HK1216640A1 - 親水性自消耗連接子及其綴合物 - Google Patents

親水性自消耗連接子及其綴合物

Info

Publication number
HK1216640A1
HK1216640A1 HK16104485.6A HK16104485A HK1216640A1 HK 1216640 A1 HK1216640 A1 HK 1216640A1 HK 16104485 A HK16104485 A HK 16104485A HK 1216640 A1 HK1216640 A1 HK 1216640A1
Authority
HK
Hong Kong
Prior art keywords
conjugates
hydrophilic self
immolative linkers
immolative
linkers
Prior art date
Application number
HK16104485.6A
Other languages
English (en)
Inventor
Rong-Hwa Lin
Shih-Yao Lin
Yu-Chi Hsieh
Chiu-Chen Huang
Original Assignee
Bioalliance Cv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioalliance Cv filed Critical Bioalliance Cv
Publication of HK1216640A1 publication Critical patent/HK1216640A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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    • C07D295/182—Radicals derived from carboxylic acids
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Organic Chemistry (AREA)
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  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK16104485.6A 2012-12-21 2016-04-19 親水性自消耗連接子及其綴合物 HK1216640A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261745448P 2012-12-21 2012-12-21
US201361785027P 2013-03-14 2013-03-14
PCT/US2013/077306 WO2014100762A1 (en) 2012-12-21 2013-12-20 Hydrophilic self-immolative linkers and conjugates thereof

Publications (1)

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HK1216640A1 true HK1216640A1 (zh) 2016-11-25

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US (5) US9943610B2 (zh)
EP (1) EP2935259B1 (zh)
JP (1) JP6482471B2 (zh)
KR (2) KR20150119848A (zh)
CN (2) CN105102455B (zh)
AR (1) AR094280A1 (zh)
AU (1) AU2013364065B2 (zh)
BR (1) BR112015014712A2 (zh)
CA (1) CA2896690A1 (zh)
CL (1) CL2015001735A1 (zh)
DK (1) DK2935259T3 (zh)
ES (1) ES2714951T3 (zh)
HK (1) HK1216640A1 (zh)
IL (1) IL239506B (zh)
MX (1) MX2015007918A (zh)
MY (1) MY169117A (zh)
NZ (1) NZ630601A (zh)
PH (1) PH12015501422B1 (zh)
PT (1) PT2935259T (zh)
RU (2) RU2019105549A (zh)
SG (2) SG11201504887TA (zh)
TW (1) TWI716339B (zh)
WO (1) WO2014100762A1 (zh)
ZA (1) ZA201504941B (zh)

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