HK1103397A1 - Cinnamide compound - Google Patents
Cinnamide compoundInfo
- Publication number
- HK1103397A1 HK1103397A1 HK07107732.1A HK07107732A HK1103397A1 HK 1103397 A1 HK1103397 A1 HK 1103397A1 HK 07107732 A HK07107732 A HK 07107732A HK 1103397 A1 HK1103397 A1 HK 1103397A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cinnamide compound
- cinnamide
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004155790 | 2004-05-26 | ||
JP2004310909 | 2004-10-26 | ||
PCT/JP2005/009537 WO2005115990A1 (ja) | 2004-05-26 | 2005-05-25 | シンナミド化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1103397A1 true HK1103397A1 (en) | 2007-12-21 |
Family
ID=35450811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK07107732.1A HK1103397A1 (en) | 2004-05-26 | 2007-07-18 | Cinnamide compound |
Country Status (16)
Country | Link |
---|---|
US (4) | US7880009B2 (de) |
EP (2) | EP2261218B1 (de) |
JP (1) | JP4101852B2 (de) |
KR (2) | KR101128065B1 (de) |
CN (1) | CN101723900B (de) |
AU (1) | AU2005247746B2 (de) |
BR (1) | BRPI0511504A (de) |
CA (1) | CA2566094A1 (de) |
HK (1) | HK1103397A1 (de) |
IL (2) | IL179374A (de) |
MX (1) | MXPA06013534A (de) |
MY (1) | MY149038A (de) |
NZ (1) | NZ551144A (de) |
RU (1) | RU2361872C2 (de) |
TW (1) | TWI335816B (de) |
WO (1) | WO2005115990A1 (de) |
Families Citing this family (131)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH072667U (ja) * | 1993-06-11 | 1995-01-13 | 日産ディーゼル工業株式会社 | 車両用多段変速装置 |
DE60234812D1 (de) | 2001-01-29 | 2010-02-04 | Shionogi & Co | Arzneipräparat, das als wirkstoff 5-methyl-1-phenyl-2-(1h)-pyridon enthält |
NZ548212A (en) | 2003-12-29 | 2010-07-30 | Sepracor Inc | Pyrrole and pyrazole DAAO inhibitors |
KR101128065B1 (ko) | 2004-05-26 | 2012-04-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물 |
AU2005297966B2 (en) * | 2004-10-26 | 2010-12-23 | Eisai R & D Management Co., Ltd. | Amorphous object of cinnamide compound |
US20060241038A1 (en) * | 2005-04-20 | 2006-10-26 | Eisai Co., Ltd. | Therapeutic agent for Abeta related disorders |
EP1904066B1 (de) | 2005-07-06 | 2018-05-23 | Sunovion Pharmaceuticals Inc. | KOMBINATIONEN VON ESZOPICLON UND TRANS-4-(3,4-DICHLORPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS-4-(3,4-DICHLORPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALINAMIN ZUR BEHANDLUNG DER MENOPAUSE, Perimenopause UND VON KOGNITIVEN STÖRUNGEN |
EP1932839A4 (de) | 2005-09-06 | 2014-09-10 | Shionogi & Co | Indolcarbonsäurederivat mit antagonistischer wirkung am pgd2-rezeptor |
WO2007058305A1 (ja) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド誘導体の製造方法 |
WO2007058304A1 (ja) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド化合物の塩またはそれらの溶媒和物 |
US20070117839A1 (en) * | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
TWI370130B (en) * | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
NZ568050A (en) * | 2005-11-24 | 2010-09-30 | Eisai R&D Man Co Ltd | Morpholine type cinnamide compound |
JP5225098B2 (ja) * | 2005-12-14 | 2013-07-03 | ブリストル−マイヤーズ スクイブ カンパニー | 第XIa因子インヒビターとしてのアリールプロピオンアミド、アリールアクリルアミド、アリールプロピンアミド、またはアリールメチルウレアアナログ |
DE102005062987A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln |
DE102005062985A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte bis(hetero)aromatische N-Ethylpropiolamide und ihre Verwendung zur Herstellung von Arzneimitteln |
KR101381768B1 (ko) | 2006-01-06 | 2014-04-07 | 선오비온 파마슈티컬스 인코포레이티드 | 테트랄론-기재 모노아민 재흡수 저해제 |
JP5432526B2 (ja) | 2006-01-06 | 2014-03-05 | サノビオン ファーマシューティカルズ インク | モノアミン再取り込み阻害剤としてのシクロアルキルアミン |
TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
AR059955A1 (es) * | 2006-03-09 | 2008-05-14 | Eisai R&D Man Co Ltd | Compuestos policiclicos no peptidicos, medicamentos que los contienen, y usos para prevenir o tratar enfermedades causadas por la produccion de beta amiloide |
AU2007233041B2 (en) | 2006-03-31 | 2013-05-02 | Sepracor Inc. | Preparation of chiral amides and amines |
EP2019093A4 (de) * | 2006-05-19 | 2011-02-23 | Eisai R&D Man Co Ltd | Zimtsäureamidderivat vom harnstofftyp |
EP2019094A4 (de) * | 2006-05-19 | 2011-01-05 | Eisai R&D Man Co Ltd | Zimtsäureamidderivat vom heterocyclischen typ |
JP2009184924A (ja) * | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
SA07280403B1 (ar) | 2006-07-28 | 2010-12-01 | إيساي أر أند دي منجمنت كو. ليمتد | ملح رباعي لمركب سيناميد |
JP2008044880A (ja) | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | 殺虫性イソオキサゾリン類 |
US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
AU2008214372A1 (en) * | 2007-02-08 | 2008-08-14 | Merck Sharp & Dohme Corp. | Therapeutic agents |
DE102007009810A1 (de) * | 2007-02-28 | 2008-09-04 | Man Roland Druckmaschinen Ag | Übertragungsform für einen Übertragungszylinder einer Druckmaschine |
TW200848054A (en) * | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
JP2010524844A (ja) * | 2007-04-26 | 2010-07-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 認知症のためのシンナミド化合物 |
RU2009144998A (ru) * | 2007-05-07 | 2011-06-20 | Шеринг Корпорейшн (US) | Модуляторы гамма-секретазы |
BRPI0811993A2 (pt) | 2007-05-11 | 2014-11-18 | Hoffmann La Roche | " hetarilanilinas como moduladores para beta-amiloide ". |
JPWO2008140111A1 (ja) | 2007-05-16 | 2010-08-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シンナミド誘導体のワンポット製造方法 |
NZ580429A (en) | 2007-05-31 | 2012-04-27 | Sepracor Inc | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
MX2009013131A (es) * | 2007-06-01 | 2010-01-15 | Schering Corp | Moduladores de gamma secretasa. |
EP2164852A2 (de) * | 2007-06-01 | 2010-03-24 | Schering Corporation | Gammasekretasemodulatoren |
EP2166854A4 (de) * | 2007-06-13 | 2012-05-16 | Merck Sharp & Dohme | Triazolderivate zur behandlung von morbus alzheimer und verwandten leiden |
WO2009005729A1 (en) * | 2007-06-29 | 2009-01-08 | Schering Corporation | Gamma secretase modulators |
JP2010535762A (ja) * | 2007-08-06 | 2010-11-25 | シェーリング コーポレイション | ガンマセクレターゼモジュレーター |
MX2010002098A (es) | 2007-08-31 | 2010-03-30 | Eisai R&D Man Co Ltd | Compuesto policiclico. |
US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
CA2698341A1 (en) * | 2007-09-06 | 2009-03-12 | Schering Corporation | Gamma secretase modulators |
WO2009045314A1 (en) * | 2007-09-28 | 2009-04-09 | Schering Corporation | Gamma secretase modulators |
JP2011503002A (ja) | 2007-11-05 | 2011-01-27 | シェーリング コーポレイション | γセクレターゼ調節剤 |
WO2009067493A2 (en) * | 2007-11-19 | 2009-05-28 | Envivo Pharmaceuticals, Inc. | 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders |
KR20100094554A (ko) * | 2007-12-06 | 2010-08-26 | 쉐링 코포레이션 | 감마 세크레타제 조절인자 |
JP2011506336A (ja) * | 2007-12-06 | 2011-03-03 | シェーリング コーポレイション | γ−セクレターゼ調節剤 |
CN101970433A (zh) * | 2007-12-11 | 2011-02-09 | 先灵公司 | γ分泌酶调节剂 |
WO2009076352A1 (en) * | 2007-12-11 | 2009-06-18 | Schering Corporation | Gamma secretase modulators |
JP2011507909A (ja) | 2007-12-20 | 2011-03-10 | エンビボ ファーマシューティカルズ インコーポレイテッド | 四置換ベンゼン |
KR101204213B1 (ko) * | 2007-12-21 | 2012-11-26 | 에프. 호프만-라 로슈 아게 | 오렉신 수용체 길항제로서의 헤테로아릴 유도체 |
KR101244517B1 (ko) * | 2008-01-11 | 2013-03-18 | 에프. 호프만-라 로슈 아게 | 아밀로이드 베타에 대한 조절제 |
CA2712095A1 (en) * | 2008-01-28 | 2009-08-06 | Eisai R&D Management Co., Ltd. | Crystalline cinnamide compounds or salts thereof |
CA2713716A1 (en) | 2008-02-22 | 2009-08-27 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
JP5451646B2 (ja) * | 2008-02-27 | 2014-03-26 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1型の阻害剤 |
CA2716747A1 (en) * | 2008-02-29 | 2009-09-03 | Schering Corporation | Gamma secretase modulators for the treatment of alzheimer's disease |
WO2010040661A1 (en) * | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
BRPI0921317A2 (pt) * | 2008-11-06 | 2017-06-06 | Astrazeneca Ab | composto, composição farmacêutica, e, método para tratar ou prevenir uma patologia relacionada com abeta em um mamífero |
US20120129846A1 (en) * | 2008-11-06 | 2012-05-24 | Zhaoning Zhu | Gamma secretase modulators |
KR101293421B1 (ko) | 2008-11-10 | 2013-08-05 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 감마 분비효소 조절제 |
AU2009314205A1 (en) | 2008-11-13 | 2010-05-20 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
AU2009314049B2 (en) | 2008-11-13 | 2015-03-05 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
US8575150B2 (en) | 2008-12-16 | 2013-11-05 | Merck Sharp & Dohme Corp. | Triazole derivatives for treatment of Alzheimer's disease |
PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
AU2009330234A1 (en) | 2008-12-22 | 2011-07-07 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
JP2012513399A (ja) | 2008-12-22 | 2012-06-14 | シェーリング コーポレイション | γ−セクレターゼ調節剤 |
AP2011005779A0 (en) | 2009-02-06 | 2011-08-31 | Ortho Mcneil Janssen Pharm | Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators. |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
CN102333777B (zh) | 2009-02-26 | 2014-06-25 | 卫材R&D管理有限公司 | 含氮的稠合杂环化合物及其作为β淀粉样蛋白生成抑制剂的用途 |
US8703954B2 (en) | 2009-02-26 | 2014-04-22 | Eisai R&D Management Co., Ltd. | Salt of tetrahydrotriazolopyridine derivative and crystal thereof |
NZ596843A (en) | 2009-05-07 | 2012-12-21 | Janssen Pharmaceuticals Inc | Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators |
UY32622A (es) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
EP2443118A1 (de) | 2009-06-16 | 2012-04-25 | Schering Corporation | Gammasekretasemodulatoren |
US20120245158A1 (en) | 2009-06-16 | 2012-09-27 | Xianhai Huang | Gamma secretase modulators |
EP2443121A2 (de) | 2009-06-16 | 2012-04-25 | Schering Corporation | Gammasekretasemodulatoren |
WO2011007756A1 (ja) | 2009-07-13 | 2011-01-20 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
EP2454239B1 (de) | 2009-07-15 | 2014-08-13 | Janssen Pharmaceuticals Inc. | Substituierte triazol- bzw. imidazol-derivate zur verwendung als modulatoren von gammasekretase |
JPWO2011007819A1 (ja) | 2009-07-17 | 2012-12-27 | 塩野義製薬株式会社 | ラクタムまたはベンゼンスルホンアミド化合物を含有する医薬 |
JP2012176901A (ja) | 2009-09-25 | 2012-09-13 | Eisai R & D Management Co Ltd | 新規ベンゾニトリル化合物およびその製造方法 |
BR112012017310A2 (pt) | 2010-01-15 | 2016-04-19 | Janssen Pharmaceuticals Inc | derivados de triazol substituídos como moduladores de gama secretase |
US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
JP2013522321A (ja) * | 2010-03-19 | 2013-06-13 | パーデュー・リサーチ・ファウンデーション | Hivを治療するためのccr5モジュレーター |
US10570113B2 (en) * | 2010-04-09 | 2020-02-25 | Semiconductor Energy Laboratory Co., Ltd. | Aromatic amine derivative, light-emitting element, light-emitting device, electronic device, and lighting device |
JPWO2011158833A1 (ja) * | 2010-06-15 | 2013-08-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Hcv感染症治療剤 |
EP2611805A1 (de) | 2010-09-02 | 2013-07-10 | Takeda Pharmaceutical Company Limited | Kondensierte triazole zur behandlung oder prophylaxe von leichten kognitiven störungen |
KR20140047032A (ko) | 2011-03-24 | 2014-04-21 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조정제로서의 신규 치환 트리아졸릴 피페라진 및 트리아졸릴 피페리딘 유도체 |
JP6130827B2 (ja) | 2011-05-17 | 2017-05-17 | 塩野義製薬株式会社 | ヘテロ環化合物 |
JP2014518223A (ja) * | 2011-06-20 | 2014-07-28 | アルツハイマーズ・インスティテュート・オブ・アメリカ・インコーポレイテッド | 化合物とその治療用途 |
IN2014MN00258A (de) | 2011-07-15 | 2015-09-25 | Janssen Pharmaceuticals Inc | |
US9428490B2 (en) * | 2011-07-29 | 2016-08-30 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
EP2736887B1 (de) | 2011-07-29 | 2017-10-18 | Karyopharm Therapeutics, Inc. | Hydrazidhaltige kerntransportmodulatoren und verwendungen davon |
US9346740B2 (en) | 2011-08-31 | 2016-05-24 | Showa Denko K.K. | Production method for 2-alkenylamine compound |
WO2013031839A1 (ja) | 2011-08-31 | 2013-03-07 | 昭和電工株式会社 | 2-アルケニルアミン化合物の製造方法 |
AU2013202978B2 (en) | 2012-01-25 | 2016-05-19 | Novartis Ag | Heterocyclic compounds and methods for their use |
US9096543B2 (en) | 2012-05-09 | 2015-08-04 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
AU2013261023B2 (en) | 2012-05-16 | 2016-11-24 | Cellzome Limited | Substituted 3, 4 - dihydro - 2H - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) Alzheimer's disease |
CA2889249C (en) | 2012-12-20 | 2021-02-16 | Francois Paul Bischoff | Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators |
EP2945944B1 (de) | 2013-01-17 | 2016-11-09 | Janssen Pharmaceutica, N.V. | Neuartige substituierte pyrido-piperazinon-derivate als gamma-sekretase-modulatoren |
US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
BR112015023560A8 (pt) * | 2013-03-15 | 2017-12-26 | Actelion Pharmaceuticals Ltd | Novos derivados de acrilamida como agentes antimaláricos |
NO3004079T3 (de) | 2013-06-04 | 2018-06-16 | ||
WO2014195321A1 (en) | 2013-06-04 | 2014-12-11 | Acturum Life Science AB | Triazole compounds and their use as gamma secretase modulators |
CN105263922B (zh) | 2013-06-04 | 2018-08-17 | 阿克图拉姆生命科学股份公司 | 三唑化合物及其作为γ分泌酶调节剂的用途 |
EP3010892B8 (de) | 2013-06-21 | 2019-05-22 | Karyopharm Therapeutics Inc. | 1,2,4-triazole als nukleartransportmodulatoren und verwendungen davon |
WO2015042414A1 (en) * | 2013-09-20 | 2015-03-26 | Karyopharm Therapeutics Inc. | Multicyclic compounds and methods of using same |
WO2015109109A1 (en) | 2014-01-15 | 2015-07-23 | Forum Pharmaceuticals Inc. | Fused morpholinopyrimidines and methods of use thereof |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
EP3708170A1 (de) | 2014-05-05 | 2020-09-16 | BioVentures, LLC | Zusammensetzungen und verfahren zur hemmung von antiapoptotischen bcl-2-proteinen als anti-aging mittel |
AU2015292710A1 (en) * | 2014-07-22 | 2017-02-16 | Bioventures, Llc. | Compositions and methods for selectively depleting senescent cells |
CN111484483B (zh) | 2014-08-15 | 2023-05-26 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
WO2016149099A1 (en) | 2015-03-13 | 2016-09-22 | Forma Therapeutics, Inc. | Alpha-cinnamide compounds and compositions as hdac8 inhibitors |
US9802927B2 (en) | 2015-06-10 | 2017-10-31 | Denali Therapeutics, Inc. | Oxadiazine compounds and methods of use thereof |
EP3337797A1 (de) | 2015-08-18 | 2018-06-27 | Karyopharm Therapeutics, Inc. | (s,e) -3-(6-aminopyridin-3-yl ) -n-((5-(4-(3-fluor-3-methylpyrrolidin-1-carbonyl) ) phenyl) -7-(4-fluorphenyl) benzofuran-2-yl) methyl) acrylamid zur behandlung von krebs |
EP3398952B1 (de) * | 2015-12-31 | 2021-07-14 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Syntheseverfahren für ruxolitinib |
WO2017117529A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
US10709706B2 (en) | 2015-12-31 | 2020-07-14 | Karopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
WO2017117447A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Multicyclic compounds and uses thereof |
CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
CN105837497B (zh) * | 2016-04-01 | 2018-05-22 | 南阳师范学院 | 4-氨基甲酸酯-3-甲氧基肉桂酸环胺烷基酰胺类化合物、制备方法及其用途 |
JP6936498B2 (ja) | 2016-04-21 | 2021-09-15 | バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーBioVentures, LLC | 抗アポトーシス性Bcl−2ファミリータンパク質の分解を誘導する化合物及びその使用 |
US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
PL3552017T3 (pl) * | 2016-12-09 | 2022-08-08 | Denali Therapeutics Inc. | Związki użyteczne jako inhibitory RIPK1 |
CN106749188B (zh) * | 2017-01-23 | 2019-06-18 | 南阳师范学院 | 一种n-(苄基哌啶基)-阿魏酰胺-o-烷基胺类化合物、制备方法及其用途 |
CN106831574B (zh) * | 2017-01-23 | 2019-07-12 | 南阳师范学院 | N-(1,2,3,4-四氢异喹啉基)-阿魏酰胺-o-烷基胺类化合物和应用 |
US11485725B2 (en) | 2017-12-15 | 2022-11-01 | Auransa Inc. | Derivatives of piperlongumine and uses thereof |
CN110143893B (zh) * | 2018-02-14 | 2022-11-08 | 复旦大学 | 一种能强结合α-突触核蛋白聚集体的化合物、其制备方法及其用途 |
CN114945569A (zh) * | 2019-12-26 | 2022-08-26 | 延世大学校产学协力团 | 吡咯烷衍生物,以及包含其的用于预防或治疗β-淀粉样蛋白或Tau蛋白相关疾病的药物组合物 |
TW202342425A (zh) | 2022-02-28 | 2023-11-01 | 日商安斯泰來製藥股份有限公司 | 芳基炔醯胺衍生物 |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1101156A (en) * | 1965-09-22 | 1968-01-31 | Hickson & Welch Ltd | Triazole derivatives and their use as optical whitening agents |
US3989816A (en) * | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
FR2314731A1 (fr) | 1975-06-19 | 1977-01-14 | Nelson Res & Dev | Azacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients |
DE3689506D1 (de) | 1985-10-09 | 1994-02-17 | Shell Int Research | Neue Acrylsäureamide. |
US4783463A (en) * | 1985-10-23 | 1988-11-08 | Rorer Pharmaceutical Corporation | Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure |
DE3541716A1 (de) | 1985-11-26 | 1987-05-27 | Celamerck Gmbh & Co Kg | Neue acrylsaeureamide |
FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
IT1205834B (it) * | 1987-04-22 | 1989-03-31 | Elbart | Derivati tiodiossolanici ad attivita' mucolitica a procedimento per la loro preparazione |
FI902321A0 (fi) * | 1989-05-19 | 1990-05-09 | Eisai Co Ltd | Butensyraderivat. |
JPH03206042A (ja) | 1990-01-06 | 1991-09-09 | Takeda Chem Ind Ltd | 降圧剤 |
EP0468054B1 (de) * | 1990-02-08 | 1997-05-28 | Eisai Co., Ltd. | Benzensulfonamidderivat |
AU680870B2 (en) | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
GB9402807D0 (en) | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
WO1996010559A1 (en) | 1994-10-04 | 1996-04-11 | Fujisawa Pharmaceutical Co., Ltd. | Urea derivatives and their use as acat-inhibitors |
JPH08283219A (ja) * | 1995-04-07 | 1996-10-29 | Eisai Co Ltd | アラルキルアミノアルキルアミド誘導体 |
US5804577A (en) | 1995-09-12 | 1998-09-08 | Hoffmann-La Roche Inc. | Cephalosporin derivatives |
JPH11513686A (ja) | 1995-10-19 | 1999-11-24 | メルク エンド カンパニー インコーポレーテッド | 線維素原受容体拮抗薬 |
JP3418405B2 (ja) * | 1996-05-10 | 2003-06-23 | アイコス コーポレイション | カルボリン誘導体 |
EP0939629A4 (de) | 1996-07-22 | 2002-07-17 | Monsanto Co | Thiol-sulfonamide als metalloproteinaseinhibitoren |
WO1998024785A1 (en) | 1996-12-02 | 1998-06-11 | Fujisawa Pharmaceutical Co., Ltd. | Indole-urea derivatives with 5-ht antagonist properties |
WO1998043970A1 (en) | 1997-03-31 | 1998-10-08 | Takeda Chemical Industries, Ltd. | Azole compounds, their production and their use |
JP3108997B2 (ja) | 1997-03-31 | 2000-11-13 | 武田薬品工業株式会社 | アゾール化合物、その製造法および用途 |
WO1999033846A2 (en) * | 1997-12-31 | 1999-07-08 | The University Of Kansas | Water soluble prodrugs of secondary and tertiary amine containing drugs and methods of making thereof |
GB9816984D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Plc | Novel compounds |
US6235728B1 (en) * | 1999-02-19 | 2001-05-22 | Bristol-Myers Squibb Company | Water-soluble prodrugs of azole compounds |
AU773273B2 (en) | 1999-02-26 | 2004-05-20 | Bristol-Myers Squibb Company | Novel sulfonamide compounds and uses thereof |
AU2899400A (en) | 1999-03-04 | 2000-09-21 | Nortran Pharmaceuticals Inc. | Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics |
WO2001068585A1 (fr) | 2000-03-14 | 2001-09-20 | Fujisawa Pharmaceutical Co., Ltd. | Nouveaux composes amides |
US20010051642A1 (en) * | 2000-04-17 | 2001-12-13 | Kyunghye Ahn | Method for treating Alzheimer's disease |
JP2003531194A (ja) | 2000-04-24 | 2003-10-21 | メルク フロスト カナダ アンド カンパニー | プロスタグランジンe阻害薬としてフェニルおよびビアリール誘導体を用いる治療方法および該方法に有用な化合物 |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
CN1257894C (zh) | 2000-12-04 | 2006-05-31 | 弗·哈夫曼-拉罗切有限公司 | 作为谷氨酸受体拮抗剂的苯基乙烯基或苯基乙炔基衍生物 |
GB0108770D0 (en) | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
WO2003027081A2 (en) | 2001-09-14 | 2003-04-03 | Novo Nordisk A/S | NOVEL LIGANDS FOR THE HisB10 Zn2+ SITES OF THE R-STATE INSULIN HEXAMER |
HUP0500027A2 (hu) * | 2001-11-22 | 2005-04-28 | Ono Pharmaceutical Co., Ltd. | Piperidin-2-on-származékok és hatóanyagként ezeket tartalmazó gyógyászati készítmények |
PL373484A1 (en) | 2001-12-10 | 2005-09-05 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
MXPA04005927A (es) * | 2001-12-20 | 2004-11-01 | Squibb Bristol Myers Co | Derivados de alfa-(n-sulfonamido)acetamida como inhibidores del peptido beta-amiloideo. |
JP2003206280A (ja) | 2001-12-28 | 2003-07-22 | Takeda Chem Ind Ltd | ビアリール化合物およびその用途 |
GB0207436D0 (en) | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
MXPA04011472A (es) | 2002-05-22 | 2005-02-14 | Amgen Inc | Derivados de amino-piridina, piridina y piridazina para usarse como ligandos del receptor vaniloide para el tratamiento del dolor. |
JP4568603B2 (ja) * | 2002-05-31 | 2010-10-27 | プロテオテック・インコーポレイテッド | アミロイド疾患およびシヌクレイノパチー(例えばアルツハイマー病、タイプ2型糖尿病、およびパーキンソン病)を処置するための化合物、組成物、および方法 |
BR0312697A (pt) * | 2002-07-12 | 2005-04-26 | Aventis Pharma Gmbh | Benzoiluréias substituìdas heterociclicamente, processo para a sua preparação e sua aplicação como medicamento |
US6900354B2 (en) | 2002-07-15 | 2005-05-31 | Hoffman-La Roche Inc. | 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives |
CN1747936A (zh) | 2003-02-12 | 2006-03-15 | 特兰斯泰克制药公司 | 作为治疗试剂的取代吡咯衍生物 |
AU2004247013B2 (en) | 2003-05-14 | 2010-07-08 | Neurogenetic Pharmaceuticals, Inc. | Compounds and uses thereof in modulating amyloid beta |
EP1663204B1 (de) | 2003-08-29 | 2014-05-07 | Exelixis, Inc. | C-kit-modulatoren und anwendungsverfahren |
AU2004309164B2 (en) | 2003-12-22 | 2007-11-15 | Pfizer Inc. | Triazole derivatives as vasopressin antagonists |
WO2005072731A1 (en) * | 2004-01-29 | 2005-08-11 | X-Ceptor Therapeutics, Inc. | 3-phenyl-n- ((1, 3, 4) thiadiazol-2-yl) -acrylamide derivatives and related compounds as modulators of estrogen-related receptors for the treatment of e.g. cancer, rheumatoid arthritis or neurological disorders |
NZ548208A (en) * | 2004-02-12 | 2010-09-30 | Transtech Pharma Inc | Substituted azole derivatives, compositions, and methods of use |
WO2005087767A1 (en) | 2004-03-09 | 2005-09-22 | Merck & Co., Inc. | Hiv integrase inhibitors |
KR101128065B1 (ko) | 2004-05-26 | 2012-04-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물 |
AU2005297966B2 (en) | 2004-10-26 | 2010-12-23 | Eisai R & D Management Co., Ltd. | Amorphous object of cinnamide compound |
US20060241038A1 (en) * | 2005-04-20 | 2006-10-26 | Eisai Co., Ltd. | Therapeutic agent for Abeta related disorders |
AU2006290803B2 (en) * | 2005-09-15 | 2009-11-26 | F. Hoffmann-La Roche Ag | Novel heterobicyclic derivatives useful as inhibitors of liver carnitine palmitoyl transferase |
WO2007034282A2 (en) | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists |
WO2007058304A1 (ja) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド化合物の塩またはそれらの溶媒和物 |
WO2007058305A1 (ja) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド誘導体の製造方法 |
TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
NZ568050A (en) * | 2005-11-24 | 2010-09-30 | Eisai R&D Man Co Ltd | Morpholine type cinnamide compound |
US20070117839A1 (en) | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
TWI378091B (en) * | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
AR059955A1 (es) | 2006-03-09 | 2008-05-14 | Eisai R&D Man Co Ltd | Compuestos policiclicos no peptidicos, medicamentos que los contienen, y usos para prevenir o tratar enfermedades causadas por la produccion de beta amiloide |
SA07280403B1 (ar) | 2006-07-28 | 2010-12-01 | إيساي أر أند دي منجمنت كو. ليمتد | ملح رباعي لمركب سيناميد |
AU2008214372A1 (en) | 2007-02-08 | 2008-08-14 | Merck Sharp & Dohme Corp. | Therapeutic agents |
TW200848054A (en) * | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
RU2009144998A (ru) | 2007-05-07 | 2011-06-20 | Шеринг Корпорейшн (US) | Модуляторы гамма-секретазы |
BRPI0811993A2 (pt) | 2007-05-11 | 2014-11-18 | Hoffmann La Roche | " hetarilanilinas como moduladores para beta-amiloide ". |
EP2166854A4 (de) | 2007-06-13 | 2012-05-16 | Merck Sharp & Dohme | Triazolderivate zur behandlung von morbus alzheimer und verwandten leiden |
JP2010535762A (ja) | 2007-08-06 | 2010-11-25 | シェーリング コーポレイション | ガンマセクレターゼモジュレーター |
US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
US8703954B2 (en) * | 2009-02-26 | 2014-04-22 | Eisai R&D Management Co., Ltd. | Salt of tetrahydrotriazolopyridine derivative and crystal thereof |
US9737703B2 (en) * | 2009-07-10 | 2017-08-22 | Boston Scientific Neuromodulation Corporation | Method to enhance afferent and efferent transmission using noise resonance |
-
2005
- 2005-05-25 KR KR1020097017043A patent/KR101128065B1/ko not_active IP Right Cessation
- 2005-05-25 MX MXPA06013534A patent/MXPA06013534A/es active IP Right Grant
- 2005-05-25 WO PCT/JP2005/009537 patent/WO2005115990A1/ja active Application Filing
- 2005-05-25 TW TW094117034A patent/TWI335816B/zh not_active IP Right Cessation
- 2005-05-25 JP JP2006513906A patent/JP4101852B2/ja not_active Expired - Fee Related
- 2005-05-25 US US11/596,723 patent/US7880009B2/en not_active Expired - Fee Related
- 2005-05-25 AU AU2005247746A patent/AU2005247746B2/en not_active Ceased
- 2005-05-25 KR KR1020067027247A patent/KR100966749B1/ko not_active IP Right Cessation
- 2005-05-25 CA CA002566094A patent/CA2566094A1/en not_active Abandoned
- 2005-05-25 US US11/136,355 patent/US7667041B2/en not_active Expired - Fee Related
- 2005-05-25 BR BRPI0511504-3A patent/BRPI0511504A/pt not_active IP Right Cessation
- 2005-05-25 EP EP10177579A patent/EP2261218B1/de not_active Not-in-force
- 2005-05-25 CN CN2009102227339A patent/CN101723900B/zh not_active Expired - Fee Related
- 2005-05-25 MY MYPI20052354A patent/MY149038A/en unknown
- 2005-05-25 RU RU2006146070/04A patent/RU2361872C2/ru not_active IP Right Cessation
- 2005-05-25 NZ NZ551144A patent/NZ551144A/en not_active IP Right Cessation
- 2005-05-25 EP EP05743758A patent/EP1757591A4/de not_active Withdrawn
-
2006
- 2006-11-16 IL IL179374A patent/IL179374A/en not_active IP Right Cessation
-
2007
- 2007-07-18 HK HK07107732.1A patent/HK1103397A1/xx not_active IP Right Cessation
-
2009
- 2009-07-02 US US12/497,251 patent/US7687640B2/en not_active Expired - Fee Related
-
2010
- 2010-05-31 IL IL206109A patent/IL206109A/en not_active IP Right Cessation
- 2010-12-21 US US12/974,447 patent/US20110086860A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL206109A (en) | Cinnamide compound | |
HK1122806A1 (en) | Bicyclic cinnamide compound | |
IL181732A0 (en) | 2-morpholino-4-pyrimidone compound | |
EP1737831A4 (de) | Neurologisch aktive verbindungen | |
GB0415663D0 (en) | Compound | |
EP1755617A4 (de) | Perfluorcarbon-lösliche verbindungen | |
ZA200609845B (en) | Cinnamide compound | |
GB0408771D0 (en) | Compound | |
GB0421106D0 (en) | Compound | |
GB0401269D0 (en) | Compounds | |
GB0425969D0 (en) | Compound | |
GB0411562D0 (en) | Compound | |
ZA200804446B (en) | Bicyclic cinnamide compound | |
GB0403593D0 (en) | Compounds | |
GB0428295D0 (en) | Compound | |
GB0403595D0 (en) | Compounds | |
GB0413763D0 (en) | Novel compound | |
GB0413367D0 (en) | Novel compound | |
GB0413757D0 (en) | Novel compound | |
GB0413764D0 (en) | Novel compound | |
GB0413765D0 (en) | Novel compound | |
GB0413766D0 (en) | Novel compound | |
GB0413768D0 (en) | Novel compound | |
GB0413769D0 (en) | Novel compound | |
GB0413770D0 (en) | Novel compound |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20170525 |