ITRM980293A0 - Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti - Google Patents
Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di compostiInfo
- Publication number
- ITRM980293A0 ITRM980293A0 IT98RM000293A ITRM980293A ITRM980293A0 IT RM980293 A0 ITRM980293 A0 IT RM980293A0 IT 98RM000293 A IT98RM000293 A IT 98RM000293A IT RM980293 A ITRM980293 A IT RM980293A IT RM980293 A0 ITRM980293 A0 IT RM980293A0
- Authority
- IT
- Italy
- Prior art keywords
- alcanoil
- carnitine
- usable
- compounds
- cationic lipids
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000003834 intracellular effect Effects 0.000 title 1
- 150000002632 lipids Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98RM000293A IT1299172B1 (it) | 1998-05-06 | 1998-05-06 | Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti |
| ES99921126T ES2226384T3 (es) | 1998-05-06 | 1999-05-04 | Esteres perfluorados de alcanoil l-carnitina para la preparacion de lipidos cationicos para la administracion de compuestos farmacologicamente activos por via intracelular. |
| AT99921126T ATE272047T1 (de) | 1998-05-06 | 1999-05-04 | Perfluorierte ester von alkanoyl l-carnitin zur herstellung von kationischen lipiden zur intrazellulären verabreichung pharmakologisch aktiver verbindungen |
| JP2000547064A JP4366014B2 (ja) | 1998-05-06 | 1999-05-04 | 薬理学的に活性な化合物の細胞内送達のためのカチオン性脂質の調製のための、アルカノイルｌ−カルニチンのペルフッ素化エステル |
| AU38465/99A AU3846599A (en) | 1998-05-06 | 1999-05-04 | Perfluorinated esters of alkanoyl l-carnitine for the preparation of cationic lipids for the intracellular delivery of pharmacologically active compounds |
| PCT/IT1999/000117 WO1999057094A2 (en) | 1998-05-06 | 1999-05-04 | Perfluorinated esters of alkanoyl l-carnitine for the preparation of cationic lipids for the intracellular delivery of pharmacologically active compounds |
| DK99921126T DK1075461T3 (da) | 1998-05-06 | 1999-05-04 | Perfluorerede estere af alkanoyl-L-carnitin til fremstillingen af kationiske lipider til den intracellulære levering af farmakologisk aktive forbindelser |
| KR1020007012174A KR100573008B1 (ko) | 1998-05-06 | 1999-05-04 | 약리학적 활성 화합물의 세포내 송달에 사용되는 양이온성지질 제조용 과불소화된 알카노일 ｌ-카르니틴 에스테르 |
| DE69918974T DE69918974T2 (de) | 1998-05-06 | 1999-05-04 | Perfluorierte ester von alkanoyl l-carnitin zur herstellung von kationischen lipiden zur intrazellulären verabreichung pharmakologisch aktiver verbindungen |
| EP99921126A EP1075461B1 (en) | 1998-05-06 | 1999-05-04 | Perfluorinated esters of alkanoyl l-carnitine for the preparation of cationic lipids for the intracellular delivery of pharmacologically active compounds |
| PT99921126T PT1075461E (pt) | 1998-05-06 | 1999-05-04 | Esteres perfluorinados de l-carnitina de alcanoilo para a preparacao de lipidoscationicos para a libertacao intracelular de compostos farmacologicamente activos |
| CA2329659A CA2329659C (en) | 1998-05-06 | 1999-05-04 | Perfluorinated esters of alkanoyl l-carnitine for the preparation of cationic lipids for the intracellular delivery of pharmacologically active compounds |
| US09/670,620 US6476243B1 (en) | 1998-05-06 | 2000-09-27 | Perfluorinated esters of alkanoyl L-carnitine for the preparation of cationic lipids for the intracellular delivery of pharmacologically active compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98RM000293A IT1299172B1 (it) | 1998-05-06 | 1998-05-06 | Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM980293A0 true ITRM980293A0 (it) | 1998-05-06 |
| ITRM980293A1 ITRM980293A1 (it) | 1999-11-06 |
| IT1299172B1 IT1299172B1 (it) | 2000-02-29 |
Family
ID=11405901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT98RM000293A IT1299172B1 (it) | 1998-05-06 | 1998-05-06 | Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6476243B1 (it) |
| EP (1) | EP1075461B1 (it) |
| JP (1) | JP4366014B2 (it) |
| KR (1) | KR100573008B1 (it) |
| AT (1) | ATE272047T1 (it) |
| AU (1) | AU3846599A (it) |
| CA (1) | CA2329659C (it) |
| DE (1) | DE69918974T2 (it) |
| DK (1) | DK1075461T3 (it) |
| ES (1) | ES2226384T3 (it) |
| IT (1) | IT1299172B1 (it) |
| PT (1) | PT1075461E (it) |
| WO (1) | WO1999057094A2 (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1306129B1 (it) | 1999-04-13 | 2001-05-30 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti |
| IT1316990B1 (it) * | 2000-02-17 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Metodo per aumentare l'espressione genica per geni trasfettati. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1116037B (it) * | 1979-04-23 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico |
| IT1258370B (it) * | 1992-03-02 | 1996-02-26 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono. |
| US5846516A (en) * | 1992-06-03 | 1998-12-08 | Alliance Pharmaceutial Corp. | Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications |
| FR2694195B1 (fr) * | 1992-07-30 | 1994-09-23 | Sederma Sa | Nouvelles compositions cosmétiques amincissantes. |
-
1998
- 1998-05-06 IT IT98RM000293A patent/IT1299172B1/it active IP Right Grant
-
1999
- 1999-05-04 DK DK99921126T patent/DK1075461T3/da active
- 1999-05-04 EP EP99921126A patent/EP1075461B1/en not_active Expired - Lifetime
- 1999-05-04 DE DE69918974T patent/DE69918974T2/de not_active Expired - Lifetime
- 1999-05-04 ES ES99921126T patent/ES2226384T3/es not_active Expired - Lifetime
- 1999-05-04 AU AU38465/99A patent/AU3846599A/en not_active Abandoned
- 1999-05-04 JP JP2000547064A patent/JP4366014B2/ja not_active Expired - Fee Related
- 1999-05-04 CA CA2329659A patent/CA2329659C/en not_active Expired - Fee Related
- 1999-05-04 AT AT99921126T patent/ATE272047T1/de not_active IP Right Cessation
- 1999-05-04 WO PCT/IT1999/000117 patent/WO1999057094A2/en active IP Right Grant
- 1999-05-04 PT PT99921126T patent/PT1075461E/pt unknown
- 1999-05-04 KR KR1020007012174A patent/KR100573008B1/ko not_active IP Right Cessation
-
2000
- 2000-09-27 US US09/670,620 patent/US6476243B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010043234A (ko) | 2001-05-25 |
| WO1999057094A3 (en) | 2000-01-27 |
| ITRM980293A1 (it) | 1999-11-06 |
| AU3846599A (en) | 1999-11-23 |
| ES2226384T3 (es) | 2005-03-16 |
| DE69918974D1 (de) | 2004-09-02 |
| IT1299172B1 (it) | 2000-02-29 |
| JP2002513779A (ja) | 2002-05-14 |
| CA2329659A1 (en) | 1999-11-11 |
| PT1075461E (pt) | 2004-11-30 |
| EP1075461B1 (en) | 2004-07-28 |
| JP4366014B2 (ja) | 2009-11-18 |
| KR100573008B1 (ko) | 2006-04-24 |
| DK1075461T3 (da) | 2004-12-06 |
| EP1075461A2 (en) | 2001-02-14 |
| CA2329659C (en) | 2010-07-20 |
| US6476243B1 (en) | 2002-11-05 |
| DE69918974T2 (de) | 2005-08-11 |
| WO1999057094A2 (en) | 1999-11-11 |
| ATE272047T1 (de) | 2004-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |