MX344925B - Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas. - Google Patents

Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas.

Info

Publication number
MX344925B
MX344925B MX2013009948A MX2013009948A MX344925B MX 344925 B MX344925 B MX 344925B MX 2013009948 A MX2013009948 A MX 2013009948A MX 2013009948 A MX2013009948 A MX 2013009948A MX 344925 B MX344925 B MX 344925B
Authority
MX
Mexico
Prior art keywords
chromium
insulin
hypoglycemia
prevention
treatment
Prior art date
Application number
MX2013009948A
Other languages
English (en)
Other versions
MX2013009948A (es
Inventor
James R Komorowski
Original Assignee
N21 Acquisition Holding Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by N21 Acquisition Holding Llc filed Critical N21 Acquisition Holding Llc
Publication of MX2013009948A publication Critical patent/MX2013009948A/es
Publication of MX344925B publication Critical patent/MX344925B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a una composición que comprende cromo e insulina y/o un complejo de cromo-insulina, su método de preparación y su uso en la prevención y tratamiento de hipoglucemia y condiciones relacionadas con hipoglucemia. Esta composición puede ser administrada de numerosas maneras, incluyendo parental, intranasal y oralmente. La composición estabiliza los niveles de glucosa en el suero y tiene efecto sinergista en comparación con cromo e insulina administrados separadamente.
MX2013009948A 2011-03-01 2012-03-01 Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas. MX344925B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161448134P 2011-03-01 2011-03-01
PCT/US2012/027342 WO2012119007A1 (en) 2011-03-01 2012-03-01 Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders

Publications (2)

Publication Number Publication Date
MX2013009948A MX2013009948A (es) 2014-03-27
MX344925B true MX344925B (es) 2017-01-11

Family

ID=45841644

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013009948A MX344925B (es) 2011-03-01 2012-03-01 Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas.

Country Status (11)

Country Link
US (2) US8933022B2 (es)
EP (2) EP2680861B1 (es)
JP (1) JP6152346B2 (es)
KR (1) KR101836957B1 (es)
CN (2) CN105749253A (es)
AU (1) AU2012223282B2 (es)
CA (1) CA2828572C (es)
ES (1) ES2927800T3 (es)
IL (1) IL228209B (es)
MX (1) MX344925B (es)
WO (1) WO2012119007A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE519780T1 (de) 2005-12-28 2011-08-15 Novo Nordisk As Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
EP3050568B1 (en) 2007-03-13 2020-12-02 JDS Therapeutics, LLC Methods and compositions for the sustained release of chromium
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
US20110313680A1 (en) * 2010-06-22 2011-12-22 Doyle Iii Francis J Health Monitoring System
BR112013010345A2 (pt) 2010-10-27 2017-07-25 Novo Nordisk As tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
WO2012097291A1 (en) 2011-01-14 2012-07-19 Federal Law Enforcement Development Services, Inc. Method of providing lumens and tracking of lumen consumption
ES2927800T3 (es) 2011-03-01 2022-11-11 Nutrition 21 Llc Composición de insulina y cromo para el tratamiento y la prevención de diabetes, hipoglicemia y trastornos relacionados
WO2014147141A1 (en) * 2013-03-20 2014-09-25 Novo Nordisk A/S Insulin dosing regimen
EP2991672A1 (en) 2013-04-30 2016-03-09 Novo Nordisk A/S Novel administration regime
GB2523989B (en) 2014-01-30 2020-07-29 Insulet Netherlands B V Therapeutic product delivery system and method of pairing
AU2016219961B2 (en) 2015-02-18 2020-07-02 Insulet Corporation Fluid delivery and infusion devices, and methods of use thereof
WO2017123525A1 (en) 2016-01-13 2017-07-20 Bigfoot Biomedical, Inc. User interface for diabetes management system
AU2017207484B2 (en) 2016-01-14 2021-05-13 Bigfoot Biomedical, Inc. Adjusting insulin delivery rates
GB2564295A (en) 2016-02-11 2019-01-09 Nutrition 21 Llc Chromium containing compositions for improving health and fitness
WO2018052981A1 (en) * 2016-09-13 2018-03-22 Stc.Unm Compositions and methods for treating nicotine withdrawal
US10765807B2 (en) 2016-09-23 2020-09-08 Insulet Corporation Fluid delivery device with sensor
US11033682B2 (en) 2017-01-13 2021-06-15 Bigfoot Biomedical, Inc. Insulin delivery methods, systems and devices
USD928199S1 (en) 2018-04-02 2021-08-17 Bigfoot Biomedical, Inc. Medication delivery device with icons
JP7124120B2 (ja) 2018-05-04 2022-08-23 インスレット コーポレイション 制御アルゴリズムベースの薬物送達システムのための安全制約
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
EP3856285A1 (en) 2018-09-28 2021-08-04 Insulet Corporation Activity mode for artificial pancreas system
WO2020077223A1 (en) 2018-10-11 2020-04-16 Insulet Corporation Event detection for drug delivery system
USD920343S1 (en) 2019-01-09 2021-05-25 Bigfoot Biomedical, Inc. Display screen or portion thereof with graphical user interface associated with insulin delivery
US11801344B2 (en) 2019-09-13 2023-10-31 Insulet Corporation Blood glucose rate of change modulation of meal and correction insulin bolus quantity
US11935637B2 (en) 2019-09-27 2024-03-19 Insulet Corporation Onboarding and total daily insulin adaptivity
US11957875B2 (en) 2019-12-06 2024-04-16 Insulet Corporation Techniques and devices providing adaptivity and personalization in diabetes treatment
EP4076413A1 (en) 2019-12-16 2022-10-26 Nutrition 21, LLC Methods of production of arginine-silicate complexes
US11833329B2 (en) 2019-12-20 2023-12-05 Insulet Corporation Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns
US11551802B2 (en) 2020-02-11 2023-01-10 Insulet Corporation Early meal detection and calorie intake detection
US11547800B2 (en) 2020-02-12 2023-01-10 Insulet Corporation User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system
US11986630B2 (en) 2020-02-12 2024-05-21 Insulet Corporation Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk
US11324889B2 (en) 2020-02-14 2022-05-10 Insulet Corporation Compensation for missing readings from a glucose monitor in an automated insulin delivery system
US11607493B2 (en) 2020-04-06 2023-03-21 Insulet Corporation Initial total daily insulin setting for user onboarding
US11684716B2 (en) 2020-07-31 2023-06-27 Insulet Corporation Techniques to reduce risk of occlusions in drug delivery systems
US11904140B2 (en) 2021-03-10 2024-02-20 Insulet Corporation Adaptable asymmetric medicament cost component in a control system for medicament delivery
WO2023049900A1 (en) 2021-09-27 2023-03-30 Insulet Corporation Techniques enabling adaptation of parameters in aid systems by user input
US11439754B1 (en) 2021-12-01 2022-09-13 Insulet Corporation Optimizing embedded formulations for drug delivery
WO2023212165A1 (en) 2022-04-27 2023-11-02 Afton Chemical Corporation Additives with high sulfurization for lubricating oil compositions

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK135268A (es) 1973-02-09
US4164573A (en) 1975-06-13 1979-08-14 Galinsky Alvin M Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal
DE3065342D1 (en) 1979-03-19 1983-11-24 Procter & Gamble Chromium acetylacetonate as a dietary supplement and pharmaceutical agent
US4421685A (en) 1980-03-27 1983-12-20 Eli Lilly And Company Process for producing an insulin
US4315927A (en) 1980-08-08 1982-02-16 The United States Of America As Represented By The Secretary Of Agriculture Dietary supplementation with essential metal picolinates
USRE33988E (en) 1980-08-08 1992-07-07 The United States of America as repesented by the Secretary of Agriculture Dietary supplementation with essential metal picolinates
FI78616C (fi) 1982-02-05 1989-09-11 Novo Industri As Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
US4424057A (en) 1982-04-01 1984-01-03 House Hugh A Wet-dry syringe
US5194615A (en) 1983-07-08 1993-03-16 The William Seroy Group Synthetic GTF chromium nicotinate material and its preparation
US4954492A (en) 1983-07-08 1990-09-04 The William Seroy Group Synthetic GTF chromium material for decreasing blood lipid levels and process therefor
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5731303A (en) 1985-12-04 1998-03-24 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery compositions
DK179286D0 (da) 1986-04-18 1986-04-18 Nordisk Gentofte Insulinpraeparat
US5175156A (en) 1987-11-30 1992-12-29 Nutrition 21 Chromic picolinate treatment
US5087623A (en) 1988-05-31 1992-02-11 Nitrition 21 Chromic picolinate treatment
US5085996A (en) 1988-07-29 1992-02-04 Evans Gary W Microorganism growth acceleration medium containing an effective amount of picolinic acid or metal picolinate to promote growth of the microorganism
US5057320A (en) 1988-08-01 1991-10-15 Nutrition 21 Means and method for increasing skin respiration
US6140304A (en) 1988-09-28 2000-10-31 Eicotech Corporation Method of and nutritional and pharmaceutical compositions for reduction of hyperinsulinemia
US5087624A (en) 1989-03-21 1992-02-11 Nutrition 21 Chromic picolinate treatment
ATE147592T1 (de) 1990-02-05 1997-02-15 Lifescience Corp Vitamine und mineralien enthaltende nahrungszusätze
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
IL99699A (en) 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
US5164384A (en) 1991-06-19 1992-11-17 Metagenics, Inc. Anabolic mineral formula
US5336672A (en) 1992-07-21 1994-08-09 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Increasing egg production in poultry
SE9203753D0 (sv) 1992-12-11 1992-12-11 Kabi Pharmacia Ab Expression system for producing apolipoprotein ai-m
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
DE69434418T2 (de) 1993-04-22 2005-12-22 Emisphere Technologies, Inc. Orale Dareichungsform
US5534488A (en) 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
US5474978A (en) 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5496827A (en) 1994-07-15 1996-03-05 Patrick; Jay Compositions for the transdermal delivery of nutrients
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
CN1151836C (zh) 1995-03-31 2004-06-02 艾米斯菲尔技术有限公司 用作传送活性剂的化合物和组合物
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US6099869A (en) 1995-04-18 2000-08-08 Nutrition 21 Calcium taurate and antihypertensive drug for hypertension
US5776498A (en) 1995-11-06 1998-07-07 Nutrition 21 Magnesium taurate as an adjuvant to rapid thrombolytic therapy
US5582839A (en) 1995-04-18 1996-12-10 Nutrition 21 Magnesium taurate and other mineral taurates
US6329361B1 (en) 1995-05-12 2001-12-11 Nutrition 21 High-dose chromic picolinate treatment of type II diabetes
US5597585A (en) 1995-12-26 1997-01-28 Williams; Andrew H. Vitamin/mineral composition
US5635535A (en) 1996-04-05 1997-06-03 Wagstaff; Robert K. Method for increasing blood glucose levels
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US6051561A (en) 1997-02-07 2000-04-18 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5773647A (en) 1997-02-07 1998-06-30 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5776888A (en) 1997-02-07 1998-07-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5707970A (en) 1997-02-12 1998-01-13 Nutrition 21 Arginine silicate complex and use thereof
US6291495B1 (en) * 1997-02-24 2001-09-18 Robert B. Rieveley Method and composition for the treatment of diabetes
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
DE19722618A1 (de) 1997-05-30 1998-12-03 Philips Patentverwaltung Hochtemperaturkondensator
US5789401A (en) 1997-08-08 1998-08-04 Nutrition 21 High-dose chromium/biotin treatment of type II diabetes
AU751431B2 (en) 1997-08-08 2002-08-15 Nutrition 21 Chromium/biotin treatment of type II diabetes
US5914326A (en) 1997-08-08 1999-06-22 Ambi Inc. Method for promoting weight and fat loss
US6037323A (en) 1997-09-29 2000-03-14 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6004925A (en) 1997-09-29 1999-12-21 J. L. Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6048846A (en) 1998-02-26 2000-04-11 Cochran; Timothy M. Compositions used in human treatment
US6245027B1 (en) 1998-04-10 2001-06-12 Noam Alperin Method of measuring intracranial pressure
US5948772A (en) 1998-08-28 1999-09-07 Ambi Inc. Chromium picolinate compositions and uses thereof
DE69925276T2 (de) 1998-07-27 2005-10-06 Emisphere Technologies, Inc. Stoffe und zusammensetzungen für die verabreichung aktiver substanzen
DE69931930T2 (de) 1998-08-07 2006-10-05 Emisphere Technologies, Inc. Verbindungen und zusammensetzungen zur verabreichung aktiven substanzen
US5980905A (en) 1998-08-28 1999-11-09 Ambi Inc. Chromium polynicotinate compositions and uses thereof
US6852760B1 (en) 1998-09-17 2005-02-08 Akesis Pharmaceuticals, Inc. Compositions and methods for treatment for glucose metabolism disorders
US6376549B1 (en) * 1998-09-17 2002-04-23 Akesis Pharmaceuticals, Inc. Metforimin-containing compositions for the treatment of diabetes
ES2251976T3 (es) 1999-02-11 2006-05-16 Emisphere Technologies, Inc. Compuestos y composiciones de oxadiazol para aportar agentes activos.
CA2364849A1 (en) 1999-02-26 2000-08-31 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
AU4216700A (en) 1999-04-05 2000-10-23 Emisphere Technologies, Inc. Disodium salts, monohydrates, and ethanol solvates
US6261606B1 (en) * 1999-09-14 2001-07-17 Natural Compounds, Ltd. Naturally extracted and synthetic hypoglycemic or hypolipidemic compositions
JP2001104702A (ja) 1999-10-01 2001-04-17 Air Liquide Japan Ltd ガスの集合回収装置および集合回収方法
DE19948361A1 (de) 1999-10-07 2001-04-12 Bsh Bosch Siemens Hausgeraete Kältegerät
US6689383B1 (en) 1999-10-08 2004-02-10 The United States Of America As Represented By The Secretary Of Agriculture Chromium-histidine complexes as nutrient supplements
WO2001032130A2 (en) 1999-11-05 2001-05-10 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
AU1594801A (en) 1999-11-12 2001-06-06 Emisphere Technologies, Inc. Liquid heparin formulation
DE19959351A1 (de) 1999-12-09 2001-06-13 Bilstein Spezialfab Wilhelm Schneidvorrichtung mit Eigenantrieb für eine Einrichtung zum Längsteilen von durchlaufenden Materialbahnen
JP4850379B2 (ja) 1999-12-16 2012-01-11 エミスフェアー・テクノロジーズ・インク 活性剤を輸送するための化合物及び組成物
US7151191B2 (en) 2000-01-13 2006-12-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
DE60133555T2 (de) 2000-06-29 2008-09-18 Emisphere Technologies, Inc. Verbindungen und gemische zur verabreichung eines aktiven agens
US6365176B1 (en) 2000-08-08 2002-04-02 Functional Foods, Inc. Nutritional supplement for patients with type 2 diabetes mellitus for lipodystrophy
CN1313441C (zh) 2000-09-06 2007-05-02 艾米斯菲尔技术有限公司 用于递送活性剂的氰基苯氧基羧酸化合物及其组合物
DE60134245D1 (de) 2000-09-06 2008-07-10 Emisphere Tech Inc (5-(2-hydroxy-4-chlorbenzoyl)valeriansäure und deren salze, und zusammensetzungen zur zuführung von wirkstoffen, die diese verbindungen enthalten
CN1665566A (zh) 2000-09-21 2005-09-07 营养21公司 用铬络合物、共轭脂肪酸和 /或共轭脂肪醇治疗糖尿病、减少身体脂肪、改善胰岛素敏感性、缓解高血糖症和高胆固醇血症的方法和组合物
US20020086065A1 (en) 2000-10-31 2002-07-04 Katz David P. Methods and compositions for the benefit of those suffering from polycystic ovary syndrome with chromium complexes
WO2002036202A2 (en) 2000-11-02 2002-05-10 Nutrition 21, Inc. Methods and compositions for the improvement of insulin sensitivity, reduction of hyperglycemia, and reduction of hypercholesterolemia with chromium complexes and alpha lipoic acid
DE60214849T2 (de) 2001-02-27 2007-04-26 Nutrition 21, Inc. Chromium/biotin behandlung von dyslipidämie
NZ527026A (en) 2001-03-01 2006-01-27 Emisphere Tech Inc Compounds and compositions for delivering active agents
JP4354698B2 (ja) 2001-03-01 2009-10-28 エミスフェアー・テクノロジーズ・インク ビスホスホネートデリバリー用組成物
AU2002357729A1 (en) 2001-11-16 2003-06-10 Nutrition 21, Inc. Trans-10, cis-12 conjugated linoleic acid isomer for the treatment of diseases
US20030198666A1 (en) 2002-01-07 2003-10-23 Richat Abbas Oral insulin therapy
AU2003226313A1 (en) 2002-04-23 2003-11-10 Nutrition 21, Inc. Chromium compositions and methods for using the same for inhibiting drug-induced insulin resistance
US7063865B2 (en) 2002-05-10 2006-06-20 Jeremy Park Jones Composition and method for substantially reducing the deleterious effects of alcohol on the body
US20040005368A1 (en) 2002-07-01 2004-01-08 Morris Mann Novel approach to weight loss comprising a modified protein composition that regulates blood sugar in conjunction with compositions that increase oxygen uptake and suppress appetite
US7291591B2 (en) 2003-04-11 2007-11-06 All Natural Fmg, Inc. Alcohol-free transdermal insulin composition
WO2004107881A1 (en) 2003-06-04 2004-12-16 Serfontein, Willem, Jacob Nutritional compositions and use thereof
US20050069593A1 (en) 2003-09-29 2005-03-31 Life Time Fitness, Inc. Nutritional supplement containing 7-Keto-DHEA and conjugated linoleic acid
DE602004028284D1 (de) 2003-12-08 2010-09-02 Cpex Pharmaceuticals Inc Pharmazeutische zusammensetzungen und verfahren für die insulinbehandlung
US20060024383A1 (en) 2004-07-27 2006-02-02 Roger Berlin Compositions containing policosanol and chromium and/or chromium salts and their pharmaceutical uses
CA2587601C (en) * 2004-12-03 2017-11-07 Rhode Island Hospital Diagnosis and treatment of alzheimer's disease
EP2120930A4 (en) 2007-01-31 2012-12-05 Nutrition 21 Inc USE OF CHROMIHISTIDINATE FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES
EP3050568B1 (en) 2007-03-13 2020-12-02 JDS Therapeutics, LLC Methods and compositions for the sustained release of chromium
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
US20100262434A1 (en) 2007-12-13 2010-10-14 Shaya Steven A Method and apparatus to calculate diabetic sensitivity factors affecting blood glucose
EP3513790A1 (en) 2009-07-01 2019-07-24 JDS Therapeutics, LLC Chromium complexes as enhancers of brain glucose transporters
ES2927800T3 (es) 2011-03-01 2022-11-11 Nutrition 21 Llc Composición de insulina y cromo para el tratamiento y la prevención de diabetes, hipoglicemia y trastornos relacionados

Also Published As

Publication number Publication date
AU2012223282A1 (en) 2013-09-19
MX2013009948A (es) 2014-03-27
KR101836957B1 (ko) 2018-03-09
CA2828572A1 (en) 2012-09-07
EP2680861A1 (en) 2014-01-08
CA2828572C (en) 2021-02-23
IL228209B (en) 2020-05-31
US20120225134A1 (en) 2012-09-06
EP2680861B1 (en) 2022-05-04
AU2012223282B2 (en) 2017-02-02
US8933022B2 (en) 2015-01-13
CN103702672A (zh) 2014-04-02
JP6152346B2 (ja) 2017-06-21
KR20140023298A (ko) 2014-02-26
CN103702672B (zh) 2016-04-27
WO2012119007A1 (en) 2012-09-07
EP4070801A1 (en) 2022-10-12
CN105749253A (zh) 2016-07-13
US20150094258A1 (en) 2015-04-02
JP2014506932A (ja) 2014-03-20
ES2927800T3 (es) 2022-11-11

Similar Documents

Publication Publication Date Title
MX2013009948A (es) Composiciones de insulina y cromo para el tratamiento y prevencion de diabetes, hipoglucemia y alteraciones relacionadas.
PH12015501291A1 (en) Functionalized exendin-4 derivatives
WO2013186240A3 (en) Exendin-4 peptide analogues
PH12015500688A1 (en) Exendin-4 derivatives as dual glp1/glucagon agonists
MY176863A (en) Ibat inhibitors for treatment of metabolic disorders and related conditions
MX2013004699A (es) Combinaciones farmaceuticas para el tratamiento de trastornos metabolicos.
HUE061596T2 (hu) Szubsztituált dimer kinazolin származék, annak elõállítása és alkalmazása az I. és II. típusú cukorbetegség kezelésére szolgáló gyógyszerkészítményekben
EP2621282A4 (en) GABA AGONISTS FOR THE TREATMENT OF DISEASES RELATED TO THE METABOLIC SYNDROME AND GABA COMBINATIONS FOR THE TREATMENT OR PROPHYLAXIS OF DIABETES TYPE I
WO2013158928A3 (en) Chemosensory receptor ligand-based therapies
BR112014000380A2 (pt) composição farmacêutica, métodos para tratamento e usos dos mesmos
MY153062A (en) Methods of treating gastrointestinal disorders independent of the intake of food
WO2012054526A3 (en) Chemosensory receptor ligand-based therapies
PT2691109E (pt) Prevenção de hipoglicemia em pacientes com diabetes mellitus tipo 2
MX2013011124A (es) Compuestos para el tratamiento del sindrome metabolico.
WO2015003122A3 (en) Regulation of glucose metabolism using anti-cgrp antibodies
WO2014071168A3 (en) Administering inhibitors of tgfbeta signaling to improve muscle function in cancer patients
IN2012DN00549A (es)
MX337139B (es) Composicion de miel con l-alanil-l-glutamina.
WO2014018763A3 (en) Method of treating type i diabetes using apolipoprotein aiv
WO2014014819A3 (en) Methods of treating glucose metabolism disorders
WO2013090319A3 (en) Treatment of type i and type ii diabetes
MX2013009456A (es) Compuestos de azufre aromaticos sustituidos y metodos para su uso.
WO2012091425A3 (ko) 4-하이드록시 타목시펜 유사체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는, 대사증후군 관련 질환의 예방 또는 치료용 조성물
MX2014001271A (es) Tratamiento de diabetes de tipo 2 con fty720.
EA201490712A1 (ru) Синергетическая травяная композиция для профилактики и лечения диабетической ретинопатии и катаракты

Legal Events

Date Code Title Description
FG Grant or registration