MX344925B - Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas. - Google Patents
Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas.Info
- Publication number
- MX344925B MX344925B MX2013009948A MX2013009948A MX344925B MX 344925 B MX344925 B MX 344925B MX 2013009948 A MX2013009948 A MX 2013009948A MX 2013009948 A MX2013009948 A MX 2013009948A MX 344925 B MX344925 B MX 344925B
- Authority
- MX
- Mexico
- Prior art keywords
- chromium
- insulin
- hypoglycemia
- prevention
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a una composición que comprende cromo e insulina y/o un complejo de cromo-insulina, su método de preparación y su uso en la prevención y tratamiento de hipoglucemia y condiciones relacionadas con hipoglucemia. Esta composición puede ser administrada de numerosas maneras, incluyendo parental, intranasal y oralmente. La composición estabiliza los niveles de glucosa en el suero y tiene efecto sinergista en comparación con cromo e insulina administrados separadamente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161448134P | 2011-03-01 | 2011-03-01 | |
PCT/US2012/027342 WO2012119007A1 (en) | 2011-03-01 | 2012-03-01 | Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013009948A MX2013009948A (es) | 2014-03-27 |
MX344925B true MX344925B (es) | 2017-01-11 |
Family
ID=45841644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013009948A MX344925B (es) | 2011-03-01 | 2012-03-01 | Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas. |
Country Status (11)
Country | Link |
---|---|
US (2) | US8933022B2 (es) |
EP (2) | EP2680861B1 (es) |
JP (1) | JP6152346B2 (es) |
KR (1) | KR101836957B1 (es) |
CN (2) | CN105749253A (es) |
AU (1) | AU2012223282B2 (es) |
CA (1) | CA2828572C (es) |
ES (1) | ES2927800T3 (es) |
IL (1) | IL228209B (es) |
MX (1) | MX344925B (es) |
WO (1) | WO2012119007A1 (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE519780T1 (de) | 2005-12-28 | 2011-08-15 | Novo Nordisk As | Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen |
EP3050568B1 (en) | 2007-03-13 | 2020-12-02 | JDS Therapeutics, LLC | Methods and compositions for the sustained release of chromium |
WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
US20110313680A1 (en) * | 2010-06-22 | 2011-12-22 | Doyle Iii Francis J | Health Monitoring System |
BR112013010345A2 (pt) | 2010-10-27 | 2017-07-25 | Novo Nordisk As | tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção |
WO2012097291A1 (en) | 2011-01-14 | 2012-07-19 | Federal Law Enforcement Development Services, Inc. | Method of providing lumens and tracking of lumen consumption |
ES2927800T3 (es) | 2011-03-01 | 2022-11-11 | Nutrition 21 Llc | Composición de insulina y cromo para el tratamiento y la prevención de diabetes, hipoglicemia y trastornos relacionados |
WO2014147141A1 (en) * | 2013-03-20 | 2014-09-25 | Novo Nordisk A/S | Insulin dosing regimen |
EP2991672A1 (en) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Novel administration regime |
GB2523989B (en) | 2014-01-30 | 2020-07-29 | Insulet Netherlands B V | Therapeutic product delivery system and method of pairing |
AU2016219961B2 (en) | 2015-02-18 | 2020-07-02 | Insulet Corporation | Fluid delivery and infusion devices, and methods of use thereof |
WO2017123525A1 (en) | 2016-01-13 | 2017-07-20 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
AU2017207484B2 (en) | 2016-01-14 | 2021-05-13 | Bigfoot Biomedical, Inc. | Adjusting insulin delivery rates |
GB2564295A (en) | 2016-02-11 | 2019-01-09 | Nutrition 21 Llc | Chromium containing compositions for improving health and fitness |
WO2018052981A1 (en) * | 2016-09-13 | 2018-03-22 | Stc.Unm | Compositions and methods for treating nicotine withdrawal |
US10765807B2 (en) | 2016-09-23 | 2020-09-08 | Insulet Corporation | Fluid delivery device with sensor |
US11033682B2 (en) | 2017-01-13 | 2021-06-15 | Bigfoot Biomedical, Inc. | Insulin delivery methods, systems and devices |
USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
JP7124120B2 (ja) | 2018-05-04 | 2022-08-23 | インスレット コーポレイション | 制御アルゴリズムベースの薬物送達システムのための安全制約 |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
EP3856285A1 (en) | 2018-09-28 | 2021-08-04 | Insulet Corporation | Activity mode for artificial pancreas system |
WO2020077223A1 (en) | 2018-10-11 | 2020-04-16 | Insulet Corporation | Event detection for drug delivery system |
USD920343S1 (en) | 2019-01-09 | 2021-05-25 | Bigfoot Biomedical, Inc. | Display screen or portion thereof with graphical user interface associated with insulin delivery |
US11801344B2 (en) | 2019-09-13 | 2023-10-31 | Insulet Corporation | Blood glucose rate of change modulation of meal and correction insulin bolus quantity |
US11935637B2 (en) | 2019-09-27 | 2024-03-19 | Insulet Corporation | Onboarding and total daily insulin adaptivity |
US11957875B2 (en) | 2019-12-06 | 2024-04-16 | Insulet Corporation | Techniques and devices providing adaptivity and personalization in diabetes treatment |
EP4076413A1 (en) | 2019-12-16 | 2022-10-26 | Nutrition 21, LLC | Methods of production of arginine-silicate complexes |
US11833329B2 (en) | 2019-12-20 | 2023-12-05 | Insulet Corporation | Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns |
US11551802B2 (en) | 2020-02-11 | 2023-01-10 | Insulet Corporation | Early meal detection and calorie intake detection |
US11547800B2 (en) | 2020-02-12 | 2023-01-10 | Insulet Corporation | User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system |
US11986630B2 (en) | 2020-02-12 | 2024-05-21 | Insulet Corporation | Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk |
US11324889B2 (en) | 2020-02-14 | 2022-05-10 | Insulet Corporation | Compensation for missing readings from a glucose monitor in an automated insulin delivery system |
US11607493B2 (en) | 2020-04-06 | 2023-03-21 | Insulet Corporation | Initial total daily insulin setting for user onboarding |
US11684716B2 (en) | 2020-07-31 | 2023-06-27 | Insulet Corporation | Techniques to reduce risk of occlusions in drug delivery systems |
US11904140B2 (en) | 2021-03-10 | 2024-02-20 | Insulet Corporation | Adaptable asymmetric medicament cost component in a control system for medicament delivery |
WO2023049900A1 (en) | 2021-09-27 | 2023-03-30 | Insulet Corporation | Techniques enabling adaptation of parameters in aid systems by user input |
US11439754B1 (en) | 2021-12-01 | 2022-09-13 | Insulet Corporation | Optimizing embedded formulations for drug delivery |
WO2023212165A1 (en) | 2022-04-27 | 2023-11-02 | Afton Chemical Corporation | Additives with high sulfurization for lubricating oil compositions |
Family Cites Families (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK135268A (es) | 1973-02-09 | |||
US4164573A (en) | 1975-06-13 | 1979-08-14 | Galinsky Alvin M | Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal |
DE3065342D1 (en) | 1979-03-19 | 1983-11-24 | Procter & Gamble | Chromium acetylacetonate as a dietary supplement and pharmaceutical agent |
US4421685A (en) | 1980-03-27 | 1983-12-20 | Eli Lilly And Company | Process for producing an insulin |
US4315927A (en) | 1980-08-08 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Dietary supplementation with essential metal picolinates |
USRE33988E (en) | 1980-08-08 | 1992-07-07 | The United States of America as repesented by the Secretary of Agriculture | Dietary supplementation with essential metal picolinates |
FI78616C (fi) | 1982-02-05 | 1989-09-11 | Novo Industri As | Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt. |
US4424057A (en) | 1982-04-01 | 1984-01-03 | House Hugh A | Wet-dry syringe |
US5194615A (en) | 1983-07-08 | 1993-03-16 | The William Seroy Group | Synthetic GTF chromium nicotinate material and its preparation |
US4954492A (en) | 1983-07-08 | 1990-09-04 | The William Seroy Group | Synthetic GTF chromium material for decreasing blood lipid levels and process therefor |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US5731303A (en) | 1985-12-04 | 1998-03-24 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery compositions |
DK179286D0 (da) | 1986-04-18 | 1986-04-18 | Nordisk Gentofte | Insulinpraeparat |
US5175156A (en) | 1987-11-30 | 1992-12-29 | Nutrition 21 | Chromic picolinate treatment |
US5087623A (en) | 1988-05-31 | 1992-02-11 | Nitrition 21 | Chromic picolinate treatment |
US5085996A (en) | 1988-07-29 | 1992-02-04 | Evans Gary W | Microorganism growth acceleration medium containing an effective amount of picolinic acid or metal picolinate to promote growth of the microorganism |
US5057320A (en) | 1988-08-01 | 1991-10-15 | Nutrition 21 | Means and method for increasing skin respiration |
US6140304A (en) | 1988-09-28 | 2000-10-31 | Eicotech Corporation | Method of and nutritional and pharmaceutical compositions for reduction of hyperinsulinemia |
US5087624A (en) | 1989-03-21 | 1992-02-11 | Nutrition 21 | Chromic picolinate treatment |
ATE147592T1 (de) | 1990-02-05 | 1997-02-15 | Lifescience Corp | Vitamine und mineralien enthaltende nahrungszusätze |
US5629020A (en) | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
US6099856A (en) | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
IL99699A (en) | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
US5164384A (en) | 1991-06-19 | 1992-11-17 | Metagenics, Inc. | Anabolic mineral formula |
US5336672A (en) | 1992-07-21 | 1994-08-09 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Increasing egg production in poultry |
SE9203753D0 (sv) | 1992-12-11 | 1992-12-11 | Kabi Pharmacia Ab | Expression system for producing apolipoprotein ai-m |
US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
DE69434418T2 (de) | 1993-04-22 | 2005-12-22 | Emisphere Technologies, Inc. | Orale Dareichungsform |
US5534488A (en) | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
US5496827A (en) | 1994-07-15 | 1996-03-05 | Patrick; Jay | Compositions for the transdermal delivery of nutrients |
US6090958A (en) | 1995-03-31 | 2000-07-18 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
CN1151836C (zh) | 1995-03-31 | 2004-06-02 | 艾米斯菲尔技术有限公司 | 用作传送活性剂的化合物和组合物 |
US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5965121A (en) | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5989539A (en) | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
US6099869A (en) | 1995-04-18 | 2000-08-08 | Nutrition 21 | Calcium taurate and antihypertensive drug for hypertension |
US5776498A (en) | 1995-11-06 | 1998-07-07 | Nutrition 21 | Magnesium taurate as an adjuvant to rapid thrombolytic therapy |
US5582839A (en) | 1995-04-18 | 1996-12-10 | Nutrition 21 | Magnesium taurate and other mineral taurates |
US6329361B1 (en) | 1995-05-12 | 2001-12-11 | Nutrition 21 | High-dose chromic picolinate treatment of type II diabetes |
US5597585A (en) | 1995-12-26 | 1997-01-28 | Williams; Andrew H. | Vitamin/mineral composition |
US5635535A (en) | 1996-04-05 | 1997-06-03 | Wagstaff; Robert K. | Method for increasing blood glucose levels |
US5876710A (en) | 1997-02-07 | 1999-03-02 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US6051561A (en) | 1997-02-07 | 2000-04-18 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US5879681A (en) | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
US5939381A (en) | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5990166A (en) | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5804688A (en) | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5773647A (en) | 1997-02-07 | 1998-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6060513A (en) | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5776888A (en) | 1997-02-07 | 1998-07-07 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5707970A (en) | 1997-02-12 | 1998-01-13 | Nutrition 21 | Arginine silicate complex and use thereof |
US6291495B1 (en) * | 1997-02-24 | 2001-09-18 | Robert B. Rieveley | Method and composition for the treatment of diabetes |
US5863944A (en) | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
DE19722618A1 (de) | 1997-05-30 | 1998-12-03 | Philips Patentverwaltung | Hochtemperaturkondensator |
US5789401A (en) | 1997-08-08 | 1998-08-04 | Nutrition 21 | High-dose chromium/biotin treatment of type II diabetes |
AU751431B2 (en) | 1997-08-08 | 2002-08-15 | Nutrition 21 | Chromium/biotin treatment of type II diabetes |
US5914326A (en) | 1997-08-08 | 1999-06-22 | Ambi Inc. | Method for promoting weight and fat loss |
US6037323A (en) | 1997-09-29 | 2000-03-14 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6004925A (en) | 1997-09-29 | 1999-12-21 | J. L. Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6048846A (en) | 1998-02-26 | 2000-04-11 | Cochran; Timothy M. | Compositions used in human treatment |
US6245027B1 (en) | 1998-04-10 | 2001-06-12 | Noam Alperin | Method of measuring intracranial pressure |
US5948772A (en) | 1998-08-28 | 1999-09-07 | Ambi Inc. | Chromium picolinate compositions and uses thereof |
DE69925276T2 (de) | 1998-07-27 | 2005-10-06 | Emisphere Technologies, Inc. | Stoffe und zusammensetzungen für die verabreichung aktiver substanzen |
DE69931930T2 (de) | 1998-08-07 | 2006-10-05 | Emisphere Technologies, Inc. | Verbindungen und zusammensetzungen zur verabreichung aktiven substanzen |
US5980905A (en) | 1998-08-28 | 1999-11-09 | Ambi Inc. | Chromium polynicotinate compositions and uses thereof |
US6852760B1 (en) | 1998-09-17 | 2005-02-08 | Akesis Pharmaceuticals, Inc. | Compositions and methods for treatment for glucose metabolism disorders |
US6376549B1 (en) * | 1998-09-17 | 2002-04-23 | Akesis Pharmaceuticals, Inc. | Metforimin-containing compositions for the treatment of diabetes |
ES2251976T3 (es) | 1999-02-11 | 2006-05-16 | Emisphere Technologies, Inc. | Compuestos y composiciones de oxadiazol para aportar agentes activos. |
CA2364849A1 (en) | 1999-02-26 | 2000-08-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
AU4216700A (en) | 1999-04-05 | 2000-10-23 | Emisphere Technologies, Inc. | Disodium salts, monohydrates, and ethanol solvates |
US6261606B1 (en) * | 1999-09-14 | 2001-07-17 | Natural Compounds, Ltd. | Naturally extracted and synthetic hypoglycemic or hypolipidemic compositions |
JP2001104702A (ja) | 1999-10-01 | 2001-04-17 | Air Liquide Japan Ltd | ガスの集合回収装置および集合回収方法 |
DE19948361A1 (de) | 1999-10-07 | 2001-04-12 | Bsh Bosch Siemens Hausgeraete | Kältegerät |
US6689383B1 (en) | 1999-10-08 | 2004-02-10 | The United States Of America As Represented By The Secretary Of Agriculture | Chromium-histidine complexes as nutrient supplements |
WO2001032130A2 (en) | 1999-11-05 | 2001-05-10 | Emisphere Technologies, Inc. | Phenyl amine carboxylic acid compounds and compositions for delivering active agents |
AU1594801A (en) | 1999-11-12 | 2001-06-06 | Emisphere Technologies, Inc. | Liquid heparin formulation |
DE19959351A1 (de) | 1999-12-09 | 2001-06-13 | Bilstein Spezialfab Wilhelm | Schneidvorrichtung mit Eigenantrieb für eine Einrichtung zum Längsteilen von durchlaufenden Materialbahnen |
JP4850379B2 (ja) | 1999-12-16 | 2012-01-11 | エミスフェアー・テクノロジーズ・インク | 活性剤を輸送するための化合物及び組成物 |
US7151191B2 (en) | 2000-01-13 | 2006-12-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
DE60133555T2 (de) | 2000-06-29 | 2008-09-18 | Emisphere Technologies, Inc. | Verbindungen und gemische zur verabreichung eines aktiven agens |
US6365176B1 (en) | 2000-08-08 | 2002-04-02 | Functional Foods, Inc. | Nutritional supplement for patients with type 2 diabetes mellitus for lipodystrophy |
CN1313441C (zh) | 2000-09-06 | 2007-05-02 | 艾米斯菲尔技术有限公司 | 用于递送活性剂的氰基苯氧基羧酸化合物及其组合物 |
DE60134245D1 (de) | 2000-09-06 | 2008-07-10 | Emisphere Tech Inc | (5-(2-hydroxy-4-chlorbenzoyl)valeriansäure und deren salze, und zusammensetzungen zur zuführung von wirkstoffen, die diese verbindungen enthalten |
CN1665566A (zh) | 2000-09-21 | 2005-09-07 | 营养21公司 | 用铬络合物、共轭脂肪酸和 /或共轭脂肪醇治疗糖尿病、减少身体脂肪、改善胰岛素敏感性、缓解高血糖症和高胆固醇血症的方法和组合物 |
US20020086065A1 (en) | 2000-10-31 | 2002-07-04 | Katz David P. | Methods and compositions for the benefit of those suffering from polycystic ovary syndrome with chromium complexes |
WO2002036202A2 (en) | 2000-11-02 | 2002-05-10 | Nutrition 21, Inc. | Methods and compositions for the improvement of insulin sensitivity, reduction of hyperglycemia, and reduction of hypercholesterolemia with chromium complexes and alpha lipoic acid |
DE60214849T2 (de) | 2001-02-27 | 2007-04-26 | Nutrition 21, Inc. | Chromium/biotin behandlung von dyslipidämie |
NZ527026A (en) | 2001-03-01 | 2006-01-27 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
JP4354698B2 (ja) | 2001-03-01 | 2009-10-28 | エミスフェアー・テクノロジーズ・インク | ビスホスホネートデリバリー用組成物 |
AU2002357729A1 (en) | 2001-11-16 | 2003-06-10 | Nutrition 21, Inc. | Trans-10, cis-12 conjugated linoleic acid isomer for the treatment of diseases |
US20030198666A1 (en) | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
AU2003226313A1 (en) | 2002-04-23 | 2003-11-10 | Nutrition 21, Inc. | Chromium compositions and methods for using the same for inhibiting drug-induced insulin resistance |
US7063865B2 (en) | 2002-05-10 | 2006-06-20 | Jeremy Park Jones | Composition and method for substantially reducing the deleterious effects of alcohol on the body |
US20040005368A1 (en) | 2002-07-01 | 2004-01-08 | Morris Mann | Novel approach to weight loss comprising a modified protein composition that regulates blood sugar in conjunction with compositions that increase oxygen uptake and suppress appetite |
US7291591B2 (en) | 2003-04-11 | 2007-11-06 | All Natural Fmg, Inc. | Alcohol-free transdermal insulin composition |
WO2004107881A1 (en) | 2003-06-04 | 2004-12-16 | Serfontein, Willem, Jacob | Nutritional compositions and use thereof |
US20050069593A1 (en) | 2003-09-29 | 2005-03-31 | Life Time Fitness, Inc. | Nutritional supplement containing 7-Keto-DHEA and conjugated linoleic acid |
DE602004028284D1 (de) | 2003-12-08 | 2010-09-02 | Cpex Pharmaceuticals Inc | Pharmazeutische zusammensetzungen und verfahren für die insulinbehandlung |
US20060024383A1 (en) | 2004-07-27 | 2006-02-02 | Roger Berlin | Compositions containing policosanol and chromium and/or chromium salts and their pharmaceutical uses |
CA2587601C (en) * | 2004-12-03 | 2017-11-07 | Rhode Island Hospital | Diagnosis and treatment of alzheimer's disease |
EP2120930A4 (en) | 2007-01-31 | 2012-12-05 | Nutrition 21 Inc | USE OF CHROMIHISTIDINATE FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES |
EP3050568B1 (en) | 2007-03-13 | 2020-12-02 | JDS Therapeutics, LLC | Methods and compositions for the sustained release of chromium |
WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
US20100262434A1 (en) | 2007-12-13 | 2010-10-14 | Shaya Steven A | Method and apparatus to calculate diabetic sensitivity factors affecting blood glucose |
EP3513790A1 (en) | 2009-07-01 | 2019-07-24 | JDS Therapeutics, LLC | Chromium complexes as enhancers of brain glucose transporters |
ES2927800T3 (es) | 2011-03-01 | 2022-11-11 | Nutrition 21 Llc | Composición de insulina y cromo para el tratamiento y la prevención de diabetes, hipoglicemia y trastornos relacionados |
-
2012
- 2012-03-01 ES ES12709222T patent/ES2927800T3/es active Active
- 2012-03-01 EP EP12709222.9A patent/EP2680861B1/en active Active
- 2012-03-01 CA CA2828572A patent/CA2828572C/en active Active
- 2012-03-01 AU AU2012223282A patent/AU2012223282B2/en not_active Ceased
- 2012-03-01 CN CN201610172098.8A patent/CN105749253A/zh active Pending
- 2012-03-01 WO PCT/US2012/027342 patent/WO2012119007A1/en active Application Filing
- 2012-03-01 CN CN201280020399.9A patent/CN103702672B/zh not_active Expired - Fee Related
- 2012-03-01 JP JP2013556874A patent/JP6152346B2/ja not_active Expired - Fee Related
- 2012-03-01 MX MX2013009948A patent/MX344925B/es active IP Right Grant
- 2012-03-01 KR KR1020137025794A patent/KR101836957B1/ko active IP Right Grant
- 2012-03-01 US US13/409,960 patent/US8933022B2/en active Active
- 2012-03-01 EP EP22160569.4A patent/EP4070801A1/en not_active Withdrawn
-
2013
- 2013-08-29 IL IL228209A patent/IL228209B/en active IP Right Grant
-
2014
- 2014-12-08 US US14/563,783 patent/US20150094258A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2012223282A1 (en) | 2013-09-19 |
MX2013009948A (es) | 2014-03-27 |
KR101836957B1 (ko) | 2018-03-09 |
CA2828572A1 (en) | 2012-09-07 |
EP2680861A1 (en) | 2014-01-08 |
CA2828572C (en) | 2021-02-23 |
IL228209B (en) | 2020-05-31 |
US20120225134A1 (en) | 2012-09-06 |
EP2680861B1 (en) | 2022-05-04 |
AU2012223282B2 (en) | 2017-02-02 |
US8933022B2 (en) | 2015-01-13 |
CN103702672A (zh) | 2014-04-02 |
JP6152346B2 (ja) | 2017-06-21 |
KR20140023298A (ko) | 2014-02-26 |
CN103702672B (zh) | 2016-04-27 |
WO2012119007A1 (en) | 2012-09-07 |
EP4070801A1 (en) | 2022-10-12 |
CN105749253A (zh) | 2016-07-13 |
US20150094258A1 (en) | 2015-04-02 |
JP2014506932A (ja) | 2014-03-20 |
ES2927800T3 (es) | 2022-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2013009948A (es) | Composiciones de insulina y cromo para el tratamiento y prevencion de diabetes, hipoglucemia y alteraciones relacionadas. | |
PH12015501291A1 (en) | Functionalized exendin-4 derivatives | |
WO2013186240A3 (en) | Exendin-4 peptide analogues | |
PH12015500688A1 (en) | Exendin-4 derivatives as dual glp1/glucagon agonists | |
MY176863A (en) | Ibat inhibitors for treatment of metabolic disorders and related conditions | |
MX2013004699A (es) | Combinaciones farmaceuticas para el tratamiento de trastornos metabolicos. | |
HUE061596T2 (hu) | Szubsztituált dimer kinazolin származék, annak elõállítása és alkalmazása az I. és II. típusú cukorbetegség kezelésére szolgáló gyógyszerkészítményekben | |
EP2621282A4 (en) | GABA AGONISTS FOR THE TREATMENT OF DISEASES RELATED TO THE METABOLIC SYNDROME AND GABA COMBINATIONS FOR THE TREATMENT OR PROPHYLAXIS OF DIABETES TYPE I | |
WO2013158928A3 (en) | Chemosensory receptor ligand-based therapies | |
BR112014000380A2 (pt) | composição farmacêutica, métodos para tratamento e usos dos mesmos | |
MY153062A (en) | Methods of treating gastrointestinal disorders independent of the intake of food | |
WO2012054526A3 (en) | Chemosensory receptor ligand-based therapies | |
PT2691109E (pt) | Prevenção de hipoglicemia em pacientes com diabetes mellitus tipo 2 | |
MX2013011124A (es) | Compuestos para el tratamiento del sindrome metabolico. | |
WO2015003122A3 (en) | Regulation of glucose metabolism using anti-cgrp antibodies | |
WO2014071168A3 (en) | Administering inhibitors of tgfbeta signaling to improve muscle function in cancer patients | |
IN2012DN00549A (es) | ||
MX337139B (es) | Composicion de miel con l-alanil-l-glutamina. | |
WO2014018763A3 (en) | Method of treating type i diabetes using apolipoprotein aiv | |
WO2014014819A3 (en) | Methods of treating glucose metabolism disorders | |
WO2013090319A3 (en) | Treatment of type i and type ii diabetes | |
MX2013009456A (es) | Compuestos de azufre aromaticos sustituidos y metodos para su uso. | |
WO2012091425A3 (ko) | 4-하이드록시 타목시펜 유사체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는, 대사증후군 관련 질환의 예방 또는 치료용 조성물 | |
MX2014001271A (es) | Tratamiento de diabetes de tipo 2 con fty720. | |
EA201490712A1 (ru) | Синергетическая травяная композиция для профилактики и лечения диабетической ретинопатии и катаракты |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |