (it) * | 1993-06-22 | 1996-06-11 | Avantgarde Spa | Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee. |
| DE69407292T2 (de) * | 1993-06-30 | 1998-06-25 | Genentech Inc | Verfahren zur herstellung von liposomen |
| IT1273987B (it) * | 1994-09-29 | 1997-07-14 | Sigma Tau Ind Farmaceuti | Uso di esteri ftalidilidenici della carnitina e di alcanoil carnitine per il trattamento dello shock endotossico |
| US6008202A (en) * | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US6316652B1 (en) * | 1995-06-06 | 2001-11-13 | Kosta Steliou | Drug mitochondrial targeting agents |
| US5811406A (en) * | 1995-06-07 | 1998-09-22 | Regents Of The University Of California | Dry powder formulations of polynucleotide complexes |
| EP0833667A4 (en) * | 1995-06-07 | 2001-11-21 | Univ California | STABILIZATION OF POLYNUCLEOTIDE COMPLEXES |
| IT1283955B1 (it) * | 1996-03-20 | 1998-05-07 | Sigma Tau Ind Farmaceuti | Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria. |
| WO1998004720A1 (en) * | 1996-07-26 | 1998-02-05 | Sloan-Kettering Institute For Cancer Research | Method and reagents for genetic immunization |
| US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| US6071532A (en) * | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
| IT1299172B1 (it) * | 1998-05-06 | 2000-02-29 | Sigma Tau Ind Farmaceuti | Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti |
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1999
- 1999-04-13 IT IT1999RM000220A patent/IT1306129B1/it active
-
2000
- 2000-04-11 SK SK1431-2001A patent/SK287253B6/sk not_active IP Right Cessation
- 2000-04-11 DK DK00922852T patent/DK1183228T3/da active
- 2000-04-11 EE EEP200100518A patent/EE05514B1/et not_active IP Right Cessation
- 2000-04-11 CA CA2650202A patent/CA2650202C/en not_active Expired - Fee Related
- 2000-04-11 PL PL351112A patent/PL204418B1/pl unknown
- 2000-04-11 PT PT03020049T patent/PT1426044E/pt unknown
- 2000-04-11 EP EP04006990A patent/EP1435232A1/en not_active Withdrawn
- 2000-04-11 WO PCT/IT2000/000137 patent/WO2000061543A2/en active Application Filing
- 2000-04-11 ME MEP-2008-240A patent/ME00113B/me unknown
- 2000-04-11 EA EA200300745A patent/EA006021B1/ru not_active IP Right Cessation
- 2000-04-11 TR TR2002/02358T patent/TR200202358T2/xx unknown
- 2000-04-11 EP EP03020049A patent/EP1426044B1/en not_active Expired - Lifetime
- 2000-04-11 BR BRPI0017460A patent/BRPI0017460B1/pt not_active IP Right Cessation
- 2000-04-11 AT AT03020049T patent/ATE317257T1/de active
- 2000-04-11 KR KR1020017013018A patent/KR100684378B1/ko not_active IP Right Cessation
- 2000-04-11 EE EEP201100028A patent/EE05719B1/et not_active IP Right Cessation
- 2000-04-11 CZ CZ20013617A patent/CZ302628B6/cs not_active IP Right Cessation
- 2000-04-11 SI SI200030799T patent/SI1426044T1/sl unknown
- 2000-04-11 NZ NZ515270A patent/NZ515270A/xx not_active IP Right Cessation
- 2000-04-11 KR KR1020067021555A patent/KR100798499B1/ko not_active IP Right Cessation
- 2000-04-11 IL IL14576500A patent/IL145765A0/xx active IP Right Grant
- 2000-04-11 JP JP2000610820A patent/JP4703855B2/ja not_active Expired - Fee Related
- 2000-04-11 BG BG109876A patent/BG65501B1/bg unknown
- 2000-04-11 AT AT00922852T patent/ATE286873T1/de active
- 2000-04-11 CA CA2370143A patent/CA2370143C/en not_active Expired - Fee Related
- 2000-04-11 HU HU0201446A patent/HU229366B1/hu not_active IP Right Cessation
- 2000-04-11 NZ NZ528874A patent/NZ528874A/en not_active IP Right Cessation
- 2000-04-11 EA EA200101076A patent/EA004459B1/ru not_active IP Right Cessation
- 2000-04-11 TR TR2001/02941T patent/TR200102941T2/xx unknown
- 2000-04-11 ES ES03020049T patent/ES2258688T3/es not_active Expired - Lifetime
- 2000-04-11 AU AU43123/00A patent/AU776301B2/en not_active Ceased
- 2000-04-11 PL PL386640A patent/PL211710B1/pl unknown
- 2000-04-11 RS RS20090448A patent/RS52682B/en unknown
- 2000-04-11 ME MEP-240/08A patent/MEP24008A/xx unknown
- 2000-04-11 EP EP00922852A patent/EP1183228B1/en not_active Expired - Lifetime
- 2000-04-11 RS YUP-702/01A patent/RS50911B/sr unknown
- 2000-04-11 ES ES00922852T patent/ES2234591T3/es not_active Expired - Lifetime
- 2000-04-11 CN CNB008070539A patent/CN1263730C/zh not_active Expired - Fee Related
- 2000-04-11 MX MXPA01010359A patent/MXPA01010359A/es active IP Right Grant
- 2000-04-11 DE DE60025961T patent/DE60025961T2/de not_active Expired - Lifetime
- 2000-04-11 SI SI200030596T patent/SI1183228T1/xx unknown
- 2000-04-11 SK SK5094-2008A patent/SK288246B6/sk not_active IP Right Cessation
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- 2000-11-04 US US09/958,328 patent/US6797281B1/en not_active Expired - Lifetime
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2001
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2002
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2003
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2004
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2006
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2007
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2008
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