HK1218837A1 - 组合物和方法 - Google Patents

组合物和方法 Download PDF

Info

Publication number
HK1218837A1
HK1218837A1 HK16106858.0A HK16106858A HK1218837A1 HK 1218837 A1 HK1218837 A1 HK 1218837A1 HK 16106858 A HK16106858 A HK 16106858A HK 1218837 A1 HK1218837 A1 HK 1218837A1
Authority
HK
Hong Kong
Prior art keywords
methods
subject
compositions
spore
gastrointestinal tract
Prior art date
Application number
HK16106858.0A
Other languages
English (en)
Chinese (zh)
Inventor
Mckenzie Gregory
Lombardo Mckenzie Mary-Jane
Cook David
Vulic Marin
Von Maltzahn Geoffrey
Goodman Brian
G. Aunins John
R. Henn Matthew
A. Berry David
Winkler Jonathan
Original Assignee
Seres Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seres Therapeutics, Inc. filed Critical Seres Therapeutics, Inc.
Publication of HK1218837A1 publication Critical patent/HK1218837A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/742Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745Bifidobacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK16106858.0A 2013-02-04 2014-02-04 组合物和方法 HK1218837A1 (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201361760584P 2013-02-04 2013-02-04
US201361760585P 2013-02-04 2013-02-04
US201361760606P 2013-02-04 2013-02-04
US201361760574P 2013-02-04 2013-02-04
US201361760584P 2013-02-04
US201361760574P 2013-02-04
US201361760606P 2013-02-04
US201361760585P 2013-02-04
US201461926918P 2014-01-13 2014-01-13
US201461926918P 2014-01-13
PCT/US2014/014745 WO2014121302A2 (en) 2013-02-04 2014-02-04 Compositions and methods

Publications (1)

Publication Number Publication Date
HK1218837A1 true HK1218837A1 (zh) 2017-03-17

Family

ID=51263061

Family Applications (3)

Application Number Title Priority Date Filing Date
HK16106858.0A HK1218837A1 (zh) 2013-02-04 2014-02-04 组合物和方法
HK16106460.0A HK1218559A1 (zh) 2013-02-04 2014-02-04 抑制致病细菌生长的配方和方法
HK16107086.2A HK1219022A1 (zh) 2013-02-04 2014-02-04 填充胃肠道的方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK16106460.0A HK1218559A1 (zh) 2013-02-04 2014-02-04 抑制致病细菌生长的配方和方法
HK16107086.2A HK1219022A1 (zh) 2013-02-04 2014-02-04 填充胃肠道的方法

Country Status (13)

Country Link
US (14) US10064900B2 (enExample)
EP (5) EP2953474A4 (enExample)
JP (6) JP2016509003A (enExample)
KR (3) KR20230110367A (enExample)
CN (2) CN110917220A (enExample)
AU (7) AU2014212003C1 (enExample)
BR (2) BR122021010444B1 (enExample)
CA (2) CA2899925A1 (enExample)
HK (3) HK1218837A1 (enExample)
MX (2) MX369877B (enExample)
NZ (1) NZ711771A (enExample)
RU (1) RU2664479C2 (enExample)
WO (3) WO2014121301A1 (enExample)

Families Citing this family (352)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
US9457077B2 (en) 2009-11-18 2016-10-04 Katherine Rose Kovarik Method and system for targeting the microbiome to promote health and treat allergic and inflammatory diseases
US9585920B2 (en) 2011-02-04 2017-03-07 Katherine Rose Kovarik Method and system for treating cancer cachexia
ES2916399T3 (es) 2010-02-01 2022-06-30 Rebiotix Inc Bacterioterapia para la colitis por Clostridium difficile
WO2011103274A1 (en) * 2010-02-17 2011-08-25 Gen-Probe Incorporated Compositions and methods to detect atopobium vaginae nucleic acid
WO2011151941A1 (ja) 2010-06-04 2011-12-08 国立大学法人東京大学 制御性t細胞の増殖または集積を誘導する作用を有する組成物
KR20130098320A (ko) 2010-08-04 2013-09-04 토마스 줄리어스 보로디 분변 세균총 이식을 위한 조성물, 그의 제조 방법과 사용 방법, 및 그를 전달하기 위한 장치
US10111913B2 (en) 2011-02-04 2018-10-30 Joseph E. Kovarik Method of reducing the likelihood of skin cancer in an individual human being
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US11357722B2 (en) 2011-02-04 2022-06-14 Seed Health, Inc. Method and system for preventing sore throat in humans
US10842834B2 (en) 2016-01-06 2020-11-24 Joseph E. Kovarik Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
US11273187B2 (en) 2015-11-30 2022-03-15 Joseph E. Kovarik Method and system for reducing the likelihood of developing depression in an individual
US9730967B2 (en) 2011-02-04 2017-08-15 Katherine Rose Kovarik Method and system for treating cancer cachexia
US10085938B2 (en) 2011-02-04 2018-10-02 Joseph E. Kovarik Method and system for preventing sore throat in humans
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US10245288B2 (en) 2011-02-04 2019-04-02 Joseph E. Kovarik Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease
US10835560B2 (en) 2013-12-20 2020-11-17 Joseph E. Kovarik Reducing the likelihood of skin cancer in an individual human being
US11191665B2 (en) 2011-02-04 2021-12-07 Joseph E. Kovarik Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US11523934B2 (en) 2011-02-04 2022-12-13 Seed Health, Inc. Method and system to facilitate the growth of desired bacteria in a human's mouth
US10086018B2 (en) 2011-02-04 2018-10-02 Joseph E. Kovarik Method and system for reducing the likelihood of colorectal cancer in a human being
US11419903B2 (en) 2015-11-30 2022-08-23 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US10940169B2 (en) 2015-11-30 2021-03-09 Joseph E. Kovarik Method for reducing the likelihood of developing cancer in an individual human being
US10687975B2 (en) 2011-02-04 2020-06-23 Joseph E. Kovarik Method and system to facilitate the growth of desired bacteria in a human's mouth
US10583033B2 (en) 2011-02-04 2020-03-10 Katherine Rose Kovarik Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US10314865B2 (en) 2011-02-04 2019-06-11 Katherine Rose Kovarik Method and system for treating cancer and other age-related diseases by extending the healthspan of a human
US10010568B2 (en) 2011-02-04 2018-07-03 Katherine Rose Kovarik Method and system for reducing the likelihood of a spirochetes infection in a human being
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US10512661B2 (en) 2011-02-04 2019-12-24 Joseph E. Kovarik Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
US10548761B2 (en) 2011-02-04 2020-02-04 Joseph E. Kovarik Method and system for reducing the likelihood of colorectal cancer in a human being
US9987224B2 (en) 2011-02-04 2018-06-05 Joseph E. Kovarik Method and system for preventing migraine headaches, cluster headaches and dizziness
CN103561752B (zh) 2011-03-09 2016-04-20 明尼苏达大学评议会 用于移植结肠微生物群的组合物和方法
GB201112091D0 (en) 2011-07-14 2011-08-31 Gt Biolog Ltd Bacterial strains isolated from pigs
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
CN104160014A (zh) 2011-12-01 2014-11-19 国立大学法人东京大学 诱导调节性t细胞的增殖或积累的人源细菌
CN104780932A (zh) 2012-02-29 2015-07-15 伊西康内外科公司 微生物区系的组合物及与其相关的方法
EP2825676B1 (en) 2012-03-17 2017-12-20 The Regents of The University of California Fast diagnosis and personalized treatments for acne
WO2013139861A1 (en) 2012-03-20 2013-09-26 Luc Montagnier Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
CA2868362C (en) 2012-03-29 2018-07-31 Jerome Schentag Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix
WO2013176774A1 (en) 2012-05-25 2013-11-28 Arizona Board Of Regents Microbiome markers and therapies for autism spectrum disorders
US20150305329A1 (en) 2012-06-04 2015-10-29 Michael Fefer Formulations Containing Paraffinic Oil and Anti-Settling Agent
CN114949001A (zh) 2012-08-29 2022-08-30 加州理工学院 孤独症谱系障碍的诊断和治疗
NZ709392A (en) 2012-11-23 2016-10-28 Seres Therapeutics Inc Synergistic bacterial compositions and methods of production and use thereof
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
JP2016509003A (ja) * 2013-02-04 2016-03-24 セレス セラピューティクス インコーポレイテッド 組成物および方法
WO2014121304A1 (en) 2013-02-04 2014-08-07 Seres Health, Inc. Compositions and methods
BR112015023124A2 (pt) 2013-03-14 2017-07-18 Therabiome Llc liberação de organismos probióticos e/ou agentes terapêuticos almejada para o trato gastrintestinal
EP2967056B1 (en) 2013-03-15 2018-02-21 Suncor Energy Inc. Herbicidal compositions
AU2014232370B2 (en) 2013-03-15 2018-11-01 Société des Produits Nestlé S.A. Network-based microbial compositions and methods
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
US10383901B2 (en) 2013-06-05 2019-08-20 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
AU2014275025B2 (en) 2013-06-05 2016-12-01 Ferring Microbiome Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9694039B2 (en) 2013-06-05 2017-07-04 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9782445B2 (en) 2013-06-05 2017-10-10 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9511099B2 (en) 2013-06-05 2016-12-06 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9511100B2 (en) 2013-06-05 2016-12-06 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US11274144B2 (en) 2013-06-13 2022-03-15 Research Institute At Nationwide Children's Hospital Compositions and methods for the removal of biofilms
JP6637885B2 (ja) 2013-07-21 2020-01-29 ペンデュラム セラピューティクス, インコーポレイテッド マイクロバイオームの特性解明、モニタリング、および処置のための方法およびシステム
DK3074027T3 (da) 2013-11-25 2025-03-17 Nestle Sa Synergistiske bakteriesammensætninger og fremgangsmåder til fremstilling og anvendelse heraf
WO2015095241A2 (en) 2013-12-16 2015-06-25 Seres Health, Inc. Bacterial compositions and methods of use thereof for treatment of immune system disorders
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11026982B2 (en) 2015-11-30 2021-06-08 Joseph E. Kovarik Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
US12318377B2 (en) 2013-12-20 2025-06-03 Seed Health, Inc. Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US10624934B2 (en) 2014-03-06 2020-04-21 Research Institute At Nationwide Children's Hospital Prebiotic formulations
EP3536168A3 (en) 2014-03-06 2019-10-16 The Research Institute at Nationwide Children's Hospital Probiotic formulations and methods for use
US9783858B2 (en) * 2014-04-02 2017-10-10 Northwestern University Altered microbiome of chronic pelvic pain
US10766799B2 (en) 2014-05-23 2020-09-08 Nch Corporation Method for improving quality of aquaculture pond water using a nutrient germinant composition and spore incubation method
FI127671B (en) 2014-05-28 2018-11-30 Filip Scheperjans Method for diagnostics of Parkinson’s disease
US20160016002A1 (en) * 2014-07-17 2016-01-21 John Todd Kuenstner Treatment of Diseases Using Combination of Ultraviolet Blood Irradiation and Probiotics
DK3174553T3 (en) * 2014-07-25 2018-07-23 Biosynth Srl GLYCOCOONJUGATE VACCINES INCLUDING BASIC UNITS OF A MOLECULE CONSTRUCTION THAT EXPRESSES MULTIPLE INTEGRATED EPITOPES FOR THE FORMULATION OF A WIDE-SPECTED VACCINE AGAINST INFECTIONS BASED ON BACTEROGEN
HUE045008T2 (hu) 2014-08-04 2019-12-30 Basf Se Antifungális Paenibacillus törzsek, fusaricidin-típusú vegyületek és alkalmazásuk
US10900043B2 (en) 2014-09-02 2021-01-26 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating bacterial disease
WO2016036839A1 (en) * 2014-09-02 2016-03-10 The Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating gonorrhea
KR20170052626A (ko) 2014-09-05 2017-05-12 심바이오믹스 세러퓨틱스 엘엘씨 세균질증 치료에 사용하기 위한 세크니다졸
US10046030B2 (en) 2014-10-07 2018-08-14 University Of Virginia Patent Foundation Compositions and methods for preventing and treating infection
US10311973B2 (en) 2014-10-21 2019-06-04 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions
US10793907B2 (en) 2014-10-21 2020-10-06 Psomagen, Inc. Method and system for microbiome-derived diagnostics and therapeutics for endocrine system conditions
US10357157B2 (en) 2014-10-21 2019-07-23 uBiome, Inc. Method and system for microbiome-derived characterization, diagnostics and therapeutics for conditions associated with functional features
US10410749B2 (en) 2014-10-21 2019-09-10 uBiome, Inc. Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions
WO2016065075A1 (en) 2014-10-21 2016-04-28 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics
US9760676B2 (en) 2014-10-21 2017-09-12 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for endocrine system conditions
US10265009B2 (en) 2014-10-21 2019-04-23 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome taxonomic features
US9754080B2 (en) 2014-10-21 2017-09-05 uBiome, Inc. Method and system for microbiome-derived characterization, diagnostics and therapeutics for cardiovascular disease conditions
US10346592B2 (en) 2014-10-21 2019-07-09 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for neurological health issues
US10409955B2 (en) 2014-10-21 2019-09-10 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for locomotor system conditions
US10777320B2 (en) 2014-10-21 2020-09-15 Psomagen, Inc. Method and system for microbiome-derived diagnostics and therapeutics for mental health associated conditions
US10395777B2 (en) 2014-10-21 2019-08-27 uBiome, Inc. Method and system for characterizing microorganism-associated sleep-related conditions
US10169541B2 (en) 2014-10-21 2019-01-01 uBiome, Inc. Method and systems for characterizing skin related conditions
US9710606B2 (en) 2014-10-21 2017-07-18 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for neurological health issues
US9758839B2 (en) 2014-10-21 2017-09-12 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome functional features
US10325685B2 (en) 2014-10-21 2019-06-18 uBiome, Inc. Method and system for characterizing diet-related conditions
US10073952B2 (en) 2014-10-21 2018-09-11 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions
CA2966360C (en) 2014-10-30 2023-09-05 California Institute Of Technology Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders
US10124025B2 (en) 2014-10-30 2018-11-13 California Institute Of Technology Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders
EP4529950A3 (en) 2014-10-31 2025-08-20 Pendulum Therapeutics, Inc. Methods and compositions relating to microbial treatment
MA41020A (fr) * 2014-11-25 2017-10-03 Evelo Biosciences Inc Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome
ES3010296T3 (en) * 2014-11-25 2025-04-02 Memorial Sloan Kettering Cancer Center Intestinal microbiota and gvhd
KR102523805B1 (ko) 2014-12-23 2023-04-20 4디 파마 리서치 리미티드 면역 조정
US9744221B2 (en) 2014-12-23 2017-08-29 Synthetic Biologics, Inc. Method and compositions for inhibiting or preventing adverse effects of oral antibiotics
WO2016103005A1 (en) 2014-12-23 2016-06-30 Institut Pasteur Method of culturing segmented filamentous bacteria in vitro
KR20170091157A (ko) 2014-12-23 2017-08-08 4디 파마 리서치 리미티드 피린 폴리펩티드 및 면역 조정
CA2973894A1 (en) * 2015-02-06 2016-08-11 Western University Of Health Sciences Probiotic compositions and methods of use
US10709773B2 (en) 2015-03-06 2020-07-14 Synthetic Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
JP2018515426A (ja) * 2015-03-12 2018-06-14 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア 細菌組成物およびその使用方法
MA49538A (fr) 2015-03-16 2018-01-24 Ecole Polytechnique Fed Lausanne Epfl Archées dans des aliments pour animaux bioactifs, procédé de fabrication de la composition et procédés utilisant cette composition
WO2016161412A2 (en) * 2015-04-03 2016-10-06 Quest Diagnostics Investments Incorporated Assay for detection of pathogenic leptospira strains
WO2016168352A1 (en) * 2015-04-13 2016-10-20 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome taxonomic features
US10246753B2 (en) 2015-04-13 2019-04-02 uBiome, Inc. Method and system for characterizing mouth-associated conditions
WO2016168350A1 (en) * 2015-04-13 2016-10-20 uBiome, Inc. Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions
CN107708715B (zh) * 2015-04-13 2022-06-03 普梭梅根公司 用于微生物组功能特征相关的状况的微生物组来源的诊断和治疗的方法及系统
AU2016250159A1 (en) * 2015-04-14 2017-11-09 Psomagen, Inc. Method and system for microbiome-derived diagnostics and therapeutics for endocrine system conditions
US12050161B2 (en) 2015-04-24 2024-07-30 Maat Pharma Microorganism sampling method, microorganism sampling device and sampling kit comprising such a sampling device
FR3035317B1 (fr) 2015-04-24 2019-06-14 Maat Pharma Dispositif de prelevement de micro-organismes, kit de prelevement comprenant un tel dispositif et procede de prelevement mettant en œuvre un tel dispositif
FR3035328B1 (fr) 2015-04-24 2019-08-23 Maat Pharma Procede de preparation d'un echantillon de microbiote fecal
KR102561989B1 (ko) * 2015-05-14 2023-07-31 핀치 테라퓨틱스 홀딩스 엘엘씨 대변 균무리 이식용 조성물, 및 이의 제조 및 사용 방법, 및 이의 전달을 위한 장치
KR102358879B1 (ko) 2015-05-22 2022-02-08 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 자폐 스펙트럼 장애 및 관련된 증상을 치료하는 방법
CA2988082C (en) 2015-06-01 2020-09-29 Symbiomix Therapeutics, Llc Novel nitroimidazole formulations and uses thereof
CN105067731B (zh) * 2015-06-05 2017-06-16 中国农业科学院兰州兽医研究所 一种弓形虫感染后血清中生物标记物的筛选方法及筛选出的生物标记物的应用
US10828340B2 (en) 2015-06-09 2020-11-10 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
US10799539B2 (en) 2015-06-09 2020-10-13 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
JP6616431B2 (ja) 2015-06-09 2019-12-04 レビオティクス インコーポレイテッド マイクロバイオータ回復治療(mrt)組成物の製造方法
US10905726B2 (en) 2015-06-09 2021-02-02 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
JP6426264B2 (ja) 2015-06-15 2018-11-21 フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited 細菌株を含む組成物
MA41010B1 (fr) * 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
MA41060B1 (fr) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
PL3240554T3 (pl) * 2015-06-15 2020-02-28 4D Pharma Research Limited Blautia stercosis i wexlerae do stosowania w leczeniu chorób zapalnych i autoimmunologicznych
RS59038B1 (sr) 2015-06-15 2019-08-30 4D Pharma Res Ltd Kompozicije koje sadrže bakterijske sojeve
US10851399B2 (en) 2015-06-25 2020-12-01 Native Microbials, Inc. Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
US10632157B2 (en) 2016-04-15 2020-04-28 Ascus Biosciences, Inc. Microbial compositions and methods of use for improving fowl production
JP6839666B2 (ja) 2015-06-25 2021-03-10 ネイティブ マイクロビアルズ, インコーポレイテッド 複雑な異種群集由来微生物株の解析、機能的な関係及びそれらの相互作用の予測及び同定、ならびにそれに基づく微生物アンサンブルの選択及び合成のための方法、装置、及びシステム
WO2017120495A1 (en) 2016-01-07 2017-07-13 Ascus Biosciences, Inc. Methods for improving milk production by administration of microbial consortia
US9938558B2 (en) 2015-06-25 2018-04-10 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
KR20180025908A (ko) * 2015-07-08 2018-03-09 세레스 테라퓨틱스, 인코포레이티드 대장염의 치료 방법
HK1255383A1 (zh) 2015-07-31 2019-08-16 The Research Institute At Nationwide Children's Hospital 去除生物膜的肽及抗體
JP7088827B2 (ja) * 2015-08-24 2022-06-21 ニューバイヨタ エルエルシー 糞便由来細菌集団を使用する腸内毒素症の治療システム及び方法
US11597979B2 (en) * 2015-09-04 2023-03-07 Memorial Sloan-Kettering Cancer Center Methods and compositions for detecting risk of cancer relapse
CN108348167B (zh) * 2015-09-09 2022-06-03 普梭梅根公司 用于脑-颅面健康相关病症的源自微生物群系的诊断及治疗方法和系统
WO2017053544A1 (en) * 2015-09-22 2017-03-30 Mayo Foundation For Medical Education And Research Methods and materials for using biomarkers which predict susceptibility to clostridium difficile infection
US11191249B2 (en) 2015-09-24 2021-12-07 Agriculture Victoria Services Pty Ltd Brachiaria endophytes and related methods
AU2015410635B2 (en) 2015-09-29 2021-08-19 Kimberly-Clark Worldwide, Inc. Synergistic composition for maintenance of healthy balance of microflora
EP3365027B1 (en) 2015-10-14 2022-03-30 Research Institute at Nationwide Children's Hospital Hu specific antibodies and their use in inhibiting biofilm
EP3370748B1 (en) * 2015-11-03 2022-06-08 The Brigham and Women's Hospital, Inc. Therapeutic microbiota for the treatment and/or prevention of food allergy
CA3005781C (en) 2015-11-20 2019-01-22 4D Pharma Research Limited Compositions comprising bacterial strains
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520638D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520631D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
MX2018006283A (es) * 2015-11-24 2019-09-06 Seres Therapeutics Inc Composiciones bacterianas diseñadas.
US12239706B2 (en) 2015-11-30 2025-03-04 Seed Health, Inc. Method and system for protecting monarch butterflies from pesticides
US11529412B2 (en) 2015-11-30 2022-12-20 Seed Health, Inc. Method and system for protecting honey bees from pesticides
US10933128B2 (en) 2015-11-30 2021-03-02 Joseph E. Kovarik Method and system for protecting honey bees from pesticides
US10675347B2 (en) 2015-11-30 2020-06-09 Joseph E. Kovarik Method and system for protecting honey bees from fipronil pesticides
US10086024B2 (en) 2015-11-30 2018-10-02 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
US10568916B2 (en) 2015-11-30 2020-02-25 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
US11066711B2 (en) * 2015-12-08 2021-07-20 Mayo Foundation For Medical Education And Research Biomarkers for predicting Clostridium difficile infection treatment outcome
FR3045383B1 (fr) 2015-12-18 2019-06-14 Maat Pharma Procede de lyophilisation d'un echantillon de microbiote fecal
CN106974940B (zh) * 2016-01-15 2020-08-25 深圳华大生命科学研究院 厚壁菌类益生菌在治疗和预防肥胖及其相关疾病中的应用
IL243707A0 (en) 2016-01-20 2016-05-01 Galmed Res And Dev Ltd Treatment to regulate the microbiota in the intestine
PT3639834T (pt) * 2016-02-04 2023-10-12 Univ Gent Utilização de comunidades microbianas para a saúde humana e animal
WO2017137834A1 (en) * 2016-02-08 2017-08-17 University Of Oslo Bacterial growth media
EP3205209A1 (en) 2016-02-09 2017-08-16 Basf Se Mixtures and compositions comprising paenibacillus strains or metabolites thereof and other biopesticides
EP3423093A4 (en) 2016-03-04 2019-11-13 The Regents of The University of California MICROBIAL CONSORTIUM AND USES THEREOF
GB201612191D0 (en) 2016-07-13 2016-08-24 4D Pharma Plc Compositions comprising bacterial strains
HK1246670B (en) 2016-03-04 2020-05-15 4D Pharma Plc Compositions comprising bacterial blautia strains for treating visceral hypersensitivity
EP3429604A1 (en) 2016-03-14 2019-01-23 Holobiome, Inc. Modulation of the gut microbiome to treat mental disorders or diseases of the central nervous system
CN119454720A (zh) * 2016-03-24 2025-02-18 帕拉特克Spv2有限责任公司 用于治疗和预防艰难梭菌感染的方法
US10897922B2 (en) 2016-04-05 2021-01-26 Nch Corporation Composition and method for germinative compounds in probiotic food and beverage products for human consumption
PH12018502063B1 (en) * 2016-04-05 2024-02-02 Nch Corp Nutrient rich germinant composition and spore incubation method
US12097226B2 (en) 2016-04-05 2024-09-24 Nch Corporation System and method for using a single-serve nutrient spore composition for small scale farm applications
RU2018140070A (ru) 2016-04-15 2020-05-15 Аскус Байосайенсиз, Инк. Способы улучшения сельскохозяйственного производства птицы путем применения микробных консорциумов или их штаммов
JP2019515918A (ja) * 2016-04-19 2019-06-13 ゲノム・リサーチ・リミテッド 細菌療法
JP2019514885A (ja) 2016-04-21 2019-06-06 ネイキッド バイオーム,インク. 皮膚障害の処置のための組成物および方法
US10252145B2 (en) 2016-05-02 2019-04-09 Bao Tran Smart device
JP7655693B2 (ja) 2016-05-23 2025-04-02 カリフォルニア インスティチュート オブ テクノロジー 神経変性障害を治療するための腸内微生物叢の制御
CN109803534A (zh) * 2016-06-01 2019-05-24 克雷斯顿沃控股公司 用于治疗炎性肠病(ibd)和其他疾病的组合物和方法
US9999641B2 (en) 2016-06-14 2018-06-19 Vedanta Biosciences, Inc. Treatment of clostridium difficile infection
KR102554351B1 (ko) * 2016-06-14 2023-07-13 베단타 바이오사이언시즈, 인크. 클로스트리디움 디피실레 감염의 치료
US20170360848A1 (en) 2016-06-15 2017-12-21 Arizona Board Of Regents On Behalf Of Arizona State University Methods for treating autism spectrum disorder and associated symptoms
WO2017218889A1 (en) * 2016-06-16 2017-12-21 Ohio State Innovation Foundation Eubacterium probiotics and methods of treating or preventing heart disease
US10849936B2 (en) 2016-07-01 2020-12-01 Regents Of The University Of Minnesota Compositions and methods for C. difficile treatment
JP2019521706A (ja) * 2016-07-13 2019-08-08 ユーバイオーム, インコーポレイテッド 微生物ゲノム薬理学のための方法およびシステム
TW201821093A (zh) * 2016-07-13 2018-06-16 英商4D製藥有限公司 包含細菌菌株之組合物
GB201703552D0 (en) * 2017-03-06 2017-04-19 4D Pharma Plc Compositions comprising bacterial strains
GB201703548D0 (en) * 2017-03-06 2017-04-19 4D Pharma Plc Compositions comprising bacterial strains
KR101815692B1 (ko) * 2016-07-25 2018-01-16 주식회사 고바이오랩 구강 세균의 군집을 이용한 대사성 질환 진단용 바이오 마커
US20180036352A1 (en) 2016-08-03 2018-02-08 Crestovo Holdings Llc Methods for treating ulcerative colitis
WO2018031545A1 (en) * 2016-08-11 2018-02-15 The Trustees Of The University Of Pennsylvania Compositions and methods for detecting oral squamous cell carcinomas
WO2018046485A1 (en) 2016-09-09 2018-03-15 Swecure Ab Use of butyricimonas and/or oxalobacter for treating irritable bowel syndrome
WO2018071537A1 (en) 2016-10-11 2018-04-19 Crestovo Holdings Llc Compositions and methods for treating multiple sclerosis and related disorders
WO2018071536A1 (en) 2016-10-11 2018-04-19 Crestovo Holdings Llc Compositions and methods for treating primary sclerosing cholangitis and related disorders
US10092601B2 (en) 2016-10-11 2018-10-09 Crestovo Holdings Llc Compositions and methods for treating multiple sclerosis and related disorders
JP6927512B2 (ja) * 2016-10-26 2021-09-01 地方独立行政法人神奈川県立産業技術総合研究所 物体表面の抗菌性試験用菌液媒体
EP3551201A4 (en) * 2016-12-06 2020-06-24 Pendulum Therapeutics, Inc. METHODS AND COMPOSITIONS ASSOCIATED WITH INSULATED AND PURIFIED MICROBES
GB201621123D0 (en) 2016-12-12 2017-01-25 4D Pharma Plc Compositions comprising bacterial strains
EP3554518A4 (en) 2016-12-15 2020-07-29 The Board of Trustees of the Leland Stanford Junior University COMPOSITIONS AND METHODS FOR MODULATING THE GROWTH OF A GENETICALLY MODIFIED INTESTINAL BACTERIAL CELL
EP3554520A4 (en) * 2016-12-16 2020-09-30 Vedanta Biosciences, Inc. METHODS AND COMPOSITIONS FOR DETERMINING BACTERIAL INTEGRITY
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
AU2017381697B2 (en) 2016-12-23 2020-12-24 Keio University Compositions and methods for the induction of CD8+ T-cells
US12018313B2 (en) 2016-12-28 2024-06-25 Native Microbials, Inc. Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles
JP2020504620A (ja) 2016-12-28 2020-02-13 アスカス バイオサイエンシーズ, インコーポレイテッド 複雑な不均一コミュニティの完全微生物株の解析、その機能的関連性及び相互作用の決定、ならびにそれに基づく生物反応性の改変剤の同定及び合成、のための方法、装置、及びシステム
WO2018129249A1 (en) * 2017-01-05 2018-07-12 The University Of Chicago Inhibition of enteric infection through the modulation of microbiota
CN107058490B (zh) * 2017-01-12 2018-03-06 杨俊杰 肠道及口腔菌群多样性及差异性的分析方法
US10381105B1 (en) 2017-01-24 2019-08-13 Bao Personalized beauty system
US12029748B2 (en) 2017-02-28 2024-07-09 Kimberly-Clark Worldwide, Inc. Synergistic composition for maintenance of healthy balance of microflora
US10052026B1 (en) 2017-03-06 2018-08-21 Bao Tran Smart mirror
EP3606325B1 (en) 2017-04-03 2024-09-04 Gusto Global, LLC Rational design of microbial-based biotherapeutics
US11040073B2 (en) 2017-04-05 2021-06-22 Finch Therapeutics Holdings Llc Compositions and methods for treating diverticulitis and related disorders
EP3606541A1 (en) 2017-04-05 2020-02-12 Crestovo Holdings LLC Compositions and methods for treating parkinson's disease (pd) and related disorders
EP3388069B1 (en) 2017-04-12 2019-05-01 ETH Zurich Consortia of living bacteria useful for treatment of microbiome dysbiosis
CA3057692A1 (en) 2017-04-28 2018-11-01 Ascus Biosciences, Inc. Methods for supporting grain intensive and/or energy intensive diets in ruminants by administration of a synthetic bioensemble of microbes or purified strains thereof
WO2018213204A1 (en) 2017-05-15 2018-11-22 Axial Biotherapeutics, Inc. Inhibitors of microbially induced amyloid
EP3630136B1 (en) 2017-05-22 2021-04-21 4D Pharma Research Limited Compositions comprising bacterial strains
MA41708A (fr) 2017-05-24 2020-04-08 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
EP3630190B1 (en) 2017-05-26 2024-02-21 Finch Therapeutics Holdings LLC Lyophilized compositions comprising fecal microbe-based therapeutic agents and methods for making and using same
EP3600363B1 (en) 2017-06-14 2020-12-02 4D Pharma Research Limited Compositions comprising bacterial strains
WO2018229188A1 (en) 2017-06-14 2018-12-20 4D Pharma Research Limited Compositions comprising bacterial strains
HUE052258T2 (hu) 2017-06-14 2021-04-28 4D Pharma Res Ltd Megasphaera nemzetségbe tartozó baktériumtörzset tartalmazó készítmény, és alkalmazása
WO2018236979A1 (en) * 2017-06-20 2018-12-27 Cornell University Probiotic compositions and methods
CN107854495B (zh) * 2017-08-04 2021-04-13 青岛东海药业有限公司 凝结芽孢杆菌在制备降低血尿酸制剂中的应用
WO2019028402A1 (en) * 2017-08-04 2019-02-07 Second Genome, Inc. ROSEBURIA HOMINIS, EUBACTERIUM ELIGENS AND COMBINATIONS THEREOF AS BIOTHERAPEUTIC AGENTS
EP3662087B1 (en) * 2017-08-06 2022-10-05 Second Genome, Inc. Streptococcus australis as a biotherapeutics
CA3072032A1 (en) 2017-08-07 2019-02-14 Finch Therapeutics, Inc. Compositions and methods for maintaining and restoring a healthy gut barrier
US20200360450A1 (en) * 2017-08-07 2020-11-19 Finch Therapeutics, Inc. Treatment of liver disease by modulation of the microbiome
BR112020002419A2 (pt) 2017-08-14 2020-07-28 Axcella Health Inc. aminoácido para o tratamento de doença do fígado
EP3668527A1 (en) 2017-08-14 2020-06-24 Seres Therapeutics, Inc. Compositions and methods for treating cholestatic disease
TWI640314B (zh) * 2017-08-22 2018-11-11 長庚生物科技股份有限公司 戈氏副擬桿菌用於降低胰島素抗性及提升葡萄糖耐受性之用途
US11241461B2 (en) 2017-08-29 2022-02-08 Evelo Biosciences, Inc. Treating cancer using a blautia strain
EP3675833A1 (en) 2017-08-29 2020-07-08 Chr. Hansen A/S Stable capsules with fecal microbiota or a culture of microorganisms
WO2019046646A1 (en) 2017-08-30 2019-03-07 Whole Biome Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS
EP3453395B1 (en) 2017-09-08 2023-10-18 Deutsches Rheuma-Forschungszentrum Berlin Anaeroplasmatales for use in the treatment or prevention of an inflammatory disorder of the digestive system
JP7369690B2 (ja) 2017-09-08 2023-10-26 エヴェロ バイオサイエンシズ,インコーポレーテッド 細菌の細胞外小胞
CN111132684A (zh) * 2017-09-26 2020-05-08 第二基因组股份有限公司 作为生物治疗药物的血孪生球菌
WO2019079629A1 (en) 2017-10-18 2019-04-25 Ascus Biosciences, Inc. IMPROVING POULTRY PRODUCTION BY ADMINISTERING A SYNTHETIC BIO-ASSEMBLY OF MICROBES OR PURIFIED STEM THEREFOR
EP3703720A1 (en) * 2017-10-30 2020-09-09 Seres Therapeutics, Inc. Compositions and methods for treating antibiotic resistance
FI128395B (en) * 2017-11-09 2020-04-30 Kemira Oyj Method for making a fibrous web
CN107653243B (zh) * 2017-11-15 2021-06-15 中国农业科学院农业基因组研究所 一种从肠道内容物中提取微生物宏基因组dna的方法
JP7460531B2 (ja) 2017-12-05 2024-04-02 バイオピーエルエックス,インコーポレイティド 微生物感染を防ぐための方法および組成物
CN107828705A (zh) * 2017-12-31 2018-03-23 佛山市艳晖生物科技有限公司 一株解淀粉芽孢杆菌及其在防治孤独症上的应用
US20210038663A1 (en) 2018-02-02 2021-02-11 The Chinese University Of Hong Kong Fecal fungome and therapeutic efficacy of fecal microbiota transplantation
US11730772B2 (en) * 2018-02-09 2023-08-22 Noster Inc. Lipopolysaccharide-regulated enteric bacteria and use thereof
CN111886333A (zh) * 2018-02-09 2020-11-03 学校法人庆应义塾 诱导cd8+t细胞的组合物和方法
CN110211629A (zh) * 2018-02-11 2019-09-06 中国科学院昆明动物研究所 一种评估微生物群落宏基因(或普通生物群落宏遗传)多样性和相似性的概念和方法
US11638699B2 (en) 2018-03-20 2023-05-02 Theriva Biologics, Inc. Intestinal alkaline phosphatase formulations
KR20200138333A (ko) * 2018-03-29 2020-12-09 세레스 테라퓨틱스, 인코포레이티드 염증성 장 질환을 치료하는 조성물 및 방법
EP3773645A4 (en) 2018-04-10 2021-11-24 Siolta Therapeutics, Inc. MICROBIAL CONSORTIA
EP3773642A4 (en) 2018-04-13 2022-03-02 White Dog Labs, Inc. IMPROVED METHOD OF SELECTING PROBIOTICS
KR102225939B1 (ko) * 2018-04-19 2021-03-10 주식회사 고바이오랩 신규한 Bacteroides vulgatus 균주 및 이를 유효 성분으로 하는 면역 및 대사성 질환 예방 또는 치료용 조성물
US20210352889A1 (en) * 2018-04-30 2021-11-18 Suncor Energy Inc. Macrocyclic tetrapyrrole compounds, compositions and methods for increasing abiotic stress resistance in plants
CN113151036B (zh) * 2018-05-11 2024-08-23 韩国亿诺生物有限公司 具有预防或治疗癌症的效果的新型菌株
US11986502B2 (en) 2018-05-23 2024-05-21 Optium, LLC Bacteriophage compositions and kits and related methods
EP3796781A4 (en) 2018-05-23 2022-04-20 Brigham Young University BACTERIOPHAGE COMPOSITIONS AND KITS AND METHODS
US20210196766A1 (en) * 2018-05-24 2021-07-01 Seres Therapeutics, Inc. Designed bacterial compositions and uses thereof
US20210121511A1 (en) * 2018-05-29 2021-04-29 Unm Rainforest Innovations Virus-like particle compositions and methods of using same
BR112020024798B1 (pt) * 2018-06-07 2023-05-02 Artugen Therapeutics Ltd Composição compreendendo cepas bacterianas
KR20240091008A (ko) * 2018-06-14 2024-06-21 리바이오틱스, 인코퍼레이티드 미생물총 회복 요법 조성물 및 제조 방법
SG11202012621VA (en) * 2018-06-19 2021-01-28 4D Pharma Res Ltd Dosage form comprising a live biotherapeutic product
EP3810123A1 (en) 2018-06-20 2021-04-28 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
EP3594321A1 (en) * 2018-07-10 2020-01-15 Université catholique de Louvain Dusodibacter, a novel bacterial genus of the gastroinstestinal microbiota and uses thereof
US11166990B2 (en) 2018-07-13 2021-11-09 Finch Therapeutics Holdings Llc Methods and compositions for treating ulcerative colitis
WO2020018949A2 (en) 2018-07-19 2020-01-23 Pendulum Therapeutics, Inc. Methods and compositions for microbial engraftment
WO2020033130A1 (en) 2018-08-06 2020-02-13 The Johns Hopkins University Treatment of irritable bowel syndrome with molybdenum
IL280779B2 (en) 2018-08-17 2025-05-01 Vedanta Biosciences Inc Compositions for use in the treatment or prevention of Clostridium difficile infection
US12150967B2 (en) 2018-08-18 2024-11-26 Seed Health, Inc. Methods and compositions for honey bee health
WO2020041581A1 (en) * 2018-08-23 2020-02-27 Cornell University Methods and compositions for preventing and treating inflammatory bowel disease and nonalcoholic fatty liver disease
US11401500B2 (en) 2018-08-29 2022-08-02 Nch Corporation System, method, and composition for incubating spores for use in aquaculture, agriculture, wastewater, and environmental remediation applications
EP3870691A4 (en) 2018-09-13 2022-09-07 Xbiome Inc. METHODS AND COMPOSITIONS FOR TREATING GASTROINTESTINAL AND INFLAMMATORY DISORDERS
KR20210065969A (ko) 2018-09-27 2021-06-04 핀치 테라퓨틱스 홀딩스 엘엘씨 간질 및 관련 장애를 치료하기 위한 조성물 및 방법
CN109234195A (zh) * 2018-09-28 2019-01-18 邓州市汇海农业科技有限公司 一种稻田微生物复合菌剂
KR102135195B1 (ko) * 2018-10-08 2020-07-17 아주대학교산학협력단 테트라제노코커스 할로필러스를 포함하는 베체트병 또는 헤르페스 바이러스 감염증의 예방 또는 치료용 조성물
EP3863653A1 (en) * 2018-10-09 2021-08-18 4D Pharma Research Limited Compositions comprising bacterial strains
US20210355431A1 (en) * 2018-10-15 2021-11-18 Pharmabiome Ag Method of manufacturing a consortium of bacterial strains
US20220096566A1 (en) * 2018-11-09 2022-03-31 The Brigham And Women's Hospital, Inc. Therapeutic microbiota for the treatment and/or prevention of dysbiosis
BR112021011221A2 (pt) 2018-12-10 2021-08-31 Novome Biotechnologies, Inc. Métodos e composições para tratar hiperoxalúria
WO2020139852A1 (en) * 2018-12-28 2020-07-02 General Probiotics, Inc. Combinations of engineered antimicrobial probiotics for treatment of gastrointestinal tract pathogens
EP3923729B1 (en) 2019-02-15 2025-08-13 Nutrien Ag Solutions (Canada) Inc. The use of protoporphyrin ix derivatives to improve the health of plants
WO2020166708A1 (ja) * 2019-02-15 2020-08-20 コンビ株式会社 新規乳酸菌およびそれを含有する組成物
CN110195027B (zh) * 2019-03-08 2022-03-01 大连理工大学 烟草节杆菌zl-1及其堆肥低温发酵菌剂的制备方法与应用
EP3946608A4 (en) * 2019-03-25 2022-12-28 The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Institute) Method of treating bovine mastitis
US20220193151A1 (en) * 2019-03-26 2022-06-23 The Children's Medical Center Corporation Therapeutic microbiota for the treatment and/or prevention of dysbiosis
CN114072160A (zh) * 2019-05-10 2022-02-18 4D制药研究有限公司 包含细菌菌株的组合物
CA3141664A1 (en) * 2019-05-23 2020-11-26 American Molecular Laboratories, Inc. Methods for detecting a level of h. pylori in a fecal sample
US20220233612A1 (en) * 2019-05-31 2022-07-28 South Dakota Board Of Regents Technology Transfer Office Probiotics to inhibit enteric pathogens
CA3142272A1 (en) 2019-06-03 2020-12-10 Research Institute At Nationwide Children's Hospital Prebiotic formulations for prevention of sepsis and necroenterocolitis induced neurodevelopmental deficiencies
WO2021011887A1 (en) * 2019-07-17 2021-01-21 University Of Utah Research Foundation Clostridia consortia compositions and methods of treating obesity, metabolic syndrome and irritable bowel disease
PE20221399A1 (es) 2019-07-19 2022-09-15 Finch Therapeutics Holdings Llc Metodos y productos para el tratamiento de trastornos gastrointestinales
US20220287995A1 (en) * 2019-07-30 2022-09-15 The Regents Of The University Of California Compositions and methods for inhibiting bacterial virulence and flim-based device and method for antibiotic susceptibility testing
CN110358849A (zh) * 2019-07-30 2019-10-22 中国医学科学院北京协和医院 源于肠道的诊断胰腺炎的生物标志物、筛选方法及其用途
CN112438995A (zh) 2019-09-04 2021-03-05 台达电子工业股份有限公司 抑制具万古霉素抗药性肠球菌的益生菌及其组合与其用途
EP4028558A4 (en) * 2019-09-12 2024-01-03 MarvelBiome, Inc. Compositions and methods for characterizing a microbiome
US12364721B2 (en) 2019-09-24 2025-07-22 Prolacta Bioscience, Inc. Compositions and methods for treatment of inflammatory and immune diseases
WO2021071864A1 (en) 2019-10-07 2021-04-15 Siolta Therapeutics, Inc. Therapeutic pharmaceutical compositions
US20220378851A1 (en) * 2019-11-04 2022-12-01 Vedanta Biosciences, Inc. Compositions and methods for enhancing immune checkpoint inhibitor therapy
AU2020394211A1 (en) * 2019-11-27 2022-07-14 Seres Therapeutics, Inc. Designed bacterial compositions and uses thereof
KR102215592B1 (ko) * 2019-12-11 2021-02-15 주식회사 에이치이엠 신규한 락토바실러스 퍼멘텀 hem 1036 균주, 및 상기 균주 또는 이의 배양물을 포함하는 장내 환경 개선용 조성물
AU2020408410B2 (en) 2019-12-16 2024-03-14 Colgate-Palmolive Company Oral care compositions containing inulin
EP3838276A1 (en) * 2019-12-17 2021-06-23 Exeliom Biosciences Association of faecalibacterium prausnitzii strain cncm i-4573 with pentasa® for the treatment and prevention of gastrointestinal inflammation
TWI854077B (zh) * 2019-12-20 2024-09-01 瑞士商葛德瑪控股公司 生產肉毒桿菌毒素的方法
BR112022014917A2 (pt) 2020-01-27 2023-02-14 General Probiotics Inc Composições incluindo bactérias probióticas para a expressão e secreção de enterocinas para controlar a enterite necrótica induzida por clostridia perfringens em animais de pecuária e métodos relacionados
US11576937B2 (en) 2020-02-06 2023-02-14 Nch Corporation Method of reducing gut inflammation reduction in humans by consuming a heated probiotic composition
JP2023513702A (ja) 2020-02-10 2023-04-03 ネイティブ マイクロビアルズ, インコーポレイテッド イヌの腸疾患およびディスバイオシスのための微生物組成物および使用方法
AU2021224185A1 (en) * 2020-02-18 2022-09-15 Memorial Sloan-Kettering Cancer Center Methods and compositions for identifying and treating subjects at risk of poor cancer survival
JPWO2021167088A1 (enExample) * 2020-02-21 2021-08-26
EP4110269A4 (en) * 2020-02-28 2024-01-17 Emory University PENTAGALLOYL GLUCOSE DERIVED FROM SCHINUS PLANTS AND METHODS OF USE
TW202146036A (zh) * 2020-04-28 2021-12-16 香港中文大學 針對covid-19的微生物的治療和診斷用途
WO2021221110A1 (ja) * 2020-04-29 2021-11-04 学校法人慶應義塾 Th1細胞及び/又はTh17細胞の増殖又は活性化を誘導する小腸内細菌
GB202007452D0 (en) * 2020-05-19 2020-07-01 Microbiotica Ltd Threrapeutic bacterial composition
WO2021252632A2 (en) * 2020-06-09 2021-12-16 Flagship Pioneering, Inc. Physiologically acceptable compositions containing microorganisms or microbial products
NL2025863B1 (en) 2020-06-19 2022-02-17 Acad Medisch Ct Fecal matter for treatment of cachexia
WO2022027040A2 (en) * 2020-07-28 2022-02-03 Icahn School Of Medicine At Mount Sinai Compositions and methods for treating infections of the gastrointestinal tract
WO2022036225A1 (en) 2020-08-14 2022-02-17 Prolacta Bioscience, Inc. Human milk oligosaccharide compositions for use with bacteriotherapies
CN112040091B (zh) 2020-09-01 2023-07-21 先临三维科技股份有限公司 相机增益的调整方法和装置、扫描系统
CN116847859A (zh) * 2020-09-11 2023-10-03 奇迹生物公司 微生物组组合物的方法和用途
US12280037B2 (en) 2020-09-22 2025-04-22 Evofem Biosciences, Inc. Method and pharmaceutical composition for treating or preventing trichomoniasis and uses thereof
KR102470808B1 (ko) * 2020-11-02 2022-11-28 주식회사 바이오미 염증성 장질환 예방 또는 치료용 조성물
JP2023550652A (ja) * 2020-11-25 2023-12-04 セレス セラピューティクス インコーポレイテッド 移植片対宿主病を処置するための設計された細菌組成物
EP4288559B1 (en) * 2021-02-03 2025-11-26 Tata Consultancy Services Limited Method and system for designing personalized therapeutics and diet based on functions of microbiome
CN114948986A (zh) * 2021-02-19 2022-08-30 星聚樊生物科技有限公司 中草药多醣及其细菌组成物改善疾病的用途
KR102373886B1 (ko) 2021-03-26 2022-03-15 주식회사 에이치이엠파마 머신러닝 모델을 이용하여 장염 유무를 판별하는 방법 및 진단 장치
KR102373888B1 (ko) 2021-03-26 2022-03-15 주식회사 에이치이엠파마 머신러닝 모델을 이용하여 변비 유무를 판별하는 방법 및 진단장치
CN113106042A (zh) * 2021-05-20 2021-07-13 广西壮族自治区兽医研究所 预防鸽形目念珠菌病的微生物菌剂、制剂及其制备方法和应用
NL2028324B1 (en) 2021-05-28 2022-12-12 Caelus Pharmaceuticals B V Insulin-sensitizing agent and butyrate-producing bacterium
WO2023006940A1 (en) * 2021-07-30 2023-02-02 Oncomedics Compositions and methods for decontaminating and culturing a gastrointestinal tract sample
KR102583365B1 (ko) * 2021-08-11 2023-09-27 코스맥스 주식회사 마이크로코커스 안타르크티쿠스 균주 및 그의 피부 상태 개선 용도
CA3237750A1 (en) * 2021-11-11 2023-05-19 Concerto Biosciences, Inc. Microbial compositions for the treatment of skin diseases
CN116135205A (zh) * 2021-11-16 2023-05-19 葡萄王生技股份有限公司 戊醣片球菌gkp4用于制备改善肌少症之口服组成物的用途
EP4183403A1 (en) * 2021-11-19 2023-05-24 Lietuvos Sveikatos Mokslu Universitetas Modification of fecal microbiota with capsules containing gram-positive bacteria
WO2023132628A1 (ko) * 2022-01-04 2023-07-13 주식회사 바이오뱅크힐링 신규 균주, 및 그의 유래의 소포체 및 그의 항염증 및 항균 용도
KR102438867B1 (ko) * 2022-03-11 2022-09-02 주식회사 바이오뱅크힐링 코프로코커스 캐터스 균주, 및 그의 유래의 소포체 및 그의 항염증 및 항균 용도
CN114317368B (zh) * 2022-01-05 2022-09-09 中国水产科学研究院南海水产研究所 一种利用盐渍四生球菌改善快速发酵鱼露风味的方法
JP2025505760A (ja) * 2022-02-23 2025-02-28 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 腸内微生物叢におけるブラウチア・オベウムを増加/増強させることによって下痢の発生を低減するための組成物及び方法
WO2023212492A2 (en) * 2022-04-26 2023-11-02 Cedars-Sinai Medical Center Methanogens and prevotella as microbial convener for the treatment of diseases and diagnosis thereof
CN114965764B (zh) * 2022-05-18 2024-12-31 陕西安宁云生生物技术有限公司 便秘的诊断和治疗
CN115466690A (zh) * 2022-05-19 2022-12-13 同济大学 一种地芽孢杆菌新菌种及其培养方法和应用
US12064451B2 (en) * 2022-08-01 2024-08-20 Novel Biome Solutions Inc. Fecal microbiota transplant compositions and methods of manufacture
CN116790402B (zh) * 2023-01-14 2024-05-14 西北农林科技大学 一株具有抗炎特性的单形拟杆菌菌株、培养方法及应用
WO2025064408A1 (en) 2023-09-18 2025-03-27 The Broad Institute, Inc. Compositions and methods for treating cardiovascular disease
WO2025093777A1 (en) 2023-11-05 2025-05-08 Human Biome Institute S.A. Functional compositions and methods of use thereof in the treatment and recurrence prophylaxis of clostridioides difficile infection and restoration of healthy microbiota
WO2025147266A1 (en) * 2024-01-06 2025-07-10 Jose Vega Method of mitigation of death from epileptic seizures
CN118360215B (zh) * 2024-05-22 2025-03-07 吉林省农业科学院(中国农业科技东北创新中心) 一种用于降低反刍动物甲烷排放量的菌剂及其制备方法以及含有该菌剂的配合饲料

Family Cites Families (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3009864A (en) 1958-09-18 1961-11-21 Union Carbide Corp Process control
US3228838A (en) 1959-04-23 1966-01-11 Union Carbide Corp Preservation of biological substances
US3009861A (en) * 1961-01-13 1961-11-21 Alderton Gordon Isolation of bacterial spores
US3608030A (en) 1969-05-21 1971-09-21 Howard Tint Method of preparing a tablet dosage-form for the immunization of the intestinal tract with live virus preparations
US3892842A (en) * 1971-09-01 1975-07-01 Alza Corp Intrauterine contraceptive device for releasing steroid having double bond functionality
DE2414156A1 (de) * 1974-03-23 1975-09-25 Kleist Johann Georg Dr Arzneimittel zur beseitigung uraemischer symptome und verfahren zu seiner herstellung
US4077227A (en) 1976-11-12 1978-03-07 Regents Of The University Of Minnesota Method of freezing liquid material in which agglomeration is inhibited
US4205132A (en) 1978-07-17 1980-05-27 Microlife Technics, Inc. Lyophilization of bacteria
FI59925C (fi) 1980-01-11 1981-11-10 Esko Viljo Nurmi Foerfarande foer framstaellning av ett bakteriepreparat anvaendbart foer foerhindrande av salmonellainfektion hos fjaederfae
US4780987A (en) * 1983-10-25 1988-11-01 Plant Genetics, Inc. Method for the preparation of hydrated, pregerminated seeds in gel capsules
US4655047A (en) 1985-03-25 1987-04-07 I.Q.F. Inc. Process for freezing or chilling
JPS61252212A (ja) 1985-04-12 1986-11-10 Mitsubishi Petrochem Co Ltd 高吸水性ポリマ−の製造方法
US4839281A (en) 1985-04-17 1989-06-13 New England Medical Center Hospitals, Inc. Lactobacillus strains and methods of selection
JP2733849B2 (ja) 1987-10-12 1998-03-30 ボロディー,ソーマス・ユリウス 胃腸障害治療のための改良された方法
US5045446A (en) 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
CA1333564C (en) 1988-08-02 1994-12-20 Thomas Julius Borody Treatment of gastro-intestinal disorders
US5443826A (en) 1988-08-02 1995-08-22 Borody; Thomas J. Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli
GB2233343B (en) 1989-06-30 1993-07-07 Farmos Oy A bacterial preparation for use in poultry
JP2961182B2 (ja) * 1990-03-09 1999-10-12 ミヤリサン株式会社 クロストリジウム・ディフィシル下痢症および偽膜性大腸炎の予防ならびに治療用医薬組成物
JP2961184B2 (ja) 1990-05-07 1999-10-12 ミヤリサン株式会社 クロストリジウム・ディフィシル下痢症および偽膜性大腸炎の予防ならびに治療用医薬組成物
US5436002A (en) 1991-01-29 1995-07-25 Mycogen Corporation Bacillus thuringiensisisolate PS201T6 toxin
RU2035186C1 (ru) 1992-07-09 1995-05-20 Семен Рафаилович Резник Профилактический биопрепарат споролакт
ES2157225T3 (es) 1992-10-09 2001-08-16 Advanced Tissue Sciences Inc Celulas hepaticas de reserva.
US5599795A (en) 1994-08-19 1997-02-04 Mccann; Michael Method for treatment of idiopathic inflammatory bowel disease (IIBD)
WO1997008598A1 (de) 1995-08-25 1997-03-06 Gff Technopark Verfahren zur simultanen, digitalen phasenempfindlichen detektion von zeitaufgelösten, quasi-gleichzeitig erfassten datenarrays eines periodisch stimulierten systems
US5851545A (en) * 1995-08-25 1998-12-22 Sandoz Ltd. Insecticidal matrix and process for preparation thereof
ES2248822T3 (es) 1995-09-15 2006-03-16 Dale N. Gerding Procedimientos y composiciones para la prevencion y el tratamiento de enfermedades asociadas al clostridium difficile.
AUPO430496A0 (en) 1996-12-19 1997-01-23 Arnott's Biscuits Limited Prebiotics and probiotics
US6024370A (en) 1997-07-03 2000-02-15 Rockshox, Inc. Damping cartridge for high performance suspension systems
US5965128A (en) 1997-08-13 1999-10-12 University Of Georgia Research Foundation Inc. Control of enterohemorrhagic E. coli 0157:H7 in cattle by probiotic bacteria and specific strains of E. coli
US5951977A (en) 1997-10-14 1999-09-14 The United States Of America, As Represented By The Secretary Of Agriculture Competitive exclusion culture for swine
US6461607B1 (en) 1998-08-24 2002-10-08 Ganeden Biotech, Inc. Probiotic, lactic acid-producing bacteria and uses thereof
US6589771B1 (en) 1999-10-28 2003-07-08 Immunom Technologies, Inc. Methods for arousing dormant bacteria
US20030118547A1 (en) 2000-01-27 2003-06-26 Vandenberg Grant William Composition for intestinal delivery
US6613549B2 (en) 2000-02-10 2003-09-02 Urex Biotech, Inc. Probiotic therapy for newborns
US20020013270A1 (en) 2000-06-05 2002-01-31 Bolte Ellen R. Method for treating a mental disorder
US20040170617A1 (en) 2000-06-05 2004-09-02 Finegold Sydney M. Method of treating diseases associated with abnormal gastrointestinal flora
AUPQ899700A0 (en) * 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
WO2002024172A1 (en) * 2000-09-22 2002-03-28 Galephar M/F Pharmaceutical semi-solid composition of isotretinoin
EP1343370A4 (en) 2000-11-30 2004-02-11 Bio Balance Corp BACTERIAL STEM, PROCESSED PLANT EXTRACTS, THE COMPOSITIONS CONTAINING THEM, PROCESS FOR THEIR PRODUCTION AND THEIR APPLICATION IN THERAPY AND INDUSTRY
KR100437497B1 (ko) * 2001-03-07 2004-06-25 주식회사 프로바이오닉 로타바이러스 및 유해 미생물 억제 활성을 가지는 신규내산성 락토바실러스 루테리 프로바이오-16 및 이를함유하는 생균활성제
EP1527164A4 (en) 2001-05-04 2006-02-01 Univ Florida CLONING AND SEQUENCING OF PYRUVATE CARBOXYLASE (PDC) GENES FROM BACTERIA AND USES THEREOF
ITMI20011632A1 (it) 2001-07-27 2003-01-27 Sanofi Synthelabo Composizione solida contenente spore di batteri non patogeni del genere bacillus
GB0130789D0 (en) 2001-12-21 2002-02-06 King S College London Application of spores
US8383342B2 (en) 2002-04-24 2013-02-26 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
GB0212975D0 (en) 2002-06-06 2002-07-17 Mars Uk Ltd Mammalian animal composition
AU2002951692A0 (en) 2002-09-23 2002-10-17 Vital Biotech (Hong Kong) Limited Improvements in or relating to vaccines
AU2003303894A1 (en) 2003-01-30 2004-08-30 The Regents Of The University Of California Inactivated probiotic bacteria and methods of use thereof
CA2559596A1 (en) 2003-03-13 2004-11-25 Universite De Moncton (Bureau De Soutien A L'innovation) Antioxidant producing bacterium and uses thereof
MXPA05011409A (es) 2003-04-23 2005-12-12 Medarex Inc Composiciones y metodos para la terapia de enfermedad inflamatoria intestinal.
US20060046246A1 (en) 2003-04-24 2006-03-02 Qiandong Zeng Genus, group, species and/or strain specific 16S rDNA sequences
US7261861B2 (en) 2003-04-24 2007-08-28 Haemoscope Corporation Hemostasis analyzer and method
WO2004104175A2 (en) 2003-05-14 2004-12-02 University Of Georgia Research Foundation, Inc. Probiotic bacteria and methods
EP1656025A4 (en) 2003-08-18 2007-12-05 Bio Balance Corp STABLE LIQUID PROBIOTIC COMPOSITION, PREPARATION AND CORRESPONDING APPLICATIONS
US7731976B2 (en) 2003-08-29 2010-06-08 Cobb And Company, Llp Treatment of irritable bowel syndrome using probiotic composition
US20050048515A1 (en) 2003-08-29 2005-03-03 Garner Bryan E. Methods for detecting and quantifying specific probiotic microorganisms in animal feed
US20050239706A1 (en) 2003-10-31 2005-10-27 Washington University In St. Louis Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject
US20050158294A1 (en) 2003-12-19 2005-07-21 The Procter & Gamble Company Canine probiotic Bifidobacteria pseudolongum
DK1715755T3 (en) 2004-02-03 2015-03-09 Prevtec Microbia Inc Use of live bacteria to promote growth in animals
US7632520B2 (en) 2004-02-16 2009-12-15 Sanjeev Khandelwal Synergistic antibacterial formulation and to a method of making the same
US7854927B2 (en) * 2004-05-11 2010-12-21 Ganeden Biotech, Inc. Methods and compositions for the dietary management of autoimmune disorders
PL1812585T3 (pl) 2004-11-01 2015-03-31 Erber Ag Bakteriofagi jako czynniki selekcyjne
US20090197249A1 (en) 2004-11-01 2009-08-06 George Mason University Compositions and methods for diagnosing colon disorders
US20060188523A1 (en) 2005-01-10 2006-08-24 Zhiheng Pei Methods for diagnosing and treating chronic tonsillitis
US7993667B2 (en) 2005-03-25 2011-08-09 Kimberly-Clark Worldwide, Inc. Methods of manufacturing a medicated tampon assembly
WO2006130188A1 (en) 2005-05-31 2006-12-07 The Iams Company Feline probiotic bifidobacteria
US7452872B2 (en) 2005-08-24 2008-11-18 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
ES2561629T3 (es) 2005-09-28 2016-02-29 Nordisk Rebalance A/S Tratamiento del SII usando como efectores de tratamiento tanto bacterias probióticas como cereales fermentados
US8968721B2 (en) * 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
CA2652558A1 (en) 2006-05-18 2007-11-29 Biobalance Llc Bacterial strains, compositions including same and probiotic use thereof
US20090324638A1 (en) * 2006-06-12 2009-12-31 Biopeptides Corp. Live bacterial vaccine
JP5019563B2 (ja) 2006-06-16 2012-09-05 旭化成ケミカルズ株式会社 腸内細菌賦活剤
CN101472639A (zh) 2006-06-20 2009-07-01 皇家飞利浦电子股份有限公司 用于治疗胃肠疾病的电子胶囊
TW200819540A (en) 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
EE05459B1 (et) 2006-12-08 2011-08-15 Tartu �likool Sporogeense Bacillus smithii tvi TBMI12 MSCL P737 ja selle endospooride kasutamine probiootikumina, toidulisandina ning probiootiline kompositsioon
WO2008076696A2 (en) 2006-12-18 2008-06-26 Washington University In St. Louis The gut microbiome as a biomarker and therapeutic target for treating obesity or an obesity related disorder
DE102006062250A1 (de) 2006-12-22 2008-06-26 Roland Saur-Brosch Verwendung einer Zusammensetzung aus Mineralstoffen und/oder Vitaminen und gegebenenfalls acetogenen und/oder butyrogenen Bakterien zur oralen oder rektalen Verabreichung für die Behandlung und Vorbeugung von abdominalen Beschwerden
WO2008083157A2 (en) 2006-12-29 2008-07-10 Washington University In St. Louis Altering pgc-1alapha, ampk, fiaf, or the gastrointestinal microbiota as a means to modulate body fat and/or weight loss in a subject
AU2008298987B2 (en) * 2007-09-12 2013-12-05 Melinta Therapeutics, Inc. Method of inhibiting clostridium difficile by administration of oritavancin
JP4905558B2 (ja) 2007-10-16 2012-03-28 富士通株式会社 中継局、無線通信システムおよび負荷分散方法
US8236508B2 (en) 2008-01-29 2012-08-07 Drexel University Detecting and measuring live pathogens utilizing a mass detection device
US8021654B2 (en) 2008-03-14 2011-09-20 Danisco A/S Methods of treating pigs with Bacillus strains
RU2010144789A (ru) 2008-04-01 2012-05-10 Метаметрикс Клиникал Лэборетери (Us) Процесс и способ мониторинга желудочно-кишечной микрофлоры
CN101264107A (zh) * 2008-05-09 2008-09-17 东北制药集团公司沈阳第一制药厂 地衣芽孢杆菌药物组合物及其制剂
CN102940652B (zh) 2008-05-28 2015-03-25 青岛东海药业有限公司 两形真杆菌制剂及其应用
JP2011528117A (ja) 2008-07-15 2011-11-10 メタノミクス ヘルス ゲーエムベーハー 胃バイパス及びそれに関連する状態を診断する手段及び方法
CN102131928A (zh) 2008-08-26 2011-07-20 奥林巴斯株式会社 粪便试样的调制方法、粪便试样调制用溶液、及粪便采集用试剂盒
WO2010030997A1 (en) 2008-09-12 2010-03-18 The Washington University Regulating intestinal microbiota dependent signaling as a means to modulate body fat and/or weight loss
US9603876B2 (en) 2008-09-25 2017-03-28 New York University Compositions and methods for restoring gastrointestinal microbiota following antibiotic treatment
JP5620392B2 (ja) 2008-11-03 2014-11-05 タフツ ユニヴァーシティーTufts University クロストリジウム・ディフィシレ胞子の発芽および伸長を阻害するための方法および組成物
FR2938057B1 (fr) 2008-11-05 2013-05-17 Patrick Wozna Doseur a delta de pression
GB0821913D0 (en) * 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
IT1393931B1 (it) 2009-02-25 2012-05-17 Neuroscienze Pharmaness S C A R L Composizione di spore di batteri non patogeni
EP2432484A1 (en) 2009-04-30 2012-03-28 Compagnie Gervais Danone Use of collinsella aerofaciens for reducing bloating
CN102481322A (zh) 2009-05-01 2012-05-30 微制药有限公司 预防和治疗退化性疾病的细菌组合物
US9050276B2 (en) 2009-06-16 2015-06-09 The Trustees Of Columbia University In The City Of New York Autism-associated biomarkers and uses thereof
DK2446062T3 (da) 2009-06-26 2014-10-06 Univ California Fremgangsmåder og systemer til phylogenetisk analyse
US20120264637A1 (en) 2009-06-26 2012-10-18 The Regents Of The University Of California Methods and systems for phylogenetic analysis
WO2011005756A1 (en) 2009-07-06 2011-01-13 Puretech Ventures, Llc Delivery of agents targeted to microbiota niches
WO2011020780A1 (en) 2009-08-18 2011-02-24 Nestec S.A. A nutritional composition comprising lactococcus strains and reducing allergy symptoms, especially in infants and children.
WO2011022542A2 (en) 2009-08-19 2011-02-24 Puretech Ventures, Llc Administration of factors normally present in a microbial niche to improve health
WO2011022660A1 (en) 2009-08-21 2011-02-24 Puretech Ventures, Llc Methods of diagnosing and treating microbiome-associated disease using interaction network parameters
GB0916335D0 (en) 2009-09-17 2009-10-28 Martin W J Medicaments
JP2013505289A (ja) 2009-09-23 2013-02-14 トーマス・ジュリアス・ボロディ 腸管感染症の治療法
WO2011043654A1 (en) 2009-10-05 2011-04-14 Aak Patent B.V. Methods for diagnosing irritable bowel syndrome
US20110081320A1 (en) 2009-10-06 2011-04-07 Nubiome, Inc. Treatment/Cure of Autoimmune Disease
US20120276149A1 (en) 2009-10-15 2012-11-01 Dan Littman Methods for modulating bacterial infection
ES2545597T3 (es) 2009-11-12 2015-09-14 Nestec S.A. Composición nutritiva para fomentar el equilibrio de la flora intestinal y para fomentar la salud
AU2010339573B2 (en) 2009-12-31 2014-08-28 Ira Milton Trachtman Compositions and method for treatment and prophylaxis of inflammatory bowel disease
ES2916399T3 (es) 2010-02-01 2022-06-30 Rebiotix Inc Bacterioterapia para la colitis por Clostridium difficile
US9492487B2 (en) 2010-02-01 2016-11-15 Matthew Ryan Garner Microbial product containing multiple microorganisms
US20130230498A1 (en) 2010-02-16 2013-09-05 Arizona Board Of Regents For And On Behalf Of Arizona State University Reducing short-chain fatty acids and energy uptake in obese humans by managing their intestinal microbial communities
EP2542695A2 (en) 2010-03-01 2013-01-09 Institut National de la Recherche Agronomique Method of diagnostic of obesity
NZ602704A (en) 2010-03-01 2015-01-30 Agronomique Inst Nat Rech Method of diagnostic of inflammatory bowel diseases
IT1398553B1 (it) 2010-03-08 2013-03-01 Probiotical Spa Composizione comprendente batteri probiotici per il trattamento di patologie associate con le alterazioni del sistema immunitario.
WO2011113801A1 (en) 2010-03-16 2011-09-22 Universiteit Gent Use of clostridium perfringens strain 23 to protect against necrotic enteritis
US8951512B2 (en) 2010-05-04 2015-02-10 New York University Methods for treating bone disorders by characterizing and restoring mammalian bacterial microbiota
WO2011151941A1 (ja) 2010-06-04 2011-12-08 国立大学法人東京大学 制御性t細胞の増殖または集積を誘導する作用を有する組成物
ES2586580T3 (es) 2010-07-06 2016-10-17 Glaxosmithkline Biologicals Sa Inmunización de mamíferos grandes con dosis bajas de ARN
EP2593187A4 (en) 2010-07-16 2014-04-09 Univ Arkansas PROCESSES AND COMPOSITIONS WITH SPORTS-BUILDING BACTERIA TO IMPROVE THE HEALTH OF ANIMALS
FI20105825A7 (fi) 2010-07-26 2012-01-27 Suomen Punainen Risti Veripalvelu Veriryhmästatuksen käyttö III
KR20130098320A (ko) 2010-08-04 2013-09-04 토마스 줄리어스 보로디 분변 세균총 이식을 위한 조성물, 그의 제조 방법과 사용 방법, 및 그를 전달하기 위한 장치
EP2605746A2 (en) * 2010-08-19 2013-06-26 Merz Pharma GmbH & Co. KGaA Filler composition comprising beta-glucans
WO2012024638A2 (en) 2010-08-20 2012-02-23 New York University Compositions and methods for treating obesity and related disorders by characterizing and restoring mammalian bacterial microbiota
AU2011299285B2 (en) 2010-09-10 2017-01-05 Ntcd, Llc Environmental Clostridial bacteriotherapy and related formulations and methods of manufacture and use
AU2011313763A1 (en) 2010-10-04 2013-05-30 Emma Allen-Vercoe Detection of Fusobacterium in a gastrointestinal sample to diagnose gastrointestinal cancer
EP2662078A1 (en) 2010-11-10 2013-11-13 National Jewish Health Methods to Treat Allergic Conditions
US20120064592A1 (en) 2011-01-26 2012-03-15 Qteros, Inc. Biocatalysts synthesizing deregulated cellulases
LT2672980T (lt) 2011-02-09 2018-03-12 Lavivo Ab Simbiozinės kompozicijos žarnyno mikrobiotos atkūrimui ir rekonstrukcijai
WO2012116289A2 (en) 2011-02-25 2012-08-30 Tricorder Diagnostics, Llc Microbial signatures as indicators of radiation exposure
WO2012122522A2 (en) 2011-03-09 2012-09-13 Washington University Cultured collection of gut microbial community
CN103561752B (zh) * 2011-03-09 2016-04-20 明尼苏达大学评议会 用于移植结肠微生物群的组合物和方法
WO2012142605A1 (en) 2011-04-15 2012-10-18 Samaritan Health Services Rapid recolonization deployment agent
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
US20120278201A1 (en) 2011-04-26 2012-11-01 Dwolla Corp. Location transaction processing system
US20120276056A1 (en) 2011-04-26 2012-11-01 Wieslaw Janusz Bochenek Method for Use of Biologic Agents Including Live or Dormant Forms of Bacteria and other organisms in Treating Infections, Inflammation and Other Diseases of Distal Small Intestine and Large Intestine
US20120284637A1 (en) 2011-05-02 2012-11-08 John Edward Boyer Unified Virtual Group Calendar System
US20140179726A1 (en) 2011-05-19 2014-06-26 Virginia Commonwealth University Gut microflora as biomarkers for the prognosis of cirrhosis and brain dysfunction
US9579353B2 (en) 2011-06-10 2017-02-28 Prothera, Inc. Pharmaceutical compositions containing pediococcus and methods for reducing the symptoms of gastroenterological syndromes
US20130017999A1 (en) 2011-07-14 2013-01-17 Marc Fremont Methods and Compositions for Evaluating and/or Treating Chronic Immune Diseases
US20130022575A1 (en) 2011-07-19 2013-01-24 Microbial Rx Systems and methods of replacing intestinal flora
US20140348811A1 (en) 2011-07-27 2014-11-27 Max International, Llc Compositions comprising sugar-cysteine products
WO2013019896A1 (en) 2011-08-01 2013-02-07 Symbiotix Biotherapies, Inc. Platform for identifying and/or characterizing immunomodulatory agents
KR101982491B1 (ko) 2011-08-30 2019-05-27 아카데미쉬 메디쉬 센트륨 인슐린 저항 예방 및/또는 치료 방법
CA2848757C (en) * 2011-09-14 2021-11-09 University Of Guelph Methods to culture human gastrointestinal microorganisms
US20130115232A1 (en) 2011-10-03 2013-05-09 Fred Hutchinson Cancer Research Center Methods for detecting graft-versus-host disease
US20130121968A1 (en) 2011-10-03 2013-05-16 Atossa Genetics, Inc. Methods of combining metagenome and the metatranscriptome in multiplex profiles
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
JP2014530229A (ja) 2011-10-11 2014-11-17 エイキム・バイオセラピューティクス・エイビーAchim Biotherapeutics Ab 嫌気的に培養されたヒト腸内微生物叢を含む組成物
CN104160014A (zh) 2011-12-01 2014-11-19 国立大学法人东京大学 诱导调节性t细胞的增殖或积累的人源细菌
GB201201766D0 (en) 2012-02-01 2012-03-14 Imp Innovations Ltd Method
US20150125883A1 (en) 2012-04-30 2015-05-07 Washington University Method of isolating and characterizing microorganisms that are targets of host immune responses
ES2792106T3 (es) 2012-05-18 2020-11-10 Genome Res Ltd Métodos y grupos
WO2013176774A1 (en) 2012-05-25 2013-11-28 Arizona Board Of Regents Microbiome markers and therapies for autism spectrum disorders
WO2013177596A2 (en) 2012-05-25 2013-11-28 Sloan Kettering Institute For Cancer Methods for treating gi syndrome and graft versus host disease
EP2684469A1 (en) 2012-07-13 2014-01-15 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Methods for strengthening and assessment of the natural defence of the colon against C. difficile overgrowth
US20140112985A1 (en) * 2012-10-22 2014-04-24 Polonez Therapeutics Llc Method of prevention and treatment of clostridium difficile infection
NZ709392A (en) 2012-11-23 2016-10-28 Seres Therapeutics Inc Synergistic bacterial compositions and methods of production and use thereof
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
JP2016509003A (ja) 2013-02-04 2016-03-24 セレス セラピューティクス インコーポレイテッド 組成物および方法
WO2014121304A1 (en) 2013-02-04 2014-08-07 Seres Health, Inc. Compositions and methods
WO2014153194A2 (en) 2013-03-14 2014-09-25 Seres Health, Inc. Methods for pathogen detection and enrichment from materials and compositions
AU2014232370B2 (en) 2013-03-15 2018-11-01 Société des Produits Nestlé S.A. Network-based microbial compositions and methods
WO2014177667A1 (en) 2013-05-03 2014-11-06 Nestec S.A. Lachnospiraceae in the gut microbiota and association with body weight
DK3074027T3 (da) 2013-11-25 2025-03-17 Nestle Sa Synergistiske bakteriesammensætninger og fremgangsmåder til fremstilling og anvendelse heraf
WO2015095241A2 (en) 2013-12-16 2015-06-25 Seres Health, Inc. Bacterial compositions and methods of use thereof for treatment of immune system disorders
US20170087196A1 (en) 2014-05-19 2017-03-30 Memorial Sloan-Kettering Cancer Center Methods and compositions for reducing clostridium difficile infection
ES3010296T3 (en) 2014-11-25 2025-04-02 Memorial Sloan Kettering Cancer Center Intestinal microbiota and gvhd
MA41020A (fr) 2014-11-25 2017-10-03 Evelo Biosciences Inc Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome
KR20180025908A (ko) 2015-07-08 2018-03-09 세레스 테라퓨틱스, 인코포레이티드 대장염의 치료 방법
MX2018006283A (es) 2015-11-24 2019-09-06 Seres Therapeutics Inc Composiciones bacterianas diseñadas.
WO2017091753A1 (en) 2015-11-25 2017-06-01 Memorial Sloan-Kettering Cancer Center Methods and compositions for reducing vancomycin-resistant enterococci infection or colonization
EP3429604A1 (en) 2016-03-14 2019-01-23 Holobiome, Inc. Modulation of the gut microbiome to treat mental disorders or diseases of the central nervous system
EP3703720A1 (en) 2017-10-30 2020-09-09 Seres Therapeutics, Inc. Compositions and methods for treating antibiotic resistance

Also Published As

Publication number Publication date
EP2951285A4 (en) 2016-10-26
AU2014212004B2 (en) 2018-09-20
US20220249578A1 (en) 2022-08-11
JP7409743B2 (ja) 2024-01-09
US9855303B2 (en) 2018-01-02
AU2014212003A1 (en) 2015-09-24
JP2016509002A (ja) 2016-03-24
US11730775B2 (en) 2023-08-22
EP2956006A4 (en) 2017-02-22
EP2951285A1 (en) 2015-12-09
US20190192581A1 (en) 2019-06-27
US20160243172A1 (en) 2016-08-25
HK1218559A1 (zh) 2017-02-24
JP2021181440A (ja) 2021-11-25
AU2014212003C1 (en) 2020-07-16
CA2899925A1 (en) 2014-08-07
JP2024045100A (ja) 2024-04-02
KR20150115888A (ko) 2015-10-14
JP6479685B2 (ja) 2019-03-06
AU2014212003B2 (en) 2020-01-02
US20240050490A1 (en) 2024-02-15
US20170196914A1 (en) 2017-07-13
BR122021010444B1 (pt) 2022-07-12
US10064901B2 (en) 2018-09-04
US20160158294A1 (en) 2016-06-09
JP6908332B2 (ja) 2021-07-28
US20210244774A1 (en) 2021-08-12
EP2956006A2 (en) 2015-12-23
EP2953474A2 (en) 2015-12-16
JP2019104742A (ja) 2019-06-27
JP2019116488A (ja) 2019-07-18
EP3587558A3 (en) 2020-03-04
AU2018282348A1 (en) 2019-01-17
AU2024202421A1 (en) 2024-06-27
US9585921B2 (en) 2017-03-07
BR112015018625A2 (pt) 2017-09-19
WO2014121302A2 (en) 2014-08-07
RU2015137399A (ru) 2017-03-10
KR102553134B1 (ko) 2023-07-07
CA2899926C (en) 2025-11-18
NZ711771A (en) 2016-11-25
AU2020202312B2 (en) 2022-11-24
WO2014121298A2 (en) 2014-08-07
MX2019014045A (es) 2020-02-05
US20250000915A1 (en) 2025-01-02
US20160199423A1 (en) 2016-07-14
US9180147B2 (en) 2015-11-10
EP3584308A2 (en) 2019-12-25
US20190099455A1 (en) 2019-04-04
US20180200310A1 (en) 2018-07-19
KR102222273B1 (ko) 2021-03-08
KR20210024683A (ko) 2021-03-05
US11185562B2 (en) 2021-11-30
EP3584308A3 (en) 2020-03-04
AU2020260564A1 (en) 2020-11-26
MX2015009991A (es) 2016-02-05
WO2014121301A1 (en) 2014-08-07
AU2014212004A1 (en) 2015-09-24
AU2020202312A1 (en) 2020-04-23
CN105451561A (zh) 2016-03-30
CN110917220A (zh) 2020-03-27
WO2014121298A3 (en) 2014-10-09
US20150093360A1 (en) 2015-04-02
EP2953474A4 (en) 2016-12-28
JP2016509003A (ja) 2016-03-24
JP6942745B2 (ja) 2021-09-29
WO2014121302A3 (en) 2014-10-09
US10064900B2 (en) 2018-09-04
US9011834B1 (en) 2015-04-21
US9446080B2 (en) 2016-09-20
AU2023201132A1 (en) 2023-06-01
US10967011B2 (en) 2021-04-06
US20160184370A1 (en) 2016-06-30
EP3587558A2 (en) 2020-01-01
RU2664479C2 (ru) 2018-08-17
HK1219022A1 (zh) 2017-03-24
US20140328803A1 (en) 2014-11-06
KR20230110367A (ko) 2023-07-21
MX369877B (es) 2019-11-25
AU2014212003A8 (en) 2015-10-22
CA2899926A1 (en) 2014-08-07

Similar Documents

Publication Publication Date Title
HK1218837A1 (zh) 组合物和方法
PH12018500810A1 (en) Antibody agents specific for human cd19 and uses thereof
MX344530B (es) Compuestos de benceno substituido.
HK1213552A1 (zh) 经取代的苯化合物
ZA201304638B (en) Composition for use in the prevention and /or treatment of skin condition and skin diseases.
HK1218560A1 (zh) 组成与方法
MX2020010535A (es) Inhibidor de ezh2 para usarse en el tratamiento de sarcoma epiteloide.
MY166171A (en) Aryl- or heteroaryl-substituted benzene compounds
PL2444081T3 (pl) Kompozycja do leczenia chorób zapalnych, zawierająca kwas bosweliowy i kannabidiol
WO2012024620A3 (en) Autotaxin inhibitors and uses thereof
MX344238B (es) Compuestos de tetrazol y métodos para preparar y usar los mismos.
UA99839C2 (ru) Бензодиазепиноновые соединения, применяемые при лечении кожных состояний
MX2014011623A (es) Metodos y composiciones para tratar inflamacion.
MX2015016527A (es) Polimeros enlazados al proton para administracion oral.
MX2013013649A (es) Compuestos de quinona para tratar enfermedades mediadas por ape1.
GB201205739D0 (en) Treatment of acute inflammation in the respiratory tract
PH12019501439B1 (en) Use of lactic acid bacteria to treat or prevent gestational diabetes mellitus
HK1215391A1 (zh) 使用胎盘细胞外基质治疗口腔病变
MA32416B1 (fr) 7-sulfanylmethyl-, 7-sulfinymethyl-et 7-sulfonylmethyl-indoles substitues et leur utilisation
MX2015005733A (es) Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad.
MX2010005915A (es) Derivados de fenil-oxetanilo.
NZ601661A (en) Compositions and methods for treating viral diseases
MX2014008194A (es) Cefovecina util en el tratamiento de la enfermedad de lyme.
UA63764U (ru) Применение экстракта из листьев сныти обыкновенной в качестве лечебно-профилактического средства с гепатопротекторным действием
MY169877A (en) Treatment of malphigia coccigera on liver cirrhosis