CA2390631A1 - Carboxamide-substituted benzimidazole derivatives, processes for preparing them and their use as pharmaceutical compositions - Google Patents
Carboxamide-substituted benzimidazole derivatives, processes for preparing them and their use as pharmaceutical compositions Download PDFInfo
- Publication number
- CA2390631A1 CA2390631A1 CA002390631A CA2390631A CA2390631A1 CA 2390631 A1 CA2390631 A1 CA 2390631A1 CA 002390631 A CA002390631 A CA 002390631A CA 2390631 A CA2390631 A CA 2390631A CA 2390631 A1 CA2390631 A1 CA 2390631A1
- Authority
- CA
- Canada
- Prior art keywords
- carboxamide
- pharmaceutical compositions
- benzimidazole derivatives
- preparing
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
The invention relates to carboxamide-substituted benzimidazole derivatives of general formula (I) (see formula I) wherein the groups R1, R2, R3 and R4 may have the meanings given in the claims and in the specification, processes for preparing them and the use of carboxamide-substituted benzimidazole derivatives as pharmaceutical compositions, particularly as pharmaceutical compositions with a tryptase-inhibiting effect.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19953899.9 | 1999-11-10 | ||
DE19953899A DE19953899A1 (en) | 1999-11-10 | 1999-11-10 | Carboxamide-substituted benzimidazole derivatives, process for their preparation and their use as medicaments |
PCT/EP2000/010996 WO2001034572A2 (en) | 1999-11-10 | 2000-11-08 | Carboxamide-substituted benzimidazol derivatives, method for the production thereof and their use as tryptase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2390631A1 true CA2390631A1 (en) | 2001-05-17 |
CA2390631C CA2390631C (en) | 2009-01-13 |
Family
ID=7928443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002390631A Expired - Fee Related CA2390631C (en) | 1999-11-10 | 2000-11-08 | Carboxamide-substituted benzimidazole derivatives, processes for preparing them and their use as pharmaceutical compositions |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1237877B1 (en) |
JP (1) | JP2003513959A (en) |
AR (1) | AR026423A1 (en) |
AT (1) | ATE300524T1 (en) |
AU (1) | AU2155901A (en) |
CA (1) | CA2390631C (en) |
CO (1) | CO5300519A1 (en) |
DE (2) | DE19953899A1 (en) |
ES (1) | ES2246916T3 (en) |
MX (1) | MXPA02004649A (en) |
WO (1) | WO2001034572A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6656956B2 (en) | 2001-02-08 | 2003-12-02 | Boehringer Ingelheim Pharma Kg | Benzimidazole derivatives, processes for preparing them and their use as pharmaceutical compositions |
DE10105628A1 (en) * | 2001-02-08 | 2002-08-22 | Boehringer Ingelheim Pharma | Benzimidazole derivatives, process for their preparation and their use as medicines |
WO2003024451A1 (en) * | 2001-09-08 | 2003-03-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 2-(2-phenylethyl)-benzimidazole-5-carboxamide derivatives and their use as tryptase inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI20115A (en) * | 1997-04-07 | 2000-06-30 | Axys Pharmaceuticals, Inc. | Compounds and compositions for treating diseases associated with serine protease, particularly tryptase, activity |
JP2002502844A (en) * | 1998-02-03 | 2002-01-29 | ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト | 5-membered heterocyclic fused benzo derivatives, their preparation and their use as pharmaceuticals |
JP2000143635A (en) * | 1998-06-10 | 2000-05-26 | Takeda Chem Ind Ltd | Arterialization inhibitor |
DE19834751A1 (en) * | 1998-08-01 | 2000-02-03 | Boehringer Ingelheim Pharma | Disubstituted bicyclic heterocycles, their preparation and their use as medicines |
JP2000095767A (en) * | 1998-09-28 | 2000-04-04 | Takeda Chem Ind Ltd | Antagonist for gonadotrophic hormone-releasing hormone |
DE19939463A1 (en) * | 1999-08-20 | 2001-02-22 | Boehringer Ingelheim Pharma | Tryptase inhibitors useful e.g. for treating inflammatory or allergic disease, arteriosclerosis or neoplasia, comprising new or known 2-phenethyl-benzimidazole-5-carboxamides |
DE19945810A1 (en) * | 1999-09-24 | 2001-03-29 | Boehringer Ingelheim Pharma | Substituted benzimidazole derivatives, process for their preparation and their use as medicaments |
-
1999
- 1999-11-10 DE DE19953899A patent/DE19953899A1/en not_active Withdrawn
-
2000
- 2000-11-08 MX MXPA02004649A patent/MXPA02004649A/en active IP Right Grant
- 2000-11-08 ES ES00984982T patent/ES2246916T3/en not_active Expired - Lifetime
- 2000-11-08 EP EP00984982A patent/EP1237877B1/en not_active Expired - Lifetime
- 2000-11-08 AT AT00984982T patent/ATE300524T1/en not_active IP Right Cessation
- 2000-11-08 WO PCT/EP2000/010996 patent/WO2001034572A2/en active Search and Examination
- 2000-11-08 JP JP2001536520A patent/JP2003513959A/en active Pending
- 2000-11-08 DE DE50010843T patent/DE50010843D1/en not_active Expired - Lifetime
- 2000-11-08 CA CA002390631A patent/CA2390631C/en not_active Expired - Fee Related
- 2000-11-08 AU AU21559/01A patent/AU2155901A/en not_active Abandoned
- 2000-11-09 CO CO00085305A patent/CO5300519A1/en not_active Application Discontinuation
- 2000-11-10 AR ARP000105931A patent/AR026423A1/en not_active Suspension/Interruption
Also Published As
Publication number | Publication date |
---|---|
ES2246916T3 (en) | 2006-03-01 |
EP1237877B1 (en) | 2005-07-27 |
ATE300524T1 (en) | 2005-08-15 |
AU2155901A (en) | 2001-06-06 |
EP1237877A2 (en) | 2002-09-11 |
CO5300519A1 (en) | 2003-07-31 |
WO2001034572A3 (en) | 2001-10-11 |
AR026423A1 (en) | 2003-02-12 |
JP2003513959A (en) | 2003-04-15 |
DE19953899A1 (en) | 2001-05-17 |
WO2001034572A2 (en) | 2001-05-17 |
CA2390631C (en) | 2009-01-13 |
MXPA02004649A (en) | 2002-10-23 |
DE50010843D1 (en) | 2005-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |