SI2900277T1 - Odmerki imunokonjugatov protiteles in SN-38 za boljšo učinkovitost in zmanjšano toksičnost - Google Patents

Odmerki imunokonjugatov protiteles in SN-38 za boljšo učinkovitost in zmanjšano toksičnost

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Publication number
SI2900277T1
SI2900277T1 SI201331977T SI201331977T SI2900277T1 SI 2900277 T1 SI2900277 T1 SI 2900277T1 SI 201331977 T SI201331977 T SI 201331977T SI 201331977 T SI201331977 T SI 201331977T SI 2900277 T1 SI2900277 T1 SI 2900277T1
Authority
SI
Slovenia
Prior art keywords
immunoconjugates
dosages
antibodies
improved efficacy
decreased toxicity
Prior art date
Application number
SI201331977T
Other languages
English (en)
Inventor
Serengulam V. Govindan
David M. Goldenberg
Original Assignee
Immunomedics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics, Inc. filed Critical Immunomedics, Inc.
Publication of SI2900277T1 publication Critical patent/SI2900277T1/sl

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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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