HK1145322A1 - - Google Patents

Info

Publication number
HK1145322A1
HK1145322A1 HK10111709.7A HK10111709A HK1145322A1 HK 1145322 A1 HK1145322 A1 HK 1145322A1 HK 10111709 A HK10111709 A HK 10111709A HK 1145322 A1 HK1145322 A1 HK 1145322A1
Authority
HK
Hong Kong
Prior art keywords
amides
preparing
relates
present
novel
Prior art date
Application number
HK10111709.7A
Other languages
English (en)
Inventor
Olivier Loiseleur
Daniel Kaufmann
Stephan Abel
Hans Michael Buerger
Mark Meisenbach
Beat Schmitz
Gottfried Sedelmeier
Original Assignee
Novartis Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Ag filed Critical Novartis Pharma Ag
Publication of HK1145322A1 publication Critical patent/HK1145322A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK10111709.7A 2002-02-07 2005-04-28 HK1145322A1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0202873.6A GB0202873D0 (en) 2002-02-07 2002-02-07 Organic compounds

Publications (1)

Publication Number Publication Date
HK1145322A1 true HK1145322A1 (el) 2011-04-15

Family

ID=9930607

Family Applications (2)

Application Number Title Priority Date Filing Date
HK05103664.4A HK1070893A1 (el) 2002-02-07 2005-04-28
HK10111709.7A HK1145322A1 (el) 2002-02-07 2005-04-28

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK05103664.4A HK1070893A1 (el) 2002-02-07 2005-04-28

Country Status (26)

Country Link
US (8) US7456283B2 (el)
EP (2) EP2248807B1 (el)
JP (2) JP4653954B2 (el)
KR (1) KR101027044B1 (el)
CN (2) CN101016262A (el)
AU (1) AU2003244444B2 (el)
BR (2) BRPI0307529B1 (el)
CA (2) CA2737565C (el)
CO (1) CO5601018A2 (el)
CY (2) CY1112938T1 (el)
DK (2) DK2248807T3 (el)
EC (2) ECSP045220A (el)
ES (2) ES2384872T3 (el)
GB (1) GB0202873D0 (el)
HK (2) HK1070893A1 (el)
IL (3) IL163158A (el)
MX (1) MXPA04007642A (el)
NO (2) NO327366B1 (el)
NZ (3) NZ554430A (el)
PL (1) PL209475B1 (el)
PT (2) PT1474408E (el)
RU (2) RU2370493C2 (el)
SG (1) SG160195A1 (el)
SI (2) SI2248807T1 (el)
WO (1) WO2003066613A1 (el)
ZA (1) ZA200405970B (el)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0202873D0 (en) * 2002-02-07 2002-03-27 Novartis Ag Organic compounds
WO2004108699A1 (en) * 2003-06-06 2004-12-16 Natco Pharma Limited Process for the preparation of the anti-cancer drug imatinib and its analogues
JP2006527230A (ja) * 2003-06-13 2006-11-30 ノバルティス アクチエンゲゼルシャフト Ｒａｆキナーゼ阻害剤としての２−アミノピリミジン誘導体
MY144177A (en) * 2004-02-04 2011-08-15 Novartis Ag Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide.
US7507821B2 (en) 2004-12-30 2009-03-24 Chemagis Ltd. Process for preparing Imatinib
US7977348B2 (en) 2006-04-27 2011-07-12 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US8067421B2 (en) 2006-04-27 2011-11-29 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US20060223816A1 (en) * 2006-05-08 2006-10-05 Chemagis Ltd. Imatinib mesylate alpha form and production process therefor
MX2009002336A (es) * 2006-09-01 2009-03-20 Teva Pharma Composiciones de imatinib.
KR20090065512A (ko) 2006-09-22 2009-06-22 노파르티스 아게 Ａｂｌ 티로신 키나제 억제제에 의해 필라델피아-양성 백혈병의 치료를 최적화시키는 방법
EP2009008A1 (en) 2006-10-26 2008-12-31 Sicor, Inc. Imatinib base, and imatinib mesylate and processes for preparation thereof
JP2009514988A (ja) * 2006-10-26 2009-04-09 シコール インコーポレイティド イマチニブ塩基及びイマチニブメシレート、及びそれらの調製方法
EP2074095B1 (en) * 2006-11-16 2014-07-02 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of imatinib and intermediates thereof
CN100451015C (zh) * 2007-02-14 2009-01-14 杭州盛美医药科技开发有限公司 一种伊马替尼的制备方法
US7550591B2 (en) * 2007-05-02 2009-06-23 Chemagis Ltd. Imatinib production process
WO2008151183A1 (en) 2007-06-04 2008-12-11 Avila Therapeutics, Inc. Heterocyclic compounds and uses thereof
WO2009042809A1 (en) * 2007-09-25 2009-04-02 Teva Pharmaceutical Industries Ltd. Stable imatinib compositions
EP2231161A1 (en) * 2007-12-22 2010-09-29 Synthon B.V. A process of making imatinib
CN101497601B (zh) * 2008-01-29 2012-11-07 福建南方制药股份有限公司 伊马替尼的合成方法
PL215042B1 (pl) * 2008-08-01 2013-10-31 Temapharm Spolka Z Ograniczona Odpowiedzialnoscia Sposób wytwarzania imatinibu
KR20100021321A (ko) * 2008-08-14 2010-02-24 일양약품주식회사 Ν-페닐-2-피리미딘-아민 유도체의 제조방법
EP2370078A1 (en) 2008-12-01 2011-10-05 Novartis AG Method of optimizing the treatment of philadelphia-positive leukemia with imatinib mesylate
US20100330130A1 (en) 2009-05-22 2010-12-30 Actavis Group Ptc Ehf Substantially pure imatinib or a pharmaceutically acceptable salt thereof
CN101654416B (zh) * 2009-09-16 2013-06-05 成都神黄医药科技开发有限公司 N-[3-硝基-4-甲基-苯基]-4-醛基-苯甲酰胺及其制备方法以及其衍生物的制备方法
US20110306763A1 (en) 2009-12-10 2011-12-15 Shanghai Parling Pharmatech Co., Ltd. Process for the preparation of imatinib and salts thereof
WO2011095835A1 (en) 2010-02-02 2011-08-11 Actavis Group Ptc Ehf Highly pure imatinib or a pharmaceutically acceptable salt thereof
WO2011130918A1 (zh) * 2010-04-23 2011-10-27 上海百灵医药科技有限公司 一种伊马替尼的合成方法
EA024088B1 (ru) 2010-06-18 2016-08-31 КРКА, д.д., НОВО МЕСТО α-ФОРМА МЕЗИЛАТА ИМАТИНИБА, СПОСОБЫ ЕЕ ПОЛУЧЕНИЯ И СОДЕРЖАЩАЯ ЕЁ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
TR201007005A2 (tr) 2010-08-23 2011-09-21 Mustafa Nevzat İlaç Sanayi̇i̇ A.Ş. İmatinib baz üretim yöntemi
WO2013035102A1 (en) 2011-09-05 2013-03-14 Natco Pharma Limited Processes for the preparation of imatinib base and intermediates thereof
WO2013063003A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
CA2853095A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
WO2013120852A1 (en) 2012-02-13 2013-08-22 Grindeks, A Joint Stock Company Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors
IN2014DN10801A (el) 2012-07-11 2015-09-04 Novartis Ag
CN102827144A (zh) * 2012-09-05 2012-12-19 湖南欧亚生物有限公司 一种伊马替尼的制备方法
RU2537398C1 (ru) * 2013-08-20 2015-01-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный технологический университет" (СибГТУ) Гексазамещенные пара-аминофенолы с ариламидными группами в 2,6-положениях по отношению к гидроксилу
CN103588754B (zh) * 2013-11-04 2015-05-27 遵义医学院 伊马替尼的制备方法
WO2018074409A1 (ja) 2016-10-17 2018-04-26 Ｄｅｌｔａ－Ｆｌｙ Ｐｈａｒｍａ株式会社 慢性骨髄性白血病を治療又は寛解するための医薬組成物
PL3539138T3 (pl) 2016-11-11 2021-12-13 Curium Us Llc Sposoby generowania germanu-68 ze zmniejszoną ilością części lotnych
EP3333162A1 (en) 2016-12-12 2018-06-13 Silesian Catalysts sp. z o.o. Metod for preparing n-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
BR112020005489A2 (pt) 2017-09-22 2020-09-24 Jubilant Epipad Llc, composto da fórmula (i), composto de fórmula (ii), composto de fórmula (iii), processo de preparação de compostos de fórmula (i), processo de preparação de compostos de fórmula (ii), processo de preparação de compostos de fórmula (iii), composição farmacêutica, método para inibir uma ou mais famílias pad em uma célula, método para tratar uma afeção mediada por um ou mais pads, utilização do composto, método para o tratamento e/ou prevenção de uma afeção mediada por um ou mais distúrbios da família pad, método para o tratamento de artrite reumatoide e método de tratamento de câncer
PT3697785T (pt) 2017-10-18 2023-04-03 Jubilant Epipad LLC Compostos de imidazopiridina como inibidores de pad
BR112020008851A2 (pt) 2017-11-06 2020-10-20 Jubilant Prodel LLC composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas
JP7368369B2 (ja) 2017-11-24 2023-10-24 ジュビラント・エピスクライブ・エルエルシー Ｐｒｍｔ５阻害剤としてのヘテロ環式化合物
CN108164505B (zh) * 2018-01-16 2020-11-03 扬州大学 一种伊马替尼的合成方法
EP3749697A4 (en) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. CHROMATOGRAPHIC RESIN WITH A LIGAND WITH ANION EXCHANGE-HYDROPHOBIC MIXED MODE
WO2019175897A1 (en) 2018-03-13 2019-09-19 Jubilant Biosys Limited Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE531480C (de) * 1929-07-03 1931-08-10 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Aryliden einer unsymmetrischen o-Xylenolcarbonsaeure
US2808433A (en) 1953-08-21 1957-10-01 Du Pont Benzene dicarboxylic acid derivatives
GB862127A (en) * 1958-07-04 1961-03-01 Ici Ltd Derivatives of 2-hydroxy-3-naphthanilide
US3505433A (en) * 1965-03-08 1970-04-07 Hooker Chemical Corp 2-haloperfluoro-1-cycloalken-1-ylphosphoryl compounds
US3505389A (en) * 1966-08-18 1970-04-07 Hooker Chemical Corp 4-amino-2,3,5,6-tetrachlorobenzoic acid and derivatives thereof
US3505398A (en) 1966-09-22 1970-04-07 Standard Oil Co Terephthalic acid crystallization
US3763234A (en) * 1970-12-03 1973-10-02 Halcon International Inc Preparation of amides
JPS4987761U (el) 1972-11-17 1974-07-30
JPS563375B2 (el) * 1972-12-25 1981-01-24
JPS5720923B2 (el) * 1974-04-02 1982-05-04
US4281000A (en) 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
JPS5665804A (en) * 1979-11-01 1981-06-03 Ishihara Sangyo Kaisha Ltd Control agent against injurious organism
DE3305755A1 (de) 1983-02-19 1984-08-23 Gödecke AG, 1000 Berlin N-phenyl-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkranungen des immunsystems
US4623486A (en) * 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
NZ219974A (en) 1986-04-22 1989-08-29 Goedecke Ag N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases
JP2894804B2 (ja) * 1989-07-19 1999-05-24 武田薬品工業株式会社 ２―アミノ―５―メチルベンゾフェノン類及びその製造法
JPH03130252U (el) 1990-04-11 1991-12-27
FR2664895B1 (fr) * 1990-07-20 1992-10-30 Theramex Laboratoire Nouveaux derives de la 6-methyl 19-nor progesterone, substitues en 3 et leur procede d'obtention.
DE4110483A1 (de) * 1991-03-30 1992-10-01 Bayer Ag Substituierte salicylamide, mittel gegen pflanzenkrankheiten
TW225528B (el) * 1992-04-03 1994-06-21 Ciba Geigy Ag
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
FR2689925B1 (fr) 1992-04-08 1994-05-27 Valeo Securite Habitacle Dispositif de verrouillage d'une serrure dans son support.
US5543520A (en) 1993-10-01 1996-08-06 Ciba-Geigy Corporation Pyrimidine derivatives
DE4428380A1 (de) * 1994-08-11 1996-02-15 Bayer Ag 4-Trifluormethylbenzamide
JPH0987761A (ja) 1995-09-22 1997-03-31 Nikko Kinzoku Kk 銅転炉スラグからの銅の回収方法
JP3130252B2 (ja) 1996-07-12 2001-01-31 小糸工業株式会社 座席のヘッドレスト装置
CA2294990C (en) * 1997-06-30 2007-03-06 William Scott Caldwell Pharmaceutical compositions and methods for effecting dopamine release
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
BR9910474A (pt) * 1998-05-15 2001-01-02 Astrazeneca Ab Composto derivado de amida, processo para preparação do mesmo, composição farmacêutica, e, uso de um composto derivado de amida
ES2211172T3 (es) 1998-09-25 2004-07-01 Astrazeneca Ab Derivados de benzamida y su utilizacion como inhibidores de citoquinas.
GB9824579D0 (en) * 1998-11-10 1999-01-06 Novartis Ag Organic compounds
GB9924092D0 (en) * 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives
GB0202873D0 (en) 2002-02-07 2002-03-27 Novartis Ag Organic compounds
GB2398565A (en) * 2003-02-18 2004-08-25 Cipla Ltd Imatinib preparation and salts
US7338957B2 (en) * 2003-08-28 2008-03-04 Irm Llc Compounds and compositions as protein kinase inhibitors

Also Published As

Publication number Publication date
IL189658A0 (en) 2008-06-05
RU2370493C2 (ru) 2009-10-20
CN100347162C (zh) 2007-11-07
NO20043685L (no) 2004-11-05
US20070293683A1 (en) 2007-12-20
AU2003244444B9 (en) 2003-09-02
JP2010138194A (ja) 2010-06-24
AU2003244444B2 (en) 2007-08-09
ES2384872T3 (es) 2012-07-13
US20090137805A1 (en) 2009-05-28
US20120226039A1 (en) 2012-09-06
CA2737565A1 (en) 2003-08-14
CO5601018A2 (es) 2006-01-31
EP2248807A1 (en) 2010-11-10
RU2007148217A (ru) 2009-07-10
CN1630648A (zh) 2005-06-22
PT2248807E (pt) 2013-09-02
KR101027044B1 (ko) 2011-04-11
US20070293672A1 (en) 2007-12-20
JP2005528340A (ja) 2005-09-22
HK1070893A1 (el) 2005-06-30
ZA200405970B (en) 2006-05-31
JP4653954B2 (ja) 2011-03-16
US7579467B2 (en) 2009-08-25
EP1474408B1 (en) 2012-05-23
US9573928B2 (en) 2017-02-21
NO327366B1 (no) 2009-06-15
SI2248807T1 (sl) 2013-10-30
US7825247B2 (en) 2010-11-02
PT1474408E (pt) 2012-07-25
SI1474408T1 (sl) 2012-07-31
KR20040081154A (ko) 2004-09-20
ECSP045220A (es) 2004-09-28
CA2737565C (en) 2013-04-09
PL209475B1 (pl) 2011-09-30
NZ569731A (en) 2009-11-27
US7456283B2 (en) 2008-11-25
BR0307529A (pt) 2004-12-21
EP2248807B1 (en) 2013-07-03
EP1474408A1 (en) 2004-11-10
GB0202873D0 (en) 2002-03-27
PL371197A1 (en) 2005-06-13
RU2004126941A (ru) 2005-10-10
NZ534315A (en) 2007-06-29
CA2474738C (en) 2011-10-04
DK2248807T3 (da) 2013-08-26
WO2003066613A1 (en) 2003-08-14
US20070293504A1 (en) 2007-12-20
MXPA04007642A (es) 2004-11-10
IL189658A (en) 2011-05-31
IL189657A (en) 2010-12-30
IL163158A (en) 2010-11-30
CA2474738A1 (en) 2003-08-14
IL189657A0 (en) 2008-06-05
US20070293673A1 (en) 2007-12-20
DK1474408T3 (da) 2012-06-25
ECSP095220A (es) 2009-08-28
NO20091976L (no) 2004-11-05
AU2003244444A1 (en) 2003-09-02
ES2425980T3 (es) 2013-10-18
BRPI0307529B1 (pt) 2018-01-30
US20150018552A1 (en) 2015-01-15
SG160195A1 (en) 2010-04-29
CN101016262A (zh) 2007-08-15
NZ554430A (en) 2008-08-29
US7816359B2 (en) 2010-10-19
US20060142580A1 (en) 2006-06-29
CY1114351T1 (el) 2016-08-31
CY1112938T1 (el) 2016-04-13

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