ATE143376T1 - Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung

Info

Publication number
ATE143376T1
ATE143376T1 AT90909864T AT90909864T ATE143376T1 AT E143376 T1 ATE143376 T1 AT E143376T1 AT 90909864 T AT90909864 T AT 90909864T AT 90909864 T AT90909864 T AT 90909864T AT E143376 T1 ATE143376 T1 AT E143376T1
Authority
AT
Austria
Prior art keywords
monoclonal antibodies
production
leukocyte adhesion
directed against
antibodies directed
Prior art date
Application number
AT90909864T
Other languages
English (en)
Inventor
James E Hildreth
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Application granted granted Critical
Publication of ATE143376T1 publication Critical patent/ATE143376T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT90909864T 1989-06-02 1990-05-30 Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung ATE143376T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36127189A 1989-06-02 1989-06-02

Publications (1)

Publication Number Publication Date
ATE143376T1 true ATE143376T1 (de) 1996-10-15

Family

ID=23421348

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90909864T ATE143376T1 (de) 1989-06-02 1990-05-30 Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung

Country Status (10)

Country Link
US (4) US5888508A (de)
EP (1) EP0432249B1 (de)
JP (2) JP3048632B2 (de)
AT (1) ATE143376T1 (de)
AU (2) AU645016B2 (de)
CA (1) CA2033347C (de)
DE (1) DE69028684T2 (de)
DK (1) DK0432249T3 (de)
ES (1) ES2095876T3 (de)
WO (1) WO1990015076A2 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5456924A (en) * 1988-12-23 1995-10-10 Immunotec Research Corporation Ltd. Method of treatment of HIV-seropositive individuals with dietary whey proteins
CA2033347C (en) * 1989-06-02 2000-02-29 James E. Hildreth Monoclonal antibodies against leukocyte adhesion receptor beta-chain, methods of producing these antibodies and use therefore
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
JP4124480B2 (ja) 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド 免疫グロブリン変異体
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
GB9115364D0 (en) 1991-07-16 1991-08-28 Wellcome Found Antibody
CA2140933A1 (en) * 1992-08-21 1994-02-22 Paula M. Jardieu Method for treating an lfa-1 mediated disorder
US5821332A (en) * 1993-11-03 1998-10-13 The Board Of Trustees Of The Leland Stanford Junior University Receptor on the surface of activated CD4+ T-cells: ACT-4
US5646251A (en) * 1993-11-05 1997-07-08 The Board Of Trustees Of Leeland Stanford Jr. Univ. Alloreaction-associated antigen (ARAG): a novel member of the immunoglobulin gene superfamily
US6242566B1 (en) 1994-02-10 2001-06-05 Board Of Trustees Of The Leland Stanford Junior University Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
US6867203B2 (en) 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
IL145480A0 (en) 1999-03-19 2002-06-30 Genentech Inc Treatment of lfa-1 associated disorders with increasing doses of lfa-1
US6582698B1 (en) 1999-03-19 2003-06-24 Genentech, Inc. Treatment method
AU2001230920A1 (en) * 2000-01-14 2001-07-24 Genentech Inc. Diagnosis and treatment of hepatic inflammatory disorders by inhibiting the binding of lfa-1 to icam-1
AU4574501A (en) 2000-03-17 2001-10-03 Millennium Pharm Inc Method of inhibiting stenosis and restenosis
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
RU2006146939A (ru) 2004-06-09 2008-07-20 Дженентек Способ лечения кольцевидной гранулемы или саркоида
US8440264B2 (en) * 2006-12-15 2013-05-14 Ford Global Technologies, Llc Method for preparing a brazed surface for receiving a coating
DK3903829T3 (da) 2009-02-13 2023-06-26 Immunomedics Inc Immunkonjugater med en intracellulær spaltelig binding
EP3009455A1 (de) 2009-09-16 2016-04-20 Immunomedics Inc. Klasse-i-anti-cea-antikörper und verwendungen davon
IN2012DN03354A (de) 2009-12-02 2015-10-23 Immunomedics Inc
EP2704751B1 (de) 2011-05-02 2019-04-17 Immunomedics, Inc. Ultrafiltrationskonzentration ausgewählter allotypen-antikörper für kleinvolumige verabreichung
EP2885002A4 (de) 2012-08-14 2016-04-20 Ibc Pharmaceuticals Inc Umleitung t-zell-bispezifischer antikörper zur behandlung von krankheiten
CA3177936A1 (en) 2012-12-13 2014-06-19 Immunomedics, Inc. Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity
CN106132436B (zh) 2014-02-21 2021-06-15 Ibc药品公司 通过诱导对trop-2表达细胞的免疫应答的疾病疗法
US9139649B2 (en) 2014-02-25 2015-09-22 Immunomedics, Inc. Humanized anti-CD22 antibody
US9580495B2 (en) 2014-06-24 2017-02-28 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
CN106999517A (zh) 2014-10-07 2017-08-01 免疫医疗公司 抗体‑药物缀合物的新辅助剂用途
EP3029067A1 (de) 2014-12-01 2016-06-08 Deutsches Krebsforschungszentrum Verwendung von blockierenden Reagenzien zur Verringerung von unspezifischer T-Zellenaktivierung
EP3286224A4 (de) 2015-04-22 2018-11-14 Immunomedics, Inc. Isolierung, detektion, diagnose und/oder charakterisierung von zirkulierenden trop-2-positiven krebszellen
PL3313443T3 (pl) 2015-06-25 2023-11-06 Immunomedics, Inc. Łączenie przeciwciał anty-hla-dr lub anty-trop-2 z inhibitorami mikrotubuli, inhibitorami parp, 5 inhibitorami kinazy brutona lub inhibitorami 3-kinazy fosfoinozytydu istotnie poprawia wynik terapeutyczny nowotworu
SI3316885T1 (sl) 2015-07-01 2021-09-30 Immunomedics, Inc. Imunokonjugati protitelo-SN-38 z linkerjem CL2A
WO2022239720A1 (ja) 2021-05-10 2022-11-17 公益財団法人川崎市産業振興財団 抗原への結合親和性を低減させた抗体
USD1005917S1 (en) * 2021-11-04 2023-11-28 Thor Tech, Inc. Wheel

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
EP0303692A4 (en) * 1987-02-26 1990-12-05 Dana Farber Cancer Institute Cloning of lfa-1
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US4797277A (en) * 1987-09-22 1989-01-10 Pharmacia Ab Method for reperfusion therapy
US5002869A (en) * 1987-11-02 1991-03-26 Dana-Farber Cancer Institute Monoclonal antibody specific to a novel epitope of the LFA-1 antigen of human T lymphocytes
EP0314863B1 (de) * 1987-11-02 1994-12-07 Baylor College Of Medicine Verwendung von ICAM-1 oder ihre funktionelle Derivate zur Behandlung unspezifischer Entzündungen
GB8726230D0 (en) * 1987-11-10 1987-12-16 Rosen H Antibodies
US5449760A (en) * 1987-12-31 1995-09-12 Tanox Biosystems, Inc. Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils
US5147637A (en) * 1988-06-07 1992-09-15 The Rockefeller University Method of inhibiting the influx of leukocytes into organs during sepsis or other trauma
ATE125708T1 (de) * 1988-09-28 1995-08-15 Dana Farber Cancer Inst Inc Interzellulare adhäsions-moleküle und deren bindungsliganden.
US5204445A (en) * 1988-10-03 1993-04-20 The Scripps Research Institute Peptides and antibodies that inhibit integrin-ligand binding
US6307025B1 (en) * 1989-04-28 2001-10-23 Biogen, Inc. VCAM fusion proteins and DNA coding therefor
CA2033347C (en) * 1989-06-02 2000-02-29 James E. Hildreth Monoclonal antibodies against leukocyte adhesion receptor beta-chain, methods of producing these antibodies and use therefore
CA2064818A1 (en) * 1989-08-18 1991-02-19 La Jolla Cancer Research Foundation Fibulin
US6720141B1 (en) * 1999-11-01 2004-04-13 Interleukin Genetics, Inc. Diagnostics and therapeutics for restenosis

Also Published As

Publication number Publication date
CA2033347A1 (en) 1990-12-03
EP0432249A4 (en) 1992-01-02
ES2095876T3 (es) 1997-03-01
US20010014325A1 (en) 2001-08-16
DE69028684D1 (de) 1996-10-31
JP3048632B2 (ja) 2000-06-05
DE69028684T2 (de) 1997-05-22
AU666977B2 (en) 1996-02-29
AU5847190A (en) 1991-01-07
US20050158315A1 (en) 2005-07-21
AU645016B2 (en) 1994-01-06
CA2033347C (en) 2000-02-29
JP3288996B2 (ja) 2002-06-04
US6921533B2 (en) 2005-07-26
JPH04501365A (ja) 1992-03-12
DK0432249T3 (da) 1997-02-17
WO1990015076A2 (en) 1990-12-13
EP0432249A1 (de) 1991-06-19
AU5035393A (en) 1994-02-17
WO1990015076A3 (en) 1991-04-18
EP0432249B1 (de) 1996-09-25
US5888508A (en) 1999-03-30
US6187308B1 (en) 2001-02-13
US7368109B2 (en) 2008-05-06
JP2000136200A (ja) 2000-05-16

Similar Documents

Publication Publication Date Title
ATE143376T1 (de) Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung
DE3586536D1 (de) Monoklonaler antikoerper gegen ein cytotoxin, denselben erzeugendes hybridoma und verfahren fuer die herstellung des gereinigten cytotoxin.
EP0539970A3 (en) Methods for producing human lymphocytes and human monoclonal antibodies, and human monoclonal antibodies produced thereby
DE3689734D1 (de) Gereinigter immunoglobulinbezüglicher Faktor, monoklonale Antikörper, Hybridoma-Zellinien, Verfahren und Verwendungen.
IT1271461B (it) Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso.
DE3854502D1 (de) Gegen hiv-antigene spezifischer monoklonaler antikörper.
NO162179C (no) Monoklonale antistoffer for anvendelse in vitro.
AR240175A1 (es) Una linea celular producida por tecnica de hibridoma y un anticuerpo monoclonal derivado de la misma.
DE3885355D1 (de) Monoklonale Antikörper.
DE69204823T2 (de) Verfahren für die bestimmung der antikörpersätze und die t-zellrezeptoren des immunologischen systems.
DE3485733D1 (de) Spezifische antigene der cea(karzyno-embryonales-antigen)familie, spezifische antikoerper und verfahren zu ihrer verwendung.
FI862978A (fi) Onkofetaalisia spesifisiä monoklonaalisia vasta-aineita, menetelmä niiden valmistamiseksi ja niiden käyttö.
DE3886545D1 (de) Monoklonale human-antikörper, spezifisch für rh(d).
DE3851855T2 (de) Gegen die Gamma-Kette des T-Zell-Rezeptors gerichteter monoklonaler Antikörper.
DE3785175D1 (de) A-assoziierte h-antigene, spezifische monoklonale antikoerper und methoden zu deren verwendung zur blutgruppenbestimmung.
AU6189486A (en) Monoclonal antibodies to prosomal proteins
NO873488L (no) Monoklonale antistoffer.
EP0166458A3 (en) Monoclonal antibody capable of specifically distinguishing human hepato-carcinoma cells
NO890116L (no) Monoklonale antistoffer.
IL92312A0 (en) Monoclonal antibody specifically recognizing n-glycolyl type gm2,hybridoma producing the antibody and method for preparing the hybridoma
ATE144286T1 (de) Monoklonale antikörper gegen den plasmin- antiplasmin komplex, verfahren zu ihrer herstellung sowie ihre verwendung
AR243932A1 (es) Hibridoma, procedimiento para la preparacion, anticuerpo monoclonal, procedimiento para su preparacion y composicion para diagnostico de base a dicho anticuerpo.
TW288020B (en) Monoclonal antibodies specific to methamphetamine, hybridoma producing the antibodies, kits containing the antibodies and uses thereof
ATE76510T1 (de) Spezifische antigene der cea(karzyno-embryonales- antigen)familie, spezifische antikoerper und verfahren zu ihrer verwendung.
SE8701436D0 (sv) Upphengningsbeslag, snabbfeste for persienner

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee