DK1075461T3 - Perfluorerede estere af alkanoyl-L-carnitin til fremstillingen af kationiske lipider til den intracellulære levering af farmakologisk aktive forbindelser - Google Patents
Perfluorerede estere af alkanoyl-L-carnitin til fremstillingen af kationiske lipider til den intracellulære levering af farmakologisk aktive forbindelserInfo
- Publication number
- DK1075461T3 DK1075461T3 DK99921126T DK99921126T DK1075461T3 DK 1075461 T3 DK1075461 T3 DK 1075461T3 DK 99921126 T DK99921126 T DK 99921126T DK 99921126 T DK99921126 T DK 99921126T DK 1075461 T3 DK1075461 T3 DK 1075461T3
- Authority
- DK
- Denmark
- Prior art keywords
- carnitine
- alkanoyl
- active compounds
- pharmacologically active
- cationic lipids
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT98RM000293A IT1299172B1 (it) | 1998-05-06 | 1998-05-06 | Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti |
EP99921126A EP1075461B1 (de) | 1998-05-06 | 1999-05-04 | Perfluorierte ester von alkanoyl l-carnitin zur herstellung von kationischen lipiden zur intrazellulären verabreichung pharmakologisch aktiver verbindungen |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1075461T3 true DK1075461T3 (da) | 2004-12-06 |
Family
ID=11405901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99921126T DK1075461T3 (da) | 1998-05-06 | 1999-05-04 | Perfluorerede estere af alkanoyl-L-carnitin til fremstillingen af kationiske lipider til den intracellulære levering af farmakologisk aktive forbindelser |
Country Status (13)
Country | Link |
---|---|
US (1) | US6476243B1 (de) |
EP (1) | EP1075461B1 (de) |
JP (1) | JP4366014B2 (de) |
KR (1) | KR100573008B1 (de) |
AT (1) | ATE272047T1 (de) |
AU (1) | AU3846599A (de) |
CA (1) | CA2329659C (de) |
DE (1) | DE69918974T2 (de) |
DK (1) | DK1075461T3 (de) |
ES (1) | ES2226384T3 (de) |
IT (1) | IT1299172B1 (de) |
PT (1) | PT1075461E (de) |
WO (1) | WO1999057094A2 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1306129B1 (it) | 1999-04-13 | 2001-05-30 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti |
IT1316990B1 (it) * | 2000-02-17 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Metodo per aumentare l'espressione genica per geni trasfettati. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1116037B (it) * | 1979-04-23 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico |
IT1258370B (it) * | 1992-03-02 | 1996-02-26 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono. |
US5846516A (en) * | 1992-06-03 | 1998-12-08 | Alliance Pharmaceutial Corp. | Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications |
FR2694195B1 (fr) * | 1992-07-30 | 1994-09-23 | Sederma Sa | Nouvelles compositions cosmétiques amincissantes. |
-
1998
- 1998-05-06 IT IT98RM000293A patent/IT1299172B1/it active IP Right Grant
-
1999
- 1999-05-04 PT PT99921126T patent/PT1075461E/pt unknown
- 1999-05-04 CA CA2329659A patent/CA2329659C/en not_active Expired - Fee Related
- 1999-05-04 AU AU38465/99A patent/AU3846599A/en not_active Abandoned
- 1999-05-04 WO PCT/IT1999/000117 patent/WO1999057094A2/en active IP Right Grant
- 1999-05-04 JP JP2000547064A patent/JP4366014B2/ja not_active Expired - Fee Related
- 1999-05-04 EP EP99921126A patent/EP1075461B1/de not_active Expired - Lifetime
- 1999-05-04 AT AT99921126T patent/ATE272047T1/de not_active IP Right Cessation
- 1999-05-04 DE DE69918974T patent/DE69918974T2/de not_active Expired - Lifetime
- 1999-05-04 DK DK99921126T patent/DK1075461T3/da active
- 1999-05-04 ES ES99921126T patent/ES2226384T3/es not_active Expired - Lifetime
- 1999-05-04 KR KR1020007012174A patent/KR100573008B1/ko not_active IP Right Cessation
-
2000
- 2000-09-27 US US09/670,620 patent/US6476243B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1075461B1 (de) | 2004-07-28 |
IT1299172B1 (it) | 2000-02-29 |
KR100573008B1 (ko) | 2006-04-24 |
WO1999057094A2 (en) | 1999-11-11 |
AU3846599A (en) | 1999-11-23 |
ITRM980293A1 (it) | 1999-11-06 |
JP4366014B2 (ja) | 2009-11-18 |
ES2226384T3 (es) | 2005-03-16 |
PT1075461E (pt) | 2004-11-30 |
CA2329659C (en) | 2010-07-20 |
US6476243B1 (en) | 2002-11-05 |
ITRM980293A0 (it) | 1998-05-06 |
WO1999057094A3 (en) | 2000-01-27 |
ATE272047T1 (de) | 2004-08-15 |
EP1075461A2 (de) | 2001-02-14 |
KR20010043234A (ko) | 2001-05-25 |
DE69918974D1 (de) | 2004-09-02 |
CA2329659A1 (en) | 1999-11-11 |
DE69918974T2 (de) | 2005-08-11 |
JP2002513779A (ja) | 2002-05-14 |
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