DE69918974D1 - Perfluorierte ester von alkanoyl l-carnitin zur herstellung von kationischen lipiden zur intrazellulären verabreichung pharmakologisch aktiver verbindungen - Google Patents

Perfluorierte ester von alkanoyl l-carnitin zur herstellung von kationischen lipiden zur intrazellulären verabreichung pharmakologisch aktiver verbindungen

Info

Publication number
DE69918974D1
DE69918974D1 DE69918974T DE69918974T DE69918974D1 DE 69918974 D1 DE69918974 D1 DE 69918974D1 DE 69918974 T DE69918974 T DE 69918974T DE 69918974 T DE69918974 T DE 69918974T DE 69918974 D1 DE69918974 D1 DE 69918974D1
Authority
DE
Germany
Prior art keywords
alkanoyl
active compounds
pharmacologically active
perfluored
carnitin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69918974T
Other languages
English (en)
Other versions
DE69918974T2 (de
Inventor
Mose Santaniello
Lucia Critelli
Nazareno Scafetta
Grazia Cima
Ornella Tinti
Claudio Pisano
Andrea Pucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of DE69918974D1 publication Critical patent/DE69918974D1/de
Application granted granted Critical
Publication of DE69918974T2 publication Critical patent/DE69918974T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69918974T 1998-05-06 1999-05-04 Perfluorierte ester von alkanoyl l-carnitin zur herstellung von kationischen lipiden zur intrazellulären verabreichung pharmakologisch aktiver verbindungen Expired - Lifetime DE69918974T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITRM980293 1998-05-06
IT98RM000293A IT1299172B1 (it) 1998-05-06 1998-05-06 Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti
PCT/IT1999/000117 WO1999057094A2 (en) 1998-05-06 1999-05-04 Perfluorinated esters of alkanoyl l-carnitine for the preparation of cationic lipids for the intracellular delivery of pharmacologically active compounds

Publications (2)

Publication Number Publication Date
DE69918974D1 true DE69918974D1 (de) 2004-09-02
DE69918974T2 DE69918974T2 (de) 2005-08-11

Family

ID=11405901

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69918974T Expired - Lifetime DE69918974T2 (de) 1998-05-06 1999-05-04 Perfluorierte ester von alkanoyl l-carnitin zur herstellung von kationischen lipiden zur intrazellulären verabreichung pharmakologisch aktiver verbindungen

Country Status (13)

Country Link
US (1) US6476243B1 (de)
EP (1) EP1075461B1 (de)
JP (1) JP4366014B2 (de)
KR (1) KR100573008B1 (de)
AT (1) ATE272047T1 (de)
AU (1) AU3846599A (de)
CA (1) CA2329659C (de)
DE (1) DE69918974T2 (de)
DK (1) DK1075461T3 (de)
ES (1) ES2226384T3 (de)
IT (1) IT1299172B1 (de)
PT (1) PT1075461E (de)
WO (1) WO1999057094A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1306129B1 (it) * 1999-04-13 2001-05-30 Sigma Tau Ind Farmaceuti Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
IT1316990B1 (it) * 2000-02-17 2003-05-26 Sigma Tau Ind Farmaceuti Metodo per aumentare l'espressione genica per geni trasfettati.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
US5846516A (en) * 1992-06-03 1998-12-08 Alliance Pharmaceutial Corp. Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications
FR2694195B1 (fr) * 1992-07-30 1994-09-23 Sederma Sa Nouvelles compositions cosmétiques amincissantes.

Also Published As

Publication number Publication date
DK1075461T3 (da) 2004-12-06
KR20010043234A (ko) 2001-05-25
WO1999057094A2 (en) 1999-11-11
KR100573008B1 (ko) 2006-04-24
EP1075461A2 (de) 2001-02-14
ITRM980293A0 (it) 1998-05-06
ES2226384T3 (es) 2005-03-16
EP1075461B1 (de) 2004-07-28
IT1299172B1 (it) 2000-02-29
US6476243B1 (en) 2002-11-05
JP2002513779A (ja) 2002-05-14
WO1999057094A3 (en) 2000-01-27
PT1075461E (pt) 2004-11-30
CA2329659C (en) 2010-07-20
DE69918974T2 (de) 2005-08-11
AU3846599A (en) 1999-11-23
JP4366014B2 (ja) 2009-11-18
CA2329659A1 (en) 1999-11-11
ATE272047T1 (de) 2004-08-15
ITRM980293A1 (it) 1999-11-06

Similar Documents

Publication Publication Date Title
DE60041976D1 (de) Phenoxycarbonsäureverbindungen und zusammensetzungen zur verabreichung aktiver wirkstoffe
DE60038183D1 (de) Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe
CY1109457T1 (el) Παραγωγο aminoαλκοολης ή παραγωγο φωσφονικου οξεος και φαρμακευτικη συνθεση που τα περιεχει
CO4940469A1 (es) Composicion oral de estabilidad mejorada que comprende un derivado de indolinona y una mezcla de gliceridos o esteres de polietilenglicol
BR0017028A (pt) Lipopepìdeos como agentes antibacterianos
MXPA01008611A (es) Compuestos y composiciones para suministrar agentes activos.
EA200101076A1 (ru) Сложные эфиры l-карнитина или алканоил l-карнитинов, полезные в качестве катионных липидов для внутриклеточной доставки фармакологически активных соединений
NZ514409A (en) C7 ester substituted taxanes as antitumor agents
SE9904508D0 (sv) New compounds
TW359616B (en) A parenterally administered pharmaceutical composition for lipophilic, poorly soluble active compounds, in the form of liposomes with phospholipid membranes
MXPA03007857A (es) Compuestos y composiciones para entregar agentes activos.
PT1140031E (pt) Preparacao farmaceutica de libertacao controlada com mesilato de tilidina como substancia activa
ATE310010T1 (de) 6-0-substitutierte eryththromycin-verbindungen und verfahrenen zu ihrer herstellung
DE69918974D1 (de) Perfluorierte ester von alkanoyl l-carnitin zur herstellung von kationischen lipiden zur intrazellulären verabreichung pharmakologisch aktiver verbindungen
RU95113437A (ru) (h±)-сложный этиловый эфир транс-2-диметиламино-1-фенил-3-циклогексентранс-1-карбоновой кислоты в виде первичного ортофосфата и твердая фармацевтическая композиция с обезболивающей активностью
AU4770400A (en) Fused polycyclic amino acids as pharmaceutical agents
NZ527230A (en) Crystal form of a cyclic depsipeptide having improved activity
SE9902742D0 (sv) New pharmaceutical formultion
DE69615657D1 (de) Antifungal fusacandine
MXPA03009723A (es) Procedimientos e intermediarios para preparar epoxidos substituidos de bencilo.
IT1302289B1 (it) Composizioni farmaceutiche ad attivita' antineoplastica
AU4146000A (en) Remedies for glomerulosclerosis
SE9303855D0 (sv) The use of ester of inositoltrisphosphate for the preparing of an analgetic medicamnet
ES2179668T3 (es) Un compuesto wf002, su produccion y su uso.
SE9504594D0 (sv) The use of an ester inositoltrisåhosphate for the preparing of medicaments

Legal Events

Date Code Title Description
8364 No opposition during term of opposition