DE60038183D1 - Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe - Google Patents
Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffeInfo
- Publication number
- DE60038183D1 DE60038183D1 DE60038183T DE60038183T DE60038183D1 DE 60038183 D1 DE60038183 D1 DE 60038183D1 DE 60038183 T DE60038183 T DE 60038183T DE 60038183 T DE60038183 T DE 60038183T DE 60038183 D1 DE60038183 D1 DE 60038183D1
- Authority
- DE
- Germany
- Prior art keywords
- delivery
- compositions
- compounds
- active agents
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17121399P | 1999-12-16 | 1999-12-16 | |
US171213P | 1999-12-16 | ||
PCT/US2000/034329 WO2001044199A1 (en) | 1999-12-16 | 2000-12-18 | Compounds and compositions for delivering active agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60038183D1 true DE60038183D1 (de) | 2008-04-10 |
DE60038183T2 DE60038183T2 (de) | 2009-02-19 |
Family
ID=22622945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60038183T Expired - Lifetime DE60038183T2 (de) | 1999-12-16 | 2000-12-18 | Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe |
Country Status (8)
Country | Link |
---|---|
US (2) | US6693208B2 (de) |
EP (1) | EP1237872B1 (de) |
JP (1) | JP4850379B2 (de) |
AT (1) | ATE387430T1 (de) |
AU (1) | AU2274201A (de) |
DE (1) | DE60038183T2 (de) |
ES (1) | ES2298168T3 (de) |
WO (1) | WO2001044199A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US6461643B2 (en) | 1993-04-22 | 2002-10-08 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
IL126318A (en) * | 1996-03-29 | 2004-09-27 | Emisphere Tech Inc | Compounds and compositions for delivering active agents and some novel carrier compounds |
US6991798B1 (en) | 1998-08-07 | 2006-01-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
HUP0103188A2 (hu) * | 1998-08-07 | 2001-12-28 | Emisphere Technologies, Inc. | Vegyületek és készítmények hatóanyagok célbajuttatására |
ES2298168T3 (es) * | 1999-12-16 | 2008-05-16 | Emisphere Technologies, Inc. | Compuestos y composiciones para suministrar agentes activos. |
WO2001051454A1 (en) * | 2000-01-13 | 2001-07-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
SK1182003A3 (en) * | 2000-06-29 | 2003-09-11 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
US6673574B2 (en) * | 2000-11-30 | 2004-01-06 | Unigene Laboratories Inc. | Oral delivery of peptides using enzyme-cleavable membrane translocators |
AU2002245580B2 (en) | 2001-03-01 | 2006-11-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
RU2309945C2 (ru) * | 2001-03-01 | 2007-11-10 | Эмисфере Текнолоджиз, Инк. | Композиции для доставки бисфосфонатов |
JP5196701B2 (ja) * | 2001-11-29 | 2013-05-15 | エミスフィアー テクノロジーズ インコーポレイテッド | クロモリンナトリウムの経口投与用製剤 |
US20050148497A1 (en) | 2002-02-20 | 2005-07-07 | Khan Mohammed A. | Method for administering glp-1 molecules |
US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
US7318925B2 (en) * | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
MXPA06001353A (es) | 2003-08-08 | 2006-05-04 | Abgenix Inc | Anticuerpos dirigidos a hormona paratiroides(pth) y usos de los mismos. |
CA2532026C (en) | 2003-08-20 | 2012-04-17 | Eli Lilly And Company | Compounds, methods and formulations for the oral delivery of a glucagon like peptide (glp)-1 compound or an melanocortin 4 receptor (mc4) agonist peptide |
MXPA06001916A (es) | 2003-08-20 | 2006-05-17 | Lilly Co Eli | Compuestos, metodos y formulaciones para el suministro oral de un compuesto peptidico similar a glucagona (glp)-i o un peptido agonista del receptor de melanocortina 4 (mc4). |
US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
JP2005209106A (ja) * | 2004-01-26 | 2005-08-04 | Nec Corp | 携帯通信端末、受信メール管理方法、プログラムおよび記録媒体 |
RU2006138703A (ru) | 2004-05-06 | 2008-06-20 | Эмисфире Текнолоджис | Твердая лекарственная форма увлажненного гепарина |
MXPA06013252A (es) | 2004-05-14 | 2007-02-28 | Emisphere Tech Inc | Compuestos y composiciones para suministrar agentes activos. |
RU2530889C2 (ru) * | 2004-05-14 | 2014-10-20 | Эмисфире Текнолоджис, Инк. | Соединения и составы для доставки активных веществ |
BRPI0510221A (pt) | 2004-05-14 | 2007-10-23 | Emisphere Tech Inc | composto de aril cetona, composição, forma de dosagem unitária, uso da composição e método para preparar uma composição |
WO2005112937A1 (en) | 2004-05-19 | 2005-12-01 | Emisphere Technologies, Inc. | Acyclovir formulations |
AU2005244986B2 (en) | 2004-05-19 | 2011-01-27 | Emisphere Technologies, Inc. | Topical cromolyn formulations |
US20100048454A1 (en) | 2004-08-03 | 2010-02-25 | Emisphere Technologies, Inc. | Antidiabetic oral insulin-biguanide combination |
EP1799660A2 (de) * | 2004-09-17 | 2007-06-27 | Comentis, Inc. | Aminohaltige verbindungen zur inhibition der aktivität von memapsin-2-beta-sekretase und verfahren zu ihrer verwendung |
EP1797052A1 (de) * | 2004-09-17 | 2007-06-20 | Comentis, Inc. | Bizyklische verbindungen zur verhinderung der aktivität von beta-sekretase und verwendungsverfahren dafür |
AU2005321803B2 (en) | 2004-12-29 | 2012-02-09 | Emisphere Technologies, Inc. | Pharmaceutical formulations of gallium salts |
US8110547B2 (en) | 2005-01-12 | 2012-02-07 | Emisphere Technologies, Inc. | Compositions for buccal delivery of parathyroid hormone |
JP2008535863A (ja) * | 2005-04-08 | 2008-09-04 | コメンティス,インコーポレーテッド | β−セクレターゼ活性を阻害する化合物およびその使用方法 |
WO2007011958A2 (en) | 2005-07-15 | 2007-01-25 | Emisphere Technologies, Inc. | Intraoral dosage forms of glucagon |
US8927015B2 (en) * | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
US8771712B2 (en) | 2006-05-09 | 2014-07-08 | Emisphere Technologies, Inc. | Topical administration of acyclovir |
US9364502B2 (en) * | 2006-06-28 | 2016-06-14 | Emisphere Technologies, Inc. | Gallium nitrate formulations |
CA2662853C (en) * | 2006-08-31 | 2016-07-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
WO2008112706A1 (en) | 2007-03-13 | 2008-09-18 | Nutrition 21, Inc. | Methods and compositions for the sustained release of chromium |
WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
KR20100051668A (ko) * | 2007-07-26 | 2010-05-17 | 코멘티스, 인코포레이티드 | 베타-세크레타제 활성을 억제하는 이소프탈아미드 유도체 |
KR20100059919A (ko) * | 2007-09-24 | 2010-06-04 | 코멘티스, 인코포레이티드 | 치료를 위한 베타-세크레타제 억제제로서 (3-히드록시-4-아미노-부탄-2일)-3-(2-티아졸-2-일-피롤리딘-1-카르보닐) 벤즈아미드 유도체 및 관련 화합물 |
JP5985985B2 (ja) | 2009-08-03 | 2016-09-06 | エミスフィアー テクノロジーズ インコーポレイテッドEmisphere Technologies,Inc. | 胃腸への影響が減少した即効型ナプロキセン組成物 |
US20130150323A1 (en) * | 2010-02-04 | 2013-06-13 | Urigen Pharmaceuticals, Inc | Use of oral heparin preparations to treat urinary tract diseases and conditions |
MX344925B (es) | 2011-03-01 | 2017-01-11 | N21 Acquisition Holding Llc | Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas. |
SG11201501850VA (en) | 2012-09-21 | 2015-04-29 | Intensity Therapeutics Inc | Method of treating cancer |
US11865121B2 (en) | 2016-02-11 | 2024-01-09 | Nutrition21, LLC | Chromium containing compositions for improving health and fitness |
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CN1338924A (zh) * | 1999-01-08 | 2002-03-06 | 艾米斯菲尔技术有限公司 | 聚合物输送剂和输送剂化合物 |
ES2298168T3 (es) * | 1999-12-16 | 2008-05-16 | Emisphere Technologies, Inc. | Compuestos y composiciones para suministrar agentes activos. |
-
2000
- 2000-12-18 ES ES00986516T patent/ES2298168T3/es not_active Expired - Lifetime
- 2000-12-18 US US10/168,275 patent/US6693208B2/en not_active Expired - Lifetime
- 2000-12-18 JP JP2001544689A patent/JP4850379B2/ja not_active Expired - Fee Related
- 2000-12-18 WO PCT/US2000/034329 patent/WO2001044199A1/en active IP Right Grant
- 2000-12-18 AU AU22742/01A patent/AU2274201A/en not_active Abandoned
- 2000-12-18 AT AT00986516T patent/ATE387430T1/de not_active IP Right Cessation
- 2000-12-18 EP EP00986516A patent/EP1237872B1/de not_active Expired - Lifetime
- 2000-12-18 DE DE60038183T patent/DE60038183T2/de not_active Expired - Lifetime
-
2003
- 2003-12-31 US US10/750,138 patent/US20050042274A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20030216589A1 (en) | 2003-11-20 |
US20050042274A1 (en) | 2005-02-24 |
JP2003516971A (ja) | 2003-05-20 |
US6693208B2 (en) | 2004-02-17 |
EP1237872B1 (de) | 2008-02-27 |
JP4850379B2 (ja) | 2012-01-11 |
EP1237872A4 (de) | 2005-06-15 |
AU2274201A (en) | 2001-06-25 |
ES2298168T3 (es) | 2008-05-16 |
ATE387430T1 (de) | 2008-03-15 |
WO2001044199A1 (en) | 2001-06-21 |
DE60038183T2 (de) | 2009-02-19 |
EP1237872A1 (de) | 2002-09-11 |
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